Abstract：
BACKGROUND:The abnormalities in coronary hemodynamics in systolic heart failure are frequent. Myocardial oxygen demand and consumption are increased and myocardial perfusion is also impaired, which may result in myocardial ischemia, necrosis, and apoptosis. This is potentially a contributing factor for progressive heart failure. METHODS AND RESULTS:Neurohormonal abnormalities such as activated renin-angiotensin-aldosterone system, increased adrenergic activity, hemodynamic abnormalities such as decreased left ventricular perfusion pressure, and increased left ventricular diastolic pressure are important mechanisms for myocardial ischemia. CONCLUSIONS:Different pharmacologic agents may exert different effects on coronary hemodynamics although changes in systemic hemodynamics may be similar. Some agents may enhance myocardial ischemia and others may decrease it. Thus, an understanding of changes in coronary hemodynamics may have therapeutic implications.
journal_name
J Card Failjournal_title
Journal of cardiac failureauthors
Chatterjee Kdoi
10.1016/j.cardfail.2009.01.001subject
Has Abstractpub_date
2009-03-01 00:00:00pages
116-23issue
2eissn
1071-9164issn
1532-8414pii
S1071-9164(09)00018-9journal_volume
15pub_type
杂志文章,评审abstract：BACKGROUND:Disease-modifying drug treatment in heart failure (HF) reduces blood pressure. Titration of these agents is guided by clinic blood pressure readings; however, the impact of such treatment on blood pressure is unknown because diurnal blood pressure patterns remain poorly described. The aim of this study was t...
journal_title：Journal of cardiac failure
pub_type： 杂志文章
doi：10.1016/j.cardfail.2008.03.003
更新日期：2008-09-01 00:00:00
abstract：BACKGROUND:Little is known about guideline-directed pharmacotherapy use in patients with heart failure and reduced ejection fraction (HFrEF) discharged to skilled nursing facilities (SNFs). This study aimed to describe the use of angiotensin-converting enzyme inhibitors (ACEIs)/angiotensin receptor blocker (ARBs) and e...
journal_title：Journal of cardiac failure
pub_type： 杂志文章
doi：10.1016/j.cardfail.2017.09.007
更新日期：2017-12-01 00:00:00
abstract：BACKGROUND:Diabetes is associated with increased risk of mortality in heart failure. We examined the association of diabetes with expenditures, hospitalizations, and procedures among Medicare beneficiaries with heart failure during the last 6 months of life. METHODS AND RESULTS:In a 5% national Medicare sample, the pr...
journal_title：Journal of cardiac failure
pub_type： 杂志文章
doi：10.1016/j.cardfail.2011.09.011
更新日期：2012-01-01 00:00:00
abstract：BACKGROUND:Enzyme replacement therapy (ERT) for infantile-onset Pompe disease effectively reduces the left ventricular (LV) mass. This study sought to explore detailed process of LV reverse remodeling after ERT with the use of tissue Doppler and stain rate imaging. METHODS AND RESULTS:Nine infants and children with Po...
journal_title：Journal of cardiac failure
pub_type： 杂志文章
doi：10.1016/j.cardfail.2011.07.011
更新日期：2011-11-01 00:00:00
abstract：BACKGROUND:Coenzyme Q10 (CoQ10) is essential for ATP generation and has antioxidant properties. Decreased CoQ10 levels have been reported in human heart failure (CHF), but it remains unclear if this is a conserved feature of CHF. The objective of the study was to determine if tachycardia-induced CHF in the dog is assoc...
journal_title：Journal of cardiac failure
pub_type： 杂志文章
doi：10.1054/jcaf.2000.8839
更新日期：2000-09-01 00:00:00
abstract：BACKGROUND:We examined the accuracy of Medicare heart failure (HF) diagnostic codes in the identification of acute decompensated (ADHF and chronic stable (CSHF) HF. METHODS AND RESULTS:Hospitalizations were identified from medical discharge records for Atherosclerosis Risk in Communities (ARIC) study participants with...
journal_title：Journal of cardiac failure
pub_type： 杂志文章
doi：10.1016/j.cardfail.2015.07.013
更新日期：2016-01-01 00:00:00
abstract：BACKGROUND:Guyana is a small developing country with a high burden of cardiovascular disease and extensive barriers to optimal care delivery. We investigated the effectiveness of a newly established multidisciplinary inpatient cardiology service in this setting. METHODS:We performed an interrupted time-series cohort s...
journal_title：Journal of cardiac failure
pub_type： 杂志文章
doi：10.1016/j.cardfail.2018.07.002
更新日期：2018-12-01 00:00:00
abstract：BACKGROUND:Decoupling between diastolic pulmonary arterial pressure (dPAP) and pulmonary arterial wedge pressure (PAWP) is an index of pulmonary vasculature remodeling and provides prognostic information. Furthermore, decoupling may change during incremental left ventricular assist device (LVAD) speed changes. METHODS...
journal_title：Journal of cardiac failure
pub_type： 杂志文章
doi：10.1016/j.cardfail.2018.08.003
更新日期：2018-09-01 00:00:00
abstract：:In most mammalian species, activation of myocardial endothelin as well as alpha1-adrenergic and angiotensin receptors leads to an increase in contractile function and myocardial cell hypertrophy, in association with acceleration of PI hydrolysis and with resultant production of IP3 and diacylglycerol. Therefore, these...
journal_title：Journal of cardiac failure
pub_type： 杂志文章
doi：10.1016/s1071-9164(96)80058-3
更新日期：1996-12-01 00:00:00
abstract：BACKGROUND:The present study examined the influence of rapid intravenous fluid loading (RFL) on airway structure and pulmonary vascular volumes using computed tomography imaging and the subsequent impact on pulmonary function in healthy adults (n = 16). METHODS AND RESULTS:Total lung capacity (DeltaTLC = -6%), forced ...
journal_title：Journal of cardiac failure
pub_type： 杂志文章
doi：10.1016/j.cardfail.2009.08.005
更新日期：2010-02-01 00:00:00
abstract：BACKGROUND:Despite ample data from randomized clinical trials (RCTs), the management of advanced heart failure (HF) varies greatly. We examined the most common refractory questions arising in routine inpatient management of advanced HF. METHODS:From the inpatient HF service at 1 hospital, we prospectively recorded cli...
journal_title：Journal of cardiac failure
pub_type： 杂志文章
doi：10.1016/j.cardfail.2003.10.006
更新日期：2004-06-01 00:00:00
abstract：BACKGROUND:The beneficial effects of the early use of angiotensin-converting enzyme inhibitors (ACEis) in patients with acute myocardial infarction (MI) are well documented. However, the effects of ACEis in patients with an old MI and preserved cardiac function have not yet been studied. We examined the effects of 12 m...
journal_title：Journal of cardiac failure
pub_type： 临床试验,杂志文章
doi：10.1016/s1071-9164(99)91333-7
更新日期：1999-12-01 00:00:00
abstract：BACKGROUND:Chronic heart failure (CHF) patients complain of breathlessness and fatigue. Respiratory muscle function is impaired in CHF patients and may contribute to their symptoms. Beta-blockers cause fatigue but have become part of the standard management of CHF. We explored the relation between respiratory muscle po...
journal_title：Journal of cardiac failure
pub_type： 杂志文章
doi：10.1016/j.cardfail.2004.07.007
更新日期：2005-03-01 00:00:00
abstract：:Structural remodeling of the left ventricle involves myocyte growth and matrix changes that result in chamber enlargement, contractile dysfunction and dyssynchrony. Clinical and experimental data document that these structural changes correlate with progressive worsening of the syndrome of heart failure, that the chan...
journal_title：Journal of cardiac failure
pub_type： 杂志文章,评审
doi：10.1016/j.cardfail.2004.09.007
更新日期：2004-12-01 00:00:00
abstract：BACKGROUND:Atrial fibrillation (AF) is a common arrhythmia which contributes to morbidity and mortality in patients with heart failure (HF). Atrial remodeling is a key substrate for the development of AF in HF. However, experimental models that study AF in the setting of HF have important limitations. We evaluated a ne...
journal_title：Journal of cardiac failure
pub_type： 杂志文章
doi：10.1016/j.cardfail.2007.10.021
更新日期：2008-04-01 00:00:00
abstract：BACKGROUND:This study was designed to examine the hemodynamic, renal, and hormonal effects of infusion of A-type natriuretic peptide (ANP) and B-type natriuretic peptide (BNP) in patients with congestive heart failure (CHF). METHODS AND RESULTS:We infused synthetic human ANP or BNP at a rate of 0.1 microgram/kg/ min i...
journal_title：Journal of cardiac failure
pub_type： 临床试验,杂志文章
doi：10.1016/s1071-9164(96)80088-1
更新日期：1996-12-01 00:00:00
abstract：BACKGROUND:A hallmark characteristic of heart failure (HF) is reduced physical activity (PA) patterns. The relationship between key cardiopulmonary exercise testing (CPX) variables and PA patterns has not been investigated. Therefore, we evaluated PA patterns in patients with ischemic HF and its relationship to peak ox...
journal_title：Journal of cardiac failure
pub_type： 杂志文章
doi：10.1016/j.cardfail.2013.08.002
更新日期：2013-09-01 00:00:00
abstract：BACKGROUND:We investigated the relationship between nonsustained ventricular tachycardia (NSVT) and left ventricular (LV) dilatation, function, remodeling, and scar tissue extent in patients with previous myocardial infarction (MI). METHODS AND RESULTS:Eighty-two patients (ages 64+/-10 years) with first previous MI we...
journal_title：Journal of cardiac failure
pub_type： 杂志文章
doi：10.1016/j.cardfail.2009.09.001
更新日期：2010-01-01 00:00:00
abstract：BACKGROUND:The effect of elevated heart rate (HR) on outcomes after heart transplantation (HT) has not been well established. The aim of this study was to assess predictors of elevated HR following HT and its impact on outcomes. METHODS AND RESULTS:We retrospectively evaluated 394 patients who underwent HT at 2 academ...
journal_title：Journal of cardiac failure
pub_type： 杂志文章,多中心研究
doi：10.1016/j.cardfail.2019.01.009
更新日期：2019-04-01 00:00:00
abstract：BACKGROUND:Prolonged electrocardiogram (ECG) QRS duration (>or=120 ms) is a risk factor for death in systolic heart failure, but its effects in heart failure with preserved systolic function (HFPSF) have not been extensively studied. We hypothesized that prolonged ECG QRS duration would independently predict long-term ...
journal_title：Journal of cardiac failure
pub_type： 杂志文章,多中心研究
doi：10.1016/j.cardfail.2009.02.002
更新日期：2009-09-01 00:00:00
abstract：BACKGROUND:Cardiac resynchronization therapy (CRT) is now an established therapy for patients with advanced heart failure with electromechanical delay, although nonresponders have been observed. Because natriuretic peptides are relevant markers to reflect the severity of heart failure and filling pressure of cardiac ch...
journal_title：Journal of cardiac failure
pub_type： 杂志文章
doi：10.1016/j.cardfail.2005.04.007
更新日期：2005-06-01 00:00:00
abstract：INTRODUCTION:This study was designed to determine if physicians' attitudes and recommendations surrounding implantable cardioverter-defibrillators (ICDs) are regionally associated with ICD use. METHODS AND RESULTS:A national sample of 9969 members of the American College of Cardiology was surveyed electronically. Resp...
journal_title：Journal of cardiac failure
pub_type： 杂志文章
doi：10.1016/j.cardfail.2010.11.009
更新日期：2011-04-01 00:00:00
abstract：BACKGROUND:It remains unclear whether coronary microvascular response to alpha-adrenergic activation alters in chronic heart failure (CHF). METHODS AND RESULTS:We investigated the alpha-adrenergic receptor-mediated effects on coronary pressure-flow relationship (CPFR) in a tachycardia-induced canine heart failure mode...
journal_title：Journal of cardiac failure
pub_type： 杂志文章
doi：10.1016/j.cardfail.2005.01.003
更新日期：2005-06-01 00:00:00
abstract：BACKGROUND:Pregnancy-associated plasma protein A (PAPP-A) proteolyzes insulin-like growth factor (IGF)-binding proteins and thus increases IGF-1 bioactivity. PAPP-A has been reported to be involved in various pathophysiologic abnormalities; however, the clinical significance of PAPP-A has not been examined in cases of ...
journal_title：Journal of cardiac failure
pub_type： 杂志文章
doi：10.1016/j.cardfail.2011.05.011
更新日期：2011-10-01 00:00:00
abstract：BACKGROUND:In patients with heart failure and preserved ejection fraction (HF-PEF) randomized in the Americas as part of the Treatment of Preserved Cardiac Function Heart Failure with an Aldosterone Antagonist (TOPCAT) trial, treatment with spironolactone enhanced the risk of hyperkalemia but reduced the risk of hypoka...
journal_title：Journal of cardiac failure
pub_type： 杂志文章,多中心研究,随机对照试验
doi：10.1016/j.cardfail.2018.03.002
更新日期：2018-05-01 00:00:00
abstract：OBJECTIVE:In chronic heart failure (HF), diuretic doses increase as the disease progresses, often after hospitalization for instability, and have been associated with worsening renal function and increased mortality. METHODS AND RESULTS:A prospective observational analysis of 183 patients in an advanced HF clinic stra...
journal_title：Journal of cardiac failure
pub_type： 杂志文章
doi：10.1016/j.cardfail.2008.01.015
更新日期：2008-06-01 00:00:00
abstract：BACKGROUND:The gene for cardiac troponin T (TNNT2) is 1 of 7 autosomal disease genes implicated in familial dilated cardiomyopathy (FDC). Identical deletions in exon 13 of TNNT2 have been reported in 2 families with FDC, but little is known about the frequency of this deletion among patients with FDC and idiopathic dil...
journal_title：Journal of cardiac failure
pub_type： 杂志文章
doi：10.1054/jcaf.2002.31157
更新日期：2002-02-01 00:00:00
abstract：BACKGROUND:We recently reported that serum levels of pentosidine, one of the well-defined advanced glycation end products (AGE), was an independent prognostic factor for heart failure. Receptor for AGEs (RAGE) is expressed in a variety of tissues, and RAGE has a C-truncated secretory isoform of the receptor protein, te...
journal_title：Journal of cardiac failure
pub_type： 杂志文章
doi：10.1016/j.cardfail.2007.10.019
更新日期：2008-03-01 00:00:00
abstract：BACKGROUND:Autoantibody against β1-adrenergic receptors (β1-AAb) exerts agonist-like action inducing receptor uncoupling and myocardial damage. We attempted to determine the significance of β1-AAb in chronic heart failure (CHF) patients who received carvedilol in a substudy of the Japanese Chronic Heart Failure study. ...
journal_title：Journal of cardiac failure
pub_type： 杂志文章,多中心研究,随机对照试验
doi：10.1016/j.cardfail.2014.12.005
更新日期：2015-03-01 00:00:00
abstract：BACKGROUND:The role of anticoagulation in patients with chronic heart failure has long been an area of interest and controversy. Traditionally the goal of anticoagulation has been to prevent embolic events, but recent trials also demonstrated that oral anticoagulation also prevents vascular events in patients with prio...
journal_title：Journal of cardiac failure
pub_type： 临床试验,杂志文章,多中心研究,随机对照试验
doi：10.1016/j.cardfail.2004.02.006
更新日期：2004-04-01 00:00:00
