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Outcomes for Patients With Diabetes After Continuous-Flow Left Ventricular Assist Device Implantation.

Abstract：

BACKGROUND:Diabetes mellitus (DM) is a risk factor for mortality among patients with heart failure as well as for patients who undergo cardiothoracic surgery. However it is unknown whether DM is associated with increased mortality or major complications during continuous-flow left ventricular assist device (CF-LVAD) support. METHODS AND RESULTS:We retrospectively reviewed 300 consecutive adults who received CF-LVADs at a single center in the years 2006-2013; 129 patients had DM before LVAD, as defined by American Diabetes Association criteria (HbA1c ≥6.5% and/or taking DM medications). Compared with the non-DM group, DM patients were older, with a higher pre-LVAD body mass index, more ischemic heart failure etiology, and higher pre-LVAD creatinine. Ninety-three patients died on LVAD support, 43 with DM and 50 without DM (P = .4526). After control for 9 covariates in a Cox proportional hazards model, DM was unassociated with all-cause mortality (hazard ratio 0.883, 95% confidence interval 0.571-1.366; P = .5768). Diabetes was also unassociated with the adverse event end points of stroke/transient ischemic attack, intracerebral hemorrhage, pump thrombosis, and device-related infections. CONCLUSIONS:Diabetes is common in LVAD recipients (43% of the present cohort) but does not increase mortality or rates of major adverse events during CF-LVAD support.

journal_name

J Card Fail

journal_title

Journal of cardiac failure

authors

Vest AR,Mistak SM,Hachamovitch R,Mountis MM,Moazami N,Young JB

doi

10.1016/j.cardfail.2016.02.010

subject

Has Abstract

pub_date

2016-10-01 00:00:00

pages

789-96

issue

10

eissn

1071-9164

issn

1532-8414

pii

S1071-9164(16)00070-1

journal_volume

22

pub_type

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