Abstract：
OBJECTIVES:Many insulin-treated patients with type 2 diabetes (T2D) do not reach hemoglobin A1c (HbA1c) < 7%, but have clinically relevant HbA1c reductions. Using an integrated database (IDB) of 53 insulin lispro clinical trials and a real-world evidence (RWE) database of T2D patients initiating insulin therapy, an expanded HbA1c measure was used to identify responders to insulin therapy. METHODS:Analysis included 4,908 patients (IDB) and 1,134 patients (RWE) with T2D treated with any insulin regimen with a baseline and ≥1 post-baseline HbA1c. Responders were defined as patients with endpoint HbA1c < 7% (cut point [CP]) and/or either ≥1% absolute (ABS) decrease, and/or ≥10% relative (REL) decrease in HbA1c from baseline. The percentage of responders with CP vs ABS and concordance between ABS and REL were calculated. As the ABS and REL measures were highly correlated (94%), the ABS measure was used to compare characteristics of responders and non-responders by age, diabetes duration, race/ethnicity, baseline HbA1c, and insulin regimen at 24 weeks. RESULTS:In both databases, more responders were identified with ABS or REL (>62%) than CP (<41%). More ABS responders had a baseline HbA1c ≥ 9% and a shorter diabetes duration than non-responders. Basal insulin-treated patients in the IDB had 78.2% responders at 24 weeks, compared to 69.7% with basal/bolus or pre-mixed insulin (75.4%). Results were similar in the IDB and RWE. CONCLUSION:Composite HbA1c measures identified more patients with clinically meaningful responses to therapy than the broadly accepted HbA1c < 7% and may be useful in assessing clinical trials, clinical care, and quality measures.
journal_name
Curr Med Res Opinjournal_title
Current medical research and opinionauthors
Conget I,Kirkman MS,Cao D,Wong M,Reviriego J,Kendall DMdoi
10.1080/03007995.2017.1396968subject
Has Abstractpub_date
2018-02-01 00:00:00pages
329-336issue
2eissn
0300-7995issn
1473-4877journal_volume
34pub_type
杂志文章abstract：OBJECTIVE:Several different durable or disposable insulin pen delivery devices are currently available, and newer, improved devices are being introduced. One prefilled insulin device, FlexPen (FP), has recently been improved (known as the Next Generation FlexPen (NGFP) in Europe or the improved FlexPen in the United St...
journal_title：Current medical research and opinion
pub_type： 杂志文章,评审
doi：10.1185/03007995.2010.512447
更新日期：2010-10-01 00:00:00
abstract：INTRODUCTION:Detection of β-thalassemia trait or carriers (β-TT) depends significantly on an increase in Hemoglobin A2 (HbA2) levels, which is found at low levels (<3%) in normal healthy individuals and elevated levels (≥3.5%) in β-TT individuals. The study was designed to evaluate the reliability of the diagnostic par...
journal_title：Current medical research and opinion
pub_type： 杂志文章
doi：10.1080/03007995.2018.1435520
更新日期：2018-05-01 00:00:00
abstract：BACKGROUND:Atrial fibrillation (AF) represents a significant health concern, due to the increased prevalence, morbidity, and mortality. METHODS AND RESULTS:There is a growing body of evidence correlating serum uric acid (SUA) with cardiovascular diseases such as arterial hypertension and AF. CONCLUSION:Thus, a questi...
journal_title：Current medical research and opinion
pub_type： 杂志文章
doi：10.1080/03007995.2017.1378521
更新日期：2017-11-01 00:00:00
abstract：BACKGROUND:Fasting during the month of Ramadan is practiced by over 1.5 billion Muslims worldwide. It remains unclear, however, how this change in lifestyle affects heart failure, a condition that has reached epidemic dimensions. This study examined the effects of fasting in patients with acute heart failure (AHF) usin...
journal_title：Current medical research and opinion
pub_type： 杂志文章,多中心研究
doi：10.1080/03007995.2017.1376629
更新日期：2018-02-01 00:00:00
abstract：:A metabolic study was carried out in 6 patients requiring enteral feeding to investigate the effectiveness and tolerance of 'Nutrauxil', a ready-made liquid nutritional preparation, over a period of 8 days. The results of anthropometric and laboratory measurements, made initially and at the end of two 4-day periods, s...
journal_title：Current medical research and opinion
pub_type： 杂志文章
doi：10.1185/03007998309109794
更新日期：1983-01-01 00:00:00
abstract：OBJECTIVES:The objectives were to estimate the prevalence of self-treated hypoglycaemia in patients using basal insulin analogues; identify demographic, treatment related and behavioural risk factors; and describe patient and physician responses to these events. RESEARCH DESIGN AND METHODS:The GAPP2 (Global Attitude o...
journal_title：Current medical research and opinion
pub_type： 临床试验,杂志文章,多中心研究
doi：10.1185/03007995.2012.743457
更新日期：2012-12-01 00:00:00
abstract：BACKGROUND:Description of risk of cardiovascular (CV) events associated with diabetes is evolving. This US-based real-world study estimated risk of future CV events and heart failure (HF) from type 2 diabetes (T2DM) only, prior CV events only or T2DM plus prior CV events, versus controls, and evaluated healthcare resou...
journal_title：Current medical research and opinion
pub_type： 杂志文章
doi：10.1080/03007995.2020.1832455
更新日期：2020-12-01 00:00:00
abstract：OBJECTIVE:Report efficacy findings from three clinical trials (one phase 2 and two phase 3 [OPUS-1, OPUS-2]) of lifitegrast ophthalmic solution 5.0% for treatment of dry eye disease (DED). RESEARCH DESIGN AND METHODS:Three 84-day, randomized, double-masked, placebo-controlled trials. Adults (≥18 years) with DED were r...
journal_title：Current medical research and opinion
pub_type： 杂志文章
doi：10.1080/03007995.2016.1210107
更新日期：2016-10-01 00:00:00
abstract：:An open, multi-centre, non-comparative study was carried out in general practice to assess the efficacy and tolerance of piroxicam in 159 patients with osteoarthritis and 27 patients with rheumatoid arthritis. Initial dosage ranged from 10 to 40 mg piroxicam and all but a few patients continued treatment with 20 mg on...
journal_title：Current medical research and opinion
pub_type： 杂志文章
doi：10.1185/03007998309109807
更新日期：1983-01-01 00:00:00
abstract：OBJECTIVE:The objectives of this article are to review the pathophysiology of type 2 diabetes mellitus (T2DM), present the rationale for a pathophysiologically based treatment approach for patients with T2DM and discuss the role of the therapeutic combination of pioglitazone and exenatide in the management of T2DM. ME...
journal_title：Current medical research and opinion
pub_type： 杂志文章,评审
doi：10.1185/03007990802390795
更新日期：2008-11-01 00:00:00
abstract：BACKGROUND:The rising prevalence of nosocomial methicillin-resistant Staphylococcus aureus (MRSA) and the recent emergence of community-associated MRSA are major clinical, public health, and economic challenges. MRSA is a leading cause of nosocomial pneumonia and complicated skin and soft-tissue infections (cSSTI). Van...
journal_title：Current medical research and opinion
pub_type： 杂志文章,评审
doi：10.1185/03007990903512057
更新日期：2010-03-01 00:00:00
abstract：OBJECTIVES:GOAL (Gauging Osteoarthritis [OA] with Limbrel*), an open-label, post-marketing study was performed to determine the overall efficacy and gastrointestinal (GI) tolerability of flavocoxid, a novel, plant-based, anti-inflammatory medication, in a 'real world' clinical practice setting. To this end, the study e...
journal_title：Current medical research and opinion
pub_type： 杂志文章,多中心研究
doi：10.1185/03007991003694522
更新日期：2010-05-01 00:00:00
abstract：:Nine patients with persistently elevated diastolic blood pressure, exceeding 130 mmHg, received an oral dose of labetalol ranging from 200 mg to 400 mg. In all patients, this produced a significant and gradual decline in recumbent systolic and diastolic blood pressure, unaccompanied by symptoms or complications, with ...
journal_title：Current medical research and opinion
pub_type： 临床试验,杂志文章
doi：10.1185/03007997709110155
更新日期：1977-01-01 00:00:00
abstract：INTRODUCTION:Azelastine hydrochloride (Astelin) nasal spray 0.1% solution is a second-generation intranasal antihistamine available in the US for treatment of both seasonal allergic rhinitis (SAR) and nonallergic vasomotor rhinitis (VMR). SCOPE:Searches of journal articles including the title word 'azelastine' from 19...
journal_title：Current medical research and opinion
pub_type： 杂志文章,评审
doi：10.1185/030079907X226302
更新日期：2007-10-01 00:00:00
abstract：:Objective: A prior study found that hyaluronic acid (HA) treatment may help reduce pain medication use (such as steroids, non-steroidal anti-inflammatory drugs [NSAIDs] and opioids) among knee osteoarthritis (OA) patients in the real-world setting. This study aims to update the prior study results to include only the ...
journal_title：Current medical research and opinion
pub_type： 杂志文章
doi：10.1080/03007995.2019.1596670
更新日期：2019-09-01 00:00:00
abstract：:Forty-nine patients participated in a randomized double-blind, parallel group comparison of beclomethasone dipropionate aqueous nasal spray with terfenadine tablets in the treatment of hay fever. Symptom scores for nasal and ocular symptoms as well as grass pollen counts were registered daily for at least 1 month. Eva...
journal_title：Current medical research and opinion
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1185/03007998509109635
更新日期：1985-01-01 00:00:00
abstract：OBJECTIVE:In addition to direct weight reduction, there may be other benefits of obesity treatment including improved insulin sensitivity. The purpose of this study was to characterise concomitant diabetes drug use and the related costs in patients with diabetes treated with orlistat (Xenical) in the first 6 months of ...
journal_title：Current medical research and opinion
pub_type： 杂志文章
doi：10.1185/030079905X74943
更新日期：2005-11-01 00:00:00
abstract：OBJECTIVE:Vesicoureteral reflux (VUR) occurs in approximately 1% of infants and children and is associated with recurrent urinary tract infections (UTIs). The objective of this paper is to examine the use of endoscopic injection with dextranomer/hyaluronic acid copolymer (Dx/HA) as a curative option and as an alternati...
journal_title：Current medical research and opinion
pub_type： 杂志文章,评审
doi：10.1185/030079907X226230
更新日期：2007-09-01 00:00:00
abstract：OBJECTIVE:Research indicates that insomnia may contribute significantly to healthcare costs; however, information on the effects of treatments on costs has not been thoroughly published. This study presents predictive models that forecast, from the perspective of commercial managed care, the effects of insomnia medicat...
journal_title：Current medical research and opinion
pub_type： 杂志文章
doi：10.1185/030079907X199619
更新日期：2007-06-01 00:00:00
abstract：:Zolmitriptan is a 5-HT1B/1D receptor agonist for the acute treatment of migraine. This study examined the efficacy of a second dose of zolmitriptan for the treatment of persistent or recurrent headache. Part 1 was a randomised, placebo-controlled, double-blind evaluation of 2.5 mg and 5 mg zolmitriptan for the treatme...
journal_title：Current medical research and opinion
pub_type： 临床试验,杂志文章,多中心研究,随机对照试验
doi：10.1185/03007999909116498
更新日期：1999-01-01 00:00:00
abstract：:In gouty patients, urate lowering therapies (ULTs) are recommended to bring serum uric acid (SUA) levels below 6.0 mg/dL, with the aim of dissolving urate depositions, thereby reducing disease impact. However, patients with hyperuricemia often present with other conditions associated with cardiovascular (CV) risk, suc...
journal_title：Current medical research and opinion
pub_type： 杂志文章,评审
doi：10.1185/03007995.2015.1087979
更新日期：2015-01-01 00:00:00
abstract：:Three methods for the determination of azapropazone were studied for the analysis of blood plasma samples taken after oral administration of azapropazone. A gas chromatographic method was compared with two simple spectrophotometric assay methods and the effect of metabolites of the drug on each method is described. It...
journal_title：Current medical research and opinion
pub_type： 杂志文章
doi：10.1185/03007997609109279
更新日期：1976-01-01 00:00:00
abstract：:Studies in several populations have indicated that genetic variation at the apolipoprotein E (apoE) structural locus influences the risk of coronary artery disease (CAD) and myocardial infarction (MI). This study aimed at investigating whether apoE polymorphism has an allelic and/or genotypic impact on the risk of MI ...
journal_title：Current medical research and opinion
pub_type： 杂志文章
doi：10.1185/030079902125000444
更新日期：2002-01-01 00:00:00
abstract：OBJECTIVES:To compare the efficacy and safety of ciprofloxacin 0.3%/dexamethasone 0.1% (CIP/DEX) otic suspension with that of neomycin 0.35%/polymyxin B 10,000 IU/mL/hydrocortisone 1.0% (N/P/H) otic suspension in patients with acute otitis externa (AOE). STUDY DESIGN:Randomized, observer-masked, parallel-group, multic...
journal_title：Current medical research and opinion
pub_type： 临床试验,杂志文章,多中心研究,随机对照试验
doi：10.1185/030079902125004312
更新日期：2004-08-01 00:00:00
abstract：OBJECTIVE:To evaluate the intraocular pressure lowering effect of the dorzolamide/timolol fixed combination (DTFC) in non-responder glaucoma patients to prostaglandin analogs/prostamides (prostas). PATIENTS AND METHODS:All glaucoma patients treated with DTFC, between June 2003 and December 2005, who were unresponsive ...
journal_title：Current medical research and opinion
pub_type： 杂志文章
doi：10.1185/030079906X167688
更新日期：2007-03-01 00:00:00
abstract：:A double-blind, crossover trial was carried out in 40 in-patients with gastro-intestinal spasmodic syndromes to compare the effectiveness and tolerance of fenoverine and trimebutine. Patients were allocated at random to receive either 100 mg fenoverine or 150 mg trimebutine 3-times daily for 20 days and were then cros...
journal_title：Current medical research and opinion
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1185/03007998609111090
更新日期：1986-01-01 00:00:00
abstract：OBJECTIVE:To determine resource utilization in controller naïve children diagnosed with asthma receiving initial therapy with fluticasone propionate (FP) and salmeterol (SAL) in a single inhaler (FSC), FP alone, montelukast (MON), inhaled corticosteroid (ICS) + SAL from separate inhalers, or ICS + MON. RESEARCH DESIGN...
journal_title：Current medical research and opinion
pub_type： 杂志文章
doi：10.1185/030079906X89711
更新日期：2006-03-01 00:00:00
abstract：OBJECTIVE:Patients with type 2 diabetes (T2DM) often have multiple comorbidities which may impact the selection of antihyperglycemic therapies. The purpose of this study was to quantify the prevalence and co-prevalence of common comorbidities. RESEARCH DESIGN AND METHODS:A retrospective study was conducted using the Q...
journal_title：Current medical research and opinion
pub_type： 杂志文章
doi：10.1185/03007995.2016.1168291
更新日期：2016-07-01 00:00:00
abstract：OBJECTIVE:The impact of multiple sclerosis (MS) center type on outcomes has not been investigated. This study aimed to evaluate baseline characteristics and clinical and magnetic resonance imaging (MRI) outcomes in patients with MS receiving fingolimod over 16 months' follow-up at private or academic centers in the USA...
journal_title：Current medical research and opinion
pub_type： 杂志文章
doi：10.1080/03007995.2018.1458708
更新日期：2018-08-01 00:00:00
abstract：BACKGROUND:Exenatide, an incretin mimetic for adjunctive treatment of type 2 diabetes (T2DM), reduced hemoglobin A(1c) (A1C) and weight in clinical trials. The objective of this study was to evaluate the effects of > or = 3 years exenatide therapy on glycemic control, body weight, cardiometabolic markers, and safety. ...
journal_title：Current medical research and opinion
pub_type： 杂志文章,多中心研究,随机对照试验
doi：10.1185/030079908x253870
更新日期：2008-01-01 00:00:00
