Abstract：
BACKGROUND:Integrins are a large family of heterodimeric cell surface receptors that are present on all cells. These molecules link the extracellular matrix to the intracellular cytoskeleton and are multifunctional, playing roles in cell organization and differentiation, migration, alteration of gene expression, and cell survival. They signal bidirectionally across the cell membrane. Most interestingly from the cardiovascular viewpoint, they have been shown to function as mechanotransducers. METHODS:Although a great deal of studies have been performed that document the biologic function of integrins in a general sense, only recently have data shown their role in the heart. The repertoire of integrins present on cells is modulated in the remodeled myocardium. Further, hemodynamic loading may alter key integrin-mediated signaling events. Perturbation of integrin function in the heart of intact animals has documented the importance of these molecules in the myocardium. CONCLUSION:Future work is required to gain additional information on the role of integrins in the normal and pathologic heart so that we can evaluate if integrins expressed on the cardiac myocyte should be considered as a therapeutic target during cardiac remodeling.
journal_name
J Card Failjournal_title
Journal of cardiac failureauthors
Ross RSdoi
10.1054/jcaf.2002.129263keywords:
subject
Has Abstractpub_date
2002-12-01 00:00:00pages
S326-31issue
6 Suppleissn
1071-9164issn
1532-8414pii
S1071916402004712journal_volume
8pub_type
杂志文章,评审abstract：BACKGROUND:The effect of elevated heart rate (HR) on outcomes after heart transplantation (HT) has not been well established. The aim of this study was to assess predictors of elevated HR following HT and its impact on outcomes. METHODS AND RESULTS:We retrospectively evaluated 394 patients who underwent HT at 2 academ...
journal_title：Journal of cardiac failure
pub_type： 杂志文章,多中心研究
doi：10.1016/j.cardfail.2019.01.009
更新日期：2019-04-01 00:00:00
abstract：:Heart failure (HF) afflicts nearly 6 million Americans, resulting in one million emergency department (ED) visits and over one million annual hospital discharges. An aging population and improved survival from cardiovascular diseases is expected to further increase HF prevalence. Emergency providers play a significant...
journal_title：Journal of cardiac failure
pub_type： 杂志文章,评审
doi：10.1016/j.cardfail.2014.07.003
更新日期：2015-01-01 00:00:00
abstract：BACKGROUND:Current US and European guidelines recommend that ejection fraction (EF) be measured at least once in patients with congestive heart failure (CHF). However, it is not known how age and sex influence adherence to this recommendation. METHODS:We reviewed a national sample of Medicare patients discharged with ...
journal_title：Journal of cardiac failure
pub_type： 杂志文章
doi：10.1054/jcaf.2003.16
更新日期：2003-04-01 00:00:00
abstract：BACKGROUND:The abnormalities in coronary hemodynamics in systolic heart failure are frequent. Myocardial oxygen demand and consumption are increased and myocardial perfusion is also impaired, which may result in myocardial ischemia, necrosis, and apoptosis. This is potentially a contributing factor for progressive hear...
journal_title：Journal of cardiac failure
pub_type： 杂志文章,评审
doi：10.1016/j.cardfail.2009.01.001
更新日期：2009-03-01 00:00:00
abstract：BACKGROUND:It remains controversial which type of exercise elicits optimum adaptations on skeletal myopathy of heart failure (HF). Our aim was to evaluate the effect of high-intensity interval training (HIIT), with or without the addition of strength training, on skeletal muscle of HF patients. METHODS AND RESULTS:Thi...
journal_title：Journal of cardiac failure
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.cardfail.2016.06.007
更新日期：2017-01-01 00:00:00
abstract：BACKGROUND:Functional electrical stimulation (FES) improves exercise capacity and quality of life in chronic heart failure (CHF) patients. However, there is no evidence regarding the effectiveness of this treatment modality according to the severity of CHF. This study compares the effectiveness of FES on exercise capac...
journal_title：Journal of cardiac failure
pub_type： 杂志文章
doi：10.1016/j.cardfail.2009.10.023
更新日期：2010-03-01 00:00:00
abstract：BACKGROUND:Aldosterone antagonists reduce morbidity and mortality in patients with severe heart failure, but the mechanisms responsible are not fully understood. Observations in animal models suggest that elevated levels of aldosterone promote oxidative stress and inflammation in the myocardium. It is unknown if these ...
journal_title：Journal of cardiac failure
pub_type： 杂志文章
doi：10.1016/j.cardfail.2005.08.005
更新日期：2006-03-01 00:00:00
abstract：BACKGROUND:Cardiac resynchronization therapy (CRT) is now an established therapy for patients with advanced heart failure with electromechanical delay, although nonresponders have been observed. Because natriuretic peptides are relevant markers to reflect the severity of heart failure and filling pressure of cardiac ch...
journal_title：Journal of cardiac failure
pub_type： 杂志文章
doi：10.1016/j.cardfail.2005.04.007
更新日期：2005-06-01 00:00:00
abstract：BACKGROUND:We investigated the relationship between nonsustained ventricular tachycardia (NSVT) and left ventricular (LV) dilatation, function, remodeling, and scar tissue extent in patients with previous myocardial infarction (MI). METHODS AND RESULTS:Eighty-two patients (ages 64+/-10 years) with first previous MI we...
journal_title：Journal of cardiac failure
pub_type： 杂志文章
doi：10.1016/j.cardfail.2009.09.001
更新日期：2010-01-01 00:00:00
abstract：BACKGROUND:The purpose of this study was to compare the effects of immediate-release (IR) metoprolol and extended-release (XL) metoprolol on measures of heart rate variability in chronic systolic heart failure patients. METHODS AND RESULTS:Thirteen metoprolol-treated heart failure patients were randomized to a 2-way c...
journal_title：Journal of cardiac failure
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.cardfail.2005.12.002
更新日期：2006-04-01 00:00:00
abstract：:Propionyl-L-carnitine (PLC) is a naturally occurring compound that has been considered for the treatment of congestive heart failure (CHF). The rationale for its use in this pathology is related to its effects on cardiac and skeletal muscle. Chronic treatment with PLC improves the contraction of isolated and aerobic p...
journal_title：Journal of cardiac failure
pub_type： 杂志文章,评审
doi：10.1016/s1071-9164(97)90018-x
更新日期：1997-09-01 00:00:00
abstract：BACKGROUND:Numerous models predicting the risk of incident heart failure (HF) have been developed; however, evidence of their methodological rigor and reporting remains unclear. This study critically appraises the methods underpinning incident HF risk prediction models. METHODS AND RESULTS:EMBASE and PubMed were searc...
journal_title：Journal of cardiac failure
pub_type： 杂志文章,评审
doi：10.1016/j.cardfail.2017.03.005
更新日期：2017-09-01 00:00:00
abstract：BACKGROUND:In patients with pulmonary arterial hypertension (PAH) the relationship between hemodynamic impairment experienced during daily activity and that during exercise testing is not known. METHODS AND RESULTS:Ten PAH patients received an implantable hemodynamic monitor that continuously recorded and stored right...
journal_title：Journal of cardiac failure
pub_type： 杂志文章
doi：10.1016/j.cardfail.2014.04.019
更新日期：2014-07-01 00:00:00
abstract：BACKGROUND:Although substantial effort has been devoted to reducing readmissions among heart failure (HF) patients, little is known about factors identified by patients and caregivers that may contribute to readmissions. The goal of this study was to compare the perspectives of HF patients, their caregivers, and their ...
journal_title：Journal of cardiac failure
pub_type： 杂志文章
doi：10.1016/j.cardfail.2015.10.011
更新日期：2016-03-01 00:00:00
abstract：BACKGROUND:Therapies for heart failure (HF) with a low ejection fraction (EF) have delayed disease progression and prolonged survival, but the implications of these therapies on the end stages of HF have not been examined. METHODS AND RESULTS:Patients seen by the Brigham and Women's cardiomyopathy service with an EF <...
journal_title：Journal of cardiac failure
pub_type： 杂志文章
doi：10.1016/j.cardfail.2005.08.001
更新日期：2006-02-01 00:00:00
abstract：BACKGROUND:It was not until 1919 that the diuretic properties of mercury were observed in patients with syphilis; in the same year the beneficial effects of mercurial diuretics were shown in a patient with severe rheumatic heart disease and anasarca. However, mercury had been used much earlier for the treatment of drop...
journal_title：Journal of cardiac failure
pub_type： 传,历史文章,杂志文章
doi：10.1054/jcaf.2001.26564
更新日期：2001-09-01 00:00:00
abstract：BACKGROUND:Left ventricular assist device (LVAD) support as bridge to recovery (BTR) is uncommon for subjects with chronic heart failure. Myocardial recovery is more evident in recent onset nonischemic cardiomyopathy (ROCM); however, the prevalence of BTR in this subset has not been addressed. METHODS AND RESULTS:We e...
journal_title：Journal of cardiac failure
pub_type： 杂志文章
doi：10.1016/j.cardfail.2012.08.001
更新日期：2012-10-01 00:00:00
abstract：BACKGROUND:Heart failure (HF) guidelines recommend treatment with multiple medications to improve survival, functioning, and quality of life. Yet, HF treatments can be costly, resulting in significant economic burden for some patients. To date, there are few data on the impact of patients' perceived difficulties in aff...
journal_title：Journal of cardiac failure
pub_type： 杂志文章
doi：10.1016/j.cardfail.2006.03.004
更新日期：2006-06-01 00:00:00
abstract：:The aim of this study was to compare the effects on left ventricular function and exercise tolerance of a selective beta-antagonist (atenolol) with those of another selective beta 1-antagonist with vasodilator properties (nebivolol) in patients with ischemic left ventricular dysfunction but no overt congestive heart f...
journal_title：Journal of cardiac failure
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1016/s1071-9164(96)80004-2
更新日期：1996-03-01 00:00:00
abstract：BACKGROUND:Empirical evidence supporting the benefits of dietary recommendations for patients with advanced heart failure is scarce. We prospectively evaluated the relation of dietary habits to pre-transplant clinical outcomes in the multisite observational Waiting for a New Heart Study. METHODS AND RESULTS:A total of...
journal_title：Journal of cardiac failure
pub_type： 杂志文章,多中心研究
doi：10.1016/j.cardfail.2013.02.004
更新日期：2013-04-01 00:00:00
abstract：BACKGROUND:In patients admitted for heart failure (HF), unrecognized elevation of left ventricular end-diastolic pressure (LVEDP) at the time of discharge may have a role in the high rehospitalization rate for HF on follow-up. METHODS AND RESULTS:In a small, prospective study (n = 50), patients admitted for HF were ra...
journal_title：Journal of cardiac failure
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.cardfail.2011.04.014
更新日期：2011-09-01 00:00:00
abstract：:Simultaneous dysfunction of the heart and the kidney represents a distinct spectrum of disease states composed of complex clinical scenarios with adverse outcomes. Worsening renal function (WRF) in the setting of acute decompensated heart failure (ADHF) is one such clinical setup for which the underlying mechanisms ar...
journal_title：Journal of cardiac failure
pub_type： 杂志文章,评审
doi：10.1016/j.cardfail.2014.09.005
更新日期：2014-12-01 00:00:00
abstract：OBJECTIVE:The aim of this work was to determine whether adrenergic-induced left ventricular (LV) dilation and eccentric remodeling in pressure-overload hypertrophy is sex specific. METHODS AND RESULTS:Chronic β-adrenoreceptor activation was produced in male and female spontaneously hypertensive rats (SHRs) by means of...
journal_title：Journal of cardiac failure
pub_type： 杂志文章
doi：10.1016/j.cardfail.2016.09.017
更新日期：2017-02-01 00:00:00
abstract：BACKGROUND:The total artificial heart (TAH) replaces the heart with 2 pneumatic pumps and 4 tilting disk mechanical valves. It was hypothesized that patients receiving TAH support have persistent hemolysis that resolves after heart transplantation (HT). METHODS AND RESULTS:Hematocrit (HCT) was compared in patients on ...
journal_title：Journal of cardiac failure
pub_type： 杂志文章
doi：10.1016/j.cardfail.2012.03.003
更新日期：2012-06-01 00:00:00
abstract：BACKGROUND:Progress has been made in addressing pain in specific diseases such as cancer, but less attention has focused on understanding pain in nonmalignant states, including heart failure (HF). METHODS AND RESULTS:From March 2006 to June 2007, 672 veterans were surveyed and scores for the Brief Pain Inventory, pain...
journal_title：Journal of cardiac failure
pub_type： 杂志文章,多中心研究
doi：10.1016/j.cardfail.2008.09.002
更新日期：2009-02-01 00:00:00
abstract：BACKGROUND:The proinflammatory cytokines have been implicated in the pathogenesis of heart failure. Recent studies have shown that beta-adrenergic blockade can modulate cytokine production. This study investigates the different impact of different degrees of sympathetic antagonism on circulating levels of cytokines in ...
journal_title：Journal of cardiac failure
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1016/j.cardfail.2004.07.006
更新日期：2005-04-01 00:00:00
abstract：:Heart failure (HF) is a syndrome characterized by high mortality, frequent hospitalization, reduced quality of life, and a complex therapeutic regimen. Knowledge about HF is accumulating so rapidly that individual clinicians may be unable to readily and adequately synthesize new information into effective strategies o...
journal_title：Journal of cardiac failure
pub_type： 杂志文章,实务指引
doi：10.1016/j.cardfail.2005.11.005
更新日期：2006-02-01 00:00:00
abstract：BACKGROUND:Fixed pulmonary hypertension is common in patients with advanced heart failure and is a contraindication for heart transplantation. Left ventricular assist devices (LVAD) and inotropes have been used to reduce pulmonary vascular resistance (PVR) and allow transplantation. However, little is known about the e...
journal_title：Journal of cardiac failure
pub_type： 杂志文章
doi：10.1016/j.cardfail.2016.06.421
更新日期：2017-03-01 00:00:00
abstract：BACKGROUND:The present study was designed to study the progression of heart failure in rabbits with catecholamine-induced cardiomyopathy. METHODS AND RESULTS:We investigated the effects of three repetitive applications (at 16-day intervals) of high-dose epinephrine (first infusion, 5 micrograms/kg/min for 60 minutes; ...
journal_title：Journal of cardiac failure
pub_type： 杂志文章
doi：10.1016/s1071-9164(99)90033-7
更新日期：1999-06-01 00:00:00
abstract：BACKGROUND:Two recent literature-based meta-analyses revealed that restrictive filling pattern (RFP) was associated with a 4-fold increase in the risk of death in patients with heart failure (HF) and postacute myocardial infarction (AMI). This similar but unique analysis evaluated the link between RFP and morbidity. M...
journal_title：Journal of cardiac failure
pub_type： 杂志文章,meta分析
doi：10.1016/j.cardfail.2007.01.010
更新日期：2007-06-01 00:00:00
