Abstract：
BACKGROUND:Myocardial recovery after ventricular assist devices (VAD) is rare but appears more common in nonischemic cardiomyopathies (NICM). We sought to evaluate left ventricular (LV) end diastolic diameter (LVEDD) for predicting recovery after VAD. METHODS AND RESULTS:NICM patients receiving long-term mechanical support between 1996 and 2008 were reviewed. Subjects were divided into 3 groups: mild, moderate, and severe dilation (Group A: LVEDD <6.0 cm [n = 22]; Group B: 6.0-7.0 cm [n = 32]; Group C: >7.0 cm [n = 48], respectively). Overall, recovery (successful explant without transplantation) occurred in 14 of 102 subjects (14%). Of these, 2 died and 2 required transplantation within 1 year. Recovery was more common in patients without LV dilation (Groups A/B/C = 32%/22%/0%, P < .001), as was sustained recovery (alive and transplant free 1 year after explant; A/B/C = 27%/10%/0%, P = .001). Of the recovery patients in Group A, 6/7 (86%) had sustained recovery versus 3/6 (50%) in Group B. CONCLUSIONS:Recovery occurred in 32% of NICM patients without significant LV dilation at time of VAD, the majority of whom experienced significant sustained recovery. Recovery was not evident in those with severe LV dilation. Routine echocardiography at the time of implant may assist in targeting patients for recovery after VAD.
journal_name
J Card Failjournal_title
Journal of cardiac failureauthors
Simon MA,Primack BA,Teuteberg J,Kormos RL,Bermudez C,Toyoda Y,Shah H,Gorcsan J 3rd,McNamara DMdoi
10.1016/j.cardfail.2009.10.018subject
Has Abstractpub_date
2010-02-01 00:00:00pages
99-105issue
2eissn
1071-9164issn
1532-8414pii
S1071-9164(09)01128-2journal_volume
16pub_type
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