Influence of pentoxifylline on erythrocyte deformability in peripheral occlusive arterial disease.

abstract：BACKGROUND:Pain is usually assessed by spontaneous pain ratings. Time-dependent (brief attacks) or evoked (allodynia) phenomena, common in neuropathic pain, are not captured. To evaluate the overall effectiveness of a treatment, improvement of all sensory symptoms should be measured. Since the pattern of sensory abnorm...

journal_title：Current medical research and opinion

authors： Höper J,Helfert S,Heskamp ML,Maihöfner CG,Baron R

更新日期：2014-04-01 00:00:00

abstract：BACKGROUND:Obstructive sleep apnea syndrome (OSAS) is mostly seen in adult populations. It is known that increased levels of several inflammatory mediators play roles in OSAS and related comorbidities. Calprotectin is an inflammatory mediator that increases in some diseases such as Behçet's syndrome, bowel diseases and...

journal_title：Current medical research and opinion

authors： Torun MT,Ünver E,Yalçın Y,Kanmaz L,Seçkin E

更新日期：2018-03-01 00:00:00

abstract：OBJECTIVE:Delayed-release dimethyl fumarate (DMF; also known as gastro-resistant DMF) and fingolimod are approved oral disease-modifying treatments for relapsing-remitting multiple sclerosis. In phase 3 trials, DMF (DEFINE/CONFIRM) and fingolimod (FREEDOMS/FREEDOMS II) resulted in significant reductions in clinical and...

journal_title：Current medical research and opinion

authors： Fox RJ,Chan A,Zhang A,Xiao J,Levison D,Lewin JB,Edwards MR,Marantz JL

更新日期：2017-02-01 00:00:00

abstract：:Objectives: Ethics guidelines such as the Declaration of Helsinki and the CIOMS International Ethical Guidelines for Health-related Research Involving Humans require the sponsors, in cooperation with relevant stakeholders, to provide post-trial access (PTA) to intervention and knowledge, especially in clinical trials ...

journal_title：Current medical research and opinion

authors： Jimenez EB,Virtudazo JMP,Torres CE,Bernabe RD

更新日期：2019-11-01 00:00:00

abstract：:A study was carried out in 21 patients with Type IIb or Type IV hyperlipoproteinaemia to evaluate the effect of treatment with 600 mg bezafibrate per day over a period of 3 months. The results of the lipid parameters studied showed that there were significant reductions after 1 and 3-months' treatment, respectively, o...

journal_title：Current medical research and opinion

authors： Neuman MP,Kurlat MI,Neuman J

更新日期：1983-01-01 00:00:00

abstract：:Seventy frail elderly patients attending a day hospital were studied to investigate the incidence of postural hypotension in control patients on no diuretic treatment (n = 30), patients on loop diuretics (frusemide) for mild cardiac failure (n = 20) and patients on thiazide diuretics for mild cardiac failure (n = 20)....

journal_title：Current medical research and opinion

authors： Heseltine D,Bramble MG

更新日期：1988-01-01 00:00:00

abstract：:Cholinesterase inhibitors, which act by inhibiting the degradation of acetylcholine in the brain, form the mainstay of therapy for AD. Predominant adverse events are cholinergic in nature, the most frequent being gastrointestinal side effects. Here we present a case series of patients with dementia who were treated wi...

journal_title：Current medical research and opinion

authors： Venkatesh K,Bullock R,Akbaş A

更新日期：2007-01-01 00:00:00

abstract：INTRODUCTION AND OBJECTIVE:The management of hyponatremia has evolved in recent years, particularly with the introduction of tolvaptan for hyponatremia secondary to the syndrome of inappropriate antidiuretic hormone secretion (SIADH). This commentary presents a summary of recent international recommendations in the for...

journal_title：Current medical research and opinion

authors： Aylwin S,Burst V,Peri A,Runkle I,Thatcher N

更新日期：2015-01-01 00:00:00

abstract：OBJECTIVE:The Physician Payments Sunshine Act, enacted in 2010, is intended to increase the transparency of relationships between US physicians and teaching hospitals and manufacturers of drugs, biologics, and medical devices. We examined current opinion regarding the impact of the Sunshine Act on peer-reviewed medical...

journal_title：Current medical research and opinion

authors： Toroser D,Robinson M,Gegner J,Smith G,Nilsen J,Hyatt L,Johnson T,Hassan A,Gatchalian C

更新日期：2016-01-01 00:00:00

abstract：:A study was carried out to compare the efficacy and tolerability of etodolac and piroxicam in patients with rheumatoid arthritis. Sixty patients entered this double-blind, parallel study and after a wash-out period of up to 2 weeks were randomly assigned to receive 200 mg etodolac twice daily or 20 mg piroxicam once d...

journal_title：Current medical research and opinion

authors： Schattenkirchner M

更新日期：1991-01-01 00:00:00

abstract：OBJECTIVE:Patients that undergo total hip replacement (THA) are at risk of revision surgery. This study evaluated the cumulative incidence of revision following a medial collared, triple tapered (MCTT) primary hip stem versus other implants in real-world settings using electronic medical records. METHODS:This was a re...

journal_title：Current medical research and opinion

authors： Chitnis AS,Mantel J,Ruppenkamp J,Bourcet A,Holy CE

更新日期：2020-11-01 00:00:00

abstract：INTRODUCTION:The systematic use of 2-octyl cyanoacrylate (2-OCA) became routine in our cardiac unit in 2000. This topical skin adhesive has been used in conjunction with conventional suturing for skin closure and prevention of postoperative wound infections by means of its performance as a microbial barrier to exogenou...

journal_title：Current medical research and opinion

authors： Souza EC,Fitaroni RB,Januzelli DM,Macruz HM,Camacho JC,Souza MR

更新日期：2008-01-01 00:00:00

abstract：:Twenty-seven patients with tennis elbow were treated with triamcinolone acetonide (40 mg/ml) injected locally into the tender area without local anaesthetic. Reduction of pain or complete relief was achieved in 1 to 72 hours, although in 9 cases exacerbation of pain occurred before relief was given. The recurrence rat...

journal_title：Current medical research and opinion

authors： Nevelös AB

更新日期：1980-01-01 00:00:00

abstract：OBJECTIVES:To describe multiple myeloma (MM) treatment patterns and comorbidities over time in the US. RESEARCH DESIGN AND METHODS:Study patients were newly diagnosed with MM (ICD-9-CM 203.0x) between 1 July 2006 and 31 March 2014 and had ≥6 months of data prior to the initial MM diagnosis in MarketScan Research Datab...

journal_title：Current medical research and opinion

authors： Song X,Cong Z,Wilson K

更新日期：2016-01-01 00:00:00

abstract：OBJECTIVE:To better understand depression's impact on family functioning from the perspectives of patients with major depressive disorder (MDD) and their partners; to develop and test patient and partner versions of a new self-reported measure, the Depression and Family Functioning Scale (DFFS), for use in clinical tri...

journal_title：Current medical research and opinion

authors： DiBenedetti DB,Danchenko N,François C,Lewis S,Davis KH,Fehnel SE

更新日期：2012-03-01 00:00:00

abstract：OBJECTIVE:To determine the efficacy and safety of lumiracoxib for knee osteoarthritis (OA). METHODS:This was a 13-week, multicentre, randomized, double-blind, double-dummy, placebo-controlled study. Males or females aged >/= 18 years with primary knee OA received lumiracoxib 100 mg od, lumiracoxib 100 mg od with a loa...

journal_title：Current medical research and opinion

authors： Lehmann R,Brzosko M,Kopsa P,Nischik R,Kreisse A,Thurston H,Litschig S,Sloan VS

更新日期：2005-04-01 00:00:00

abstract：:An investigator-blind, parallel-group, multicentre study was undertaken to compare the efficacy and tolerability of once-daily, sustained-release (s-r) ibuprofen and diclofenac sodium in patients (mean age 59.8 years) suffering from painful osteoarthritis affecting chiefly the knee and/or hip. Patients attending eight...

journal_title：Current medical research and opinion

authors： Baumgartner H,Schwarz HA,Blum W,Bruhin A,Gallachi G,Goldinger G,Saxer M,Trost H

更新日期：1996-01-01 00:00:00

abstract：AIM:Non-peer-reviewed manuscripts posted as preprints can be cited in peer-reviewed articles, which has both merits and demerits. International Committee of Medical Journal Editors guidelines mandate authors to declare preprints at the time of manuscript submission. We evaluated the trends in pharma-authored research p...

journal_title：Current medical research and opinion

authors： Subramanian K,Nalli A,Senthil V,Bhat A

更新日期：2020-12-09 00:00:00

abstract：OBJECTIVE:The objectives of this survey were to understand (1) the effects of overactive bladder (OAB) and urinary incontinence (UI) on women's lives and to understand (2) women's needs and expectations of health care providers and treatment related to these disorders. METHODS:Women (N = 1046) with self-reported sympt...

journal_title：Current medical research and opinion

authors： MacDiarmid S,Rosenberg M

更新日期：2005-09-01 00:00:00

abstract：:In order to assess the effect of ACTH on the adrenal cortex when used as a therapeutic or diagnostic agent, adrenocortical function was tested before and 2 hours after 0.5 mg tetracosactrin given intramuscularly in 31 healthy children, divided into 4 groups according to age and sex. Mean plasma cortisol levels were sh...

journal_title：Current medical research and opinion

authors： Tsvetkova V

更新日期：1977-01-01 00:00:00

abstract：OBJECTIVE:Estimate the proportion of phosphodiesterase type-5 inhibitor (PDE5-I) patients who co-possess nitrates and compare the proportion of tadalafil patients dispensed nitrates to a matched control group. Secondarily, examine the percentage of co-possession of PDE5-Is and nitrates where the products were dispensed...

journal_title：Current medical research and opinion

authors： Chang LL,Ma M,Allmen Hv,Henderson SC,Harper K,Hornbuckle K

更新日期：2010-06-01 00:00:00

abstract：OBJECTIVE:To determine resource utilization in controller naïve children diagnosed with asthma receiving initial therapy with fluticasone propionate (FP) and salmeterol (SAL) in a single inhaler (FSC), FP alone, montelukast (MON), inhaled corticosteroid (ICS) + SAL from separate inhalers, or ICS + MON. RESEARCH DESIGN...

journal_title：Current medical research and opinion

authors： Stempel DA,Riedel AA,Carranza Rosenzweig JR

更新日期：2006-03-01 00:00:00

abstract：:Background: To investigate the effects of 1-month treatment in addition to standard care with a food supplement containing both Curcuma longa and Boswellia serrata extracts on tendinopathy symptoms. Method: This open-label, non-controlled, post-observational study included 670 patients suffering from tendinopathy recr...

journal_title：Current medical research and opinion

authors： Henrotin Y,Dierckxsens Y,Delisse G,Seidel L,Albert A

更新日期：2020-12-21 00:00:00

abstract：:Evidence is needed to guide therapeutic decisions on patients who had ischaemic cerebral events. The recently published European/Australasian Stroke Prevention in Reversible Ischaemia Trial (ESPRIT), an open-label randomised controlled study, compared long-term treatment of patients randomised to aspirin 30-325 mg dai...

journal_title：Current medical research and opinion

authors： Einhäupl K

更新日期：2007-02-01 00:00:00

abstract：BACKGROUND:Proton pump inhibitors (PPIs) are the most commonly used pharmacological treatment for gastroesophageal reflux disease (GERD). OBJECTIVE:To examine the utilization patterns of PPIs and other GERD-related medications, satisfaction with PPI treatment and presence of GERD symptoms. PATIENTS AND METHODS:GERD p...

journal_title：Current medical research and opinion

authors： Chey WD,Mody RR,Wu EQ,Chen L,Kothari S,Persson B,Beaulieu N,Lu M

更新日期：2009-08-01 00:00:00

abstract：OBJECTIVE:Chronic respiratory failure (CRF) is a syndrome defined by certain disturbances in arterial blood gases. Non-invasive mechanical ventilation (NIMV) is an increasingly used treatment modality in respiratory failure. The aim of this study was to investigate the long-term effects of NIMV on pulmonary function an...

journal_title：Current medical research and opinion

authors： Dogan OT,Turkyilmaz S,Berk S,Epozturk K,Akkurt I

更新日期：2010-09-01 00:00:00

abstract：:Oesophageal mucosa has well established protective mechanisms, which operate within pre-epithelial, epithelial and post-epithelial compartments. Since refluxed acid and pepsin always act from the luminal side of the mucosa, protective factors like EGF, operating as a part of pre-epithelial defence, are thought to be p...

journal_title：Current medical research and opinion

authors： Marcinkiewicz M,Grabowska SZ,Czyzewska E

更新日期：1998-01-01 00:00:00

abstract：OBJECTIVE:Evaluation of the safety and efficacy of insulin detemir (IDet) in the observational and non-interventional PREDICTIVE study. METHODS:A total of 2923 patients with type 1 or 2 diabetes on basal-bolus regimens were followed for 6 months: Group (1) NPH + human insulin (HI) bolus switching to IDet + analogue bo...

journal_title：Current medical research and opinion

authors： Hermansen K,Dornhorst A,Sreenan S

更新日期：2009-11-01 00:00:00

abstract：OBJECTIVES:Many insulin-treated patients with type 2 diabetes (T2D) do not reach hemoglobin A1c (HbA1c) < 7%, but have clinically relevant HbA1c reductions. Using an integrated database (IDB) of 53 insulin lispro clinical trials and a real-world evidence (RWE) database of T2D patients initiating insulin therapy, an exp...

journal_title：Current medical research and opinion

authors： Conget I,Kirkman MS,Cao D,Wong M,Reviriego J,Kendall DM

更新日期：2018-02-01 00:00:00

abstract：BACKGROUND:Tumor necrosis factor (TNF)-α plays a critical role in psoriasis pathogenesis, and several anti-TNF agents have been developed as therapeutic drugs in this indication. SCOPE:To present the preclinical rationale and clinical data for onercept, a novel anti-TNF agent developed for the treatment of moderate-to...

journal_title：Current medical research and opinion

authors： Papp K

更新日期：2010-10-01 00:00:00