当前位置： SCI文献检索 > JOURNAL OF CARDIAC FAILURE期刊下所有文献 > Clinical predictors and hemodynamic consequences of elevated peripheral chemosensitivity in optimally treated men with chronic systolic heart failure.

Clinical predictors and hemodynamic consequences of elevated peripheral chemosensitivity in optimally treated men with chronic systolic heart failure.

Abstract：

AIMS:Augmented peripheral chemoreflex response is an important mechanism in the pathophysiology of chronic heart failure (CHF). This study characterizes prevalence and clinical predictors of this phenomenon in optimally managed male CHF patients, and seeks to describe the hemodynamic consequences of chemoreceptor hypersensitivity. METHODS AND RESULTS:Thirty-four optimally managed CHF patients and 16 control subjects were prospectively studied. Hypoxic ventilatory response (HVR)-a measure of peripheral chemosensitivity-was calculated with the use of short nitrogen gas administrations. Systolic blood pressure (SBP) and heart rate (HR) following transient hypoxic challenges were recorded with a Nexfin monitor. Hemodynamic responses to hypoxia were expressed by the linear slopes between oxygen saturation (%) and SBP (mm Hg) or HR (beats/min). Elevated HVR was present in 15 (44%) of the CHF patients. Patients with elevated HVR exhibited higher levels of N-terminal pro-B-type natriuretic peptide, lower left ventricular ejection fraction, and higher prevalence of atrial fibrillation. CHF patients with elevated HVR had significantly greater SBP and HR responses to hypoxia than CHF patients with normal HVR. CONCLUSIONS:Despite comprehensive pharmacotherapy, elevated HVR is prevalent in CHF patients, related to severity of the disease and associated with augmented hemodynamic responses to hypoxia. CHF patients with elevated HVR may be prone to unfavorable hemodynamic changes.

journal_name

J Card Fail

journal_title

Journal of cardiac failure

authors

Niewinski P,Engelman ZJ,Fudim M,Tubek S,Paleczny B,Jankowska EA,Banasiak W,Sobotka PA,Ponikowski P

doi

10.1016/j.cardfail.2013.03.013

subject

Has Abstract

pub_date

2013-06-01 00:00:00

pages

408-15

issue

6

eissn

1071-9164

issn

1532-8414

pii

S1071-9164(13)00099-7

journal_volume

19

pub_type

杂志文章

相关文献

JOURNAL OF CARDIAC FAILURE文献大全
  • Did Frédéric Chopin Die From Heart Failure?

    abstract：:On October 17, 1849, Poland's greatest composer, Frédéric Chopin (1810-1849) died aged 39. His cause of death remains unknown. An investigation of the documental sources was performed to reconstruct the medical history of the artist. Since his earliest years, his life had been dominated by poor health. Recurrent episo...

    journal_title：Journal of cardiac failure

    pub_type： 传,历史文章

    doi：10.1016/j.cardfail.2018.03.009

    authors： Perciaccante A,Charlier P,Negri C,Coralli A,Appenzeller O,Bianucci R

    更新日期：2018-05-01 00:00:00

  • The association between high-dose diuretics and clinical stability in ambulatory chronic heart failure patients.

    abstract：OBJECTIVE:In chronic heart failure (HF), diuretic doses increase as the disease progresses, often after hospitalization for instability, and have been associated with worsening renal function and increased mortality. METHODS AND RESULTS:A prospective observational analysis of 183 patients in an advanced HF clinic stra...

    journal_title：Journal of cardiac failure

    pub_type： 杂志文章

    doi：10.1016/j.cardfail.2008.01.015

    authors： Mielniczuk LM,Tsang SW,Desai AS,Nohria A,Lewis EF,Fang JC,Baughman KL,Stevenson LW,Givertz MM

    更新日期：2008-06-01 00:00:00

  • The role of right ventricular endomyocardial biopsy for idiopathic giant cell myocarditis.

    abstract：BACKGROUND:Idiopathic giant cell myocarditis (GCM) is an uncommon cause of cardiac failure distinguished clinically from lymphocytic myocarditis by rapidly progressive heart failure, arrhythmias, and heart block. Unlike fulminant lymphocytic myocarditis, patients with fulminant cardiac failure caused by GCM may respond...

    journal_title：Journal of cardiac failure

    pub_type： 杂志文章

    doi：10.1054/jcaf.2002.32196

    authors： Shields RC,Tazelaar HD,Berry GJ,Cooper LT Jr

    更新日期：2002-04-01 00:00:00

  • Multiple neurohumoral modulating agents in systolic dysfunction heart failure: are we lowering blood pressure too much?

    abstract：BACKGROUND:Disease-modifying drug treatment in heart failure (HF) reduces blood pressure. Titration of these agents is guided by clinic blood pressure readings; however, the impact of such treatment on blood pressure is unknown because diurnal blood pressure patterns remain poorly described. The aim of this study was t...

    journal_title：Journal of cardiac failure

    pub_type： 杂志文章

    doi：10.1016/j.cardfail.2008.03.003

    authors： Mak G,Murphy NF,Ali A,Walsh A,O'Loughlin C,Conlon C,McCaffrey D,Ledwidge M,McDonald K

    更新日期：2008-09-01 00:00:00

  • Presence of autoantibody directed against β1-adrenergic receptors is associated with amelioration of cardiac function in response to carvedilol: Japanese Chronic Heart Failure (J-CHF) Study.

    abstract：BACKGROUND:Autoantibody against β1-adrenergic receptors (β1-AAb) exerts agonist-like action inducing receptor uncoupling and myocardial damage. We attempted to determine the significance of β1-AAb in chronic heart failure (CHF) patients who received carvedilol in a substudy of the Japanese Chronic Heart Failure study. ...

    journal_title：Journal of cardiac failure

    pub_type： 杂志文章,多中心研究,随机对照试验

    doi：10.1016/j.cardfail.2014.12.005

    authors： Nagatomo Y,Yoshikawa T,Okamoto H,Kitabatake A,Hori M,Japanese Chronic Heart Failure Study Investigators.

    更新日期：2015-03-01 00:00:00

  • Decreased heart rate recovery after exercise in patients with congestive heart failure: effect of beta-blocker therapy.

    abstract：BACKGROUND:Decreased heart rate recovery (HRR) is a predictor of mortality in patients with coronary artery disease and preserved left ventricular function. We investigated the changes in HRR and assessed the impact of beta-blockade therapy on these parameters in patients with symptomatic congestive heart failure (CHF)...

    journal_title：Journal of cardiac failure

    pub_type： 杂志文章

    doi：10.1054/jcaf.2003.47

    authors： Racine N,Blanchet M,Ducharme A,Marquis J,Boucher JM,Juneau M,White M

    更新日期：2003-08-01 00:00:00

  • Airway resistance in chronic heart failure measured by impulse oscillometry.

    abstract：BACKGROUND:Patients with chronic heart failure (CHF) complain of breathlessness and fatigue on exertion, have reduced peak oxygen consumption (pV(O(2))), and an increased ventilatory response to exercise (V(E)/V(CO(2)) slope). These limitations correlate with abnormalities of spirometry (forced expiratory volume in 1 s...

    journal_title：Journal of cardiac failure

    pub_type： 杂志文章

    doi：10.1054/jcaf.2002.126916

    authors： Witte KK,Morice A,Clark AL,Cleland JG

    更新日期：2002-08-01 00:00:00

  • Plasma MMP-9 and MMP-2 following acute myocardial infarction in man: correlation with echocardiographic and neurohumoral parameters of left ventricular dysfunction.

    abstract：BACKGROUND:Left ventricular dilatation and elevated plasma natriuretic peptide levels predict adverse prognosis and the development of congestive heart failure after myocardial infarction. Altered matrix metalloproteinase (MMP) activity has been implicated in the structural changes associated with development of heart ...

    journal_title：Journal of cardiac failure

    pub_type： 杂志文章

    doi：10.1016/j.cardfail.2003.11.003

    authors： Squire IB,Evans J,Ng LL,Loftus IM,Thompson MM

    更新日期：2004-08-01 00:00:00

  • Myocardial hypertrophy in transgenic mice overexpressing human interleukin 1alpha.

    abstract：BACKGROUND:Interleukin (IL)-1 has profound effects on nonimmune cells and organs, including the heart. The effects of IL-1 on transgenic hearts have not yet been described. METHODS AND RESULTS:We generated transgenic mice overexpressing the human IL-1 gene under control of the cytomegalovirus enhancer/chicken beta-act...

    journal_title：Journal of cardiac failure

    pub_type： 杂志文章

    doi：10.1054/jcaf.2001.28221

    authors： Isoda K,Kamezawa Y,Tada N,Sato M,Ohsuzu F

    更新日期：2001-12-01 00:00:00

  • Alterations of alpha-adrenergic modulations of coronary microvascular tone in dogs with heart failure.

    abstract：BACKGROUND:It remains unclear whether coronary microvascular response to alpha-adrenergic activation alters in chronic heart failure (CHF). METHODS AND RESULTS:We investigated the alpha-adrenergic receptor-mediated effects on coronary pressure-flow relationship (CPFR) in a tachycardia-induced canine heart failure mode...

    journal_title：Journal of cardiac failure

    pub_type： 杂志文章

    doi：10.1016/j.cardfail.2005.01.003

    authors： Tamagawa K,Saito T,Oikawa Y,Maehara K,Yaoita H,Maruyama Y

    更新日期：2005-06-01 00:00:00

  • Influence of Donor Transmitted and Rapidly Progressive Coronary Vascular Disease on Long-Term Outcomes After Heart Transplantation: A Contemporary Intravascular Ultrasound Analysis.

    abstract：BACKGROUND:Donor-transmitted atherosclerosis (DTA) and rapidly progressive cardiac allograft vasculopathy (CAV) at 1 year are intravascular ultrasound (IVUS)-derived measures shown to predict adverse cardiovascular outcomes in the setting of early generation immunosuppressive agents. Given the paucity of data on the pr...

    journal_title：Journal of cardiac failure

    pub_type： 杂志文章

    doi：10.1016/j.cardfail.2020.12.012

    authors： Sperry BW,Qarajeh R,Omer MA,Brandt H,Safley D,Borkon AM,Everley MP,Fendler TJ,Khumri TM,Lawhorn SL,Magalski A,Nassif ME,Vodnala D,Kao AC,Austin BA

    更新日期：2021-01-20 00:00:00

  • Levels of circulating pro-angiogenic cells predict cardiovascular outcomes in patients with chronic heart failure.

    abstract：BACKGROUND:Circulating pro-angiogenic cells (PACs) contribute to vascular and myocardial regeneration. A low level of PACs is associated with worse outcome in patients with coronary heart disease. However, little is known about PACs in heart failure (HF). METHODS AND RESULTS:Blood was sampled at baseline in 111 patien...

    journal_title：Journal of cardiac failure

    pub_type： 杂志文章,多中心研究

    doi：10.1016/j.cardfail.2009.05.011

    authors： Balconi G,Lehmann R,Fiordaliso F,Assmus B,Dimmeler S,Sarto P,Carbonieri E,Gualco A,Campana C,Angelici L,Masson S,Mohammed SA,Dejana E,Gorini M,Zeiher AM,Latini R,GISSI-HF Investigators.

    更新日期：2009-11-01 00:00:00

  • Teneligliptin Prevents Cardiomyocyte Hypertrophy, Fibrosis, and Development of Hypertensive Heart Failure in Dahl Salt-Sensitive Rats.

    abstract：BACKGROUND:We investigated the effects of the dipeptidyl peptidase 4 inhibitor teneligliptin on cardiac function and hemodynamics during heart failure in hypertensive model rats. METHODS AND RESULTS:Fifty-five male Dahl salt-sensitive rats were divided into 4 groups: control group (0.3% NaCl chow; n = 13), hypertensio...

    journal_title：Journal of cardiac failure

    pub_type： 杂志文章

    doi：10.1016/j.cardfail.2017.09.001

    authors： Yamamoto M,Ishizu T,Seo Y,Suto Y,Sai S,Xu D,Murakoshi N,Kimura T,Kawakami Y,Aonuma K

    更新日期：2018-01-01 00:00:00

  • Sex-Specific Effects of Adrenergic-Induced Left Ventricular Remodeling in Spontaneously Hypertensive Rats.

    abstract：OBJECTIVE:The aim of this work was to determine whether adrenergic-induced left ventricular (LV) dilation and eccentric remodeling in pressure-overload hypertrophy is sex specific. METHODS AND RESULTS:Chronic β-adrenoreceptor activation was produced in male and female spontaneously hypertensive rats (SHRs) by means of...

    journal_title：Journal of cardiac failure

    pub_type： 杂志文章

    doi：10.1016/j.cardfail.2016.09.017

    authors： Michel FS,Magubane M,Mokotedi L,Norton GR,Woodiwiss AJ

    更新日期：2017-02-01 00:00:00

  • Sympathetic nervous system function as measured by I-123 metaiodobenzylguanidine predicts transplant-free survival in heart failure patients with idiopathic dilated cardiomyopathy.

    abstract：BACKGROUND:Heightened activity of the sympathetic nervous system in heart failure patients is a major contributor to disease progression and death. I-123 metaiodobenzylguanidine (MIBG) provides an accurate, noninvasive method to assess cardiac sympathetic nerve activity. METHODS:Thirty-seven patients with New York Hea...

    journal_title：Journal of cardiac failure

    pub_type： 临床试验,杂志文章

    doi：10.1054/s1071-9164(03)00134-9

    authors： Gerson MC,McGuire N,Wagoner LE

    更新日期：2003-10-01 00:00:00

  • Metoprolol in dilated cardiomyopathy: is it possible to identify factors predictive of improvement? The Heart Muscle Disease Study Group.

    abstract：BACKGROUND:Some controlled clinical trials showed a beneficial effect of beta-blockers on symptoms, exercise tolerance, and left ventricular function in dilated cardiomyopathy. The purpose of this study was to investigate if there are clinical variables at baseline that could predict a favorable response to long-term m...

    journal_title：Journal of cardiac failure

    pub_type： 杂志文章

    doi：10.1016/s1071-9164(96)80027-3

    authors： DiLenarda A,Gregori D,Sinagra G,Lardieri G,Perkan A,Pinamonti B,Salvatore L,Secoli G,Zecchin M,Camerini F

    更新日期：1996-06-01 00:00:00

  • Cardiovascular Magnetic Resonance May Avoid Unnecessary Coronary Angiography in Patients With Unexplained Left Ventricular Systolic Dysfunction: A Retrospective Diagnostic Pilot Study.

    abstract：BACKGROUND:Coronary angiography (CA) is usually performed in patients with reduced left ventricular ejection fraction (LVEF) to search ischemic cardiomyopathy. Our aim was to examine the agreement between CA and cardiovascular magnetic resonance (CMR) imaging among a cohort of patients with unexplained reduced LVEF, an...

    journal_title：Journal of cardiac failure

    pub_type： 杂志文章

    doi：10.1016/j.cardfail.2020.09.005

    authors： Desroche LM,Milleron O,Safar B,Ou P,Garbarz E,Lavie-Badie Y,Abtan J,Millischer D,Pathak A,Durand-Zaleski I,Cattan S,Ronchard T,Jondeau G

    更新日期：2020-12-01 00:00:00

  • Comparison of perfusion-metabolism mismatch in 99mTc-MIBI and 123I-BMIPP scintigraphy with cardiac magnetic resonance in patients with dilated cardiomyopathy.

    abstract：BACKGROUND:Cardiac magnetic resonance (CMR) imaging is an established method of detecting myocardial fibrosis related to prognosis in patients with dilated cardiomyopathy (DCM). Recent studies have found that (99m)Tc-methoxy-isobutyl-isonitrile (MIBI) and (123)I-15-(p-iodophenyl)-3(R,S)-methylpentadecanoic acid (BMIPP)...

    journal_title：Journal of cardiac failure

    pub_type： 杂志文章

    doi：10.1016/j.cardfail.2013.05.009

    authors： Yoshida A,Takano H,Asai K,Yasutake M,Amano Y,Kumita S,Shimizu W,Mizuno K

    更新日期：2013-07-01 00:00:00

  • Effect of left ventricular assist device placement on preexisting implantable cardioverter-defibrillator leads.

    abstract：BACKGROUND:The left ventricular assist device (LVAD) is a therapy for patients with end-stage heart failure, many of whom have a preexisting implantable cardioverter-defibrillator (ICD). We investigated whether the implantation of a LVAD affects ICD function. METHODS AND RESULTS:Patients implanted with a LVAD between ...

    journal_title：Journal of cardiac failure

    pub_type： 杂志文章

    doi：10.1016/j.cardfail.2009.12.003

    authors： Ambardekar AV,Lowery CM,Allen LA,Cannon AP,Cleveland JC Jr,Lindenfeld J,Brieke A,Sauer WH

    更新日期：2010-04-01 00:00:00

  • Pulmonary hemodynamics and endothelin levels in pacing-induced heart failure: during rest and exercise.

    abstract：:Elevated plasma levels of endothelin (ET) have been reported to accompany the development of heart failure (HF), and therefore, this potent vasoconstrictive peptide has been postulated to contribute to the altered pulmonary hemodynamics that occur in this disease process. The overall goal of this study was to examine ...

    journal_title：Journal of cardiac failure

    pub_type： 杂志文章

    doi：10.1016/s1071-9164(97)90025-7

    authors： Kribbs SB,Clair MJ,Krombach RS,Hendrick JW,Thomas PB,Keever AT,Houch WV,Mukherjee R,Spinale FG

    更新日期：1997-12-01 00:00:00

  • Implementation of a Multidisciplinary Inpatient Cardiology Service to Improve Heart Failure Outcomes in Guyana.

    abstract：BACKGROUND:Guyana is a small developing country with a high burden of cardiovascular disease and extensive barriers to optimal care delivery. We investigated the effectiveness of a newly established multidisciplinary inpatient cardiology service in this setting. METHODS:We performed an interrupted time-series cohort s...

    journal_title：Journal of cardiac failure

    pub_type： 杂志文章

    doi：10.1016/j.cardfail.2018.07.002

    authors： Klassen SL,Miller RJH,Hao R,Warnica JW,Fine NM,Carpen M,Isaac DL

    更新日期：2018-12-01 00:00:00

  • Assessing Barriers to Healthy Eating in Hospitalized Older Adults With Heart Failure: Psychometric Properties of Two Questionnaires.

    abstract：BACKGROUND:Dietary sodium excess and malnutrition have been associated with poor outcomes in heart failure (HF). Few previous studies have examined the barriers to following a low-sodium, nutritionally robust diet in hospitalized patients with HF. METHODS AND RESULTS:As part of a dietary intervention pilot study, 76 i...

    journal_title：Journal of cardiac failure

    pub_type： 杂志文章

    doi：10.1016/j.cardfail.2019.09.011

    authors： Marolt C,Miller A,Carlozzi NE,Karmally W,Helmke S,Teruya S,Wells J,Trumble E,Maurer MS,Hummel SL

    更新日期：2020-03-01 00:00:00

  • Autoantibodies Specifically Against β1 Adrenergic Receptors and Adverse Clinical Outcome in Patients With Chronic Systolic Heart Failure in the β-Blocker Era: The Importance of Immunoglobulin G3 Subclass.

    abstract：OBJECTIVE:To elucidate the prevalence and role of β1 adrenergic receptor autoantibodies (β1AR-AAb) belonging to the immunoglobulin (Ig)G3 subclass in patients with heart failure (HF) treated with β-adrenergic blockers. BACKGROUND:Several cardiac AAbs have been reported to be present in sera from patients with dilated ...

    journal_title：Journal of cardiac failure

    pub_type： 杂志文章

    doi：10.1016/j.cardfail.2016.03.005

    authors： Nagatomo Y,Li D,Kirsop J,Borowski A,Thakur A,Tang WH

    更新日期：2016-06-01 00:00:00

  • Decoupling Between Diastolic Pulmonary Arterial Pressure and Pulmonary Arterial Wedge Pressure at Incremental Left Ventricular Assist Device (LVAD) Speeds Is Associated With Worse Prognosis After LVAD Implantation.

    abstract：BACKGROUND:Decoupling between diastolic pulmonary arterial pressure (dPAP) and pulmonary arterial wedge pressure (PAWP) is an index of pulmonary vasculature remodeling and provides prognostic information. Furthermore, decoupling may change during incremental left ventricular assist device (LVAD) speed changes. METHODS...

    journal_title：Journal of cardiac failure

    pub_type： 杂志文章

    doi：10.1016/j.cardfail.2018.08.003

    authors： Imamura T,Kim G,Raikhelkar J,Sarswat N,Kalantari S,Smith B,Rodgers D,Chung B,Nguyen A,Ota T,Song T,Juricek C,Jeevanandam V,Burkhoff D,Sayer G,Uriel N

    更新日期：2018-09-01 00:00:00

  • HFSA 2006 Comprehensive Heart Failure Practice Guideline.

    abstract：:Heart failure (HF) is a syndrome characterized by high mortality, frequent hospitalization, reduced quality of life, and a complex therapeutic regimen. Knowledge about HF is accumulating so rapidly that individual clinicians may be unable to readily and adequately synthesize new information into effective strategies o...

    journal_title：Journal of cardiac failure

    pub_type： 杂志文章,实务指引

    doi：10.1016/j.cardfail.2005.11.005

    authors： Heart Failure Society Of America

    更新日期：2006-02-01 00:00:00

  • Soluble Receptor for advanced glycation end products (RAGE) is a prognostic factor for heart failure.

    abstract：BACKGROUND:We recently reported that serum levels of pentosidine, one of the well-defined advanced glycation end products (AGE), was an independent prognostic factor for heart failure. Receptor for AGEs (RAGE) is expressed in a variety of tissues, and RAGE has a C-truncated secretory isoform of the receptor protein, te...

    journal_title：Journal of cardiac failure

    pub_type： 杂志文章

    doi：10.1016/j.cardfail.2007.10.019

    authors： Koyama Y,Takeishi Y,Niizeki T,Suzuki S,Kitahara T,Sasaki T,Kubota I

    更新日期：2008-03-01 00:00:00

  • Low-to-moderate alcohol intake and health status in heart failure patients.

    abstract：BACKGROUND:Although heart failure (HF) guidelines recommend alcohol abstinence, existing evidence indicates that alcohol may not worsen survival and no data about associations between alcohol and health status (patients' symptoms, function, and quality of life) exist. METHODS AND RESULTS:Alcohol use was quantified in ...

    journal_title：Journal of cardiac failure

    pub_type： 杂志文章,多中心研究

    doi：10.1016/j.cardfail.2004.11.009

    authors： Salisbury AC,House JA,Conard MW,Krumholz HM,Spertus JA

    更新日期：2005-06-01 00:00:00

  • Impact of dopamine infusion on renal function in hospitalized heart failure patients: results of the Dopamine in Acute Decompensated Heart Failure (DAD-HF) Trial.

    abstract：BACKGROUND:Worsening renal function (WRF) and hypokalemia related to diuretic use for acute decompensated heart failure (ADHF) are common and associated with poor prognosis. Low-dose dopamine infusion improves renal perfusion; its effect on diuresis or renal function specifically in ADHF is not known. METHODS AND RESU...

    journal_title：Journal of cardiac failure

    pub_type： 杂志文章,随机对照试验

    doi：10.1016/j.cardfail.2010.07.246

    authors： Giamouzis G,Butler J,Starling RC,Karayannis G,Nastas J,Parisis C,Rovithis D,Economou D,Savvatis K,Kirlidis T,Tsaknakis T,Skoularigis J,Westermann D,Tschöpe C,Triposkiadis F

    更新日期：2010-12-01 00:00:00

  • Validation of a risk score for dying within 1 year of an admission for heart failure.

    abstract：BACKGROUND:Development of heart failure greatly reduces life expectancy. Accurate estimates of the risk of dying are needed in clinical practice and for risk adjustment in observational studies. A relatively simple risk score has been developed to determine the risk of dying within 1-year of an admission for heart fail...

    journal_title：Journal of cardiac failure

    pub_type： 杂志文章

    doi：10.1016/j.cardfail.2006.02.004

    authors： Rector TS,Ringwala SN,Ringwala SN,Anand IS

    更新日期：2006-05-01 00:00:00

  • Doxercalciferol, a pro-hormone of vitamin D, prevents the development of cardiac hypertrophy in rats.

    abstract：BACKGROUND:Activated vitamin D analog, paricalcitol, has been shown to attenuate the development of cardiac hypertrophy in Dahl salt sensitive (DSS) rats. To determine whether an antihypertrophic effect is class specific, we tested if doxercalciferol (a pro-hormone vitamin D2 analog) could also attenuate the developmen...

    journal_title：Journal of cardiac failure

    pub_type： 杂志文章

    doi：10.1016/j.cardfail.2011.08.006

    authors： Choi JH,Ke Q,Bae S,Lee JY,Kim YJ,Kim UK,Arbeeny C,Thadhani R,Kang PM

    更新日期：2011-12-01 00:00:00