Comparison of the new beta-adrenoceptor antagonist, nadolol, and propranolol in the treatment of angina pectoris.


:A randomized, double-blind study was carried out in 24 patients with stable angina pectoris to compare the efficacy of nadolol, a new beta-adrenoceptor antagonist, and propranolol. After a period on placebo, 14 patients received nadolol once daily and 10 patients propranolol 4-times daily over a 10-week dose-ranging period followed by a maintenance period of 4 weeks. Optimal daily dosage for nadolol was 100 mg, and 112 mg for propranolol. Parameters used for evaluation of therapeutic effects included the number of anginal attacks, number of nitroglycerine tablets needed, time before onset of chest pain during exercise test, exercise time, and overall clinical impression of response. The results indicated that nadolol given once daily was equally as effective as propranolol 4-times daily in treating angina pectoris.


Curr Med Res Opin


Furberg B,Dahlqvist A,Raak A,Wrege U




Has Abstract


1978-01-01 00:00:00












  • Descriptive epidemiology of hospitalisation for psoriasis.

    abstract:BACKGROUND:The epidemiology and outcome of people hospitalised with a primary diagnosis of psoriasis has never been characterised previously in the United Kingdom. The aim of the study was to characterise the epidemiology of people admitted to hospital with a primary diagnosis of psoriasis. METHODS:Routine hospital da...

    journal_title:Current medical research and opinion

    pub_type: 杂志文章


    authors: Conway P,Currie CJ

    更新日期:2008-12-01 00:00:00

  • Safety and effectiveness of tadalafil in patients with pulmonary arterial hypertension: Japanese post-marketing surveillance data.

    abstract:OBJECTIVE:To evaluate the long-term safety and effectiveness of tadalafil in patients with pulmonary arterial hypertension (PAH) in real-world clinical practice. METHODS:This prospective, multicenter, noninterventional, post-marketing surveillance included patients with PAH who were observed for up to 2 years after in...

    journal_title:Current medical research and opinion

    pub_type: 杂志文章,多中心研究


    authors: Yamazaki H,Kobayashi N,Taketsuna M,Tajima K,Murakami M

    更新日期:2017-05-01 00:00:00

  • Clinical development of onercept, a tumor necrosis factor binding protein, in psoriasis.

    abstract:BACKGROUND:Tumor necrosis factor (TNF)-α plays a critical role in psoriasis pathogenesis, and several anti-TNF agents have been developed as therapeutic drugs in this indication. SCOPE:To present the preclinical rationale and clinical data for onercept, a novel anti-TNF agent developed for the treatment of moderate-to...

    journal_title:Current medical research and opinion

    pub_type: 杂志文章,评审


    authors: Papp K

    更新日期:2010-10-01 00:00:00

  • Loop diuretics cause less postural hypotension than thiazide diuretics in the frail elderly.

    abstract::Seventy frail elderly patients attending a day hospital were studied to investigate the incidence of postural hypotension in control patients on no diuretic treatment (n = 30), patients on loop diuretics (frusemide) for mild cardiac failure (n = 20) and patients on thiazide diuretics for mild cardiac failure (n = 20)....

    journal_title:Current medical research and opinion

    pub_type: 杂志文章


    authors: Heseltine D,Bramble MG

    更新日期:1988-01-01 00:00:00

  • The determination of azapropazone in blood plasma.

    abstract::Three methods for the determination of azapropazone were studied for the analysis of blood plasma samples taken after oral administration of azapropazone. A gas chromatographic method was compared with two simple spectrophotometric assay methods and the effect of metabolites of the drug on each method is described. It...

    journal_title:Current medical research and opinion

    pub_type: 杂志文章


    authors: Leach H

    更新日期:1976-01-01 00:00:00

  • Cardioprotective effects of trimetazidine: a review.

    abstract::The efficacy of trimetazidine, an anti-ischaemic agent, has been largely assessed and presented in the international literature through its metabolic effects, selective and specific fatty acid oxidation inhibition and lack of haemodynamic effects in stable angina pectoris. As such, trimetazidine has opened up a new cl...

    journal_title:Current medical research and opinion

    pub_type: 杂志文章,评审


    authors: Marzilli M

    更新日期:2003-01-01 00:00:00

  • Online survey: knowledge about risks, prevention and consequences of infections with HBV among travellers from four European countries.

    abstract:OBJECTIVE:To evaluate knowledge about risks, prevention and consequences of infection with hepatitis B virus (HBV) among travellers from four low HBV risk, European countries. METHODS:Individuals from an internet panel and based in the Czech Republic, the Netherlands, Spain and Sweden were invited to take part in an o...

    journal_title:Current medical research and opinion

    pub_type: 杂志文章


    authors: Herbinger KH,Nothdurft HD,Prymula R

    更新日期:2011-03-01 00:00:00

  • Generic drug approval: a US perspective.

    abstract:OBJECTIVE:Generic drugs are identical or bioequivalent versions of the brand name drugs. They are the economic alternative of the costlier brand name drugs. This article presents a general overview of the procedure and regulatory aspects relating to generic drug approval in the US. METHODS:A computerized search was co...

    journal_title:Current medical research and opinion

    pub_type: 杂志文章,评审


    authors: Nagori BP,Mathur V,Garg S

    更新日期:2011-03-01 00:00:00

  • The prevalence, correlates and treatment of pain in the European Union.

    abstract:OBJECTIVES:To report on the results of a recent large-scale, internet-based survey of the population, prevalence and attributes of pain experience in the United Kingdom (UK), France, Spain, Germany and Italy. METHODS:The results reported here are taken from the internet-based, 2008 National Health and Wellness Survey ...

    journal_title:Current medical research and opinion

    pub_type: 杂志文章


    authors: Langley PC

    更新日期:2011-02-01 00:00:00

  • Chronic kidney disease, cardiovascular disease, and osteoporotic fractures in patients with and without HIV in the US Veteran's Affairs Administration System.

    abstract::Objective: To evaluate the risk of chronic kidney disease (CKD), cardiovascular disease (CVD), and osteoporotic fractures in human immunodeficiency virus (HIV) patients utilizing data within the Veteran's Affairs (VA) Administration system.Methods: A retrospective cohort study utilizing VA system claims (January 2000-...

    journal_title:Current medical research and opinion

    pub_type: 杂志文章


    authors: Sutton SS,Magagnoli J,Cummings TH,Hardin JW,Edun B,Beaubrun A

    更新日期:2019-01-01 00:00:00

  • Comparison of sustained-release clonidine and long-acting propranolol in the treatment of hypertension.

    abstract::A double-blind crossover trial was undertaken to compare the efficacy of sustained-release clonidine and long-acting propranolol in the treatment of 20 patients (8 males and 12 females) with sustained hypertension. Each patient was stabilized with metoprolol with or without diuretic therapy prior to admission to the t...

    journal_title:Current medical research and opinion

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Rodrigues E,Lawson AA

    更新日期:1982-01-01 00:00:00

  • Overactive bladder in women: symptom impact and treatment expectations.

    abstract:OBJECTIVE:The objectives of this survey were to understand (1) the effects of overactive bladder (OAB) and urinary incontinence (UI) on women's lives and to understand (2) women's needs and expectations of health care providers and treatment related to these disorders. METHODS:Women (N = 1046) with self-reported sympt...

    journal_title:Current medical research and opinion

    pub_type: 杂志文章


    authors: MacDiarmid S,Rosenberg M

    更新日期:2005-09-01 00:00:00

  • A clinical and economic evaluation of enteral nutrition.

    abstract:MOTIVATION:The American Society of Parenteral and Enteral Nutrition (ASPEN) guidelines advise use of enteral nutrition (EN) for critically ill hospital patients requiring nutritional support, but no studies have comprehensively estimated economic benefits from adherence to this recommendation. METHODS:We systematicall...

    journal_title:Current medical research and opinion

    pub_type: 杂志文章,meta分析,评审


    authors: Cangelosi MJ,Auerbach HR,Cohen JT

    更新日期:2011-02-01 00:00:00

  • New centrally acting agents for appetite control: from biological mechanisms to clinical efficacy.

    abstract:BACKGROUND:Obesity is one of the major problems of health policy in different countries. Pharmacological attempts have been made to help affected people without a definitive solution. Some agents--either with peripheral or central effect--are available in the market. On July 2012, the FDA approved two novel preparation...

    journal_title:Current medical research and opinion

    pub_type: 杂志文章,评审


    authors: Catoira NP,Viale L,Di Girolamo G,Gonzalez C

    更新日期:2014-06-01 00:00:00

  • Effect of the novel oral dipeptidyl peptidase IV inhibitor vildagliptin on the pharmacokinetics and pharmacodynamics of warfarin in healthy subjects.

    abstract:OBJECTIVE:Vildagliptin is a potent and selective dipeptidyl peptidase-IV (DPP-4) inhibitor that improves glycemic control in patients with type 2 diabetes by increasing alpha and beta-cell responsiveness to glucose. This study assessed the effect of multiple doses of vildagliptin 100 mg once daily on warfarin pharmacok...

    journal_title:Current medical research and opinion

    pub_type: 杂志文章,随机对照试验


    authors: He YL,Sabo R,Riviere GJ,Sunkara G,Leon S,Ligueros-Saylan M,Rosenberg M,Dole WP,Howard D

    更新日期:2007-05-01 00:00:00

  • Compatibility testing of two types of pen needles with a range of injection pens for diabetes medication.

    abstract::Compatibility of two types of needles with a variety of durable and prefilled injection pens for diabetes medication was tested by attaching the needles according to ISO 11608-2 and verifying penetration into the cartridge using air shots and two-dimensional X-rays. NovoFine* and NovoFine Autocover† attached correctly...

    journal_title:Current medical research and opinion

    pub_type: 信件


    authors: Buus P,Lilleøre SK,Larsen K

    更新日期:2011-03-01 00:00:00

  • Effects of oral posaconazole on the pharmacokinetics of sirolimus.

    abstract:OBJECTIVES:Azole antifungal agents are often coadministered with immunosuppressants to recipients of solid organ and hematopoietic stem cell transplants. Posaconazole, an extended-spectrum triazole, is an inhibitor of the cytochrome P450 (CYP) isoenzyme CYP3A4, and sirolimus, an immunosuppressant, is a substrate of the...

    journal_title:Current medical research and opinion

    pub_type: 杂志文章


    authors: Moton A,Ma L,Krishna G,Martinho M,Seiberling M,McLeod J

    更新日期:2009-03-01 00:00:00

  • Characterizing and understanding body weight patterns in patients treated with pregabalin.

    abstract:OBJECTIVE:We examined patterns of weight change among patients treated with pregabalin for up to 1 year. METHODS:Patients with ≥1 pre-treatment weight measurement, ≥2 measurements in Period 1 (day 2-56), and ≥2 during Period 2 (day 57-356) were identified from pooled data of 106 studies including 43,525 patients. Seve...

    journal_title:Current medical research and opinion

    pub_type: 杂志文章,meta分析


    authors: Cabrera J,Emir B,Dills D,Murphy TK,Whalen E,Clair A

    更新日期:2012-06-01 00:00:00

  • Single inhaler triple therapy (FF/UMEC/VI) versus FF/VI and UMEC/VI in patients with COPD: subgroup analysis of the China cohort in the IMPACT trial.

    abstract:OBJECTIVES:Chronic obstructive pulmonary disease (COPD) is becoming a leading cause of morbidity and mortality in China. In the IMPACT trial, fluticasone furoate[FF]/umeclidinium[UMEC]/vilanterol[VI] single-inhaler triple therapy demonstrated lower rates of moderate/severe exacerbations than dual therapy with FF/VI or ...

    journal_title:Current medical research and opinion

    pub_type: 杂志文章


    authors: Zheng J,Zhong N,Wang C,Wei LP,Zhou XD,Zhao L,Dong Yuan Y,He B,Wu B,Du X,Song J,Lipson DA

    更新日期:2021-01-01 00:00:00

  • Comparison of methods for measuring dose escalation of the subcutaneous TNF antagonists for rheumatoid arthritis patients treated in routine clinical practice.

    abstract:OBJECTIVES:Tumor necrosis factor (TNF) antagonists, most frequently prescribed biologics for moderate to severe rheumatoid arthritis (RA), are subject to dose escalation. Even though different methods have been employed to estimate the timing and magnitude of dose escalation, there is no consensus on which method is op...

    journal_title:Current medical research and opinion

    pub_type: 杂志文章


    authors: Huang X,Gu NY,Fox KM,Harrison DJ,Globe D

    更新日期:2010-07-01 00:00:00

  • Cost-effectiveness analysis of aripiprazole vs standard-of-care in the management of community-treated patients with schizophrenia: STAR study.

    abstract:UNLABELLED:Abstract Background: The Schizophrenia Trial of Aripiprazole (STAR) showed superior efficacy for aripiprazole compared with atypical antipsychotic standard-of-care (SOC) for the community treatment of schizophrenia 1 based on the Investigator Assessment Questionnaire total score. OBJECTIVE:To determine the ...

    journal_title:Current medical research and opinion

    pub_type: 杂志文章,多中心研究,随机对照试验


    authors: King D,Knapp M,Thomas P,Razzouk D,Loze JY,Kan HJ,van Baardewijk M

    更新日期:2011-02-01 00:00:00

  • Costs of second-generation antihistamines in the treatment of allergic rhinitis: US perspective.

    abstract:OBJECTIVE:To review the pharmacoeconomic literature evaluating use of antihistamines in treating allergic rhinitis (AR) in the US. METHODS:Three independent reviewers conducted a comprehensive search of the current literature with PubMed. They identified articles describing original research comprising US cost analyse...

    journal_title:Current medical research and opinion

    pub_type: 杂志文章,评审


    authors: Hay JW,Kaliner MA

    更新日期:2009-06-01 00:00:00

  • Diagnostic accuracy of an identification tool for localized neuropathic pain based on the IASP criteria.

    abstract:OBJECTIVE:Based on the clear neuroanatomical delineation of many neuropathic pain (NP) symptoms, a simple tool for performing a short structured clinical encounter based on the IASP diagnostic criteria was developed to identify NP. This study evaluated its accuracy and usefulness. METHODS:A case-control study was perf...

    journal_title:Current medical research and opinion

    pub_type: 杂志文章


    authors: Mayoral V,Pérez-Hernández C,Muro I,Leal A,Villoria J,Esquivias A

    更新日期:2018-08-01 00:00:00

  • Preliminary evaluation of a new controlled-release oxybutynin in urinary incontinence.

    abstract:OBJECTIVE:To conduct a preliminary evaluation of a new oral formulation of controlled-release (CR) oxybutynin tablet taken once-daily in patients with urinary urge incontinence. RESEARCH DESIGN AND METHODS:A single-centre, open-label, 8-week study was conducted. Patients with urodynamically-confirmed detrusor instabil...

    journal_title:Current medical research and opinion

    pub_type: 临床试验,杂志文章


    authors: Radomski SB,Caley B,Reiz JL,Miceli PC,Harsanyi Z,Darke AC

    更新日期:2004-01-01 00:00:00

  • A randomised study comparing the efficacy and safety of rosuvastatin with atorvastatin for achieving lipid goals in clinical practice in Asian patients at high risk of cardiovascular disease (DISCOVERY-Asia study).

    abstract:BACKGROUND:Most studies investigating the benefits of statins have focused on North American and European populations. This study focuses on evaluating the lipid-lowering effects of rosuvastatin and atorvastatin in Asian patients. OBJECTIVES:The DIrect Statin COmparison of LDL-C Values: an Evaluation of Rosuvastatin t...

    journal_title:Current medical research and opinion

    pub_type: 杂志文章,多中心研究,随机对照试验


    authors: Zhu JR,Tomlinson B,Ro YM,Sim KH,Lee YT,Sriratanasathavorn C

    更新日期:2007-12-01 00:00:00

  • Severe hypoglycemia rates and associated costs among type 2 diabetics starting basal insulin therapy in the United States.

    abstract:OBJECTIVES:To derive current real-world data on the rates and costs of severe hypoglycemia (SH) for people with type 2 diabetes mellitus (T2D) who have initiated basal insulin therapy and to examine differences in SH rates and costs stratified by history of prior SH events. METHODS:We used a nation-wide electronic hea...

    journal_title:Current medical research and opinion

    pub_type: 杂志文章


    authors: Ganz ML,Wintfeld NS,Li Q,Lee YC,Gatt E,Huang JC

    更新日期:2014-10-01 00:00:00

  • The bioavailability of ofloxacin from several formulations.

    abstract::The bioavailability of ofloxacin after a single dose of one of two tablet formulations (200 or 400 mg) or a liquid formulation (1.67 mg/ml) was investigated in 24 healthy male volunteers in an open randomized, crossover design study with a 5-day wash-out period between doses. Plasma concentrations of ofloxacin were de...

    journal_title:Current medical research and opinion

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Flor S,Beals B

    更新日期:1991-01-01 00:00:00

  • Pioglitazone versus rosiglitazone treatment in patients with type 2 diabetes and dyslipidemia: cost-effectiveness in the US.

    abstract:OBJECTIVES:Pioglitazone hydrochloride (Actos † ) and rosiglitazone maleate (Avandia ‡ ) are members of the thiazolidinedione (TZD) class of oral anti-diabetic drugs (OADs) and are used to treat type 2 diabetes mellitus (T2DM). Greater beneficial effects on lipids have been demonstrated with pioglitazone, however. Study...

    journal_title:Current medical research and opinion

    pub_type: 杂志文章


    authors: Tunis SL,Minshall ME,St Charles M,Pandya BJ,Baran RW

    更新日期:2008-11-01 00:00:00

  • Assessment of liposome bupivacaine infiltration versus continuous femoral nerve block for postsurgical analgesia following total knee arthroplasty: a retrospective cohort study.

    abstract:OBJECTIVE:Perioperative pain management is an important aspect of recovery from total knee arthroplasty (TKA) because severe pain can delay ambulation and hospital discharge. The objective of this retrospective sequential cohort study was to determine the impact of local infiltration analgesia using liposome bupivacain...

    journal_title:Current medical research and opinion

    pub_type: 杂志文章


    authors: Kirkness CS,Asche CV,Ren J,Gordon K,Maurer P,Maurer B,Maurer BT

    更新日期:2016-10-01 00:00:00

  • 'Real-life' information on pulmonary arterial hypertension: the iPHnet Project.

    abstract:BACKGROUND:Over the last two decades the development and analysis of a number of registries have enhanced the knowledge of the epidemiology, presentation, natural history, and pathophysiology of pulmonary arterial hypertension (PAH). The understanding of the effectiveness of available treatments has also been greatly i...

    journal_title:Current medical research and opinion

    pub_type: 杂志文章


    authors: Poscia R,Ghio S,D'Alto M,Vitulo P,Mulè M,Albera C,Parisi F,Badagliacca R,Fedele F,Vizza CD

    更新日期:2014-12-01 00:00:00