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Aortic Insufficiency During HeartMate 3 Left Ventricular Assist Device Support.

Abstract：

BACKGROUND:Aortic insufficiency (AI) is associated with morbidity and mortality in patients with continuous-flow left ventricular assist devices (LVADs), whereas its impact on the HeartMate 3 LVAD cohorts remains uninvestigated. We aimed to investigate the clinical impact of AI on patients with HeartMate 3 LVADs. METHODS AND RESULTS:Consecutive 61 patients (median age 54 years; 67% male) implanted with HeartMate 3 LVAD between 2015 and 2019 were enrolled and underwent echocardiography at 3 months after LVAD implantation. AI severity was quantified by the novel Doppler echocardiographic method obtained at the outflow cannula and the calculated regurgitation fraction of 30% or greater (moderate or greater) was defined as significant. At 3 months after implant, 12 patients (20%) had significant AI. They had a higher incidence of death or heart failure readmissions compared with those without significant AI during a 1-year observational period (70% vs 24%, P = .003) with an adjusted hazard ratio of 2.76 (95% confidence interval 1.03-7.88). CONCLUSIONS:In patients with HeartMate 3 LVAD support, significant AI remains both prevalent and a clinically significant downstream complication.

journal_name

J Card Fail

journal_title

Journal of cardiac failure

authors

Imamura T,Narang N,Kim G,Nitta D,Fujino T,Nguyen A,Grinstein J,Rodgers D,Ota T,Jeevanandam V,Sayer G,Uriel N

doi

10.1016/j.cardfail.2020.05.013

subject

Has Abstract

pub_date

2020-10-01 00:00:00

pages

863-869

issue

10

eissn

1071-9164

issn

1532-8414

pii

S1071-9164(20)30151-2

journal_volume

26

pub_type

杂志文章

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