Can Biomarkers Provide Right Ventricular-Specific Prognostication in the Perioperative Setting?

Abstract:

:Since the introduction of biomarkers in the late 1980s, considerable research has been dedicated to their validation and application. As a result, many biomarkers are now commonly used in clinical practice. However, the role of biomarkers in the prediction of right ventricular failure (RVF) and in the prognostication for patients with RVF remains underexplored. Barriers include a lack of awareness of the importance of right ventricular function, especially in the perioperative setting, as well as a lack of reproducible means to assess right ventricular function in this setting. We provide an overview of biomarkers with right ventricular prognostic capabilities that could be further explored in patients expecting cardiac surgery, who are notoriously susceptible to developing RVF. We discuss biomarkers' mechanistic pathways and highlight their potential strengths and weaknesses in use in research and clinical care.

journal_name

J Card Fail

authors

Jabagi H,Ruel M,Sun LY

doi

10.1016/j.cardfail.2019.09.007

subject

Has Abstract

pub_date

2020-09-01 00:00:00

pages

776-780

issue

9

eissn

1071-9164

issn

1532-8414

pii

S1071-9164(19)30516-0

journal_volume

26

pub_type

杂志文章
  • Association of functional and health status measures in heart failure.

    abstract:BACKGROUND:A wide variety of instruments have been used to assess the functional capabilities and health status of patients with chronic heart failure (HF), but it is not known how well these tests are correlated with one another, nor which one has the best association with measured exercise capacity. METHODS AND RESU...

    journal_title:Journal of cardiac failure

    pub_type: 杂志文章

    doi:10.1016/j.cardfail.2006.04.004

    authors: Myers J,Zaheer N,Quaglietti S,Madhavan R,Froelicher V,Heidenreich P

    更新日期:2006-08-01 00:00:00

  • Quality assurance and cardiopulmonary exercise testing in clinical trials.

    abstract:BACKGROUND:Peak oxygen uptake (VO2) measured during cardiopulmonary exercise testing (CPX) is often used as an outcome measure in clinical trials. The purposes of this study are (a) to report the outcomes of a quality assurance (QA) procedure instituted in multisite clinical trials by a CPX data core laboratory and (b)...

    journal_title:Journal of cardiac failure

    pub_type: 杂志文章

    doi:10.1016/j.cardfail.2008.01.001

    authors: Brawner CA,Ehrman JK,Aldred H,Schairer JR,Keteyian SJ

    更新日期:2008-05-01 00:00:00

  • Acute Unloading Effects of Sildenafil Enhance Right Ventricular-Pulmonary Artery Coupling in Heart Failure.

    abstract:BACKGROUND:Phosphodiesterase-5A inhibitors (PDE5i) are sometimes used in patients with advanced heart failure with reduced ejection fraction before heart transplant or left ventricular assist device implantation to decrease right ventricular (RV) afterload and mitigate the risk of right heart failure. Conflicting evide...

    journal_title:Journal of cardiac failure

    pub_type: 杂志文章

    doi:10.1016/j.cardfail.2020.11.007

    authors: Monzo L,Reichenbach A,Al-Hiti H,Borlaug BA,Havlenova T,Solar N,Tupy M,Ters J,Kautzner J,Melenovsky V

    更新日期:2020-11-21 00:00:00

  • Cardiac troponin T lysine 210 deletion in a family with dilated cardiomyopathy.

    abstract:BACKGROUND:The gene for cardiac troponin T (TNNT2) is 1 of 7 autosomal disease genes implicated in familial dilated cardiomyopathy (FDC). Identical deletions in exon 13 of TNNT2 have been reported in 2 families with FDC, but little is known about the frequency of this deletion among patients with FDC and idiopathic dil...

    journal_title:Journal of cardiac failure

    pub_type: 杂志文章

    doi:10.1054/jcaf.2002.31157

    authors: Hanson EL,Jakobs PM,Keegan H,Coates K,Bousman S,Dienel NH,Litt M,Hershberger RE

    更新日期:2002-02-01 00:00:00

  • Airway resistance in chronic heart failure measured by impulse oscillometry.

    abstract:BACKGROUND:Patients with chronic heart failure (CHF) complain of breathlessness and fatigue on exertion, have reduced peak oxygen consumption (pV(O(2))), and an increased ventilatory response to exercise (V(E)/V(CO(2)) slope). These limitations correlate with abnormalities of spirometry (forced expiratory volume in 1 s...

    journal_title:Journal of cardiac failure

    pub_type: 杂志文章

    doi:10.1054/jcaf.2002.126916

    authors: Witte KK,Morice A,Clark AL,Cleland JG

    更新日期:2002-08-01 00:00:00

  • Effects of lisinopril in patients with heart failure and chronic atrial fibrillation.

    abstract::Although atrial fibrillation is common in patients with heart failure, patients with atrial fibrillation are often excluded from congestive heart failure trials or are not analyzed separately. Consequently, while the effect of angiotensin-converting enzyme inhibitors in patients with sinus rhythm is well established, ...

    journal_title:Journal of cardiac failure

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1016/s1071-9164(05)80004-1

    authors: Van Den Berg MP,Crijns HJ,Van Veldhuisen DJ,Griep N,De Kam PJ,Lie KI

    更新日期:1995-12-01 00:00:00

  • Association between prehospital delay and subsequent clinical course in patients with/hospitalized for heart failure.

    abstract:BACKGROUND:The clinical consequences of prehospital delay in heart failure (HF) patients are unknown. This study explores the relationship between prehospital delay of HF patients and length of hospital stay, plasma values of brain natriuretic peptides (BNP) as well as the association of delay with all-cause mortality,...

    journal_title:Journal of cardiac failure

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.1016/j.cardfail.2011.12.007

    authors: Johansson P,van der Wal M,van Veldhuisen DJ,Jaarsma T

    更新日期:2012-03-01 00:00:00

  • Myocardial hypertrophy in transgenic mice overexpressing human interleukin 1alpha.

    abstract:BACKGROUND:Interleukin (IL)-1 has profound effects on nonimmune cells and organs, including the heart. The effects of IL-1 on transgenic hearts have not yet been described. METHODS AND RESULTS:We generated transgenic mice overexpressing the human IL-1 gene under control of the cytomegalovirus enhancer/chicken beta-act...

    journal_title:Journal of cardiac failure

    pub_type: 杂志文章

    doi:10.1054/jcaf.2001.28221

    authors: Isoda K,Kamezawa Y,Tada N,Sato M,Ohsuzu F

    更新日期:2001-12-01 00:00:00

  • The relationship between leptin and ventilatory control in heart failure.

    abstract:BACKGROUND:Increased serum leptin concentration has been linked to increased ventilation in patients with mild heart failure (HF). However, in animal models the absence of leptin has also been associated with increased ventilation. This study evaluated the relationship of circulating leptin concentration with exercise ...

    journal_title:Journal of cardiac failure

    pub_type: 杂志文章

    doi:10.1016/j.cardfail.2013.10.004

    authors: Cundrle I Jr,Somers VK,Singh P,Johnson BD,Scott CG,Olson LJ

    更新日期:2013-11-01 00:00:00

  • Medium-term effects of beta-blockade on left ventricular mechanics: a double-blind, placebo-controlled comparison of nebivolol and atenolol in patients with ischemic left ventricular dysfunction.

    abstract::The aim of this study was to compare the effects on left ventricular function and exercise tolerance of a selective beta-antagonist (atenolol) with those of another selective beta 1-antagonist with vasodilator properties (nebivolol) in patients with ischemic left ventricular dysfunction but no overt congestive heart f...

    journal_title:Journal of cardiac failure

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1016/s1071-9164(96)80004-2

    authors: Rousseau MF,Chapelle F,Van Eyll C,Stoleru L,Hager D,Van Nueten L,Pouleur H

    更新日期:1996-03-01 00:00:00

  • Pharmacotherapy Use in Older Patients With Heart Failure and Reduced Ejection Fraction After a Skilled Nursing Facility Stay.

    abstract:BACKGROUND:Little is known about guideline-directed pharmacotherapy use in patients with heart failure and reduced ejection fraction (HFrEF) discharged to skilled nursing facilities (SNFs). This study aimed to describe the use of angiotensin-converting enzyme inhibitors (ACEIs)/angiotensin receptor blocker (ARBs) and e...

    journal_title:Journal of cardiac failure

    pub_type: 杂志文章

    doi:10.1016/j.cardfail.2017.09.007

    authors: Li L,Jesdale BM,Hume A,Gambassi G,Goldberg RJ,Lapane KL

    更新日期:2017-12-01 00:00:00

  • Effect of intravenous immunoglobulin for fulminant myocarditis on in-hospital mortality: propensity score analyses.

    abstract:BACKGROUND:Fulminant myocarditis (FM) is a rare but life-threatening disease. Intravenous immunoglobulin (IVIG) is not recommended for acute or chronic myocarditis in Western nations owing to the lack of rigorous evidence, but it is widely used in other countries, including Japan. This nationwide retrospective cohort s...

    journal_title:Journal of cardiac failure

    pub_type: 杂志文章

    doi:10.1016/j.cardfail.2015.01.004

    authors: Isogai T,Yasunaga H,Matsui H,Tanaka H,Horiguchi H,Fushimi K

    更新日期:2015-05-01 00:00:00

  • The extracellular connections: the role of integrins in myocardial remodeling.

    abstract:BACKGROUND:Integrins are a large family of heterodimeric cell surface receptors that are present on all cells. These molecules link the extracellular matrix to the intracellular cytoskeleton and are multifunctional, playing roles in cell organization and differentiation, migration, alteration of gene expression, and ce...

    journal_title:Journal of cardiac failure

    pub_type: 杂志文章,评审

    doi:10.1054/jcaf.2002.129263

    authors: Ross RS

    更新日期:2002-12-01 00:00:00

  • Young patients with nonischemic cardiomyopathy have higher likelihood of left ventricular recovery during left ventricular assist device support.

    abstract:BACKGROUND:Recovery of ventricular function during left ventricular assist device (LVAD) support allowing device explantation occurs infrequently. We explored the hypothesis that certain patient profiles are more likely to exhibit LV recovery during LVAD support. METHODS AND RESULTS:A retrospective analysis of data fr...

    journal_title:Journal of cardiac failure

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.1016/j.cardfail.2012.01.020

    authors: Goldstein DJ,Maybaum S,MacGillivray TE,Moore SA,Bogaev R,Farrar DJ,Frazier OH,HeartMate II Clinical Investigators.

    更新日期:2012-05-01 00:00:00

  • Effects of different degrees of sympathetic antagonism on cytokine network in patients with ischemic dilated cardiomyopathy.

    abstract:BACKGROUND:The proinflammatory cytokines have been implicated in the pathogenesis of heart failure. Recent studies have shown that beta-adrenergic blockade can modulate cytokine production. This study investigates the different impact of different degrees of sympathetic antagonism on circulating levels of cytokines in ...

    journal_title:Journal of cardiac failure

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1016/j.cardfail.2004.07.006

    authors: Cinquegrana G,D'Aniello L,Landi M,Spinelli L,Grande G,De Prisco F,Petretta M

    更新日期:2005-04-01 00:00:00

  • Decreased heart rate recovery after exercise in patients with congestive heart failure: effect of beta-blocker therapy.

    abstract:BACKGROUND:Decreased heart rate recovery (HRR) is a predictor of mortality in patients with coronary artery disease and preserved left ventricular function. We investigated the changes in HRR and assessed the impact of beta-blockade therapy on these parameters in patients with symptomatic congestive heart failure (CHF)...

    journal_title:Journal of cardiac failure

    pub_type: 杂志文章

    doi:10.1054/jcaf.2003.47

    authors: Racine N,Blanchet M,Ducharme A,Marquis J,Boucher JM,Juneau M,White M

    更新日期:2003-08-01 00:00:00

  • Temporal Differences in Outcomes During Long-Term Mechanical Circulatory Support.

    abstract:BACKGROUND:Device indications have changed for placement of continuous-flow left ventricular assist devices (CF-LVADs). We performed a multicenter analysis evaluating temporal variations in outcomes after CF-LVAD implantation. METHODS & RESULTS:We retrospectively defined 3 time intervals to reflect changes in CF-LVAD ...

    journal_title:Journal of cardiac failure

    pub_type: 杂志文章,多中心研究

    doi:10.1016/j.cardfail.2017.07.403

    authors: Maltais S,Anwer LA,Haglund NA,Cowger J,Shah P,Aaronson KD,Pagani FD,Dunlay SM,Singh R,Salerno CT,Stulak JM

    更新日期:2017-12-01 00:00:00

  • The association between high-dose diuretics and clinical stability in ambulatory chronic heart failure patients.

    abstract:OBJECTIVE:In chronic heart failure (HF), diuretic doses increase as the disease progresses, often after hospitalization for instability, and have been associated with worsening renal function and increased mortality. METHODS AND RESULTS:A prospective observational analysis of 183 patients in an advanced HF clinic stra...

    journal_title:Journal of cardiac failure

    pub_type: 杂志文章

    doi:10.1016/j.cardfail.2008.01.015

    authors: Mielniczuk LM,Tsang SW,Desai AS,Nohria A,Lewis EF,Fang JC,Baughman KL,Stevenson LW,Givertz MM

    更新日期:2008-06-01 00:00:00

  • Low-to-moderate alcohol intake and health status in heart failure patients.

    abstract:BACKGROUND:Although heart failure (HF) guidelines recommend alcohol abstinence, existing evidence indicates that alcohol may not worsen survival and no data about associations between alcohol and health status (patients' symptoms, function, and quality of life) exist. METHODS AND RESULTS:Alcohol use was quantified in ...

    journal_title:Journal of cardiac failure

    pub_type: 杂志文章,多中心研究

    doi:10.1016/j.cardfail.2004.11.009

    authors: Salisbury AC,House JA,Conard MW,Krumholz HM,Spertus JA

    更新日期:2005-06-01 00:00:00

  • Elevated Heart Rate Following Heart Transplantation Is Associated With Increased Graft Vasculopathy and Mortality.

    abstract:BACKGROUND:The effect of elevated heart rate (HR) on outcomes after heart transplantation (HT) has not been well established. The aim of this study was to assess predictors of elevated HR following HT and its impact on outcomes. METHODS AND RESULTS:We retrospectively evaluated 394 patients who underwent HT at 2 academ...

    journal_title:Journal of cardiac failure

    pub_type: 杂志文章,多中心研究

    doi:10.1016/j.cardfail.2019.01.009

    authors: Liebo M,Newman J,Joshi A,Lowes BD,Peled-Potashnik Y,Basha HI,Zolty R,Um JY,McGee E Jr,Heroux A,Raichlin E

    更新日期:2019-04-01 00:00:00

  • Sex-Specific Effects of Adrenergic-Induced Left Ventricular Remodeling in Spontaneously Hypertensive Rats.

    abstract:OBJECTIVE:The aim of this work was to determine whether adrenergic-induced left ventricular (LV) dilation and eccentric remodeling in pressure-overload hypertrophy is sex specific. METHODS AND RESULTS:Chronic β-adrenoreceptor activation was produced in male and female spontaneously hypertensive rats (SHRs) by means of...

    journal_title:Journal of cardiac failure

    pub_type: 杂志文章

    doi:10.1016/j.cardfail.2016.09.017

    authors: Michel FS,Magubane M,Mokotedi L,Norton GR,Woodiwiss AJ

    更新日期:2017-02-01 00:00:00

  • Anabolics and cardiomyopathy in a bodybuilder: case report and literature review.

    abstract:BACKGROUND:Athletes use androgenic-anabolic steroids to increase strength and muscle mass. Several case reports suggest that it may lead to dilated cardiomyopathy. METHODS AND RESULTS:We report a case of a 41-year-old bodybuilder with severe systolic dysfunction and Class IV heart failure despite maximal medical thera...

    journal_title:Journal of cardiac failure

    pub_type: 杂志文章,评审

    doi:10.1016/j.cardfail.2008.12.014

    authors: Ahlgrim C,Guglin M

    更新日期:2009-08-01 00:00:00

  • Hemodynamic changes and neurohumoral regulation during development of congestive heart failure in a model of epinephrine-induced cardiomyopathy in conscious rabbits.

    abstract:BACKGROUND:The present study was designed to study the progression of heart failure in rabbits with catecholamine-induced cardiomyopathy. METHODS AND RESULTS:We investigated the effects of three repetitive applications (at 16-day intervals) of high-dose epinephrine (first infusion, 5 micrograms/kg/min for 60 minutes; ...

    journal_title:Journal of cardiac failure

    pub_type: 杂志文章

    doi:10.1016/s1071-9164(99)90033-7

    authors: Muders F,Friedrich E,Luchner A,Pfeifer M,Ickenstein G,Hamelbeck B,Riegger GA,Elsner D

    更新日期:1999-06-01 00:00:00

  • Natriuretic peptides in the treatment of heart failure.

    abstract:BACKGROUND:This study was designed to examine the hemodynamic, renal, and hormonal effects of infusion of A-type natriuretic peptide (ANP) and B-type natriuretic peptide (BNP) in patients with congestive heart failure (CHF). METHODS AND RESULTS:We infused synthetic human ANP or BNP at a rate of 0.1 microgram/kg/ min i...

    journal_title:Journal of cardiac failure

    pub_type: 临床试验,杂志文章

    doi:10.1016/s1071-9164(96)80088-1

    authors: Yasue H,Yoshimura M

    更新日期:1996-12-01 00:00:00

  • Effect of exercise training on autonomic derangement and neurohumoral activation in chronic heart failure.

    abstract:BACKGROUND:In chronic heart failure (CHF), persistent autonomic derangement and neurohumoral activation cause structural end-organ damage, decrease exercise capacity, and reduce quality of life. Beneficial effects of pharmacotherapy and of exercise training in CHF have been documented at various functional and structur...

    journal_title:Journal of cardiac failure

    pub_type: 杂志文章,评审

    doi:10.1016/j.cardfail.2006.12.006

    authors: Gademan MG,Swenne CA,Verwey HF,van der Laarse A,Maan AC,van de Vooren H,van Pelt J,van Exel HJ,Lucas CM,Cleuren GV,Somer S,Schalij MJ,van der Wall EE

    更新日期:2007-05-01 00:00:00

  • Patient-reported economic burden and the health status of heart failure patients.

    abstract:BACKGROUND:Heart failure (HF) guidelines recommend treatment with multiple medications to improve survival, functioning, and quality of life. Yet, HF treatments can be costly, resulting in significant economic burden for some patients. To date, there are few data on the impact of patients' perceived difficulties in aff...

    journal_title:Journal of cardiac failure

    pub_type: 杂志文章

    doi:10.1016/j.cardfail.2006.03.004

    authors: Conard MW,Heidenreich P,Rumsfeld JS,Weintraub WS,Spertus J,Cardiovascular Outcomes Research Consortium.

    更新日期:2006-06-01 00:00:00

  • Implementation of a Multidisciplinary Inpatient Cardiology Service to Improve Heart Failure Outcomes in Guyana.

    abstract:BACKGROUND:Guyana is a small developing country with a high burden of cardiovascular disease and extensive barriers to optimal care delivery. We investigated the effectiveness of a newly established multidisciplinary inpatient cardiology service in this setting. METHODS:We performed an interrupted time-series cohort s...

    journal_title:Journal of cardiac failure

    pub_type: 杂志文章

    doi:10.1016/j.cardfail.2018.07.002

    authors: Klassen SL,Miller RJH,Hao R,Warnica JW,Fine NM,Carpen M,Isaac DL

    更新日期:2018-12-01 00:00:00

  • Prospective evaluation of beta-blocker use at the time of hospital discharge as a heart failure performance measure: results from OPTIMIZE-HF.

    abstract:BACKGROUND:The objective of this study was to prospectively evaluate beta-blocker use at hospital discharge as an indicator of quality of care and outcomes in patients with heart failure (HF). METHODS AND RESULTS:Data from the Organized Program to Initiate Lifesaving Treatment in Hospitalized Patients with Heart Failu...

    journal_title:Journal of cardiac failure

    pub_type: 杂志文章

    doi:10.1016/j.cardfail.2007.06.727

    authors: Fonarow GC,Abraham WT,Albert NM,Stough WG,Gheorghiade M,Greenberg BH,O'Connor CM,Sun JL,Yancy CW,Young JB,OPTIMIZE-HF Investigators and Coordinators.

    更新日期:2007-11-01 00:00:00

  • Increased body temperature after reperfused acute myocardial infarction is associated with adverse left ventricular remodeling.

    abstract:BACKGROUND:Fever is frequently observed in patients with acute myocardial infarction (AMI); however, its prognostic significance remains to be determined. We sought to determine the prognostic significance of increased body temperature (BT) after AMI. METHODS AND RESULTS:We examined 156 consecutive patients with reper...

    journal_title:Journal of cardiac failure

    pub_type: 杂志文章

    doi:10.1016/j.cardfail.2006.09.006

    authors: Naito K,Anzai T,Yoshikawa T,Maekawa Y,Sugano Y,Kohno T,Mahara K,Okabe T,Asakura Y,Ogawa S

    更新日期:2007-02-01 00:00:00

  • Impact of Obesity on Volume Status in Patients With Ambulatory Chronic Heart Failure.

    abstract:BACKGROUND:Fluid overload is common in heart failure (HF) and obesity; however, the relationship between the extent of intravascular volume expansion and indices such as body mass index (BMI) in obese and non-obese patients with HF has not been defined to address the issue of a HF obesity phenotype. METHODS:Total bloo...

    journal_title:Journal of cardiac failure

    pub_type: 杂志文章

    doi:10.1016/j.cardfail.2019.09.010

    authors: Miller WL,Borlaug BA

    更新日期:2020-02-01 00:00:00