Economic implications of using pegfilgrastim rather than conventional G-CSF to prevent neutropenia during small-cell lung cancer chemotherapy.

abstract：:In this narrative review, we will discuss some of the significant risks and dramatic consequences that are associated with epilepsy: depression, suicide, seizure-related injuries, and mortality, both in adults and in children. Considering the high prevalence of depression among people with epilepsy (PWE), routine and ...

journal_title：Current medical research and opinion

authors： Mesraoua B,Deleu D,Hassan AH,Gayane M,Lubna A,Ali MA,Tomson T,Khalil BA,Cross JH,Asadi-Pooya AA

更新日期：2020-09-01 00:00:00

abstract：:This double-blind, randomised, placebo-controlled study was carried out to assess the efficacy and safety of 0.025% and 0.05% azelastine eye drops twice daily administered for 14 days to patients with seasonal allergic conjunctivitis or rhinoconjunctivitis. A total of 278 patients were recruited and 226 patients were ...

journal_title：Current medical research and opinion

authors： Lenhard G,Mivsek-Music E,Perrin-Fayolle M,Obtulowicz K,Secchi A

更新日期：1997-01-01 00:00:00

abstract：BACKGROUND:Aripiprazole differs from other atypical antipsychotics in its pharmacological and clinical profile. SCOPE:As aripiprazole has been available in the USA for bipolar mania since 2004, clinical experience-sharing from clinical and research use of this agent can assist with initiation and administration in pra...

journal_title：Current medical research and opinion

authors： Fagiolini A

更新日期：2008-09-01 00:00:00

abstract：OBJECTIVE:Neurogenic bladder refers to morphofunctional alterations of the bladder-sphincter complex secondary to central or peripheral neurological lesions. Discal etiology can be suggested by clinical observation in patients complaining of classical lower back pain, but not excluded even without musculoskeletal pain....

journal_title：Current medical research and opinion

authors： Siracusa G,Sparacino A,Lentini VL

更新日期：2013-08-01 00:00:00

abstract：OBJECTIVE:It has been acknowledged that patients who receive a beta-blocker or diuretic based regimen are at increased risk of developing new-onset diabetes. Recently, angiotensin-converting enzyme inhibitors (ACEIs) and angiotensin receptor blockers (ARBs) have been shown to decrease patients' odds of developing new-o...

journal_title：Current medical research and opinion

authors： Kuti EL,Baker WL,White CM

更新日期：2007-06-01 00:00:00

abstract：OBJECTIVE:To compare the efficacy and safety of epoetin theta and epoetin beta in anaemic patients with chronic kidney disease, undergoing haemodialysis and previously on stable maintenance therapy with epoetin beta. METHODS:In this multicentre, randomised, controlled, double-blind study 270 haemodialysis patients wer...

journal_title：Current medical research and opinion

authors： Gertz B,Kohler E,Kes P,Essaian A,Bias P,Buchner A,Elsässer R

更新日期：2010-10-01 00:00:00

abstract：OBJECTIVE:The objective of this study was to estimate utility values for hypothetical health states that describe differences in weight and quality of life associated with type 2 diabetes mellitus (DM) from Canadians with type 2 DM. The impact on utility values was examined separately for participants with a body mass ...

journal_title：Current medical research and opinion

authors： Lane S,Levy AR,Mukherjee J,Sambrook J,Tildesley H

更新日期：2014-07-01 00:00:00

abstract：BACKGROUND:Alternaria alternata (AA) sensitisation is a common cause of respiratory allergies such as rhinitis and asthma. So far there are no controlled double-blind trials evaluating the efficacy and safety of specific sublingual immunotherapy (SLIT) in AA allergies. OBJECTIVE:To evaluate the efficacy of SLIT treatm...

journal_title：Current medical research and opinion

authors： Pozzan M,Milani M

更新日期：2010-12-01 00:00:00

abstract：BACKGROUND:Control of arterial hypertension in obese or overweight patients is complicated since obesity directly contributes to increased blood pressure, requiring new, highly effective antihypertensive drugs. This study evaluates the efficacy of azilsartan medoxomil in real clinical practice. METHODS:An internationa...

journal_title：Current medical research and opinion

authors： Chazova IE,Zhernakova YV

更新日期：2020-12-07 00:00:00

abstract：BACKGROUND:Elevated glucose blood levels are the key criteria for diagnosing diabetes mellitus (DM). Hyperglycaemia contributes to the pathophysiology associated with DM, including microvascular and possibly macrovascular disease. In spite of a wide range of pharmacological options available to reduce hyperglycaemia in...

journal_title：Current medical research and opinion

authors： Bays H

更新日期：2009-03-01 00:00:00

abstract：OBJECTIVE:Short-term clinical trials have demonstrated the efficacy and safety of pregabalin in the treatment of generalized anxiety disorder (GAD). This study examined long-term safety and tolerability of pregabalin in patients with GAD, social anxiety disorder (SAD), or panic disorder (PD). RESEARCH DESIGN AND METHO...

journal_title：Current medical research and opinion

authors： Montgomery S,Emir B,Haswell H,Prieto R

更新日期：2013-10-01 00:00:00

abstract：:Anaemia is an important factor in the fatigue experienced by many patients receiving chemotherapy. A recent large-scale, randomised, placebo-controlled trial has shown that treatment with epoetin alfa raises haemoglobin levels, reduces fatigue and improves overall quality of life (QoL). In order to examine the relatio...

journal_title：Current medical research and opinion

authors：

更新日期：2005-01-01 00:00:00

abstract：:In a randomized trial, 149 patients with uncomplicated gonorrhoea were treated with a single intramuscular dose of 1.0 g mezlocillin, 150 with 2.0 g ampicillin plus 1.0 g probenecid orally and 150 with a single dose of 1.8 mega units of procaine penicillin. Cure rates at 3, 10 and 17 days after treatment were 97%, 99%...

journal_title：Current medical research and opinion

authors： Khan MH,Tomkyns JG

更新日期：1982-01-01 00:00:00

abstract：BACKGROUND AND OBJECTIVES:Stroke is a major cause of disability. Certain experimental studies have suggested that a combination of almitrine + raubasine (Duxil) increases the supply of oxygen to cerebral tissues and may be beneficial in post-stroke rehabilitation. This multicentre clinical study was carried out in orde...

journal_title：Current medical research and opinion

authors： Li S,Long J,Ma Z,Xu Z,Li J,Zhang Z

更新日期：2004-03-01 00:00:00

abstract：:The bioavailability of ofloxacin after a single dose of one of two tablet formulations (200 or 400 mg) or a liquid formulation (1.67 mg/ml) was investigated in 24 healthy male volunteers in an open randomized, crossover design study with a 5-day wash-out period between doses. Plasma concentrations of ofloxacin were de...

journal_title：Current medical research and opinion

authors： Flor S,Beals B

更新日期：1991-01-01 00:00:00

abstract：OBJECTIVE:The injection force and the patient perception of the Next Generation FlexPen (NGFP) with design modifications aimed at reducing injection force was assessed. The accuracy and precision of the NGFP was also tested under standard conditions. RESEARCH DESIGN AND METHODS:Dosing accuracy was tested (according to...

journal_title：Current medical research and opinion

authors： Pfützner A,Reimer T,Hohberg C,Frøkjaer LP,Jørgensen C

更新日期：2008-09-01 00:00:00

abstract：:All the components of the kallikrein-kinin system are located in the vascular smooth muscle as well as in the heart. In recent years, numerous observations obtained from clinical and experimental models of diabetes, hypertension, cardiac failure, ischaemia, myocardial infarction and left ventricular hypertrophy, have ...

journal_title：Current medical research and opinion

authors： Sharma JN,Sharma J

更新日期：2002-01-01 00:00:00

abstract：OBJECTIVE:To understand better the true impact of widespread adoption of adjuvant aromatase inhibitor (AI) therapy on postmenopausal breast cancer patients' risk of bone fracture. METHODS:Data from three different studies were used to estimate the relative risk of bone fracture for each of the following groups of wome...

journal_title：Current medical research and opinion

authors： Bell R,Lewis J

更新日期：2007-05-01 00:00:00

abstract：INTRODUCTION AND OBJECTIVE:The management of hyponatremia has evolved in recent years, particularly with the introduction of tolvaptan for hyponatremia secondary to the syndrome of inappropriate antidiuretic hormone secretion (SIADH). This commentary presents a summary of recent international recommendations in the for...

journal_title：Current medical research and opinion

authors： Aylwin S,Burst V,Peri A,Runkle I,Thatcher N

更新日期：2015-01-01 00:00:00

abstract：OBJECTIVE:The main aim of this review was to compare the tolerability and safety between ibuprofen and paracetamol when used as anti-pyretic and analgesic agents in children up to 18 years of age. METHODS:MEDLINE (1950 to November 2008), EMBASE (1980 to November 2008), The Cochrane Library (2007, Issue 3), ACP Journal...

journal_title：Current medical research and opinion

authors： Southey ER,Soares-Weiser K,Kleijnen J

更新日期：2009-09-01 00:00:00

abstract：OBJECTIVE:Several different durable or disposable insulin pen delivery devices are currently available, and newer, improved devices are being introduced. One prefilled insulin device, FlexPen (FP), has recently been improved (known as the Next Generation FlexPen (NGFP) in Europe or the improved FlexPen in the United St...

journal_title：Current medical research and opinion

authors： Niskanen L

更新日期：2010-10-01 00:00:00

abstract：OBJECTIVE:To explore the clinical effect and radial remodeling of transradial slender 7 Fr sheath for left main bifurcation disease (LM bifurcation). METHODS:From January 2018 to September 2019, 236 patients with LM bifurcation undergoing transradial percutaneous coronary intervention (PCI) from two heart centers were...

journal_title：Current medical research and opinion

authors： Xu Y,Li Y,Shen H,Zhang B,Zhao Q,Cheng Y,Zhao Z,Guo Q,Yang J,Zhou Y

更新日期：2020-10-01 00:00:00

abstract：BACKGROUND:Adequate vitamin D and calcium nutrition play a critical role in the maintenance of musculoskeletal health and are considered the first step in osteoporosis treatment. ROUNDTABLE DISCUSSION:In February 2008 Merck Sharp & Dohme sponsored a 2-day, evidence-based expert panel on the benefits of vitamin D for t...

journal_title：Current medical research and opinion

authors： Roux C,Bischoff-Ferrari HA,Papapoulos SE,de Papp AE,West JA,Bouillon R

更新日期：2008-05-01 00:00:00

abstract：:A randomized, double-blind, parallel-group, multi-centre clinical trial was undertaken in 60 patients with dermatophytosis or pityriasis versicolor to compare topical 2% fenticonazole cream with topical 2% miconazole cream. Treatment, by twice-daily application, was for 4 weeks or until earlier complete resolution of ...

journal_title：Current medical research and opinion

authors： Athow-Frost TA,Freeman K,Mann TA,Marks R,Vollum D,Warin AP

更新日期：1986-01-01 00:00:00

abstract：BACKGROUND:Tenofovir disoproxil fumarate (TDF)-based regimens have been associated with impaired kidney function and loss of bone mineral density among patients living with HIV (PLWH). We assess the association between TDF exposure and the odds of chronic kidney disease (CKD) and osteoporotic fracture in HIV patients. ...

journal_title：Current medical research and opinion

authors： Sutton SS,Magagnoli J,Hardin JW,Hsu LI,Beaubrun A,Majethia S,Cummings TH

更新日期：2020-10-01 00:00:00

abstract：OBJECTIVE:As an ever widening array of anti-hyperglycemic agents are now available, the effect of these drugs on lipids is increasingly complex and controversial. The present meta-analysis was designed to clarify the effect of a dual combination of noninsulin anti-hyperglycemic agents on lipids in type 2 diabetes. MET...

journal_title：Current medical research and opinion

authors： Dai X,Wang H,Jing Z,Fu P

更新日期：2014-09-01 00:00:00

abstract：OBJECTIVE:To investigate whether gum chewing affects perceived levels of everyday stress among persons who (1) regularly chew gum or (2) do not chew gum on a regular basis. RESEARCH DESIGN AND METHODS:Two Internet-based studies were conducted. Study 1 enrolled participants who chewed gum > or =4 days per week, chewed ...

journal_title：Current medical research and opinion

authors： Zibell S,Madansky E

更新日期：2009-06-01 00:00:00

abstract：:A double-blind trial was carried out in 60 elderly patients with osteoarthritis of the knee or hip to compare the efficacy and tolerability of treatment with tiaprofenic acid and indomethacin. Patients received either 600 mg tiaprofenic acid or 100 mg indomethacin daily for 3 months. The results of assessments made ev...

journal_title：Current medical research and opinion

authors： Meurice J

更新日期：1983-01-01 00:00:00

abstract：:Control of hypertension is hindered by the incidence of adverse events associated with therapy, which can result in low patient compliance. Specific angiotensin II receptor subtype AT1 blockers offer an alternative to the angiotensin converting enzyme inhibitors in the treatment of hypertension, as the incidence of si...

journal_title：Current medical research and opinion

authors： Levine B

更新日期：2001-01-01 00:00:00

abstract：:A study was carried out to compare attitudes, perceptions and experiences of general practitioners and patients who had treated/suffered from herpes zoster, or shingles, in the recent past. Randomized samples of 224 general practitioners and 236 patients were drawn from different locations in Italy, Germany and the Un...

journal_title：Current medical research and opinion

authors： Henry T

更新日期：1994-01-01 00:00:00