Abstract：
:Critical thinking is crucially important in both research and practice. This article demonstrates that a lack of critical thinking in two meta-analyses resulted in a conclusion that contradicts another meta-analysis and popular opinions. Kahwati et al. and Zhao et al. drew a conclusion that "Vitamin D supplementation alone or with calcium was not associated with reduced fracture incidence among community-dwelling adults without known vitamin D deficiency, osteoporosis, or prior fracture", which apparently contradicted that of Tang et al. Kahwati et al. and Zhao et al. meta-analyzed vitamin D and/or calcium supplementation, which can decrease fracture risk factors, in a population with no known disorders of bone metabolism or vitamin D deficiency. They concluded that supplementation did not reduce fracture incidence. It is important to note that osteoporosis, which supplementation can prevent, and fractures are two distinct concepts. Zhao et al. presented their conclusion without including the conditions under which their conclusion was true. Subsequently, their conclusion was misleadingly interpreted by the public media as "Vitamin D and Calcium Don't Prevent Bone Fractures" and "Vitamin D Does Not Prevent Falls, Calcium Does Not Prevent Fractures-A $2 Billion Waste of Money". If study conclusions do not specify the applicable conditions, guidelines on medications, including supplements, are clinically unacceptable. Researchers must critically think about every step of their studies, including the way their conclusions are presented.
journal_name
Curr Med Res Opinjournal_title
Current medical research and opinionauthors
Fan H,Xiao Jdoi
10.1080/03007995.2019.1687432subject
Has Abstractpub_date
2020-03-01 00:00:00pages
497-501issue
3eissn
0300-7995issn
1473-4877journal_volume
36pub_type
杂志文章abstract：OBJECTIVE:We recently reported the efficacy of rofecoxib in two randomized controlled trials in chronic low back pain (CLBP). The objectives of this report are to present data regarding the onset of efficacy of rofecoxib from these trials and propose methods for reporting onset. RESEARCH DESIGN AND METHODS:Patients we...
journal_title：Current medical research and opinion
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1185/030079904125003160
更新日期：2004-05-01 00:00:00
abstract：OBJECTIVE:To investigate if combined intraocular pressure (IOP)-lowering medication with travoprost/timolol fixed combination and a carbonic anhydrase inhibitor, brinzolamide, is superior to both travoprost monotherapy and travoprost/timolol fixed-combination therapy in primary open-angle glaucoma and ocular hypertensi...
journal_title：Current medical research and opinion
pub_type： 临床试验,杂志文章
doi：10.1185/03007990802159273
更新日期：2008-06-01 00:00:00
abstract：OBJECTIVES:To compare retinal thickness before and after treatment with the fluocinolone acetonide (FAc) 190 µg intravitreal implant in people with diabetic macular edema (DME) using data from the Iluvien Clinical Evidence study in the UK (ICE-UK). METHODS:For this retrospective cohort study, data on people attending ...
journal_title：Current medical research and opinion
pub_type： 杂志文章
doi：10.1080/03007995.2017.1366662
更新日期：2017-10-01 00:00:00
abstract：:Objective: Hypertension is a serious health problem in Egypt, with prevalence rate of 17% as reported in 2015. Despite receiving treatment, many do not achieve blood pressure (BP) control. The current study aimed to evaluate the efficacy and tolerability of amlodipine/valsartan/hydrochlorothiazide (Aml/Val/HCTZ) singl...
journal_title：Current medical research and opinion
pub_type： 杂志文章
doi：10.1080/03007995.2020.1719394
更新日期：2020-04-01 00:00:00
abstract：BACKGROUND:Eribulin mesylate (eribulin) is indicated for patients with metastatic breast cancer (MBC) who have previously received at least two chemotherapies in the US and for patients with locally advanced breast cancer (LABC) or MBC who have progressed after at least one chemotherapy in the European Union (EU). In b...
journal_title：Current medical research and opinion
pub_type： 杂志文章
doi：10.1080/03007995.2020.1835853
更新日期：2020-12-01 00:00:00
abstract：:A study was carried out to compare the efficacy and tolerability of etodolac and piroxicam in patients with rheumatoid arthritis. Sixty patients entered this double-blind, parallel study and after a wash-out period of up to 2 weeks were randomly assigned to receive 200 mg etodolac twice daily or 20 mg piroxicam once d...
journal_title：Current medical research and opinion
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1185/03007999109111660
更新日期：1991-01-01 00:00:00
abstract：:Objective: To evaluate the risk of chronic kidney disease (CKD), cardiovascular disease (CVD), and osteoporotic fractures in human immunodeficiency virus (HIV) patients utilizing data within the Veteran's Affairs (VA) Administration system.Methods: A retrospective cohort study utilizing VA system claims (January 2000-...
journal_title：Current medical research and opinion
pub_type： 杂志文章
doi：10.1080/03007995.2018.1543183
更新日期：2019-01-01 00:00:00
abstract：BACKGROUND:The relationship between chronic pancreatitis (CP) and subsequent pyogenic liver abscess (PLA) is not well understood. METHODS:We investigated the risk of PLA in patients with CP using inpatient claims data from the Taiwan National Health Insurance Program for the period 2000-2010. We identified 17,810 pati...
journal_title：Current medical research and opinion
pub_type： 杂志文章
doi：10.1080/03007995.2016.1266312
更新日期：2017-03-01 00:00:00
abstract：:A clinical study was carried out to evaluate the usefulness of intravenous lorazepam, given for sedation instead of opiate narcotics or diazepam, in 25 seriously-ill patients being treated in a respiratory and intensive care unit. All but 3 patients were on assisted ventilation. Standard doses of 4 mg lorazepam were g...
journal_title：Current medical research and opinion
pub_type： 杂志文章
doi：10.1185/03007997609109320
更新日期：1976-01-01 00:00:00
abstract：:The manifestation of pain in any individual patient may result from a variety of underlying mechanisms that also may vary from one disease state to another. Global measures of pain intensity and relief are inadequate for characterizing specific pain qualities or identifying the unique effects of pain treatments on dif...
journal_title：Current medical research and opinion
pub_type： 社论
doi：10.1185/030079904X12924
更新日期：2004-01-01 00:00:00
abstract：UNLABELLED:Abstract Background: The Schizophrenia Trial of Aripiprazole (STAR) showed superior efficacy for aripiprazole compared with atypical antipsychotic standard-of-care (SOC) for the community treatment of schizophrenia 1 based on the Investigator Assessment Questionnaire total score. OBJECTIVE:To determine the ...
journal_title：Current medical research and opinion
pub_type： 杂志文章,多中心研究,随机对照试验
doi：10.1185/03007995.2010.542745
更新日期：2011-02-01 00:00:00
abstract：:In a double-blind investigation in 21 patients undergoing minor plastic surgery the effects of 4 mg lorazepam or a mixture of 20 mg papaveretum/400 mug hyoscine given intramuscularly as premedicants were studied. Lorazepam produced superior preoperative and post-operative anterograde amnesia, with respect to both inci...
journal_title：Current medical research and opinion
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1185/03007997609111993
更新日期：1976-01-01 00:00:00
abstract：OBJECTIVE:The Physician Payments Sunshine Act, enacted in 2010, is intended to increase the transparency of relationships between US physicians and teaching hospitals and manufacturers of drugs, biologics, and medical devices. We examined current opinion regarding the impact of the Sunshine Act on peer-reviewed medical...
journal_title：Current medical research and opinion
pub_type： 杂志文章,评审
doi：10.1185/03007995.2015.1131151
更新日期：2016-01-01 00:00:00
abstract：:Aims: We sought to investigate the reasons for, and rates of, novel oral anticoagulant (DOAC) therapy discontinuation.Methods: This was an observational cohort study of patients with atrial fibrillation (AF) referred to a regional DOAC outpatient clinic between February 2013 and October 2017. The study population cons...
journal_title：Current medical research and opinion
pub_type： 杂志文章
doi：10.1080/03007995.2020.1725743
更新日期：2020-04-01 00:00:00
abstract：INTRODUCTION:This brief review describes conservative treatment methods for pelvic venous congestion. Therapy options: The authors present an analysis of the efficacy of nonsteroidal anti-inflammatory drugs (NSAIDs), ergot alkaloid derivatives, hormonal agents, venoprotective agents, and compression therapy in the trea...
journal_title：Current medical research and opinion
pub_type： 杂志文章,评审
doi：10.1080/03007995.2017.1302414
更新日期：2017-06-01 00:00:00
abstract：OBJECTIVE:Abuse and misuse of prescription opioids is a significant public health concern. This review examines the strategies used to confer abuse-deterrent properties on opioid abuse-deterrent formulations (ADFs), the characteristics and supporting data for each of the available ADFs, and the role of opioid ADFs as p...
journal_title：Current medical research and opinion
pub_type： 杂志文章,评审
doi：10.1080/03007995.2017.1419171
更新日期：2018-04-01 00:00:00
abstract：BACKGROUND:Tumor necrosis factor (TNF)-α plays a critical role in psoriasis pathogenesis, and several anti-TNF agents have been developed as therapeutic drugs in this indication. SCOPE:To present the preclinical rationale and clinical data for onercept, a novel anti-TNF agent developed for the treatment of moderate-to...
journal_title：Current medical research and opinion
pub_type： 杂志文章,评审
doi：10.1185/03007995.2010.507492
更新日期：2010-10-01 00:00:00
abstract：OBJECTIVE:To better understand depression's impact on family functioning from the perspectives of patients with major depressive disorder (MDD) and their partners; to develop and test patient and partner versions of a new self-reported measure, the Depression and Family Functioning Scale (DFFS), for use in clinical tri...
journal_title：Current medical research and opinion
pub_type： 杂志文章,评审
doi：10.1185/03007995.2012.658910
更新日期：2012-03-01 00:00:00
abstract：:A multi-centre, double-blind trial was carried out in general practice in 44 patients with symptoms of neurotic anxiety to compare the effects of treatment with either 400 mg chlormezanone at night or 5 mg diazepam 3-times daily for 4 weeks. The results indicated tht there were similar improvements in anxiety, duratio...
journal_title：Current medical research and opinion
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1185/03007998209109754
更新日期：1982-01-01 00:00:00
abstract：PURPOSE:Recent survey data have reported the incidence rate of needlestick injuries (NIs) and NIs which draw blood sustained by nurses caring for patients with diabetes in an in-patient hospital setting. The purpose of this study was to deduce the potential short-term annual economic impact resulting from such NI, and ...
journal_title：Current medical research and opinion
pub_type： 杂志文章
doi：10.1185/030079905X65286
更新日期：2005-12-01 00:00:00
abstract：:Amlodipine, a dihydropyrimidine calcium antagonist, is effective in the treatment of patients with mild to moderate hypertension at doses of 5-10 mg daily. The aim of the study reported here was to determine whether an early increase in dosage of amlodipine provided an advantage in terms of antihypertensive effect. Th...
journal_title：Current medical research and opinion
pub_type： 临床试验,杂志文章,多中心研究,随机对照试验
doi：10.1185/03007999909115172
更新日期：1999-01-01 00:00:00
abstract：BACKGROUND:A double-blind randomized trial evaluated the efficacy and tolerability of rivastigmine and donepezil in patients with Alzheimer's disease (AD) over 2 years. Baseline data indicated that some patients had symptoms suggestive of concomitant Lewy body disease. This retrospective analysis investigated whether A...
journal_title：Current medical research and opinion
pub_type： 杂志文章,多中心研究
doi：10.1185/030079906x80279
更新日期：2006-01-01 00:00:00
abstract：OBJECTIVES:To compare the efficacy and safety of ciprofloxacin 0.3%/dexamethasone 0.1% (CIP/DEX) otic suspension with that of neomycin 0.35%/polymyxin B 10,000 IU/mL/hydrocortisone 1.0% (N/P/H) otic suspension in patients with acute otitis externa (AOE). STUDY DESIGN:Randomized, observer-masked, parallel-group, multic...
journal_title：Current medical research and opinion
pub_type： 临床试验,杂志文章,多中心研究,随机对照试验
doi：10.1185/030079902125004312
更新日期：2004-08-01 00:00:00
abstract：:Objectives: Asthma/chronic obstructive pulmonary disease (COPD) overlap (ACO) is a recently described phenomenon defined as the coexistence of both asthma and COPD. Both asthma and COPD are known to result in increased emergency department (ED) visits and hospitalizations, but it is unclear how the ACO population util...
journal_title：Current medical research and opinion
pub_type： 杂志文章
doi：10.1080/03007995.2019.1565531
更新日期：2019-07-01 00:00:00
abstract：INTRODUCTION:Tumor hormone receptor (HR) and human epidermal growth factor receptor 2 (HER2) expression are important factors influencing treatment response and selection in patients with metastatic breast cancer (mBC). Using the LifeLink Oncology Analyzer Database, we classified mBC patients by combined HR and HER2 st...
journal_title：Current medical research and opinion
pub_type： 杂志文章
doi：10.1185/03007995.2012.694364
更新日期：2012-07-01 00:00:00
abstract：OBJECTIVE:This study was undertaken to assess the long-term outcome of transcatheter arterial chemoembolization (TACE) after radiofrequency ablation (RFA) combined with a combined therapy for Chinese patients with intermediate (stage B) hepatocellular carcinoma (HCC) of single block type, and evaluate the survival rate...
journal_title：Current medical research and opinion
pub_type： 杂志文章
doi：10.1185/03007995.2015.1058249
更新日期：2015-08-01 00:00:00
abstract：INTRODUCTION:Low adherence and persistence values, which indicate real-life efficiency, have been widely reported in patients suffering from COPD (Chronic Obstructive Pulmonary Disease). Poor adherence may be related to treatment dosage, thus, simplifying the dosing regimen might improve adherence. The objective of the...
journal_title：Current medical research and opinion
pub_type： 杂志文章
doi：10.1080/03007995.2020.1841617
更新日期：2020-12-01 00:00:00
abstract：BACKGROUND:Exenatide, an incretin mimetic for adjunctive treatment of type 2 diabetes (T2DM), reduced hemoglobin A(1c) (A1C) and weight in clinical trials. The objective of this study was to evaluate the effects of > or = 3 years exenatide therapy on glycemic control, body weight, cardiometabolic markers, and safety. ...
journal_title：Current medical research and opinion
pub_type： 杂志文章,多中心研究,随机对照试验
doi：10.1185/030079908x253870
更新日期：2008-01-01 00:00:00
abstract：OBJECTIVE:Clinical evidence supports the use of cardiac resynchronization therapy (CRT) in advanced heart failure, but its cost-effectiveness is still unclear. This analysis assessed the economic and health consequences in the UK of implanting a CRT in patients with NYHA class III-IV heart failure. METHODS:A discrete ...
journal_title：Current medical research and opinion
pub_type： 杂志文章
doi：10.1185/030079906X112516
更新日期：2006-06-01 00:00:00
abstract：:An investigator-blind, parallel-group, multicentre study was undertaken to compare the efficacy and tolerability of once-daily, sustained-release (s-r) ibuprofen and diclofenac sodium in patients (mean age 59.8 years) suffering from painful osteoarthritis affecting chiefly the knee and/or hip. Patients attending eight...
journal_title：Current medical research and opinion
pub_type： 临床试验,杂志文章,多中心研究,随机对照试验
doi：10.1185/03007999609115224
更新日期：1996-01-01 00:00:00
