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Simultaneous right atrioventricular pacing: a novel model to study atrial remodeling and fibrillation in the setting of heart failure.

Abstract：

BACKGROUND:Atrial fibrillation (AF) is a common arrhythmia which contributes to morbidity and mortality in patients with heart failure (HF). Atrial remodeling is a key substrate for the development of AF in HF. However, experimental models that study AF in the setting of HF have important limitations. We evaluated a new dog model of atrial remodeling and AF. METHODS AND RESULTS:Twenty-two mongrel dogs were randomized into 2 groups: 14 dogs with simultaneous atrioventricular pacing (SAVP) for 2 weeks (220 beats/min, no AV delay) and 8 control dogs with no pacing. SAVP for 2 weeks induced marked changes in atrial mechanical function and conduction. Left atrial area fractional shortening decreased 61 +/- 17%, whereas left ventricular area fractional shortening decreased by 38 +/- 18% from baseline (both P < .05). Conduction slowed and conduction heterogeneity increased. AF was induced in 83% of SAVP dogs, lasting a median of 1600 seconds, versus no dogs with induced AF in the controls. SAVP significantly increased nonfibrillar collagen in the mid-myocardium of both atrial appendages and matrix metalloproteinase-9 activity. CONCLUSIONS:SAVP in dogs induces structural and electrical remodelling that form the substrate for reproducibly inducible AF. This novel model may be useful for studies of the pathophysiology and treatment of AF in heart failure.

journal_name

J Card Fail

journal_title

Journal of cardiac failure

authors

Laurent G,Moe GW,Hu X,Pui-Sze So P,Ramadeen A,Leong-Poi H,Doumanovskaia L,Konig A,Trogadis J,Courtman D,Strauss BH,Dorian P

doi

10.1016/j.cardfail.2007.10.021

subject

Has Abstract

pub_date

2008-04-01 00:00:00

pages

254-62

issue

3

eissn

1071-9164

issn

1532-8414

pii

S1071-9164(07)01121-9

journal_volume

14

pub_type

杂志文章

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