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Doxercalciferol, a pro-hormone of vitamin D, prevents the development of cardiac hypertrophy in rats.

Abstract：

BACKGROUND:Activated vitamin D analog, paricalcitol, has been shown to attenuate the development of cardiac hypertrophy in Dahl salt sensitive (DSS) rats. To determine whether an antihypertrophic effect is class specific, we tested if doxercalciferol (a pro-hormone vitamin D2 analog) could also attenuate the development of cardiac hypertrophy in DSS rats. METHODS AND RESULTS:Male DSS rats were fed a high salt (HS) diet for 6 weeks beginning at 6 weeks of age. Doxercalciferol was administered intraperitoneally at 150 ng, 3 times per week (Monday, Wednesday, Friday) for 6 weeks. Pathological and echocardiographic findings demonstrated that rats on HS diet with doxercalciferol administration had significant decrease in cardiac hypertrophy and improved cardiac function compared to the HS + vehicle. In addition, there was a significant decrease in plasma brain natriuretic peptide (BNP) level and tissue atrial natriuretic factor (ANF) mRNA level with doxercalciferol treatment. Doxercalciferol also significantly reduced the level of protein kinase C-α (PKCα) suggesting that PKC-mediated cardiac hypertrophy may be associated with vitamin D deficiency. CONCLUSIONS:Administration of doxercalciferol attenuated the development of HS diet induced cardiac hypertrophy and cardiac dysfunction in DSS rats.

journal_name

J Card Fail

journal_title

Journal of cardiac failure

authors

Choi JH,Ke Q,Bae S,Lee JY,Kim YJ,Kim UK,Arbeeny C,Thadhani R,Kang PM

doi

10.1016/j.cardfail.2011.08.006

subject

Has Abstract

pub_date

2011-12-01 00:00:00

pages

1051-8

issue

12

eissn

1071-9164

issn

1532-8414

pii

S1071-9164(11)01061-X

journal_volume

17

pub_type

杂志文章

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