Abstract:
BACKGROUND:Urinary liver-type fatty acid-binding protein (L-FABP) is a potential biomarker for acute kidney injury, and it in turn increases cardiovascular mortality. We tested whether the urinary L-FABP level predicted short- and mid-term outcomes in patients with acute heart failure. METHODS AND RESULTS:We enrolled consecutive patients with acute heart failure, and measured their urinary L-FABP levels before acute treatment. Worsening renal function (WRF), defined as both an absolute increase in the serum creatinine level of ≥0.3mg/dL and a ≥25% relative increase in its level from baseline, occurred in 37 (26.8%) of 138 patients. Patients with a urinary L-FABP level above the upper normal limit (8.4 µg/g creatinine) (n = 49; 35.5%) were more likely than those with a urinary L-FABP level within normal limits (n = 89; 64.5%) to develop WRF (n = 26 [53.1%] vs n = 11 [12.4%]; P < .001). A urinary L-FABP level above the upper limit was independently associated with WRF (hazard ratio 1.8; P = .01). During 1 year of follow-up, 12 patients (8.7%) died, and urinary L-FABP level had no association with all-cause mortality. There was, however, a tendency toward a higher readmission rate in patients with a urinary L-FABP level above the upper normal limit who survived the index hospitalization (n = 46) than in those without an abnormal L-FABP level (n = 88; n = 13 [28.3%] vs n = 13 [14.8%]; log-rank P = .06). CONCLUSIONS:Increased urinary L-FABP level before treatment may predict WRF in patients with acute heart failure. Further investigation is warranted for its predictive ability of adverse outcomes.
journal_name
J Card Failjournal_title
Journal of cardiac failureauthors
Okubo Y,Sairaku A,Morishima N,Ogi H,Matsumoto T,Kinoshita H,Kihara Ydoi
10.1016/j.cardfail.2018.07.003subject
Has Abstractpub_date
2018-08-01 00:00:00pages
520-524issue
8eissn
1071-9164issn
1532-8414pii
S1071-9164(18)30276-8journal_volume
24pub_type
杂志文章abstract:BACKGROUND:Treatment with specific beta-blockers and doses recommended by guidelines is often not achieved in practice. We evaluated an intervention directed to the pharmacy to improve prescribing. METHODS AND RESULTS:We conducted a pragmatic cluster-randomized trial, where facilities (n = 12) with patients (n = 220) ...
journal_title:Journal of cardiac failure
pub_type: 杂志文章,随机对照试验
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更新日期:2013-08-01 00:00:00
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journal_title:Journal of cardiac failure
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pub_type: 杂志文章
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journal_title:Journal of cardiac failure
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journal_title:Journal of cardiac failure
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journal_title:Journal of cardiac failure
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更新日期:2011-04-01 00:00:00
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journal_title:Journal of cardiac failure
pub_type: 杂志文章,评审
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journal_title:Journal of cardiac failure
pub_type: 杂志文章
doi:10.1016/j.cardfail.2005.08.005
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journal_title:Journal of cardiac failure
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.cardfail.2008.11.005
更新日期:2009-05-01 00:00:00
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journal_title:Journal of cardiac failure
pub_type: 杂志文章,多中心研究
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journal_title:Journal of cardiac failure
pub_type: 杂志文章
doi:10.1016/j.cardfail.2006.01.002
更新日期:2006-04-01 00:00:00
abstract::Pathologic left ventricular (LV) remodeling as described by adverse changes in LV mass, volume, geometry, and composition in response to mechanical and systemic neurohormonal activation portends a poor prognosis in patients with underlying LV systolic dysfunction. Conversely, reversal of LV remodeling is associated wi...
journal_title:Journal of cardiac failure
pub_type: 杂志文章,评审
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更新日期:2016-10-01 00:00:00
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journal_title:Journal of cardiac failure
pub_type: 传,历史文章,杂志文章
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更新日期:2001-09-01 00:00:00
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journal_title:Journal of cardiac failure
pub_type: 杂志文章,多中心研究
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更新日期:2009-11-01 00:00:00
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journal_title:Journal of cardiac failure
pub_type: 杂志文章
doi:10.1016/j.cardfail.2016.09.017
更新日期:2017-02-01 00:00:00
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journal_title:Journal of cardiac failure
pub_type: 杂志文章
doi:10.1016/j.cardfail.2012.03.003
更新日期:2012-06-01 00:00:00
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journal_title:Journal of cardiac failure
pub_type: 杂志文章
doi:10.1016/j.cardfail.2012.04.005
更新日期:2012-07-01 00:00:00
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pub_type: 杂志文章
doi:10.1054/jcaf.2002.129234
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更新日期:2010-01-01 00:00:00
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journal_title:Journal of cardiac failure
pub_type: 杂志文章,多中心研究
doi:10.1016/j.cardfail.2018.09.007
更新日期:2018-10-01 00:00:00
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journal_title:Journal of cardiac failure
pub_type: 杂志文章,实务指引
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更新日期:2006-02-01 00:00:00
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journal_title:Journal of cardiac failure
pub_type: 杂志文章
doi:10.1016/1071-9164(95)90012-8
更新日期:1995-03-01 00:00:00
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journal_title:Journal of cardiac failure
pub_type: 杂志文章
doi:10.1016/j.cardfail.2019.04.017
更新日期:2020-03-01 00:00:00
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journal_title:Journal of cardiac failure
pub_type: 杂志文章,评审
doi:10.1016/j.cardfail.2014.09.005
更新日期:2014-12-01 00:00:00
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journal_title:Journal of cardiac failure
pub_type: 杂志文章
doi:10.1016/j.cardfail.2007.07.005
更新日期:2007-12-01 00:00:00
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journal_title:Journal of cardiac failure
pub_type: 杂志文章,多中心研究
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更新日期:2007-08-01 00:00:00