当前位置： SCI文献检索 > JOURNAL OF CARDIAC FAILURE期刊下所有文献 > Pioglitazone and heart failure: results from a controlled study in patients with type 2 diabetes mellitus and systolic dysfunction.

Pioglitazone and heart failure: results from a controlled study in patients with type 2 diabetes mellitus and systolic dysfunction.

Abstract：

BACKGROUND:Thiazolidinediones are associated with fluid retention, often interpreted as worsening cardiac function, limiting their use in patients with heart failure (HF). We compared the effects of pioglitazone and glyburide on cardiac function in patients with type 2 diabetes, systolic dysfunction, and New York Heart Association (NYHA) functional Class II/III HF. METHODS AND RESULTS:Participants received pioglitazone or glyburide (+/-insulin) for 6 months in this double-blind, randomized, multicenter study. The primary end point was time to HF, a composite of cardiovascular mortality and hospitalization or emergency room (ER) visit for HF. Secondary endpoints included echocardiographic and functional classification assessments. An earlier time to onset and higher incidence of the primary endpoint was noted with pioglitazone (13%) versus glyburide (8%) (P = .024). Hospitalization or ER visit occurred in 30 pioglitazone and 15 glyburide participants, 19 and 12 of whom, respectively, continued treatment. Cardiac mortality (5 versus 6 participants, respectively) and cardiac function, as measured by change in ventricular mass index (P = .959), ejection fraction (P = .413), or fractional shortening (P = .280), were similar between treatments. CONCLUSIONS:Pioglitazone was associated with a higher incidence of hospitalization for HF without an increase in cardiovascular mortality or worsening cardiac function (by echocardiography).

journal_name

J Card Fail

journal_title

Journal of cardiac failure

authors

Giles TD,Miller AB,Elkayam U,Bhattacharya M,Perez A

doi

10.1016/j.cardfail.2008.02.007

subject

Has Abstract

pub_date

2008-08-01 00:00:00

pages

445-52

issue

6

eissn

1071-9164

issn

1532-8414

pii

S1071-9164(08)00060-2

journal_volume

14

pub_type

杂志文章,多中心研究,随机对照试验

相关文献

JOURNAL OF CARDIAC FAILURE文献大全
  • Implementation of a Multidisciplinary Inpatient Cardiology Service to Improve Heart Failure Outcomes in Guyana.

    abstract：BACKGROUND:Guyana is a small developing country with a high burden of cardiovascular disease and extensive barriers to optimal care delivery. We investigated the effectiveness of a newly established multidisciplinary inpatient cardiology service in this setting. METHODS:We performed an interrupted time-series cohort s...

    journal_title：Journal of cardiac failure

    pub_type： 杂志文章

    doi：10.1016/j.cardfail.2018.07.002

    authors： Klassen SL,Miller RJH,Hao R,Warnica JW,Fine NM,Carpen M,Isaac DL

    更新日期：2018-12-01 00:00:00

  • Presence of autoantibody directed against β1-adrenergic receptors is associated with amelioration of cardiac function in response to carvedilol: Japanese Chronic Heart Failure (J-CHF) Study.

    abstract：BACKGROUND:Autoantibody against β1-adrenergic receptors (β1-AAb) exerts agonist-like action inducing receptor uncoupling and myocardial damage. We attempted to determine the significance of β1-AAb in chronic heart failure (CHF) patients who received carvedilol in a substudy of the Japanese Chronic Heart Failure study. ...

    journal_title：Journal of cardiac failure

    pub_type： 杂志文章,多中心研究,随机对照试验

    doi：10.1016/j.cardfail.2014.12.005

    authors： Nagatomo Y,Yoshikawa T,Okamoto H,Kitabatake A,Hori M,Japanese Chronic Heart Failure Study Investigators.

    更新日期：2015-03-01 00:00:00

  • Incident Hyperkalemia, Hypokalemia, and Clinical Outcomes During Spironolactone Treatment of Heart Failure With Preserved Ejection Fraction: Analysis of the TOPCAT Trial.

    abstract：BACKGROUND:In patients with heart failure and preserved ejection fraction (HF-PEF) randomized in the Americas as part of the Treatment of Preserved Cardiac Function Heart Failure with an Aldosterone Antagonist (TOPCAT) trial, treatment with spironolactone enhanced the risk of hyperkalemia but reduced the risk of hypoka...

    journal_title：Journal of cardiac failure

    pub_type： 杂志文章,多中心研究,随机对照试验

    doi：10.1016/j.cardfail.2018.03.002

    authors： Desai AS,Liu J,Pfeffer MA,Claggett B,Fleg J,Lewis EF,McKinlay S,O'Meara E,Shah SJ,Sweitzer NK,Solomon S,Pitt B

    更新日期：2018-05-01 00:00:00

  • Searching for evidence: Refractory questions in advanced heart failure.

    abstract：BACKGROUND:Despite ample data from randomized clinical trials (RCTs), the management of advanced heart failure (HF) varies greatly. We examined the most common refractory questions arising in routine inpatient management of advanced HF. METHODS:From the inpatient HF service at 1 hospital, we prospectively recorded cli...

    journal_title：Journal of cardiac failure

    pub_type： 杂志文章

    doi：10.1016/j.cardfail.2003.10.006

    authors： Shah MR,Stevenson LW

    更新日期：2004-06-01 00:00:00

  • Joint Commission requirements for discharge instructions in patients with heart failure: is understanding important for preventing readmissions?

    abstract：BACKGROUND:Many approaches have been considered to reduce heart failure (HF) readmissions. The Joint Commission on Accreditation of Health Care Organizations (JC) requires hospitals to provide patients admitted for HF with discharge instructions that address 6 topics related to HF management: diet, exercise, weight mon...

    journal_title：Journal of cardiac failure

    pub_type： 杂志文章

    doi：10.1016/j.cardfail.2014.06.358

    authors： Regalbuto R,Maurer MS,Chapel D,Mendez J,Shaffer JA

    更新日期：2014-09-01 00:00:00

  • Effect of cardiac resynchronization therapy on left ventricular diastolic function: implications for clinical outcome.

    abstract：BACKGROUND:The definition of response to cardiac resynchronization therapy (CRT) remains controversial, with variable rates of response depending on the criteria used. Our aim was to analyze the impact of CRT on diastolic function in different degrees of response, particularly in patients with positive clinical but no ...

    journal_title：Journal of cardiac failure

    pub_type： 更正并重新发布的文章,杂志文章

    doi：10.1016/j.cardfail.2013.11.001

    authors： Doltra A,Bijnens B,Tolosana JM,Gabrielli L,Castel MÁ,Berruezo A,Brugada J,Mont L,Sitges M

    更新日期：2013-12-01 00:00:00

  • Presynaptic modulation of the norepinephrine-induced beta-adrenergic receptor desensitization phenomenon in vivo.

    abstract：BACKGROUND:In vivo administration of norepinephrine fails to cause beta-adrenergic receptor desensitization. However, short-term exposure of cultured cells to norepinephrine induces the phenomenon in vitro. We sought to identify the local regulatory mechanisms responsible for in vivo beta-adrenergic receptor desensitiz...

    journal_title：Journal of cardiac failure

    pub_type： 杂志文章

    doi：10.1054/jcaf.2000.19223

    authors： Nakamura I,Yoshikawa T,Anzai T,Baba A,Iwata M,Wainai Y,Suzuki M,Ogawa S

    更新日期：2000-12-01 00:00:00

  • Regional variations in physicians' attitudes and recommendations surrounding implantable cardioverter-defibrillators.

    abstract：INTRODUCTION:This study was designed to determine if physicians' attitudes and recommendations surrounding implantable cardioverter-defibrillators (ICDs) are regionally associated with ICD use. METHODS AND RESULTS:A national sample of 9969 members of the American College of Cardiology was surveyed electronically. Resp...

    journal_title：Journal of cardiac failure

    pub_type： 杂志文章

    doi：10.1016/j.cardfail.2010.11.009

    authors： Matlock DD,Kutner JS,Emsermann CB,Al-Khatib SM,Sanders GD,Dickinson LM,Rumsfeld JS,Davidson AJ,Crane LA,Masoudi FA

    更新日期：2011-04-01 00:00:00

  • Impaired glucose tolerance and insulin resistance in heart failure: underrecognized and undertreated?

    abstract：BACKGROUND:A link between diabetes mellitus (DM) and heart failure (HF) has been well-recognized for more than a century. HF is also closely linked to abnormal glucose regulation (AGR) and insulin resistance (IR) in patients without DM and, similarly, these conditions commonly coexist. In epidemiological studies, each ...

    journal_title：Journal of cardiac failure

    pub_type： 杂志文章,评审

    doi：10.1016/j.cardfail.2010.05.027

    authors： Mamas MA,Deaton C,Rutter MK,Yuille M,Williams SG,Ray SG,New J,Gibson JM,Neyses L

    更新日期：2010-09-01 00:00:00

  • Activities and Compensation of Advanced Heart Failure Specialists: Results of the Heart Failure Society of America (HFSA) Survey.

    abstract：BACKGROUND:In the current era, where advanced heart failure (AHF) has become an American Board of Internal Medicine-certified subspecialty, new data are needed to benchmark and value levels of clinical effort performed by AHF specialists (AHFMDs). METHODS AND RESULTS:A 36-question survey was sent to 728 AHFMDs, member...

    journal_title：Journal of cardiac failure

    pub_type： 杂志文章

    doi：10.1016/j.cardfail.2015.08.340

    authors： Klein L,Greenberg BH,Konstam MA,Gregory D,Kociol RD,Johnson MR,de Marco T

    更新日期：2015-11-01 00:00:00

  • Peak oxygen consumption and outcome in heart failure patients chronically treated with beta-blockers.

    abstract：BACKGROUND:Peak oxygen consumption (VO(2)) is an important criterion for listing patients for cardiac transplantation. Beta-blockers improve survival without affecting peak VO(2). We questioned the value of peak VO(2) in predicting outcome in patients treated with beta-blockers. METHODS AND RESULTS:We reviewed the rec...

    journal_title：Journal of cardiac failure

    pub_type： 杂志文章

    doi：10.1016/s1071-9164(03)00593-1

    authors： Shakar SF,Lowes BD,Lindenfeld J,Zolty R,Simon M,Robertson AD,Bristow MR,Wolfel EE

    更新日期：2004-02-01 00:00:00

  • Association of functional and health status measures in heart failure.

    abstract：BACKGROUND:A wide variety of instruments have been used to assess the functional capabilities and health status of patients with chronic heart failure (HF), but it is not known how well these tests are correlated with one another, nor which one has the best association with measured exercise capacity. METHODS AND RESU...

    journal_title：Journal of cardiac failure

    pub_type： 杂志文章

    doi：10.1016/j.cardfail.2006.04.004

    authors： Myers J,Zaheer N,Quaglietti S,Madhavan R,Froelicher V,Heidenreich P

    更新日期：2006-08-01 00:00:00

  • Safety and tolerability of angiotensin-converting enzyme inhibitor versus the combination of angiotensin-converting enzyme inhibitor and angiotensin receptor blocker in patients with left ventricular dysfunction: a systematic review and meta-analysis of r

    abstract：BACKGROUND:The addition of an angiotensin receptor blocker (ARB) to an angiotensin-converting enzyme inhibitor (ACEI) in patients with heart failure remains controversial. A recent meta-analysis showed that the combination therapy reduces hospitalization without improved survival. Whether excess risk is associated with...

    journal_title：Journal of cardiac failure

    pub_type： 杂志文章,meta分析,评审

    doi：10.1016/j.cardfail.2007.11.008

    authors： Lakhdar R,Al-Mallah MH,Lanfear DE

    更新日期：2008-04-01 00:00:00

  • Effects of endothelin-1 on [Ca2+]i-shortening trajectory and Ca2+ sensitivity in rabbit single ventricular cardiomyocytes loaded with indo-1/AM: comparison with the effects of phenylephrine and angiotensin II.

    abstract：:In most mammalian species, activation of myocardial endothelin as well as alpha1-adrenergic and angiotensin receptors leads to an increase in contractile function and myocardial cell hypertrophy, in association with acceleration of PI hydrolysis and with resultant production of IP3 and diacylglycerol. Therefore, these...

    journal_title：Journal of cardiac failure

    pub_type： 杂志文章

    doi：10.1016/s1071-9164(96)80058-3

    authors： Fujita S,Endoh M

    更新日期：1996-12-01 00:00:00

  • Beneficial effects of long-term treatment with enalapril on cardiac function and heart rate variability in patients with old myocardial infarction.

    abstract：BACKGROUND:The beneficial effects of the early use of angiotensin-converting enzyme inhibitors (ACEis) in patients with acute myocardial infarction (MI) are well documented. However, the effects of ACEis in patients with an old MI and preserved cardiac function have not yet been studied. We examined the effects of 12 m...

    journal_title：Journal of cardiac failure

    pub_type： 临床试验,杂志文章

    doi：10.1016/s1071-9164(99)91333-7

    authors： Ooie T,Saikawa T,Hara M,Takakura T,Sato Y,Sakata T

    更新日期：1999-12-01 00:00:00

  • Left Ventricular Deformation and Myocardial Fibrosis in Patients With Advanced Heart Failure Requiring Transplantation.

    abstract：PURPOSE:To evaluate potential relationships between different components of left ventricular (LV) function and histopathological evidence for myocardial fibrosis in patients undergoing heart transplantation. METHODS:The study population included patients with advanced heart failure, referred for an echocardiographic e...

    journal_title：Journal of cardiac failure

    pub_type： 杂志文章

    doi：10.1016/j.cardfail.2016.02.012

    authors： Cameli M,Mondillo S,Righini FM,Lisi M,Dokollari A,Lindqvist P,Maccherini M,Henein M

    更新日期：2016-11-01 00:00:00

  • High prevalence of sleep apnea in heart failure outpatients: even in patients with preserved systolic function.

    abstract：BACKGROUND:Sleep-disordered breathing (SDB) is common in patients with reduced ejection fraction (EF). However, little is known about the prevalence of SDB in a general heart failure population including patients with preserved EF (HFPEF). METHODS:We prospectively enrolled stable heart failure outpatients from our hea...

    journal_title：Journal of cardiac failure

    pub_type： 杂志文章

    doi：10.1016/j.cardfail.2011.01.013

    authors： Herrscher TE,Akre H,Øverland B,Sandvik L,Westheim AS

    更新日期：2011-05-01 00:00:00

  • Airway resistance in chronic heart failure measured by impulse oscillometry.

    abstract：BACKGROUND:Patients with chronic heart failure (CHF) complain of breathlessness and fatigue on exertion, have reduced peak oxygen consumption (pV(O(2))), and an increased ventilatory response to exercise (V(E)/V(CO(2)) slope). These limitations correlate with abnormalities of spirometry (forced expiratory volume in 1 s...

    journal_title：Journal of cardiac failure

    pub_type： 杂志文章

    doi：10.1054/jcaf.2002.126916

    authors： Witte KK,Morice A,Clark AL,Cleland JG

    更新日期：2002-08-01 00:00:00

  • The association between high-dose diuretics and clinical stability in ambulatory chronic heart failure patients.

    abstract：OBJECTIVE:In chronic heart failure (HF), diuretic doses increase as the disease progresses, often after hospitalization for instability, and have been associated with worsening renal function and increased mortality. METHODS AND RESULTS:A prospective observational analysis of 183 patients in an advanced HF clinic stra...

    journal_title：Journal of cardiac failure

    pub_type： 杂志文章

    doi：10.1016/j.cardfail.2008.01.015

    authors： Mielniczuk LM,Tsang SW,Desai AS,Nohria A,Lewis EF,Fang JC,Baughman KL,Stevenson LW,Givertz MM

    更新日期：2008-06-01 00:00:00

  • Quality assurance and cardiopulmonary exercise testing in clinical trials.

    abstract：BACKGROUND:Peak oxygen uptake (VO2) measured during cardiopulmonary exercise testing (CPX) is often used as an outcome measure in clinical trials. The purposes of this study are (a) to report the outcomes of a quality assurance (QA) procedure instituted in multisite clinical trials by a CPX data core laboratory and (b)...

    journal_title：Journal of cardiac failure

    pub_type： 杂志文章

    doi：10.1016/j.cardfail.2008.01.001

    authors： Brawner CA,Ehrman JK,Aldred H,Schairer JR,Keteyian SJ

    更新日期：2008-05-01 00:00:00

  • Quality of care and hospital readmission in congestive heart failure: an explicit review process.

    abstract：BACKGROUND:The effect of hospital quality of care on hospital readmission for patients with congestive heart failure (CHF) has not been widely studied. METHODS AND RESULTS:We examined the effects of clinical factors, hospital quality of care, and cardiologist involvement on 3-month readmission rates in patients with C...

    journal_title：Journal of cardiac failure

    pub_type： 杂志文章

    doi：10.1054/jcaf.2001.28931

    authors： Polanczyk CA,Newton C,Dec GW,Di Salvo TG

    更新日期：2001-12-01 00:00:00

  • The effect of a randomized trial of home telemonitoring on medical costs, 30-day readmissions, mortality, and health-related quality of life in a cohort of community-dwelling heart failure patients.

    abstract：BACKGROUND:Telemonitoring has been advocated as a way of decreasing costs and improving outcomes, but no study has looked at true Medicare payments and 30-day readmission rates in a randomized group of well treated patients. OBJECTIVE:The aim of this work was to analyze Medicare claims data to identify effects of home...

    journal_title：Journal of cardiac failure

    pub_type： 杂志文章,随机对照试验

    doi：10.1016/j.cardfail.2014.04.016

    authors： Blum K,Gottlieb SS

    更新日期：2014-07-01 00:00:00

  • A synthetic non-degradable polyethylene glycol hydrogel retards adverse post-infarct left ventricular remodeling.

    abstract：BACKGROUND:Left ventricular remodeling after myocardial infarction is a key component of heart failure and it has long been postulated that it may result from increased wall stress. It has recently been suggested that an injectable, non-degradable polymer may limit pathological remodeling in a manner analogous to that ...

    journal_title：Journal of cardiac failure

    pub_type： 杂志文章

    doi：10.1016/j.cardfail.2009.03.003

    authors： Dobner S,Bezuidenhout D,Govender P,Zilla P,Davies N

    更新日期：2009-09-01 00:00:00

  • Alterations of alpha-adrenergic modulations of coronary microvascular tone in dogs with heart failure.

    abstract：BACKGROUND:It remains unclear whether coronary microvascular response to alpha-adrenergic activation alters in chronic heart failure (CHF). METHODS AND RESULTS:We investigated the alpha-adrenergic receptor-mediated effects on coronary pressure-flow relationship (CPFR) in a tachycardia-induced canine heart failure mode...

    journal_title：Journal of cardiac failure

    pub_type： 杂志文章

    doi：10.1016/j.cardfail.2005.01.003

    authors： Tamagawa K,Saito T,Oikawa Y,Maehara K,Yaoita H,Maruyama Y

    更新日期：2005-06-01 00:00:00

  • Carvedilol improves left atrial and left ventricular function and reserve in dilated cardiomyopathy after 1 year of treatment.

    abstract：BACKGROUND:The aim of this study was to evaluate the effects of carvedilol therapy on left atrial (LA) function in patients with heart failure from nonischemic dilated cardiomyopathy. METHODS AND RESULTS:Thirty-five patients (42.4 +/- 13.5 years) in New York Heart Association functional Class II-III have been studied....

    journal_title：Journal of cardiac failure

    pub_type： 杂志文章

    doi：10.1016/j.cardfail.2006.10.011

    authors： Paraskevaidis I,Farmakis D,Parissis JT,Dodouras T,Filippatos G,Tsiapras D,Kremastinos DT

    更新日期：2007-03-01 00:00:00

  • Intravenous salt supplementation with low-dose furosemide for treatment of acute decompensated heart failure.

    abstract：BACKGROUND:Theoretically, salt supplementation should promote diuresis through increasing the glomerular filtration rate (GFR) during treatment of acute decompensated heart failure (ADHF) even with low-dose furosemide; however, there is little evidence to support this idea. METHODS AND RESULTS:This was a prospective, ...

    journal_title：Journal of cardiac failure

    pub_type： 杂志文章,随机对照试验

    doi：10.1016/j.cardfail.2014.01.012

    authors： Okuhara Y,Hirotani S,Naito Y,Nakabo A,Iwasaku T,Eguchi A,Morisawa D,Ando T,Sawada H,Manabe E,Masuyama T

    更新日期：2014-05-01 00:00:00

  • Identification of Heart Failure Events in Medicare Claims: The Atherosclerosis Risk in Communities (ARIC) Study.

    abstract：BACKGROUND:We examined the accuracy of Medicare heart failure (HF) diagnostic codes in the identification of acute decompensated (ADHF and chronic stable (CSHF) HF. METHODS AND RESULTS:Hospitalizations were identified from medical discharge records for Atherosclerosis Risk in Communities (ARIC) study participants with...

    journal_title：Journal of cardiac failure

    pub_type： 杂志文章

    doi：10.1016/j.cardfail.2015.07.013

    authors： Kucharska-Newton AM,Heiss G,Ni H,Stearns SC,Puccinelli-Ortega N,Wruck LM,Chambless L

    更新日期：2016-01-01 00:00:00

  • Validation of a risk score for dying within 1 year of an admission for heart failure.

    abstract：BACKGROUND:Development of heart failure greatly reduces life expectancy. Accurate estimates of the risk of dying are needed in clinical practice and for risk adjustment in observational studies. A relatively simple risk score has been developed to determine the risk of dying within 1-year of an admission for heart fail...

    journal_title：Journal of cardiac failure

    pub_type： 杂志文章

    doi：10.1016/j.cardfail.2006.02.004

    authors： Rector TS,Ringwala SN,Ringwala SN,Anand IS

    更新日期：2006-05-01 00:00:00

  • Peripheral Intravenous Volume Analysis (PIVA) for Quantitating Volume Overload in Patients Hospitalized With Acute Decompensated Heart Failure-A Pilot Study.

    abstract：BACKGROUND:To determine the feasibility of peripheral intravenous volume analysis (PIVA) of venous waveforms for assessing volume overload in patients admitted to the hospital with acute decompensated heart failure (ADHF). METHODS:Venous waveforms were captured from a peripheral intravenous catheter in subjects admitt...

    journal_title：Journal of cardiac failure

    pub_type： 杂志文章

    doi：10.1016/j.cardfail.2018.05.003

    authors： Miles M,Alvis BD,Hocking K,Baudenbacher F,Guth C,Lindenfeld J,Brophy C,Eagle S

    更新日期：2018-08-01 00:00:00

  • Plasma MMP-9 and MMP-2 following acute myocardial infarction in man: correlation with echocardiographic and neurohumoral parameters of left ventricular dysfunction.

    abstract：BACKGROUND:Left ventricular dilatation and elevated plasma natriuretic peptide levels predict adverse prognosis and the development of congestive heart failure after myocardial infarction. Altered matrix metalloproteinase (MMP) activity has been implicated in the structural changes associated with development of heart ...

    journal_title：Journal of cardiac failure

    pub_type： 杂志文章

    doi：10.1016/j.cardfail.2003.11.003

    authors： Squire IB,Evans J,Ng LL,Loftus IM,Thompson MM

    更新日期：2004-08-01 00:00:00