Abstract：
BACKGROUND:In patients with pulmonary arterial hypertension (PAH) the relationship between hemodynamic impairment experienced during daily activity and that during exercise testing is not known. METHODS AND RESULTS:Ten PAH patients received an implantable hemodynamic monitor that continuously recorded and stored right ventricular systolic (RVSP) and mean pulmonary arterial (MPAP) pressures. Before starting a new PAH treatment (baseline) and after 12 weeks on treatment, a 6-minute walk test (6MWT) and a maximal walk test (MAXWT) were performed. Exercise pressure range was measured as the difference between rest before exercise and maximal pressure during 6MWT or MAXWT. Ambulatory range (AMB) was measured as the difference between the lowest (4th percentile) and highest (96th percentile) values recorded over 24 hours. One week of AMBs were averaged for each patient before each exercise test. Mean age was 54 ±18 years, 9 were female, and all were in World Health Organization functional class III. At baseline, RVSP and MPAP increased, respectively, 136 ± 49% and 164 ± 49% during AMB, 63 ± 26% and 79 ± 30% during MAXWT, and 59 ± 32% and 69 ± 33% during 6MWT. There was no difference in pressure change at 12 weeks. CONCLUSIONS:Changes in RV and PA pressures during exercise tests were relatively small compared with the range seen during ambulatory conditions.
journal_name
J Card Failjournal_title
Journal of cardiac failureauthors
Kjellström B,Frantz RP,Benza RL,Bennett T,Bourge RC,McGoon MDdoi
10.1016/j.cardfail.2014.04.019subject
Has Abstractpub_date
2014-07-01 00:00:00pages
485-91issue
7eissn
1071-9164issn
1532-8414pii
S1071-9164(14)00187-0journal_volume
20pub_type
杂志文章abstract：BACKGROUND:Left ventricular remodeling after myocardial infarction is a key component of heart failure and it has long been postulated that it may result from increased wall stress. It has recently been suggested that an injectable, non-degradable polymer may limit pathological remodeling in a manner analogous to that ...
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journal_title：Journal of cardiac failure
pub_type： 杂志文章,评审
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journal_title：Journal of cardiac failure
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pub_type： 杂志文章
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更新日期：2013-01-01 00:00:00
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pub_type： 传,历史文章
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journal_title：Journal of cardiac failure
pub_type： 临床试验,杂志文章,多中心研究,随机对照试验
doi：10.1016/j.cardfail.2004.02.006
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pub_type： 杂志文章,评审
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pub_type： 临床试验,杂志文章,随机对照试验
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pub_type： 杂志文章,多中心研究
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journal_title：Journal of cardiac failure
pub_type： 杂志文章,随机对照试验
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journal_title：Journal of cardiac failure
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pub_type： 杂志文章
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journal_title：Journal of cardiac failure
pub_type： 杂志文章
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更新日期：2012-04-01 00:00:00
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