Abstract：
OBJECTIVE:To evaluate four models based on potential predictors for achieving a response to pregabalin treatment for neuropathic pain (NeP). METHODS:In total, 46 pain studies were screened, of which 27 NeP studies met the criteria for inclusion in this analysis. Data were pooled from these 27 placebo-controlled randomized trials to assess if baseline characteristics (including mean pain and pain-related sleep interference [PRSI] scores), early clinical response during weeks 1-3 of treatment (change from baseline in pain and PRSI scores), and presence of treatment-emergent adverse events (AEs) were predictive of therapeutic response. Therapeutic response was defined as a ≥30% reduction from baseline in either pain and/or PRSI scores at week 5 with supplemental analyses to predict pain outcomes at weeks 8 and 12. Predictors of Patient Global Impression of Change (PGIC) were also evaluated. Four models were assessed: Random Forest, Logistic Regression, Naïve Bayes, and Partial Least Squares. RESULTS:The number of pregabalin-treated subjects in the training/test datasets, respectively, were 2818/1407 (30% pain analysis), 2812/1405 (30% sleep analysis), and 2693/1345 (PGIC analysis). All four models demonstrated consistent results, and the most important predictors of treatment outcomes at week 5 and pain outcomes at weeks 8 and 12 were the reduction in pain score and sleep score in the first 1-3 weeks. The presence or absence of the most common AEs in the first 1-3 weeks was not correlated with any treatment outcome. CONCLUSIONS:Subjects with an early response to pregabalin are more likely to experience an end-of-treatment response.
journal_name
Curr Med Res Opinjournal_title
Current medical research and opinionauthors
Almas M,Parsons B,Whalen Edoi
10.1080/03007995.2018.1520694subject
Has Abstractpub_date
2018-12-01 00:00:00pages
2041-2052issue
12eissn
0300-7995issn
1473-4877journal_volume
34pub_type
杂志文章,meta分析abstract：:Drs Godman and Fadare review the paper by Mares-Garcia and colleagues in Spain regarding the extent of non-guideline recommended prescribing (NGRP) of proton pump inhibitors (PPIs) in ambulatory care. NGRP of PPIs is an increasing public health concern given the implications of overuse of PPIs on infection rates, oste...
journal_title：Current medical research and opinion
pub_type： 评论,杂志文章
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abstract：:Two new benzodiazepines, potassium clorazepate (15 mg. at night), and lorazepam (1 mg. t.d.s.) were compared in 50 patients presenting with anxiety in general practice. The response to treatment was assessed clinically and for patient acceptance. The single-dose regime of potassium clorazepate was significantly better...
journal_title：Current medical research and opinion
pub_type： 临床试验,杂志文章,随机对照试验
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journal_title：Current medical research and opinion
pub_type： 杂志文章,多中心研究
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abstract：OBJECTIVE:Osteoporosis is a skeletal disorder characterized by diminished bone strength, which results in an increased risk of fracture. Currently, osteoporosis is a public health priority due to the large number of individuals affected and the detrimental effect on quality of life. Primary osteoporosis, the most commo...
journal_title：Current medical research and opinion
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journal_title：Current medical research and opinion
pub_type： 杂志文章,评审
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abstract：OBJECTIVE:To assess the efficacy of fenofibrate and statin dual therapy versus a double or equivalent dose of statin monotherapy. METHODS:A systematic literature search and meta-analysis was performed for publications before 1 January 2014 in MEDLINE, Embase, and BIOSIS Previews, among others. RESULTS:The difference ...
journal_title：Current medical research and opinion
pub_type： 杂志文章,meta分析,评审
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abstract：OBJECTIVE:Clinical evidence supports the use of cardiac resynchronization therapy (CRT) in advanced heart failure, but its cost-effectiveness is still unclear. This analysis assessed the economic and health consequences in the UK of implanting a CRT in patients with NYHA class III-IV heart failure. METHODS:A discrete ...
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journal_title：Current medical research and opinion
pub_type： 杂志文章
doi：10.1185/03007995.2015.1065242
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journal_title：Current medical research and opinion
pub_type： 杂志文章
doi：10.1185/03007997709115283
更新日期：1977-01-01 00:00:00
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journal_title：Current medical research and opinion
pub_type： 杂志文章,评审
doi：10.1185/030079903125002810
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abstract：OBJECTIVE:We examined patterns of weight change among patients treated with pregabalin for up to 1 year. METHODS:Patients with ≥1 pre-treatment weight measurement, ≥2 measurements in Period 1 (day 2-56), and ≥2 during Period 2 (day 57-356) were identified from pooled data of 106 studies including 43,525 patients. Seve...
journal_title：Current medical research and opinion
pub_type： 杂志文章,meta分析
doi：10.1185/03007995.2012.684044
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abstract：OBJECTIVE:To investigate the effect of selective laser trabeculoplasty (SLT) on the intraocular pressure (IOP) of untreated fellow eyes in patients with open-angle glaucoma. STUDY DESIGN:Retrospective chart review. PATIENTS AND METHODS:Charts of all patients who underwent SLT at the University of Texas Southwestern M...
journal_title：Current medical research and opinion
pub_type： 杂志文章
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journal_title：Current medical research and opinion
pub_type： 杂志文章,评审
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abstract：OBJECTIVE:To assess the safety, tolerability and pharmacokinetics of an interleukin (IL)-12/23 monoclonal antibody (mAb) in subjects with a relapsing form of multiple sclerosis (MS). METHODS:A phase I, double-blind, placebo-controlled, sequential dose escalation study was conducted in 20 subjects with MS. Subjects wer...
journal_title：Current medical research and opinion
pub_type： 杂志文章,多中心研究,随机对照试验
doi：10.1185/030079906X120931
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pub_type： 杂志文章
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journal_title：Current medical research and opinion
pub_type： 临床试验,杂志文章,多中心研究,随机对照试验
doi：10.1185/03007999509110492
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journal_title：Current medical research and opinion
pub_type： 临床试验,杂志文章,多中心研究,随机对照试验
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pub_type： 评论,社论
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journal_title：Current medical research and opinion
pub_type： 杂志文章,多中心研究,随机对照试验
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journal_title：Current medical research and opinion
pub_type： 临床试验,杂志文章,随机对照试验
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journal_title：Current medical research and opinion
pub_type： 杂志文章,评审
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更新日期：2019-06-01 00:00:00
abstract：OBJECTIVES:An economic analysis (based on interim data from a long-term, randomised, multi-centre, controlled, clinical trial) to evaluate chemotherapy with XELOX (capecitabine/oxaliplatin) versus FOLFOX6 (5Fluorouracil/leucovorin/oxaliplatin) as an adjuvant treatment for high risk colorectal cancer patients in Greece....
journal_title：Current medical research and opinion
pub_type： 杂志文章,多中心研究,随机对照试验
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更新日期：2009-03-01 00:00:00
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journal_title：Current medical research and opinion
pub_type： 杂志文章
doi：10.1185/030079905X48410
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journal_title：Current medical research and opinion
pub_type： 杂志文章
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abstract：OBJECTIVE:To investigate the associations between obesity and any significant improvements in glycemic control, blood pressure, and lipid targets in Chinese patients with concomitant type 2 diabetes mellitus (T2DM) and hypertension. METHODS AND RESULTS:A total of 3041 dyslipidemia patients with an average age of 65.7 ...
journal_title：Current medical research and opinion
pub_type： 杂志文章
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journal_title：Current medical research and opinion
pub_type： 杂志文章,随机对照试验
doi：10.1185/030079906x80404
更新日期：2006-02-01 00:00:00
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journal_title：Current medical research and opinion
pub_type： 杂志文章,多中心研究,随机对照试验
doi：10.1185/03007995.2014.975338
更新日期：2015-01-01 00:00:00
abstract：:Fifty-two patients suffering from presumed viral pharyngeal infection or tonsillitis were treated with either benzydamine or placebo oral rinse as a gargle at 3-hourly intervals in a randomized double-blind study. Patients on the active preparation experienced faster resolution of pain and dysphagia and at 7 days 88% ...
journal_title：Current medical research and opinion
pub_type： 临床试验,杂志文章,随机对照试验
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更新日期：1982-01-01 00:00:00
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journal_title：Current medical research and opinion
pub_type： 杂志文章
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