Abstract：
BACKGROUND:In patients admitted for heart failure (HF), unrecognized elevation of left ventricular end-diastolic pressure (LVEDP) at the time of discharge may have a role in the high rehospitalization rate for HF on follow-up. METHODS AND RESULTS:In a small, prospective study (n = 50), patients admitted for HF were randomized to management guided by daily noninvasive estimated LVEDP monitoring (Group I, open) to a target LVEDP of <20 mm Hg or management based on clinical assessment alone without knowledge of the estimated LVEDP (Group II, blinded). Noninvasive estimated LVEDP was measured by the VeriCor monitor, which uses the Valsalva maneuver to derive the LVEDP. The primary endpoints were the reduction of estimated LVEDP at discharge and the HF rehospitalization rate on follow-up. Estimated LVEDP was significantly reduced at discharge in the open group compared with the blinded group (mean estimated LVEDP 19.7 ± 1.3 mm Hg vs 25.6 ± 1.5 mm Hg, respectively, P = 0.01). The rehospitalization rates for HF on follow-up were significantly improved in the open group compared with the blinded group (at 1 month: 0% vs 25%, respectively [P = .05]; at 3 months: 0% vs 32% [P = .01]; at 6 months: 4% vs 36% [P = .01]; at 1 year: 16% vs 48% [P = .03]). CONCLUSIONS:When HF is managed by clinical assessment only, estimated LVEDPs remain high at discharge, resulting in early and frequent rehospitalization for HF. Therapy guided by estimated LVEDP monitoring optimizes filling pressures and reduces HF rehospitalization rates.
journal_name
J Card Failjournal_title
Journal of cardiac failureauthors
Sharma GV,Woods PA,Lindsey N,O'Connell C,Connolly L,Joseph J,McIntyre KMdoi
10.1016/j.cardfail.2011.04.014subject
Has Abstractpub_date
2011-09-01 00:00:00pages
718-25issue
9eissn
1071-9164issn
1532-8414pii
S1071-9164(11)00174-6journal_volume
17pub_type
杂志文章,随机对照试验abstract：BACKGROUND:Ventricular remodeling often occurs after myocardial infarction, yet the natural history remains unpredictable because of the chronicity of the process and therapeutic interventions involved. We induced cardiac dysfunction in an ovine model via selective microembolization of the circumflex coronary artery (L...
journal_title：Journal of cardiac failure
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更新日期：2004-04-01 00:00:00
abstract：BACKGROUND:In patients with heart failure (HF) from left ventricular systolic dysfunction, the presence of coexistent right ventricular (RV) dysfunction is associated with poor exercise capacity and reduced survival. We sought to determine whether a simple measure of RV function, the RV myocardial performance index (RV...
journal_title：Journal of cardiac failure
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更新日期：2006-10-01 00:00:00
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journal_title：Journal of cardiac failure
pub_type： 杂志文章,评审
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abstract：BACKGROUND:The left ventricular assist device (LVAD) is a therapy for patients with end-stage heart failure, many of whom have a preexisting implantable cardioverter-defibrillator (ICD). We investigated whether the implantation of a LVAD affects ICD function. METHODS AND RESULTS:Patients implanted with a LVAD between ...
journal_title：Journal of cardiac failure
pub_type： 杂志文章
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更新日期：2010-04-01 00:00:00
abstract：BACKGROUND:Fever is frequently observed in patients with acute myocardial infarction (AMI); however, its prognostic significance remains to be determined. We sought to determine the prognostic significance of increased body temperature (BT) after AMI. METHODS AND RESULTS:We examined 156 consecutive patients with reper...
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doi：10.1016/j.cardfail.2006.09.006
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abstract：BACKGROUND:Diabetes mellitus (DM) is a risk factor for mortality among patients with heart failure as well as for patients who undergo cardiothoracic surgery. However it is unknown whether DM is associated with increased mortality or major complications during continuous-flow left ventricular assist device (CF-LVAD) su...
journal_title：Journal of cardiac failure
pub_type： 杂志文章
doi：10.1016/j.cardfail.2016.02.010
更新日期：2016-10-01 00:00:00
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journal_title：Journal of cardiac failure
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journal_title：Journal of cardiac failure
pub_type： 杂志文章
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journal_title：Journal of cardiac failure
pub_type： 杂志文章,随机对照试验
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更新日期：2006-04-01 00:00:00
abstract：BACKGROUND:We examined the accuracy of Medicare heart failure (HF) diagnostic codes in the identification of acute decompensated (ADHF and chronic stable (CSHF) HF. METHODS AND RESULTS:Hospitalizations were identified from medical discharge records for Atherosclerosis Risk in Communities (ARIC) study participants with...
journal_title：Journal of cardiac failure
pub_type： 杂志文章
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更新日期：2016-01-01 00:00:00
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journal_title：Journal of cardiac failure
pub_type： 杂志文章
doi：10.1016/j.cardfail.2005.04.007
更新日期：2005-06-01 00:00:00
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journal_title：Journal of cardiac failure
pub_type： 杂志文章,评审
doi：10.1016/j.cardfail.2008.07.230
更新日期：2008-11-01 00:00:00
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journal_title：Journal of cardiac failure
pub_type： 杂志文章
doi：10.1016/s1071-9164(00)00012-9
更新日期：2000-03-01 00:00:00
abstract：:Pathologic left ventricular (LV) remodeling as described by adverse changes in LV mass, volume, geometry, and composition in response to mechanical and systemic neurohormonal activation portends a poor prognosis in patients with underlying LV systolic dysfunction. Conversely, reversal of LV remodeling is associated wi...
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pub_type： 杂志文章,评审
doi：10.1016/j.cardfail.2016.03.017
更新日期：2016-10-01 00:00:00
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journal_title：Journal of cardiac failure
pub_type： 杂志文章
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journal_title：Journal of cardiac failure
pub_type： 杂志文章,多中心研究
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pub_type： 杂志文章
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更新日期：2008-04-01 00:00:00
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pub_type： 杂志文章
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更新日期：1997-06-01 00:00:00
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journal_title：Journal of cardiac failure
pub_type： 杂志文章
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更新日期：2012-07-01 00:00:00
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journal_title：Journal of cardiac failure
pub_type： 杂志文章
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更新日期：2002-02-01 00:00:00
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pub_type： 杂志文章,多中心研究
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pub_type： 杂志文章,评审
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journal_title：Journal of cardiac failure
pub_type： 杂志文章
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更新日期：2005-03-01 00:00:00
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doi：10.1016/s1071-9164(96)80058-3
更新日期：1996-12-01 00:00:00
