New therapeutic strategies for heart failure: left ventricular remodeling as a target.

abstract：BACKGROUND:Digitalis glycosides are known to improve the hemodynamic and neurohormonal perturbations that contribute to heart failure (HF)-induced renal dysfunction (RD). The objective of this study was to determine if randomization to digoxin is associated with improvement in renal function (IRF) and to evaluate if pa...

journal_title：Journal of cardiac failure

authors： Testani JM,Brisco MA,Tang WH,Kimmel SE,Tiku-Owens A,Forfia PR,Coca SG

更新日期：2013-05-01 00:00:00

abstract：BACKGROUND:Previous studies have shown a paradox of lower mortality in black compared with white patients after hospitalization for heart failure, in contrast to the overall higher mortality reported for nonhospitalized black patients with heart failure. We examined racial differences in factors contributing to hospita...

journal_title：Journal of cardiac failure

authors： Singh H,Gordon HS,Deswal A

更新日期：2005-02-01 00:00:00

abstract：OBJECTIVE:To elucidate the prevalence and role of β1 adrenergic receptor autoantibodies (β1AR-AAb) belonging to the immunoglobulin (Ig)G3 subclass in patients with heart failure (HF) treated with β-adrenergic blockers. BACKGROUND:Several cardiac AAbs have been reported to be present in sera from patients with dilated ...

journal_title：Journal of cardiac failure

authors： Nagatomo Y,Li D,Kirsop J,Borowski A,Thakur A,Tang WH

更新日期：2016-06-01 00:00:00

abstract：BACKGROUND:Despite ample data from randomized clinical trials (RCTs), the management of advanced heart failure (HF) varies greatly. We examined the most common refractory questions arising in routine inpatient management of advanced HF. METHODS:From the inpatient HF service at 1 hospital, we prospectively recorded cli...

journal_title：Journal of cardiac failure

authors： Shah MR,Stevenson LW

更新日期：2004-06-01 00:00:00

abstract：BACKGROUND:The role of matrix metalloproteinases (MMPs) polymorphisms on heart failure (HF) susceptibility, phenotypic characteristics, and prognosis has been poorly explored. METHODS AND RESULTS:We studied 313 HF patients with left ventricular systolic dysfunction and 367 healthy control subjects. Genotyping of MMP-1...

journal_title：Journal of cardiac failure

authors： Velho FM,Cohen CR,Santos KG,Silvello D,Martinelli N,Biolo A,Clausell N,Rohde LE

更新日期：2011-02-01 00:00:00

abstract：BACKGROUND:Cardiac magnetic resonance (CMR) imaging is an established method of detecting myocardial fibrosis related to prognosis in patients with dilated cardiomyopathy (DCM). Recent studies have found that (99m)Tc-methoxy-isobutyl-isonitrile (MIBI) and (123)I-15-(p-iodophenyl)-3(R,S)-methylpentadecanoic acid (BMIPP)...

journal_title：Journal of cardiac failure

authors： Yoshida A,Takano H,Asai K,Yasutake M,Amano Y,Kumita S,Shimizu W,Mizuno K

更新日期：2013-07-01 00:00:00

abstract：BACKGROUND:Sympathetic adrenergic stimulation and the renin-angiotensin-aldosterone system are highly elevated in right heart failure. We evaluated if treatment with the adrenergic receptor blocker bisoprolol or the angiotensin II receptor blocker losartan could prevent the progression of right ventricular (RV) hypertr...

journal_title：Journal of cardiac failure

authors： Andersen S,Schultz JG,Andersen A,Ringgaard S,Nielsen JM,Holmboe S,Vildbrad MD,de Man FS,Bogaard HJ,Vonk-Noordegraaf A,Nielsen-Kudsk JE

更新日期：2014-11-01 00:00:00

abstract：BACKGROUND:Urinary liver-type fatty acid-binding protein (L-FABP) is a potential biomarker for acute kidney injury, and it in turn increases cardiovascular mortality. We tested whether the urinary L-FABP level predicted short- and mid-term outcomes in patients with acute heart failure. METHODS AND RESULTS:We enrolled ...

journal_title：Journal of cardiac failure

authors： Okubo Y,Sairaku A,Morishima N,Ogi H,Matsumoto T,Kinoshita H,Kihara Y

更新日期：2018-08-01 00:00:00

abstract：BACKGROUND:Left ventricular assist device (LVAD) support as bridge to recovery (BTR) is uncommon for subjects with chronic heart failure. Myocardial recovery is more evident in recent onset nonischemic cardiomyopathy (ROCM); however, the prevalence of BTR in this subset has not been addressed. METHODS AND RESULTS:We e...

journal_title：Journal of cardiac failure

authors： Boehmer JP,Starling RC,Cooper LT,Torre-Amione G,Wittstein I,Dec GW,Markham DW,Zucker MJ,Gorcsan J 3rd,McTiernan C,Kip K,McNamara DM,IMAC Investigators.

更新日期：2012-10-01 00:00:00

abstract：BACKGROUND:Sustained left ventricular (LV) dyssynchrony can lead to heart failure (HF) in the absence of coronary artery stenosis. We tested whether myocardial hibernation underlies the LV functional impairment caused by high-frequency pacing, an established model of nonischemic dilated cardiomyopathy. METHODS AND RES...

journal_title：Journal of cardiac failure

authors： Lionetti V,Aquaro GD,Simioniuc A,Di Cristofano C,Forini F,Cecchetti F,Campan M,De Marchi D,Bernini F,Grana M,Nannipieri M,Mancini M,Lombardi M,Recchia FA,Pingitore A

更新日期：2009-12-01 00:00:00

abstract：:In most mammalian species, activation of myocardial endothelin as well as alpha1-adrenergic and angiotensin receptors leads to an increase in contractile function and myocardial cell hypertrophy, in association with acceleration of PI hydrolysis and with resultant production of IP3 and diacylglycerol. Therefore, these...

journal_title：Journal of cardiac failure

authors： Fujita S,Endoh M

更新日期：1996-12-01 00:00:00

abstract：BACKGROUND:Therapies for heart failure (HF) with a low ejection fraction (EF) have delayed disease progression and prolonged survival, but the implications of these therapies on the end stages of HF have not been examined. METHODS AND RESULTS:Patients seen by the Brigham and Women's cardiomyopathy service with an EF <...

journal_title：Journal of cardiac failure

authors： Teuteberg JJ,Lewis EF,Nohria A,Tsang SW,Fang JC,Givertz MM,Jarcho JA,Mudge GH,Baughman KL,Stevenson LW

更新日期：2006-02-01 00:00:00

abstract：BACKGROUND:Decoupling between diastolic pulmonary arterial pressure (dPAP) and pulmonary arterial wedge pressure (PAWP) is an index of pulmonary vasculature remodeling and provides prognostic information. Furthermore, decoupling may change during incremental left ventricular assist device (LVAD) speed changes. METHODS...

journal_title：Journal of cardiac failure

authors： Imamura T,Kim G,Raikhelkar J,Sarswat N,Kalantari S,Smith B,Rodgers D,Chung B,Nguyen A,Ota T,Song T,Juricek C,Jeevanandam V,Burkhoff D,Sayer G,Uriel N

更新日期：2018-09-01 00:00:00

abstract：BACKGROUND:We sought to systematically combine the evidence on efficacy of disease management programs (DMPs) in the treatment of congestive heart failure (CHF), to identify and explain heterogeneity of results from prior studies of DMPs, and to assess potential publication bias from these studies. METHODS AND RESULTS...

journal_title：Journal of cardiac failure

authors： Göhler A,Januzzi JL,Worrell SS,Osterziel KJ,Gazelle GS,Dietz R,Siebert U

更新日期：2006-09-01 00:00:00

abstract：BACKGROUND:The total artificial heart (TAH) replaces the heart with 2 pneumatic pumps and 4 tilting disk mechanical valves. It was hypothesized that patients receiving TAH support have persistent hemolysis that resolves after heart transplantation (HT). METHODS AND RESULTS:Hematocrit (HCT) was compared in patients on ...

journal_title：Journal of cardiac failure

authors： Mankad AK,Tang DG,Clark WB,Flattery M,Harton S,Katlaps GJ,Stribling WK,Cooke RH,Hess ML,Kasirajan V,Shah KB

更新日期：2012-06-01 00:00:00

abstract：OBJECTIVE:Disease management programs (DMPs) may reduce short-term readmission or death after heart failure (HF) hospitalization. We sought to determine if targeting of DMP to the highest-risk patients could improve efficiency. METHODS AND RESULTS:Patients (n = 412) admitted with HF were randomized to usual care or an...

journal_title：Journal of cardiac failure

authors： Huynh QL,Whitmore K,Negishi K,Marwick TH,ETHELRED Investigators.

更新日期：2019-05-01 00:00:00

abstract：BACKGROUND:Large-scale clinical trials have demonstrated the benefits of cardiac resynchronization therapy (CRT) in patients with New York Heart Association (NYHA) Class III/IV heart failure, systolic left ventricular dysfunction, and a wide QRS. However, additional patient groups may also benefit from CRT. METHODS AN...

journal_title：Journal of cardiac failure

authors： Wein S,Voskoboinik A,Wein L,Billah B,Krum H

更新日期：2010-05-01 00:00:00

abstract：BACKGROUND:Myocardial recovery after ventricular assist devices (VAD) is rare but appears more common in nonischemic cardiomyopathies (NICM). We sought to evaluate left ventricular (LV) end diastolic diameter (LVEDD) for predicting recovery after VAD. METHODS AND RESULTS:NICM patients receiving long-term mechanical su...

journal_title：Journal of cardiac failure

authors： Simon MA,Primack BA,Teuteberg J,Kormos RL,Bermudez C,Toyoda Y,Shah H,Gorcsan J 3rd,McNamara DM

更新日期：2010-02-01 00:00:00

abstract：BACKGROUND:Cardiac resynchronization therapy (CRT) is now an established therapy for patients with advanced heart failure with electromechanical delay, although nonresponders have been observed. Because natriuretic peptides are relevant markers to reflect the severity of heart failure and filling pressure of cardiac ch...

journal_title：Journal of cardiac failure

authors： Yu CM,Fung JW,Zhang Q,Chan CK,Chan I,Chan YS,Kong SL,Sanderson JE,Lam CW

更新日期：2005-06-01 00:00:00

abstract：:Heart failure (HF) afflicts nearly 6 million Americans, resulting in one million emergency department (ED) visits and over one million annual hospital discharges. An aging population and improved survival from cardiovascular diseases is expected to further increase HF prevalence. Emergency providers play a significant...

journal_title：Journal of cardiac failure

authors： Collins S,Storrow AB,Albert NM,Butler J,Ezekowitz J,Felker GM,Fermann GJ,Fonarow GC,Givertz MM,Hiestand B,Hollander JE,Lanfear DE,Levy PD,Pang PS,Peacock WF,Sawyer DB,Teerlink JR,Lenihan DJ,SAEM\/HFSA Acute Heart Fail

更新日期：2015-01-01 00:00:00

abstract：BACKGROUND:Epidemiological studies typically diagnose heart failure (HF) at the time of hospitalization, and have not evaluated the prevalence of HF symptoms in CKD patients without a prior HF diagnosis. METHODS AND RESULTS:We modified the Kansas City Cardiomyopathy Questionnaire (KCCQ) to detect and quantify symptoms...

journal_title：Journal of cardiac failure

authors： Shlipak MG,Lash JP,Yang W,Teal V,Keane M,Cappola T,Keller C,Jamerson K,Kusek J,Delafontaine P,He J,Miller ER 3rd,Schreiber M,Go AS,CRIC Investigators.

更新日期：2011-01-01 00:00:00

abstract：:Stimulation of the V1a receptor for arginine vasopressin produces myocardial and vascular effects similar to those of angiotensin II while stimulation of the V2 receptor causes fluid retention. There are no data with sustained blockade of the V1a receptor while single-dose experiments suggest benefit. Acute and chroni...

journal_title：Journal of cardiac failure

authors： Goldsmith SR,Udelson JE,Gheorghiade M

更新日期：2018-02-01 00:00:00

abstract：BACKGROUND:Autoantibody against β1-adrenergic receptors (β1-AAb) exerts agonist-like action inducing receptor uncoupling and myocardial damage. We attempted to determine the significance of β1-AAb in chronic heart failure (CHF) patients who received carvedilol in a substudy of the Japanese Chronic Heart Failure study. ...

journal_title：Journal of cardiac failure

authors： Nagatomo Y,Yoshikawa T,Okamoto H,Kitabatake A,Hori M,Japanese Chronic Heart Failure Study Investigators.

更新日期：2015-03-01 00:00:00

abstract：BACKGROUND:Patients with chronic heart failure (CHF) complain of breathlessness and fatigue on exertion, have reduced peak oxygen consumption (pV(O(2))), and an increased ventilatory response to exercise (V(E)/V(CO(2)) slope). These limitations correlate with abnormalities of spirometry (forced expiratory volume in 1 s...

journal_title：Journal of cardiac failure

authors： Witte KK,Morice A,Clark AL,Cleland JG

更新日期：2002-08-01 00:00:00

abstract：BACKGROUND:Device indications have changed for placement of continuous-flow left ventricular assist devices (CF-LVADs). We performed a multicenter analysis evaluating temporal variations in outcomes after CF-LVAD implantation. METHODS & RESULTS:We retrospectively defined 3 time intervals to reflect changes in CF-LVAD ...

journal_title：Journal of cardiac failure

authors： Maltais S,Anwer LA,Haglund NA,Cowger J,Shah P,Aaronson KD,Pagani FD,Dunlay SM,Singh R,Salerno CT,Stulak JM

更新日期：2017-12-01 00:00:00

abstract：BACKGROUND:Recent advances in cardiac multi-detector computed tomography (MDCT) technology now permits entire coronary tree evaluation in a single breath hold with submillimeter slice collimation and improved temporal resolution. METHODS AND RESULTS:Besides excellent correlation with invasive angiogram for the detecti...

journal_title：Journal of cardiac failure

authors： Butler J

更新日期：2007-04-01 00:00:00

abstract：BACKGROUND:Reduced physical activity (PA) may be one factor that contributes to cognitive decline and dementia in heart failure (HF). Yet, the longitudinal relationship between PA and cognition in HF is poorly understood owing to limitations of past work, including single-time assessments of PA. This is the first study...

journal_title：Journal of cardiac failure

authors： Alosco ML,Spitznagel MB,Cohen R,Sweet LH,Hayes SM,Josephson R,Hughes J,Gunstad J

更新日期：2015-04-01 00:00:00

abstract：BACKGROUND:Although there have been many studies on the effects of atrial fibrillation (AF) on cardiac function, few studies have been done on its effects on endothelial function. The present study was designed to examine the effects of AF on endothelial function in human subjects. METHODS AND RESULTS:Changes in forea...

journal_title：Journal of cardiac failure

authors： Takahashi N,Ishibashi Y,Shimada T,Sakane T,Ohata S,Sugamori T,Ohta Y,Inoue S,Nakamura K,Shimizu H,Katoh H,Sano K,Murakami Y,Hashimoto M

更新日期：2001-03-01 00:00:00

abstract：BACKGROUND:There are little data on the optimization of high-intensity aerobic interval exercise (HIIE) protocols in patients with chronic heart failure (CHF). Therefore, we compared acute cardiopulmonary responses to 4 different HIIE protocols to identify the optimal one. METHODS AND RESULTS:Twenty men with stable sy...

journal_title：Journal of cardiac failure

authors： Meyer P,Normandin E,Gayda M,Billon G,Guiraud T,Bosquet L,Fortier A,Juneau M,White M,Nigam A

更新日期：2012-02-01 00:00:00

abstract：:Carfilzomib is a novel irreversible proteasome inhibitor (PI) used with increasing frequency to treat patients with relapsed and/or refractory multiple myeloma (RRMM). This agent is an effective treatment for this challenging population, but proteasome inhibition has the potential of significant cardiac toxicity via t...

journal_title：Journal of cardiac failure

authors： Grandin EW,Ky B,Cornell RF,Carver J,Lenihan DJ

更新日期：2015-02-01 00:00:00