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Elevated Heart Rate Following Heart Transplantation Is Associated With Increased Graft Vasculopathy and Mortality.

Abstract：

BACKGROUND:The effect of elevated heart rate (HR) on outcomes after heart transplantation (HT) has not been well established. The aim of this study was to assess predictors of elevated HR following HT and its impact on outcomes. METHODS AND RESULTS:We retrospectively evaluated 394 patients who underwent HT at 2 academic medical centers from 2005 to 2016. Patients were divided into 2 groups based on HR 1 year after HT: HR ≥95 beats/min (n = 162; 41%) and HR <95 beats/min (n = 232; 59%). Median follow-up time was 6.6 (interquartile range [IQR] 2.2-7.5) years. HR ≥95 beats/min 1 year after HT was associated with younger donor age, whereas HR <95 beats/min was associated with heavy donor alcohol use and African-American recipient race. Left ventricular (LV) end-diastolic dimension, mass, and ejection fraction were lower and E/E' higher in the HR ≥95 group at the time of the last follow up. HR ≥95 beats/min at 1 year after HT was independently associated with the development of cardiac allograft vasculopathy and increased mortality. CONCLUSIONS:HR ≥95 beats/min 1 year after HT is associated with a reduction in LV size and function, increased incidence of cardiac allograft vasculopathy, and reduced survival. Studies investigating the effect of medical HR reduction on post-HT outcomes are warranted.

journal_name

J Card Fail

journal_title

Journal of cardiac failure

authors

Liebo M,Newman J,Joshi A,Lowes BD,Peled-Potashnik Y,Basha HI,Zolty R,Um JY,McGee E Jr,Heroux A,Raichlin E

doi

10.1016/j.cardfail.2019.01.009

subject

Has Abstract

pub_date

2019-04-01 00:00:00

pages

249-256

issue

4

eissn

1071-9164

issn

1532-8414

pii

S1071-9164(18)31021-2

journal_volume

25

pub_type

杂志文章,多中心研究

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