Systematic review of Real-World effectiveness of eribulin for locally advanced or metastatic breast cancer.

abstract：:A randomized double-blind antacid-controlled study was carried out to investigate the speed of onset of relief from dyspeptic pain with a novel, chewable formulation of cimetidine in 80 patients with persistent dyspepsia. Inclusion and exclusion criteria were chosen to identify patients with an acid-related dyspeptic ...

journal_title：Current medical research and opinion

authors： Parr SN

更新日期：1989-01-01 00:00:00

abstract：OBJECTIVES:Tumor necrosis factor (TNF) antagonists, most frequently prescribed biologics for moderate to severe rheumatoid arthritis (RA), are subject to dose escalation. Even though different methods have been employed to estimate the timing and magnitude of dose escalation, there is no consensus on which method is op...

journal_title：Current medical research and opinion

authors： Huang X,Gu NY,Fox KM,Harrison DJ,Globe D

更新日期：2010-07-01 00:00:00

abstract：:The glomerular and tubular function of 7 patients with a spectrum of renal impairment was measured before, during and after 4-days' treatment with cefuroxime and gentamicin. Neither the mean plasma urea nor creatinine concentrations of the group increased after combined treatment, nor was the excretion of cefuroxime s...

journal_title：Current medical research and opinion

authors： Cockram CS,Richards P,Bax RP

更新日期：1980-01-01 00:00:00

abstract：OBJECTIVE:The European Forsteo Observational Study (EFOS) study was primarily designed to assess fracture incidence, degree of pain, health-related quality of life (HRQoL) and compliance in women prescribed teriparatide in a community setting. This report describes the design of the study and characteristics of the pat...

journal_title：Current medical research and opinion

authors： Rajzbaum G,Jakob F,Karras D,Ljunggren O,Lems WF,Langdahl BL,Fahrleitner-Pammer A,Walsh JB,Gibson A,Tynan AJ,Marin F

更新日期：2008-02-01 00:00:00

abstract：:Amlodipine, a dihydropyrimidine calcium antagonist, is effective in the treatment of patients with mild to moderate hypertension at doses of 5-10 mg daily. The aim of the study reported here was to determine whether an early increase in dosage of amlodipine provided an advantage in terms of antihypertensive effect. Th...

journal_title：Current medical research and opinion

authors： Hayduk K,Adamczak M,Nowitzki G

更新日期：1999-01-01 00:00:00

abstract：BACKGROUND:Untreated and under-treated pain represent one of the most pervasive health problems, which is worsening as the population ages and accrues risk for pain. Multiple treatment options are available, most of which have one mechanism of action, and cannot be prescribed at unlimited doses due to the ceiling of ef...

journal_title：Current medical research and opinion

authors： Varrassi G,Hanna M,Macheras G,Montero A,Montes Perez A,Meissner W,Perrot S,Scarpignato C

更新日期：2017-06-01 00:00:00

abstract：:Thirteen young adult patients suffering from heterozygotic familial hypercholesterolaemia with tendinous xanthomatosis, previously treated with a suitable special diet, were studied to assess the effect of bezafibrate, given for 2 years at a dose of 800 mg/day, on plasma lipid and lipoprotein levels and on changes in ...

journal_title：Current medical research and opinion

authors： Rouffy J,Chanu B,Bakir R,Goy-Loeper J,Djian F,Monsuez JJ,Gomberg R,Laval-Jeantet M

更新日期：1988-01-01 00:00:00

abstract：OBJECTIVE:Report efficacy findings from three clinical trials (one phase 2 and two phase 3 [OPUS-1, OPUS-2]) of lifitegrast ophthalmic solution 5.0% for treatment of dry eye disease (DED). RESEARCH DESIGN AND METHODS:Three 84-day, randomized, double-masked, placebo-controlled trials. Adults (≥18 years) with DED were r...

journal_title：Current medical research and opinion

authors： Holland EJ,Whitley WO,Sall K,Lane SS,Raychaudhuri A,Zhang SY,Shojaei A

更新日期：2016-10-01 00:00:00

abstract：:In a multi-centre study, the antidepressant efficacy and incidence of on-therapy events of trazodone (100 to 400 mg daily) and mianserin (30 to 120 mg daily) was compared using a double-blind pre-determined randomized parallel group design in depressed patients unresponsive to placebo after a 7-day screening period. O...

journal_title：Current medical research and opinion

authors： Bennie EH,Khan MC,Tyrer SP,Siddiqui U,Ankier SI

更新日期：1984-01-01 00:00:00

abstract：:All the components of the kallikrein-kinin system are located in the vascular smooth muscle as well as in the heart. In recent years, numerous observations obtained from clinical and experimental models of diabetes, hypertension, cardiac failure, ischaemia, myocardial infarction and left ventricular hypertrophy, have ...

journal_title：Current medical research and opinion

authors： Sharma JN,Sharma J

更新日期：2002-01-01 00:00:00

abstract：BACKGROUND:Patients with hypereosinophilic syndrome (HES) vary considerably in their clinical presentation with regard to the severity and pattern of end-organ involvement. Clinical manifestations range from nonspecific symptoms to life-threatening, multisystem damage caused by eosinophil infiltration and local release...

journal_title：Current medical research and opinion

authors： Schwartz LB,Sheikh J,Singh A

更新日期：2010-08-01 00:00:00

abstract：OBJECTIVE:To evaluate intraocular pressure (IOP)-lowering efficacy, tolerability, and safety of the fixed combination of bimatoprost 0.03% and timolol 0.5% (Ganfort) among German patients. METHODS:Multicenter, observational, open-label study of patients with primary open angle glaucoma or ocular hypertension (n = 606)...

journal_title：Current medical research and opinion

authors： Feuerhake C,Buchholz P,Kimmich F

更新日期：2009-04-01 00:00:00

abstract：BACKGROUND:Many children with severe persistent allergic (IgE-mediated) asthma remain inadequately controlled despite treatment with high-dose inhaled corticosteroids (ICS) plus a long-acting beta(2)-agonist (LABA). RESEARCH AND DESIGN METHODS:This pre-specified analysis of a randomized, double-blind, placebo-controll...

journal_title：Current medical research and opinion

authors： Kulus M,Hébert J,Garcia E,Fowler Taylor A,Fernandez Vidaurre C,Blogg M

更新日期：2010-06-01 00:00:00

abstract：OBJECTIVE:Thiazide diuretics such as hydrochlorothiazide (HCT) are a widely used first-line treatment for hypertension, but most patients will not achieve blood pressure (BP) control with HCT alone and so will require combination therapy. In this study the efficacy, safety and tolerability of a single-pill combination ...

journal_title：Current medical research and opinion

authors： Blumenstein M,Romaszko J,Calderón A,Andersen K,Ibram G,Liu Z,Zhang J

更新日期：2009-04-01 00:00:00

abstract：BACKGROUND:Migraine is frequently under-treated. The 4-item Migraine Assessment of Current Therapy (Migraine-ACT) questionnaire is a simple, patient-friendly tool to identify patients requiring change in acute migraine treatment. OBJECTIVE:To establish a predictive model for the Migraine-ACT questionnaire in primary c...

journal_title：Current medical research and opinion

authors： Pascual J,Láinez MJ,Baos V,García ML,López-Gil A

更新日期：2007-12-01 00:00:00

abstract：OBJECTIVE:Several different durable or disposable insulin pen delivery devices are currently available, and newer, improved devices are being introduced. One prefilled insulin device, FlexPen (FP), has recently been improved (known as the Next Generation FlexPen (NGFP) in Europe or the improved FlexPen in the United St...

journal_title：Current medical research and opinion

authors： Niskanen L

更新日期：2010-10-01 00:00:00

abstract：OBJECTIVE:Healthcare providers managing older patients with type 2 diabetes mellitus (T2DM) face a complex milieu of medical conditions and comorbidities, which increase the risk of unintended treatment consequences. The objective of this study was to understand factors associated with hypoglycemia-related hospitalizat...

journal_title：Current medical research and opinion

authors： Fu H,Xie W,Curtis B,Schuster D

更新日期：2014-09-01 00:00:00

abstract：OBJECTIVE:Patients that undergo total hip replacement (THA) are at risk of revision surgery. This study evaluated the cumulative incidence of revision following a medial collared, triple tapered (MCTT) primary hip stem versus other implants in real-world settings using electronic medical records. METHODS:This was a re...

journal_title：Current medical research and opinion

authors： Chitnis AS,Mantel J,Ruppenkamp J,Bourcet A,Holy CE

更新日期：2020-11-01 00:00:00

abstract：OBJECTIVE:To determine the ability of statins to prevent the development of new-onset type 2 diabetes mellitus through a meta-analysis of randomized, controlled trials. RESEARCH DESIGN AND METHODS:A systematic literature search through November 6, 2007 was conducted to identify randomized, placebo-controlled trials of...

journal_title：Current medical research and opinion

authors： Coleman CI,Reinhart K,Kluger J,White CM

更新日期：2008-05-01 00:00:00

abstract：OBJECTIVE:To identify and compare health-economic models that were developed to evaluate the cost-effectiveness of treatments for type 2 diabetes mellitus (T2DM), and their use within Health Technology Assessments (HTAs). METHODS:In total, six commonly used databases were searched for articles published between Octobe...

journal_title：Current medical research and opinion

authors： Charokopou M,Sabater FJ,Townsend R,Roudaut M,McEwan P,Verheggen BG

更新日期：2016-01-01 00:00:00

abstract：:Five-year results are reported of a controlled long-term comparative study to assess the effects of ergoloid mesylates (1.5 mg 3-times daily) and placebo on medical, psychological and electrophysiological variables. Initially, 148 healthy elderly volunteers of both sexes were included. Eighty-nine subjects (48 on ergo...

journal_title：Current medical research and opinion

authors： Huber F,Köberle S,Prestele H,Spiegel R

更新日期：1986-01-01 00:00:00

abstract：:Lowering cholesterol levels is a primary approach for reducing the risk of coronary heart disease (CHD), yet patients rarely achieve the lipid targets recommended by international guidelines. Although high rates of compliance and achievement of lipid targets have been reported in clinical trials, this situation is inf...

journal_title：Current medical research and opinion

authors： Riesen WF,Darioli R,Noll G

更新日期：2004-01-01 00:00:00

abstract：:Four hundred and twenty-seven hypertensive patients in the United Kingdom have so far been admitted to two on-going open multicentre trials, and have been treated with acebutolol for periods ranging from 1 to 6 months. Oral dosages were within the range of 100 mg to 1200 mg/day in divided doses and were increased or d...

journal_title：Current medical research and opinion

authors： Ashton WL

更新日期：1976-01-01 00:00:00

abstract：:A comparative controlled study was carried out in 40 patients suffering from rheumatoid arthritis, osteoarthrosis or ankylosing spondylitis to assess the efficacy of ketoprofen and ibuprofen. Patients were allocated at random to receive either 100 mg ketoprofen twice daily or 400 mg ibuprofen 3-times daily over a peri...

journal_title：Current medical research and opinion

authors： Saxena RP,Saxena U

更新日期：1978-01-01 00:00:00

abstract：BACKGROUND:Breast cancer cells can develop resistance to standard hormonal treatment and chemotherapy with the activation of the mTOR pathway; this is supported by results of preclinical and clinical studies. In clinical trials, the addition of everolimus to hormonal treatment or anti-HER2 treatment improved the outcom...

journal_title：Current medical research and opinion

authors： Sendur MA,Zengin N,Aksoy S,Altundag K

更新日期：2014-01-01 00:00:00

abstract：OBJECTIVE:This retrospective study assessed the incidence and timing of adverse events (AEs) among patients prescribed varying dose levels of corticosteroids in the US. METHODS:Patients with selected autoimmune or inflammatory disease diagnoses between 2006 and 2015 were identified from a privately insured administrat...

journal_title：Current medical research and opinion

authors： Rice JB,White AG,Johnson M,Wagh A,Qin Y,Bartels-Peculis L,Ciepielewska G,Nelson WW

更新日期：2018-08-01 00:00:00

abstract：:A double-blind trial of methocarbamol versus placebo was carried out in 59 matched pairs of patients suffering from painful muscle spasm. Methocarbamol (1500 mg. q.d.s.) was found to be effective in approximately 60% of patients compared with 30% of patients receiving placebo (p less than 0.01). Side-effects were of a...

journal_title：Current medical research and opinion

authors： Valtonen EJ

更新日期：1975-01-01 00:00:00

abstract：:A double-blind trial was carried out in 37 patients with osteoarthrosis to compare the efficacy and tolerance of 250 mg diflunisal twice daily with that of 400 mg ibuprofen 3-times daily over an 8-week period. Rating scale assessments were made, at the end of a preceding 1-week, wash-out period on placebo and at regul...

journal_title：Current medical research and opinion

authors： Bresnihan B,Hughes G,Essigman WK

更新日期：1978-01-01 00:00:00

abstract：:Venous thromboembolism (VTE) is a major cause of morbidity and mortality and is associated with substantial healthcare costs. Identification of patients at risk of developing VTE enables appropriate thromboprophylaxis to be implemented. Although no predisposing risk factors can be identified in many patients in whom V...

journal_title：Current medical research and opinion

authors： Shirvanian S,Tapson VF

更新日期：2015-12-01 00:00:00

abstract：OBJECTIVE:To evaluate knowledge about risks, prevention and consequences of infection with hepatitis B virus (HBV) among travellers from four low HBV risk, European countries. METHODS:Individuals from an internet panel and based in the Czech Republic, the Netherlands, Spain and Sweden were invited to take part in an o...

journal_title：Current medical research and opinion

authors： Herbinger KH,Nothdurft HD,Prymula R

更新日期：2011-03-01 00:00:00