Abstract：
BACKGROUND:Sympathetic adrenergic stimulation and the renin-angiotensin-aldosterone system are highly elevated in right heart failure. We evaluated if treatment with the adrenergic receptor blocker bisoprolol or the angiotensin II receptor blocker losartan could prevent the progression of right ventricular (RV) hypertrophy and failure in rats after pulmonary trunk banding (PTB). METHODS AND RESULTS:Male Wistar rats were randomized to severe PTB with a 0.5-mm banding clip (PTB0.5, n = 29), moderate PTB with a 0.6-mm banding clip (PTB0.6, n = 28), or sham operation (SHAM, n = 13). The PTB0.5 and PTB0.6 rats were randomized to 6 weeks of 10 mg/kg/d bisoprolol treatment, 20 mg/kg/d losartan treatment, or vehicle treatment. The PTB caused hypertrophy, dilation, and reduced function of the RV in all rats subjected to the procedure. Rats subjected to the more severe banding developed decompensated RV failure with extracardiac manifestations. Treatment with bisoprolol slowed the heart rate, and treatment with losartan lowered mean arterial pressure, confirming adequate dosing, but none of the treatments improved RV function or arrested the progression of RV hypertrophy and failure compared with vehicle. CONCLUSIONS:In our PTB model of pressure overload-induced RV hypertrophy and failure, treatment with bisoprolol and losartan did not demonstrate any beneficial effects in compensated or decompensated RV failure.
journal_name
J Card Failjournal_title
Journal of cardiac failureauthors
Andersen S,Schultz JG,Andersen A,Ringgaard S,Nielsen JM,Holmboe S,Vildbrad MD,de Man FS,Bogaard HJ,Vonk-Noordegraaf A,Nielsen-Kudsk JEdoi
10.1016/j.cardfail.2014.08.003subject
Has Abstractpub_date
2014-11-01 00:00:00pages
864-73issue
11eissn
1071-9164issn
1532-8414pii
S1071-9164(14)01128-2journal_volume
20pub_type
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