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Dietary habits are related to outcomes in patients with advanced heart failure awaiting heart transplantation.

Abstract：

BACKGROUND:Empirical evidence supporting the benefits of dietary recommendations for patients with advanced heart failure is scarce. We prospectively evaluated the relation of dietary habits to pre-transplant clinical outcomes in the multisite observational Waiting for a New Heart Study. METHODS AND RESULTS:A total of 318 heart transplant candidates (82% male, age 53 ± 11 years) completed a Food Frequency Questionnaire (foods high in salt, saturated fats, poly-/monounsaturated fats [PUFA+MUFA], fruit/vegetables/legumes, and fluid intake) at time of waitlisting. Cox proportional hazard models controlling for heart failure severity (eg, Heart Failure Survival Score, creatinine) estimated cause-specific hazard ratios (HRs) associated with each dietary habit individually, and with all dietary habits entered simultaneously. During follow-up (median 338 days, range 13-1,394), 54 patients died, 151 received transplants (110 in high-urgency status, 41 electively), and 45 became delisted (15 deteriorated, 30 improved). Two robust findings emerged: Frequent intake of salty foods, which correlated positively with saturated fat and fluid intake, was associated with transplantation in high-urgency status (HR 2.90, 95% confidence interval [CI] 1.55-5.42); and frequent intake of foods rich in PUFA+MUFA reduced the risk for death/deterioration (HR 0.49, 95% CI 0.26-0.92). CONCLUSIONS:These results support the importance of dietary habits for the prognosis of patients listed for heart transplantation, independently from heart failure severity.

journal_name

J Card Fail

journal_title

Journal of cardiac failure

authors

Spaderna H,Zahn D,Pretsch J,Connor SL,Zittermann A,Schulze Schleithoff S,Bramstedt KA,Smits JM,Weidner G

doi

10.1016/j.cardfail.2013.02.004

subject

Has Abstract

pub_date

2013-04-01 00:00:00

pages

240-50

issue

4

eissn

1071-9164

issn

1532-8414

pii

S1071-9164(13)00067-5

journal_volume

19

pub_type

杂志文章,多中心研究

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