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Serum pregnancy-associated plasma protein a in patients with heart failure.

Abstract：

BACKGROUND:Pregnancy-associated plasma protein A (PAPP-A) proteolyzes insulin-like growth factor (IGF)-binding proteins and thus increases IGF-1 bioactivity. PAPP-A has been reported to be involved in various pathophysiologic abnormalities; however, the clinical significance of PAPP-A has not been examined in cases of heart failure (HF). We hypothesized that PAPP-A levels might be correlated with the severity of HF. METHODS AND RESULTS:PAPP-A and B-type natriuretic peptide (BNP) levels were measured in 262 subjects (182 HF patients and 80 control subjects). PAPP-A levels were higher in patients with HF than in control subjects and increased with advancing New York Heart Association functional class. There were 53 cardiac events during a mean follow-up period of 796 days. PAPP-A levels were higher in patients with cardiac events than in event-free patients. Patients were divided into 3 groups on the basis of their PAPP-A and BNP levels. Kaplan-Meier analysis demonstrated that the group with both high BNP with high PAPP-A had a significantly higher cardiac event rate than other groups. CONCLUSIONS:Serum PAPP-A levels were related to the severity of HF and associated with a high risk for adverse cardiac events in HF patients, suggesting that PAPP-A might be involved in the pathogenesis of HF.

journal_name

J Card Fail

journal_title

Journal of cardiac failure

authors

Funayama A,Shishido T,Netsu S,Ishino M,Sasaki T,Katoh S,Takahashi H,Arimoto T,Miyamoto T,Nitobe J,Watanabe T,Kubota I

doi

10.1016/j.cardfail.2011.05.011

subject

Has Abstract

pub_date

2011-10-01 00:00:00

pages

819-26

issue

10

eissn

1071-9164

issn

1532-8414

pii

S1071-9164(11)00252-1

journal_volume

17

pub_type

杂志文章

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