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Multiple neurohumoral modulating agents in systolic dysfunction heart failure: are we lowering blood pressure too much?

Abstract：

BACKGROUND:Disease-modifying drug treatment in heart failure (HF) reduces blood pressure. Titration of these agents is guided by clinic blood pressure readings; however, the impact of such treatment on blood pressure is unknown because diurnal blood pressure patterns remain poorly described. The aim of this study was to examine the impact of additional neurohumoral modulating agents on ambulatory blood pressure monitoring (ABPM) control in patients with systolic HF and examine the relationship between the burden of hypotension and clinical outcomes. METHODS AND RESULTS:In a prospective analysis on 45 patients undergoing initiation and optimization of additional medications (angiotensin-converting enzyme inhibitors, angiotensin II receptor blockers, or beta-blockers), mean daytime systolic (P = .035) and mean daytime and nocturnal diastolic hypotensive episodes (both P < .001) increased significantly posttitration. There was no change in clinic blood pressure before and after titration. In a cross-sectional analysis on 144 patients, those with the most diastolic hypotensive episodes had higher rates of HF readmissions (P = .01) and the composite end point of all-cause mortality and all-cause readmissions (P = .03). CONCLUSIONS:Additional neurohumoral modulating agents could produce significant increases in 24-hour hypotension burden despite reassuring clinic blood pressure readings. The burden of diastolic hypotension is independently predictive of HF readmissions and the composite end point of all-cause mortality and emergency readmissions.

journal_name

J Card Fail

journal_title

Journal of cardiac failure

authors

Mak G,Murphy NF,Ali A,Walsh A,O'Loughlin C,Conlon C,McCaffrey D,Ledwidge M,McDonald K

doi

10.1016/j.cardfail.2008.03.003

subject

Has Abstract

pub_date

2008-09-01 00:00:00

pages

555-60

issue

7

eissn

1071-9164

issn

1532-8414

pii

S1071-9164(08)00102-4

journal_volume

14

pub_type

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