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Alterations of alpha-adrenergic modulations of coronary microvascular tone in dogs with heart failure.

Abstract：

BACKGROUND:It remains unclear whether coronary microvascular response to alpha-adrenergic activation alters in chronic heart failure (CHF). METHODS AND RESULTS:We investigated the alpha-adrenergic receptor-mediated effects on coronary pressure-flow relationship (CPFR) in a tachycardia-induced canine heart failure model. The dogs studied were male (29 of 31) and the drugs were given intracoronary. The slope of CPFR during long diastole was evaluated as an index of coronary vascular resistance, during alpha1- or alpha2-adrenergic stimulation or inhibition under anesthesia in the baseline and failing state after 3 weeks of rapid ventricular pacing. Resting coronary blood flow and CPFR did not change in the failing state from the baseline state. Neither alpha1 nor alpha2 stimulation changed the slope of CPFR in the baseline state. However, in the failing state, alpha1 stimulation decreased the slope of CPFR by 23 +/- 5% (P < .05), whereas alpha2 stimulation increased it by 73 +/- 10% (P < .05), which was nearly abolished by pretreatment with NG-nitro-L-arginine methyl ester. CONCLUSION:Alpha2-mediated vasodilatory action, presumably via endothelium-derived nitric oxide release, would be enhanced in the coronary microvascular bed, which may antagonize enhanced alpha1-induced vasoconstriction in CHF.

journal_name

J Card Fail

journal_title

Journal of cardiac failure

authors

Tamagawa K,Saito T,Oikawa Y,Maehara K,Yaoita H,Maruyama Y

doi

10.1016/j.cardfail.2005.01.003

keywords:

subject

Has Abstract

pub_date

2005-06-01 00:00:00

pages

388-95

issue

5

eissn

1071-9164

issn

1532-8414

pii

S1071916405000187

journal_volume

11

pub_type

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