Abstract:
OBJECTIVE:To examine outcomes associated with colesevelam treatment among patients with hypercholesterolemia in real-world clinical practice. METHODS:This analysis was conducted as a retrospective, observational cohort study in an ambulatory-care medical network in Northern California. Patients with orders for colesevelam were identified in the electronic health record between January 2004 and December 2011. The date of the first order during the study period was designated the index date. Patients were evaluated for the following eligibility criteria: a diagnosis of hypercholesterolemia, ≥18 years of age at index date, baseline laboratory values ≤3 months before the index date, ≥12 months of treatment and follow-up, and no prior orders for colesevelam ≤12 months before the index date. Patients who were pregnant during the study period were excluded. Changes in LDL-C and percentage of patients at LDL-C goal were examined. Among patients with diabetes mellitus (DM), changes in glycated hemoglobin (HBA1C) and percentage of patients at HBA1C goal were also examined. RESULTS:Overall, 468 and 181 patients with hypercholesterolemia met the predefined inclusion criteria with treatment and follow-up through 12 and 24 months, respectively. LDL-C decreased significantly from baseline by a mean of 11.4 mg/dL and 15.7 mg/dL (P < 0.0001, for each) at 12 and 24 months, respectively, and the percentages of patients at LDL-C goal increased by 13.9% and 21.0%. Among patients with DM and a baseline HBA1C ≥8%, 113 and 39 had treatment and follow-up through 12 and 24 months, respectively. HBA1C decreased significantly by a mean of 0.72% (P = 0.0001) and 0.75% (P = 0.010) and 11.5% and 12.8% were at HBA1C goal at 12 and 24 months, respectively. This study is limited by its retrospective and observational study design. CONCLUSIONS:Colesevelam treatment in a real-world setting was associated with improvements in LDL-C and HBA1C through 24 months of follow-up.
journal_name
Curr Med Res Opinjournal_title
Current medical research and opinionauthors
Romanelli RJ,Leahy A,Jukes T,Ye X,Qian C,Ishisaka DYdoi
10.1185/03007995.2013.842162subject
Has Abstractpub_date
2013-12-01 00:00:00pages
1747-56issue
12eissn
0300-7995issn
1473-4877journal_volume
29pub_type
临床试验,杂志文章,多中心研究abstract:BACKGROUND:Patients with chronic myeloid leukemia (CML) who do not adhere to treatment may experience suboptimal outcomes. OBJECTIVE:To examine the association between adherence with imatinib and direct healthcare costs and resource utilization in a large group of privately insured CML patients. PATIENTS AND METHODS:...
journal_title:Current medical research and opinion
pub_type: 杂志文章
doi:10.1185/03007990903396469
更新日期:2010-01-01 00:00:00
abstract::A double-blind trial was carried out in 60 elderly patients with osteoarthritis of the knee or hip to compare the efficacy and tolerability of treatment with tiaprofenic acid and indomethacin. Patients received either 600 mg tiaprofenic acid or 100 mg indomethacin daily for 3 months. The results of assessments made ev...
journal_title:Current medical research and opinion
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1185/03007998309112387
更新日期:1983-01-01 00:00:00
abstract:BACKGROUND:Calcipotriol 50 µg/g and betamethasone 0.5 mg/g dipropionate (Cal/BD) aerosol foam formulation provides greater effectiveness and improved patient preference compared with traditional Cal/BD formulations for the topical treatment of plaque psoriasis. OBJECTIVE:To determine the cost-effectiveness of Cal/BD f...
journal_title:Current medical research and opinion
pub_type: 杂志文章
doi:10.1080/03007995.2018.1428542
更新日期:2018-07-01 00:00:00
abstract::Cardiac arrhythmias are the most common cardiac complication reported in pregnant women with and without structural heart disease (SHD); they are more frequent among women with SHD, such as cardiomyopathy and congenital heart disease (CHD). While older studies had indicated supraventricular tachycardia as the most com...
journal_title:Current medical research and opinion
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journal_title:Current medical research and opinion
pub_type: 杂志文章
doi:10.1080/03007995.2020.1832455
更新日期:2020-12-01 00:00:00
abstract:BACKGROUND:A double-blind randomized trial evaluated the efficacy and tolerability of rivastigmine and donepezil in patients with Alzheimer's disease (AD) over 2 years. Baseline data indicated that some patients had symptoms suggestive of concomitant Lewy body disease. This retrospective analysis investigated whether A...
journal_title:Current medical research and opinion
pub_type: 杂志文章,多中心研究
doi:10.1185/030079906x80279
更新日期:2006-01-01 00:00:00
abstract:OBJECTIVE:Patients receiving levodopa for Parkinson's disease experience motor fluctuations and immobility ('off' episodes) between doses. This study assessed adjunctive Zelapar (selegiline orally disintegrating tablet (ODT)) for managing off episodes and for long-term safety. METHODS:This open-label extension evaluat...
journal_title:Current medical research and opinion
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1185/030079906x167697
更新日期:2007-04-01 00:00:00
abstract:OBJECTIVES:Due to the high cost of nonvalvular atrial fibrillation (NVAF), this condition may be a suitable candidate for condition-specific bundled payments. This paper evaluates the healthcare cost of NVAF and uses common bleeding and stroke risk scores (HAS-BLED and CHA2DS2-VASc) to explore the risk-based healthcare...
journal_title:Current medical research and opinion
pub_type: 杂志文章
doi:10.1080/03007995.2017.1409200
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abstract:OBJECTIVES:In ST-segment elevation myocardial infarction (STEMI), current guidelines discourage treatment of the non-culprit lesions at the time of the primary intervention. Latest trials have challenged this strategy suggesting benefit of early complete revascularization. We performed a Bayesian multiple treatment net...
journal_title:Current medical research and opinion
pub_type: 杂志文章
doi:10.1080/03007995.2016.1260534
更新日期:2017-03-01 00:00:00
abstract::In an electropharmacokinetic study, the effects of lormetazepam and flunitrazepam were compared by the means of a sleep EEG and waking EEG during the following daytime. At a 1-week interval, 6 normal subjects received at random either 2 mg lormetazepam or 2 mg flunitrazepam in a double-blind, crossover fashion. Sleep ...
journal_title:Current medical research and opinion
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1185/03007998509109634
更新日期:1985-01-01 00:00:00
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journal_title:Current medical research and opinion
pub_type: 杂志文章,评审
doi:10.1185/03007990802597456
更新日期:2009-01-01 00:00:00
abstract::Doxofylline (7-(1,3-dioxalan-2-ylmethyl) theophylline) is a novel xanthine bronchodilator which differs from theophylline in that it contains a dioxalane group in position 7. Similarly to theophylline, its mechanism of action is related to the inhibition of phosphodiesterase activities, but in contrast it appears to h...
journal_title:Current medical research and opinion
pub_type: 杂志文章,评审
doi:10.1185/030079901750120196
更新日期:2001-01-01 00:00:00
abstract:BACKGROUND:Basal cell carcinoma (BCC) is the most common cancer. Most cases of BCCs are treated with only optimal surgical resection. However, unresectable, locally advanced or metastatic tumors might have potential to progress. In this patient group, there is no standardized treatment approach. Vismodegib is a new sel...
journal_title:Current medical research and opinion
pub_type: 杂志文章,评审
doi:10.1185/03007995.2015.1018988
更新日期:2015-04-01 00:00:00
abstract:BACKGROUND:This survey assessed the impact of symptoms of COPD on patients' ability to perform activities throughout the day and the extent to which physicians provided advice including how medications may help maintain quality of life. METHODS:The survey had three inclusion criteria--physician's diagnosis of COPD, ag...
journal_title:Current medical research and opinion
pub_type: 杂志文章
doi:10.1185/03007995.2013.857648
更新日期:2014-02-01 00:00:00
abstract:BACKGROUND:Insulin resistance alone does not result in the development of type 2 diabetes; progressive dysfunction of pancreatic islet alpha and beta cells, which results in inadequate control of hyperglycemia, must be present for the disease to develop. Because of these defects, meal-stimulated insulin secretion from ...
journal_title:Current medical research and opinion
pub_type: 杂志文章,评审
doi:10.1185/030079906x167336
更新日期:2007-04-01 00:00:00
abstract:OBJECTIVE:To investigate the associations between obesity and any significant improvements in glycemic control, blood pressure, and lipid targets in Chinese patients with concomitant type 2 diabetes mellitus (T2DM) and hypertension. METHODS AND RESULTS:A total of 3041 dyslipidemia patients with an average age of 65.7 ...
journal_title:Current medical research and opinion
pub_type: 杂志文章
doi:10.1185/03007995.2015.1058770
更新日期:2015-01-01 00:00:00
abstract:OBJECTIVE:The prevalence of non-steroidal anti-inflammatory drug (NSAID) and concurrent gastroprotective agent (GPA) use in the US is not known. As such, the prevalence of GPA use among arthritis patients taking NSAIDs was examined. METHODS:Men and women aged ≥ 40 with self-reported arthritis and members of a web-base...
journal_title:Current medical research and opinion
pub_type: 临床试验,杂志文章
doi:10.1185/03007995.2013.781017
更新日期:2013-05-01 00:00:00
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journal_title:Current medical research and opinion
pub_type: 杂志文章
doi:10.1080/03007995.2018.1497957
更新日期:2018-11-01 00:00:00
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journal_title:Current medical research and opinion
pub_type: 杂志文章
doi:10.1185/03007997609109292
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journal_title:Current medical research and opinion
pub_type: 评论,杂志文章
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journal_title:Current medical research and opinion
pub_type: 杂志文章
doi:10.1185/03007997409114769
更新日期:1974-01-01 00:00:00
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journal_title:Current medical research and opinion
pub_type: 杂志文章,评审
doi:10.1185/03007995.2010.548374
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journal_title:Current medical research and opinion
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doi:10.1080/03007995.2019.1698416
更新日期:2020-03-01 00:00:00
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journal_title:Current medical research and opinion
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1185/03007998209109774
更新日期:1982-01-01 00:00:00
abstract:BACKGROUND:Long-term oral corticosteroid (OCS) therapy and related adverse events are associated with a significant burden on patients and healthcare resources. METHODS:This subgroup analysis of a randomized, open-label, parallel-group study evaluated the OCS-sparing effect of omalizumab (OMA) added to optimized asthm...
journal_title:Current medical research and opinion
pub_type: 杂志文章,随机对照试验
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abstract:OBJECTIVE:The rates of blood pressure (BP) control worldwide are discouraging. This study had the purpose of assessing the effectiveness of perindopril/amlodipine fixed dose combination on BP-lowering efficacy, and recording adherence, safety and tolerability during a 4 month treatment period. RESEARCH DESIGN AND METH...
journal_title:Current medical research and opinion
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journal_title:Current medical research and opinion
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abstract:OBJECTIVES:Tumor necrosis factor (TNF) antagonists, most frequently prescribed biologics for moderate to severe rheumatoid arthritis (RA), are subject to dose escalation. Even though different methods have been employed to estimate the timing and magnitude of dose escalation, there is no consensus on which method is op...
journal_title:Current medical research and opinion
pub_type: 杂志文章
doi:10.1185/03007995.2010.483127
更新日期:2010-07-01 00:00:00
abstract::The therapeutic efficacy and tolerability of a new controlled-release 1000 mg tablet of naproxen (naproxen CR) were compared with 200 mg isoxicam in 100 out-patients with osteoarthritis. Medications were administered once daily for 4 weeks in a controlled, randomized, double-blind, parallel trial. Patients were assess...
journal_title:Current medical research and opinion
pub_type: 临床试验,杂志文章,随机对照试验
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更新日期:1988-01-01 00:00:00
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journal_title:Current medical research and opinion
pub_type: 杂志文章,多中心研究
doi:10.1185/03007995.2015.1014030
更新日期:2015-04-01 00:00:00