Dynamics of chronic myeloid leukaemia.

abstract：:A product encoded at the claret locus in Drosophila is needed for normal chromosome segregation in meiosis in females and in early mitotic divisions of the embryo. The predicted amino-acid sequence of the segregation protein was shown recently to be strikingly similar to Drosophila kinesin heavy chain. We have express...

journal_title：Nature

authors： Walker RA,Salmon ED,Endow SA

更新日期：1990-10-25 00:00:00

abstract：:A main limitation of therapies that selectively target kinase signalling pathways is the emergence of secondary drug resistance. Cetuximab, a monoclonal antibody that binds the extracellular domain of epidermal growth factor receptor (EGFR), is effective in a subset of KRAS wild-type metastatic colorectal cancers. Aft...

journal_title：Nature

authors： Misale S,Yaeger R,Hobor S,Scala E,Janakiraman M,Liska D,Valtorta E,Schiavo R,Buscarino M,Siravegna G,Bencardino K,Cercek A,Chen CT,Veronese S,Zanon C,Sartore-Bianchi A,Gambacorta M,Gallicchio M,Vakiani E,Boscaro V,

更新日期：2012-06-28 00:00:00

abstract：:Fluctuations in the counting rate of photons originating from uncorrelated point sources become, within the coherently illuminated area, slightly enhanced compared to a random sequence of classical particles. This phenomenon, known in astronomy as the Hanbury Brown-Twiss effect, is a consequence of quantum interferenc...

journal_title：Nature

authors： Kiesel H,Renz A,Hasselbach F

更新日期：2002-07-25 00:00:00

abstract：:Since the early 1980s, most electronics have relied on the use of complementary metal-oxide-semiconductor (CMOS) transistors. However, the principles of CMOS operation, involving a switchable semiconductor conductance controlled by an insulating gate, have remained largely unchanged, even as transistors are miniaturiz...

journal_title：Nature

authors： Manipatruni S,Nikonov DE,Lin CC,Gosavi TA,Liu H,Prasad B,Huang YL,Bonturim E,Ramesh R,Young IA

更新日期：2019-01-01 00:00:00

abstract：:Aggregation of amyloid-β peptides into fibrils or other self-assembled states is central to the pathogenesis of Alzheimer's disease. Fibrils formed in vitro by 40- and 42-residue amyloid-β peptides (Aβ40 and Aβ42) are polymorphic, with variations in molecular structure that depend on fibril growth conditions. Recent e...

journal_title：Nature

authors： Qiang W,Yau WM,Lu JX,Collinge J,Tycko R

更新日期：2017-01-12 00:00:00

abstract：:The spontaneously hypertensive rat and the stroke-prone spontaneously hypertensive rat are useful models for human hypertension. In these strains hypertension is a polygenic trait, in which both autosomal and sex-linked genes can influence blood pressure. Linkage studies in crosses between the stroke-prone spontaneous...

journal_title：Nature

authors： Hilbert P,Lindpaintner K,Beckmann JS,Serikawa T,Soubrier F,Dubay C,Cartwright P,De Gouyon B,Julier C,Takahasi S

更新日期：1991-10-10 00:00:00

abstract：:Researchers recognize that society needs accurate and comprehensive estimates of the economic value of rain forests to assess conservation and management options. Valuation of forests can help us to decide whether to implement policies that reconcile the value different groups attach to forests. Here we have measured ...

journal_title：Nature

authors： Godoy R,Wilkie D,Overman H,Cubas A,Cubas G,Demmer J,McSweeney K,Brokaw N

更新日期：2000-07-06 00:00:00

abstract：: ...

journal_title：Nature

authors： Hills R,Kulkarni G,Meerburg PD,Puchwein E

更新日期：2018-12-01 00:00:00

abstract：:The toxicity of misfolded proteins and mitochondrial dysfunction are pivotal factors that promote age-associated functional neuronal decline and neurodegenerative disease. Accordingly, neurons invest considerable cellular resources in chaperones, protein degradation, autophagy and mitophagy to maintain proteostasis an...

journal_title：Nature

authors： Melentijevic I,Toth ML,Arnold ML,Guasp RJ,Harinath G,Nguyen KC,Taub D,Parker JA,Neri C,Gabel CV,Hall DH,Driscoll M

更新日期：2017-02-16 00:00:00

abstract：:Oligodendrocytes and astrocytes are macroglial cells of the vertebrate central nervous system. These cells have diverse roles in the maintenance of neurological function. In the embryo, the genetic mechanisms that underlie the specification of macroglial precursors in vivo appear strikingly similar to those that regul...

journal_title：Nature

authors： Rowitch DH,Kriegstein AR

更新日期：2010-11-11 00:00:00

abstract：:The receptor for insulin-like growth factor type 2, also known as the cation-independent mannose-6-phosphate receptor (Igf2/Mpr), is a multifunctional receptor thought to play a role in lysosomal targeting, cell growth and signal transduction. Igf2/Mpr has been mapped to the mouse Tme locus and shown to be an imprinte...

journal_title：Nature

authors： Wang ZQ,Fung MR,Barlow DP,Wagner EF

更新日期：1994-12-01 00:00:00

abstract：:Signal sequences target proteins for secretion from cells or for integration into cell membranes. As nascent proteins emerge from the ribosome, signal sequences are recognized by the signal recognition particle (SRP), which subsequently associates with its receptor (SR). In this complex, the SRP and SR stimulate each ...

journal_title：Nature

authors： Egea PF,Shan SO,Napetschnig J,Savage DF,Walter P,Stroud RM

更新日期：2004-01-15 00:00:00

abstract：:The central nervous system has extraordinary plasticity in early life. This is thought to involve N-methyl-D-aspartate (NMDA) receptors which, along with the non-NMDA receptors, mediate fast excitatory synaptic transmission. Although NMDA receptors may be transiently enhanced early in life, it has not been possible to...

journal_title：Nature

authors： Hestrin S

更新日期：1992-06-25 00:00:00

abstract：:According to the generally accepted scenario, the last giant impact on Earth formed the Moon and initiated the final phase of core formation by melting Earth's mantle. A key goal of geochemistry is to date this event, but different ages have been proposed. Some argue for an early Moon-forming event, approximately 30 m...

journal_title：Nature

authors： Jacobson SA,Morbidelli A,Raymond SN,O'Brien DP,Walsh KJ,Rubie DC

更新日期：2014-04-03 00:00:00

abstract：:Three subfamilies of grasses, the Ehrhartoideae, Panicoideae and Pooideae, provide the bulk of human nutrition and are poised to become major sources of renewable energy. Here we describe the genome sequence of the wild grass Brachypodium distachyon (Brachypodium), which is, to our knowledge, the first member of the P...

journal_title：Nature

authors： International Brachypodium Initiative.

更新日期：2010-02-11 00:00:00

abstract：:The hydroxyl radical (OH) is a key oxidant involved in the removal of air pollutants and greenhouse gases from the atmosphere. The ratio of Northern Hemispheric to Southern Hemispheric (NH/SH) OH concentration is important for our understanding of emission estimates of atmospheric species such as nitrogen oxides and m...

journal_title：Nature

authors： Patra PK,Krol MC,Montzka SA,Arnold T,Atlas EL,Lintner BR,Stephens BB,Xiang B,Elkins JW,Fraser PJ,Ghosh A,Hintsa EJ,Hurst DF,Ishijima K,Krummel PB,Miller BR,Miyazaki K,Moore FL,Mühle J,O'Doherty S,Prinn RG,Steele

更新日期：2014-09-11 00:00:00

abstract：:Ageing is characterized by the development of persistent pro-inflammatory responses that contribute to atherosclerosis, metabolic syndrome, cancer and frailty1-3. The ageing brain is also vulnerable to inflammation, as demonstrated by the high prevalence of age-associated cognitive decline and Alzheimer's disease4-6. ...

journal_title：Nature

authors： Minhas PS,Latif-Hernandez A,McReynolds MR,Durairaj AS,Wang Q,Rubin A,Joshi AU,He JQ,Gauba E,Liu L,Wang C,Linde M,Sugiura Y,Moon PK,Majeti R,Suematsu M,Mochly-Rosen D,Weissman IL,Longo FM,Rabinowitz JD,Andreasson K

更新日期：2021-01-20 00:00:00

abstract：:It is widely accepted that obesity and associated metabolic diseases, including type 2 diabetes, are intimately linked to diet. However, the gut microbiota has also become a focus for research at the intersection of diet and metabolic health. Mechanisms that link the gut microbiota with obesity are coming to light thr...

journal_title：Nature

authors： Sonnenburg JL,Bäckhed F

更新日期：2016-07-07 00:00:00

abstract：:Exploring visual illusions reveals fundamental principles of cortical processing. Illusory motion perception of non-moving stimuli was described almost a century ago by Gestalt psychologists. However, the underlying neuronal mechanisms remain unknown. To explore cortical mechanisms underlying the 'line-motion' illusio...

journal_title：Nature

authors： Jancke D,Chavane F,Naaman S,Grinvald A

更新日期：2004-03-25 00:00:00

abstract：:The vertical structure of the recent Arctic warming contains information about the processes governing Arctic climate trends. Graversen et al. argue, on the basis of ERA-40 reanalysis data, that a distinct maximum in 1979-2001 warm-season (April-October) Arctic temperature trends appears around 3 km above ground. Here...

journal_title：Nature

authors： Grant AN,Brönnimann S,Haimberger L

更新日期：2008-09-11 00:00:00

abstract：:Fermi-liquid theory (the standard model of metals) has been challenged by the discovery of anomalous properties in an increasingly large number of metals. The anomalies often occur near a quantum critical point--a continuous phase transition in the limit of absolute zero, typically between magnetically ordered and par...

journal_title：Nature

authors： Doiron-Leyraud N,Walker IR,Taillefer L,Steiner MJ,Julian SR,Lonzarich GG

更新日期：2003-10-09 00:00:00

abstract：:Metazoan gene regulation often involves the pausing of RNA polymerase II (Pol II) in the promoter-proximal region. Paused Pol II is stabilized by the protein complexes DRB sensitivity-inducing factor (DSIF) and negative elongation factor (NELF). Here we report the cryo-electron microscopy structure of a paused transcr...

journal_title：Nature

authors： Vos SM,Farnung L,Urlaub H,Cramer P

更新日期：2018-08-01 00:00:00

abstract：:Cleavage of the gasdermin proteins to produce pore-forming amino-terminal fragments causes inflammatory cell death (pyroptosis)1. Gasdermin E (GSDME, also known as DFNA5)-mutated in familial ageing-related hearing loss2-can be cleaved by caspase 3, thereby converting noninflammatory apoptosis to pyroptosis in GSDME-ex...

journal_title：Nature

authors： Zhang Z,Zhang Y,Xia S,Kong Q,Li S,Liu X,Junqueira C,Meza-Sosa KF,Mok TMY,Ansara J,Sengupta S,Yao Y,Wu H,Lieberman J

更新日期：2020-03-01 00:00:00

abstract：:We have shown previously that chromosome VI of Saccharomyces cerevisiae contains nine origins of DNA replication that differ in initiation frequency and replicate sequentially during the S phase of the cell cycle. Here we show that there are links between activation of these multiple origins and regulation of S-phase ...

journal_title：Nature

authors： Shirahige K,Hori Y,Shiraishi K,Yamashita M,Takahashi K,Obuse C,Tsurimoto T,Yoshikawa H

更新日期：1998-10-08 00:00:00

abstract：:The B cells of the immune system, which secrete antibodies against foreign antigens, are fully specific and effective only after maturation in lymph nodes and other lymphoid tissues. Immunocompetent T cells play a crucial part in this process, but the molecular details of the way in which the two cell types interact h...

journal_title：Nature

authors： Clark EA,Ledbetter JA

更新日期：1994-02-03 00:00:00

abstract：:Long-term potentiation (LTP) in the hippocampus is widely studied as the mechanisms involved in its induction and maintenance are believed to underlie fundamental properties of learning and memory in vertebrates. Most synapses that exhibit LTP use an excitatory amino-acid neurotransmitter that acts on two types of rec...

journal_title：Nature

authors： Davies SN,Lester RA,Reymann KG,Collingridge GL

更新日期：1989-04-06 00:00:00

abstract：:Although it is well established that family members resemble each other in intelligence , the extent to which this results from either shared genes or a shared environment remains controversial, perhaps especially since the relevant evidence presented by Burt has been shown probably to have been fabricated. The influe...

journal_title：Nature

authors： Teasdale TW,Owen DR

更新日期：1984-06-14 00:00:00

abstract：:Connectivity in the cortex is organized at multiple scales, suggesting that scale-dependent correlated activity is particularly important for understanding the behaviour of sensory cortices and their function in stimulus encoding. We analysed the scale-dependent structure of cortical interactions by using maximum entr...

journal_title：Nature

authors： Ohiorhenuan IE,Mechler F,Purpura KP,Schmid AM,Hu Q,Victor JD

更新日期：2010-07-29 00:00:00

abstract：:The cartilage and skin of animals, which are made up of more than fifty per cent water, are rather stiff (having elastic moduli of up to 100 megapascals) as well as tough and hard to break (with fracture energies of up to 9,000 joules per square metre). Such features make these biological materials mechanically superi...

journal_title：Nature

authors： Rauner N,Meuris M,Zoric M,Tiller JC

更新日期：2017-03-16 00:00:00

abstract：:Long-term potentiation (LTP) and long-term depression (LTD) are activity-dependent changes in synaptic strength that may serve as the cellular mechanisms of information storage in the vertebrate brain. The mossy fibre-CA3 synapse displays NMDA (M-methyl-D-aspartate) receptor-independent forms of LTP and LTD that were ...

journal_title：Nature

authors： Derrick BE,Martinez JL Jr

更新日期：1996-05-30 00:00:00