Abstract：
:Cardiac arrhythmias are the most common cardiac complication reported in pregnant women with and without structural heart disease (SHD); they are more frequent among women with SHD, such as cardiomyopathy and congenital heart disease (CHD). While older studies had indicated supraventricular tachycardia as the most common tachyarrhythmia in pregnancy, more recent data indicate an increase in the frequency of arrhythmias, with atrial fibrillation (AF) emerging as the most frequent arrhythmia in pregnancy, attributed to an increase in maternal age, cardiovascular risk factors and CHD in pregnancy. Importantly, the presence of any tachyarrhythmia during pregnancy may be associated with adverse maternal and fetal outcomes, including death. Thus, both the mother and the offspring need to be protected from such consequences. The use of antiarrhythmic drugs (AADs) depends on clinical presentation and on the presence of underlying SHD, which requires caution as it promotes pro-arrhythmia. In hemodynamically compromised women, electrical cardioversion is successful and safe to both mother and fetus. Use of beta-blockers appears quite safe; however, caution is advised when using other AADs, while no AAD should be used, if at all possible, during the first trimester when organogenesis takes place. Regarding the anticoagulation regimen in patients with AF, warfarin should be substituted with heparin during the first trimester, while direct oral anticoagulants are not indicated given the lack of data in pregnancy. Finally, for refractory arrhythmias, ablation and/or device implantation can be performed with current techniques in pregnant women, when needed, using minimal exposure to radiation. All these issues and relevant current guidelines are herein reviewed.
journal_name
Curr Med Res Opinjournal_title
Current medical research and opinionauthors
Manolis TA,Manolis AA,Apostolopoulos EJ,Papatheou D,Melita H,Manolis ASdoi
10.1080/03007995.2020.1762555subject
Has Abstractpub_date
2020-07-01 00:00:00pages
1225-1243issue
7eissn
0300-7995issn
1473-4877journal_volume
36pub_type
杂志文章abstract：BACKGROUND:Adequate vitamin D and calcium nutrition play a critical role in the maintenance of musculoskeletal health and are considered the first step in osteoporosis treatment. ROUNDTABLE DISCUSSION:In February 2008 Merck Sharp & Dohme sponsored a 2-day, evidence-based expert panel on the benefits of vitamin D for t...
journal_title：Current medical research and opinion
pub_type： 杂志文章,评审
doi：10.1185/030079908x301857
更新日期：2008-05-01 00:00:00
abstract：:A double-blind, multi-centre trial was carried out in 191 patients with acute musculoskeletal conditions to compare the efficacy of naproxen and indomethacin. Patients were randomly allocated to receive either 250 mg naproxen or 50 mg indomethacin twice daily. Treatment was for 7 or 14 days. The results, assessed by t...
journal_title：Current medical research and opinion
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1185/03007997609109332
更新日期：1976-01-01 00:00:00
abstract：OBJECTIVE:The prevalence of non-steroidal anti-inflammatory drug (NSAID) and concurrent gastroprotective agent (GPA) use in the US is not known. As such, the prevalence of GPA use among arthritis patients taking NSAIDs was examined. METHODS:Men and women aged ≥ 40 with self-reported arthritis and members of a web-base...
journal_title：Current medical research and opinion
pub_type： 临床试验,杂志文章
doi：10.1185/03007995.2013.781017
更新日期：2013-05-01 00:00:00
abstract：:A double-blind controlled, cross-over trial was carried out in 70 depressed patients to compare the effectiveness and tolerability of amineptine with that of maprotiline. Patients were allocated at random to receive treatment with either 150 mg amineptine or 75 mg maprotiline daily for 6 weeks before being treated for...
journal_title：Current medical research and opinion
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1185/03007997909109406
更新日期：1979-01-01 00:00:00
abstract：OBJECTIVE:The European Forsteo Observational Study (EFOS) study was primarily designed to assess fracture incidence, degree of pain, health-related quality of life (HRQoL) and compliance in women prescribed teriparatide in a community setting. This report describes the design of the study and characteristics of the pat...
journal_title：Current medical research and opinion
pub_type： 杂志文章
doi：10.1185/030079908x261087
更新日期：2008-02-01 00:00:00
abstract：:Twenty-seven patients with tennis elbow were treated with triamcinolone acetonide (40 mg/ml) injected locally into the tender area without local anaesthetic. Reduction of pain or complete relief was achieved in 1 to 72 hours, although in 9 cases exacerbation of pain occurred before relief was given. The recurrence rat...
journal_title：Current medical research and opinion
pub_type： 杂志文章
doi：10.1185/03007998009109477
更新日期：1980-01-01 00:00:00
abstract：OBJECTIVE:To review clinical trial evidence supporting treatment of patients to a near-normal HbA(1c) target level and outline therapeutic strategies that optimize glycemic control. RESEARCH DESIGN AND METHODS:The current MEDLINE database and bibliographies were searched for literature relevant to diabetic complicatio...
journal_title：Current medical research and opinion
pub_type： 杂志文章,评审
doi：10.1185/030079904X6291
更新日期：2004-12-01 00:00:00
abstract：OBJECTIVE:The injection force and the patient perception of the Next Generation FlexPen (NGFP) with design modifications aimed at reducing injection force was assessed. The accuracy and precision of the NGFP was also tested under standard conditions. RESEARCH DESIGN AND METHODS:Dosing accuracy was tested (according to...
journal_title：Current medical research and opinion
pub_type： 杂志文章
doi：10.1185/03007990802329264
更新日期：2008-09-01 00:00:00
abstract：BACKGROUND:Tobacco smoking is a major risk factor for cardiovascular disease, respiratory disease and cancer and, for current smokers, smoking cessation is one of the most effective therapeutic interventions for reducing the risk of all-cause morbidity and mortality. However, smoking cessation causes nicotine withdrawa...
journal_title：Current medical research and opinion
pub_type： 杂志文章
doi：10.1185/03007990802707600
更新日期：2009-02-01 00:00:00
abstract：:Poor nutritional status may impair well being indirectly as a consequence of increased morbidity and decline in functional status. The aim of this study was to examine the independent effect of body mass index on the well being of older people. Thirty one hospital-based patients over 65 years of age were studied. Well...
journal_title：Current medical research and opinion
pub_type： 杂志文章
doi：
更新日期：2001-01-01 00:00:00
abstract：BACKGROUND:Small cell lung cancer (SCLC) patients, who have achieved complete or partial response after chemotherapy, should be followed with prophylactic cranial irradiation (PCI). PCI for extrapulmonary small cell carcinoma (EPSCC) is not routinely recommended. The purpose of this review is to discuss all aspects of ...
journal_title：Current medical research and opinion
pub_type： 杂志文章,评审
doi：10.1185/03007995.2014.904771
更新日期：2014-07-01 00:00:00
abstract：OBJECTIVE:Ramelteon is an MT(1)/MT(2) melatonin receptor agonist indicated for the treatment of insomnia characterized by difficulty with sleep onset. In previous clinical studies, ramelteon reduced latency to persistent sleep (LPS) in subjects with chronic insomnia. The goal of the current analysis was to determine th...
journal_title：Current medical research and opinion
pub_type： 杂志文章,meta分析
doi：10.1185/03007990902858527
更新日期：2009-05-01 00:00:00
abstract：OBJECTIVE:To evaluate the long-term safety and effectiveness of tadalafil in patients with pulmonary arterial hypertension (PAH) in real-world clinical practice. METHODS:This prospective, multicenter, noninterventional, post-marketing surveillance included patients with PAH who were observed for up to 2 years after in...
journal_title：Current medical research and opinion
pub_type： 杂志文章,多中心研究
doi：10.1080/03007995.2017.1297931
更新日期：2017-05-01 00:00:00
abstract：OBJECTIVE:To better understand depression's impact on family functioning from the perspectives of patients with major depressive disorder (MDD) and their partners; to develop and test patient and partner versions of a new self-reported measure, the Depression and Family Functioning Scale (DFFS), for use in clinical tri...
journal_title：Current medical research and opinion
pub_type： 杂志文章,评审
doi：10.1185/03007995.2012.658910
更新日期：2012-03-01 00:00:00
abstract：:A large, open, multi-centre study was carried out in general practice to evaluate the effectiveness and tolerance of a combination of 10 mg pindolol plus 5 mg clopamide, in single tablet form, in the treatment of patients with essential hypertension. Computer analysis of the records of 8989 patients who completed the ...
journal_title：Current medical research and opinion
pub_type： 临床试验,杂志文章
doi：10.1185/03007997909109449
更新日期：1979-01-01 00:00:00
abstract：:A double-blind trial was carried out in 76 patients with active rheumatoid arthritis to compare the analgesic and anti-inflammatory activity of 3 g. alclofenac with 4.8 g. aspirin daily over a 6-week period. All patients selected showed reversible inflammatory swelling of the finger joints. Of the 60 patients successf...
journal_title：Current medical research and opinion
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1185/03007997509114781
更新日期：1975-01-01 00:00:00
abstract：OBJECTIVE:Migraine is a chronic, disabling neurological disease affecting >1 billion people worldwide. Migraine remains undertreated in Asia, including Taiwan. Galcanezumab is a humanized monoclonal antibody that selectively binds calcitonin gene-related peptide, a peptide firmly established in the pathophysiology of m...
journal_title：Current medical research and opinion
pub_type： 杂志文章
doi：10.1080/03007995.2020.1815181
更新日期：2020-10-01 00:00:00
abstract：AIM:The aim of this case series was to report the use of 8% topical capsaicin patch (marketed under the trade name Qutenza®) a in the management of refractory neuropathic pain (NP) in adult patients with type 1 neurofibromatosis (NF1). METHODS:Capsaicin has been suggested for NF1 patients suffering from refractory per...
journal_title：Current medical research and opinion
pub_type： 杂志文章
doi：10.1080/03007995.2018.1433142
更新日期：2018-05-01 00:00:00
abstract：OBJECTIVE:In the four SMILE (Survival of Myocardial Infarction Long-Term Evaluation) studies, early administration of zofenopril in acute myocardial infarction (AMI) showed beneficial effects as compared to placebo and other angiotensin converting enzyme inhibitors (ACEIs). This study investigated whether the concomita...
journal_title：Current medical research and opinion
pub_type： 杂志文章,随机对照试验
doi：10.1080/03007995.2018.1496076
更新日期：2018-10-01 00:00:00
abstract：:A double-blind, parallel group study was carried out in 50 patients with an anxiety disorder to compare the anxiolytic efficacy and tolerability of a recently developed benzodiazepine, metaclazepam, with that of bromazepam. Patients were allocated at random to receive treatment for 2 weeks with either 15 mg metaclazep...
journal_title：Current medical research and opinion
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1185/03007998809111129
更新日期：1988-01-01 00:00:00
abstract：:A double-blind trial of methocarbamol versus placebo was carried out in 59 matched pairs of patients suffering from painful muscle spasm. Methocarbamol (1500 mg. q.d.s.) was found to be effective in approximately 60% of patients compared with 30% of patients receiving placebo (p less than 0.01). Side-effects were of a...
journal_title：Current medical research and opinion
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1185/03007997509114791
更新日期：1975-01-01 00:00:00
abstract：BACKGROUND:Persisting pain is demoralising and debilitating for patients and their carers. Most patients with chronic pain do not need the services of a specialised pain clinic and are appropriately managed by their general practitioner (GP). METHOD:Interviewers approached 569 GPs to assess their satisfaction with the...
journal_title：Current medical research and opinion
pub_type： 杂志文章
doi：10.1185/030079903125002478
更新日期：2003-01-01 00:00:00
abstract：OBJECTIVES:To compare retinal thickness before and after treatment with the fluocinolone acetonide (FAc) 190 µg intravitreal implant in people with diabetic macular edema (DME) using data from the Iluvien Clinical Evidence study in the UK (ICE-UK). METHODS:For this retrospective cohort study, data on people attending ...
journal_title：Current medical research and opinion
pub_type： 杂志文章
doi：10.1080/03007995.2017.1366662
更新日期：2017-10-01 00:00:00
abstract：OBJECTIVE:To assess the impact of the decision by Kela (The Social Insurance Institution) to adopt guidelines for the management of food allergies in children, developed by the Finnish Medical Society Duodecim, as the basis for reimbursing clinical nutrition preparations for the treatment of cow milk allergy (CMA) in F...
journal_title：Current medical research and opinion
pub_type： 杂志文章
doi：10.1185/030079908x280455
更新日期：2008-04-01 00:00:00
abstract：BACKGROUND:The selection of the most appropriate treatment combinations requires the balancing of benefits and harms of these treatment options as well as the patients' preferences for the resulting outcomes. OBJECTIVE:This research aimed at estimating and comparing the utility weights between elderly women with early...
journal_title：Current medical research and opinion
pub_type： 杂志文章
doi：10.1080/03007995.2016.1257983
更新日期：2017-02-01 00:00:00
abstract：:One hundred and twenty healthy volunteers were recruited for a study to evaluate the reactogenicity and serological response of differing doses of the 1986/87 World Health Organization-recommended influenza viral strains. Each vaccine was prepared by Institut Merieux and contained A/Mississippi/1/85, A/Chile/1/83 and ...
journal_title：Current medical research and opinion
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1185/03007998709111111
更新日期：1987-01-01 00:00:00
abstract：:Optimal management of hypertension has been shown to reduce the risk of stroke. In recent years, newer classes of antihypertensive such as the angiotensin II (Ang II) antagonists have become available. Results from the Losartan Intervention for Endpoint reduction in hypertension (LIFE) study suggest the utility of thi...
journal_title：Current medical research and opinion
pub_type： 杂志文章,评审
doi：10.1185/030079904X10160
更新日期：2004-11-01 00:00:00
abstract：:A trial to compare the therapeutic potential of 1200 mg. azapropazone daily with 3.9 g. aspirin daily was carried out in 108 out-patients with rheumatoid arthritis over a 14-day period. Analysis of results from the 85 patients with completed assessment data (49 on azapropazone; 36 on aspirin) showed that azapropazone ...
journal_title：Current medical research and opinion
pub_type： 临床试验,杂志文章
doi：10.1185/03007997609109281
更新日期：1976-01-01 00:00:00
abstract：:This double-blind, randomised, placebo-controlled study was carried out to assess the efficacy and safety of 0.025% and 0.05% azelastine eye drops twice daily administered for 14 days to patients with seasonal allergic conjunctivitis or rhinoconjunctivitis. A total of 278 patients were recruited and 226 patients were ...
journal_title：Current medical research and opinion
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1185/03007999709113339
更新日期：1997-01-01 00:00:00
abstract：:Anaemia is an important factor in the fatigue experienced by many patients receiving chemotherapy. A recent large-scale, randomised, placebo-controlled trial has shown that treatment with epoetin alfa raises haemoglobin levels, reduces fatigue and improves overall quality of life (QoL). In order to examine the relatio...
journal_title：Current medical research and opinion
pub_type： 临床试验,杂志文章,多中心研究,随机对照试验
doi：10.1185/174234305X13798
更新日期：2005-01-01 00:00:00
