Abstract：
BACKGROUND:Coenzyme Q10 (CoQ10) is essential for ATP generation and has antioxidant properties. Decreased CoQ10 levels have been reported in human heart failure (CHF), but it remains unclear if this is a conserved feature of CHF. The objective of the study was to determine if tachycardia-induced CHF in the dog is associated with reduced CoQ10 levels. Furthermore, it was hypothesized that CoQ10 supplementation may improve CHF severity by preventing CoQ10 deficiency (if present) or via antioxidant effects. METHODS AND RESULTS:Serum and myocardial levels of CoQ10 were examined in normal dogs (n = 6), dogs with CHF (control, n = 5), and dogs with CHF treated with CoQ10 (CoQ10; 10 mg/kg/day, n = 5). Serum CoQ10 levels did not change with CHF in control dogs, and myocardial levels were similar to those of normal dogs. CoQ10 therapy increased serum but not myocardial levels of CoQ10. In early CHF, CoQ10-treated dogs had lower filling pressures, and, in severe CHF, CoQ10-treated dogs had less hypertrophy as compared with untreated dogs. Other indices of CHF severity were similar in control and CoQ10-treated dogs. CONCLUSION:These data indicate that CoQ10 deficiency is not present in this model of CHF. Although dramatic effects on hemodynamics were not observed, CoQ10 supplementation did appear to attenuate the hypertrophic response associated with CHF. Key words: enzymes, cardiomyopathy, hormones, antioxidant.
journal_name
J Card Failjournal_title
Journal of cardiac failureauthors
Harker-Murray AK,Tajik AJ,Ishikura F,Meyer D,Burnett JC,Redfield MMdoi
10.1054/jcaf.2000.8839keywords:
subject
Has Abstractpub_date
2000-09-01 00:00:00pages
233-42issue
3eissn
1071-9164issn
1532-8414pii
S1071-9164(00)71566-1journal_volume
6pub_type
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更新日期：2010-01-01 00:00:00
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更新日期：2019-12-01 00:00:00
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