Abstract：
BACKGROUND:Insulin resistance is present in the setting of congestive heart failure. Glucagon-like peptide-1 (GLP-1) is a naturally occurring incretin with both insulinotropic and insulinomimetic properties. METHODS AND RESULTS:We investigated the safety and efficacy of a 5-week infusion of GLP-1 (2.5 pmol/kg/min) added to standard therapy in 12 patients with New York Heart Association class III/IV heart failure and compared the results with those of 9 patients with heart failure on standard therapy alone. Echocardiograms, maximum myocardial ventilation oxygen consumption (VO2 max), 6-minute walk test, and Minnesota Living with Heart Failure quality of life score (MNQOL) were assessed. Baseline demographics, background therapy, and the degree of left ventricular dysfunction were similar between groups. GLP-1 significantly improved left ventricular ejection fraction (21 +/- 3% to 27 +/- 3% P < .01), VO2 max (10.8 +/- .9 ml/O2/min/kg to 13.9 +/- .6 ml/O2/min/kg; P < .001), 6-minute walk distance (232 +/- 15 m to 286 +/- 12 m; P < .001) and MNQOL score (64 +/- 4 to 44 +/- 5; P < .01). Benefits were seen in both diabetic and non-diabetic patients. There were no significant changes in any of the parameters in the control patients on standard therapy. GLP-1 was well tolerated with minimal episodes of hypoglycemia and gastrointestinal side effects. CONCLUSION:Chronic infusion of GLP-1 significantly improves left ventricular function, functional status, and quality of life in patients with severe heart failure.
journal_name
J Card Failjournal_title
Journal of cardiac failureauthors
Sokos GG,Nikolaidis LA,Mankad S,Elahi D,Shannon RPdoi
10.1016/j.cardfail.2006.08.211subject
Has Abstractpub_date
2006-12-01 00:00:00pages
694-9issue
9eissn
1071-9164issn
1532-8414pii
S1071-9164(06)01109-2journal_volume
12pub_type
杂志文章abstract：BACKGROUND:Studies of animal models and human subjects with cardiomyopathies suggest that cardiac myocyte and ventricular chamber remodeling show distinct phenotypic characteristics that may be dependent on specific signaling pathways. METHODS AND RESULTS:In this study, we characterize right ventricular (RV) chamber s...
journal_title：Journal of cardiac failure
pub_type： 杂志文章
doi：10.1016/s1071-9164(99)90024-6
更新日期：1999-03-01 00:00:00
abstract：BACKGROUND:Interleukin (IL)-1 has profound effects on nonimmune cells and organs, including the heart. The effects of IL-1 on transgenic hearts have not yet been described. METHODS AND RESULTS:We generated transgenic mice overexpressing the human IL-1 gene under control of the cytomegalovirus enhancer/chicken beta-act...
journal_title：Journal of cardiac failure
pub_type： 杂志文章
doi：10.1054/jcaf.2001.28221
更新日期：2001-12-01 00:00:00
abstract：BACKGROUND:Frailty reflects decreased resilience to physiological stressors; its prevalence and prognosis are not fully defined in heart failure with preserved ejection fraction (HFpEF). METHODS:The Short Physical Performance Battery (SPPB) was prospectively obtained in 114 outpatients with HFpEF. The SPPB tests gait ...
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doi：10.1016/j.cardfail.2018.09.002
更新日期：2019-01-01 00:00:00
abstract：BACKGROUND:Telemonitoring has been advocated as a way of decreasing costs and improving outcomes, but no study has looked at true Medicare payments and 30-day readmission rates in a randomized group of well treated patients. OBJECTIVE:The aim of this work was to analyze Medicare claims data to identify effects of home...
journal_title：Journal of cardiac failure
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.cardfail.2014.04.016
更新日期：2014-07-01 00:00:00
abstract：BACKGROUND:Activated vitamin D analog, paricalcitol, has been shown to attenuate the development of cardiac hypertrophy in Dahl salt sensitive (DSS) rats. To determine whether an antihypertrophic effect is class specific, we tested if doxercalciferol (a pro-hormone vitamin D2 analog) could also attenuate the developmen...
journal_title：Journal of cardiac failure
pub_type： 杂志文章
doi：10.1016/j.cardfail.2011.08.006
更新日期：2011-12-01 00:00:00
abstract：BACKGROUND:Renal impairment is associated with increased mortality in heart failure (HF). Recently, reports suggest that worsening renal function (WRF) is another predictor of clinical outcome in HF. The present study was designed to establish the proportion of patients with HF that exhibits (WRF) and the associated ri...
journal_title：Journal of cardiac failure
pub_type： 杂志文章,meta分析,评审
doi：10.1016/j.cardfail.2007.04.008
更新日期：2007-10-01 00:00:00
abstract：BACKGROUND:Limited data exist on outcomes in patients ≥70 years of age supported with the use of continuous-flow left ventricular assist devices (LVADs). METHODS:Data on 1149 continuous-flow LVAD recipients was queried from the Mechanical Circulatory Support Research Network. Groups were assigned based on age: ≥70 yea...
journal_title：Journal of cardiac failure
pub_type： 杂志文章
doi：10.1016/j.cardfail.2016.10.004
更新日期：2016-12-01 00:00:00
abstract：BACKGROUND:Current US and European guidelines recommend that ejection fraction (EF) be measured at least once in patients with congestive heart failure (CHF). However, it is not known how age and sex influence adherence to this recommendation. METHODS:We reviewed a national sample of Medicare patients discharged with ...
journal_title：Journal of cardiac failure
pub_type： 杂志文章
doi：10.1054/jcaf.2003.16
更新日期：2003-04-01 00:00:00
abstract：BACKGROUND:We examined the accuracy of Medicare heart failure (HF) diagnostic codes in the identification of acute decompensated (ADHF and chronic stable (CSHF) HF. METHODS AND RESULTS:Hospitalizations were identified from medical discharge records for Atherosclerosis Risk in Communities (ARIC) study participants with...
journal_title：Journal of cardiac failure
pub_type： 杂志文章
doi：10.1016/j.cardfail.2015.07.013
更新日期：2016-01-01 00:00:00
abstract：BACKGROUND:The left ventricular assist device (LVAD) is a therapy for patients with end-stage heart failure, many of whom have a preexisting implantable cardioverter-defibrillator (ICD). We investigated whether the implantation of a LVAD affects ICD function. METHODS AND RESULTS:Patients implanted with a LVAD between ...
journal_title：Journal of cardiac failure
pub_type： 杂志文章
doi：10.1016/j.cardfail.2009.12.003
更新日期：2010-04-01 00:00:00
abstract：BACKGROUND:In patients with heart failure and preserved ejection fraction (HF-PEF) randomized in the Americas as part of the Treatment of Preserved Cardiac Function Heart Failure with an Aldosterone Antagonist (TOPCAT) trial, treatment with spironolactone enhanced the risk of hyperkalemia but reduced the risk of hypoka...
journal_title：Journal of cardiac failure
pub_type： 杂志文章,多中心研究,随机对照试验
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更新日期：2018-05-01 00:00:00
abstract：BACKGROUND:Worsening renal function (WRF) and hypokalemia related to diuretic use for acute decompensated heart failure (ADHF) are common and associated with poor prognosis. Low-dose dopamine infusion improves renal perfusion; its effect on diuresis or renal function specifically in ADHF is not known. METHODS AND RESU...
journal_title：Journal of cardiac failure
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.cardfail.2010.07.246
更新日期：2010-12-01 00:00:00
abstract：BACKGROUND:We investigated the relationship between nonsustained ventricular tachycardia (NSVT) and left ventricular (LV) dilatation, function, remodeling, and scar tissue extent in patients with previous myocardial infarction (MI). METHODS AND RESULTS:Eighty-two patients (ages 64+/-10 years) with first previous MI we...
journal_title：Journal of cardiac failure
pub_type： 杂志文章
doi：10.1016/j.cardfail.2009.09.001
更新日期：2010-01-01 00:00:00
abstract：BACKGROUND:The role of matrix metalloproteinases (MMPs) polymorphisms on heart failure (HF) susceptibility, phenotypic characteristics, and prognosis has been poorly explored. METHODS AND RESULTS:We studied 313 HF patients with left ventricular systolic dysfunction and 367 healthy control subjects. Genotyping of MMP-1...
journal_title：Journal of cardiac failure
pub_type： 杂志文章
doi：10.1016/j.cardfail.2010.09.017
更新日期：2011-02-01 00:00:00
abstract：BACKGROUND:Guyana is a small developing country with a high burden of cardiovascular disease and extensive barriers to optimal care delivery. We investigated the effectiveness of a newly established multidisciplinary inpatient cardiology service in this setting. METHODS:We performed an interrupted time-series cohort s...
journal_title：Journal of cardiac failure
pub_type： 杂志文章
doi：10.1016/j.cardfail.2018.07.002
更新日期：2018-12-01 00:00:00
abstract：BACKGROUND:In vivo administration of norepinephrine fails to cause beta-adrenergic receptor desensitization. However, short-term exposure of cultured cells to norepinephrine induces the phenomenon in vitro. We sought to identify the local regulatory mechanisms responsible for in vivo beta-adrenergic receptor desensitiz...
journal_title：Journal of cardiac failure
pub_type： 杂志文章
doi：10.1054/jcaf.2000.19223
更新日期：2000-12-01 00:00:00
abstract：BACKGROUND:Reduced left ventricular systolic function predicts worse outcomes. However, the optimal threshold for "normal" left ventricular ejection fraction (LVEF) is uncertain. In general, LVEF ≥ 55% is considered to be "normal" by guidelines, with a low normal designation for LVEF being 50%-55%. We assessed the prog...
journal_title：Journal of cardiac failure
pub_type： 杂志文章
doi：10.1016/j.cardfail.2016.03.013
更新日期：2016-10-01 00:00:00
abstract：BACKGROUND:Previous studies have shown a paradox of lower mortality in black compared with white patients after hospitalization for heart failure, in contrast to the overall higher mortality reported for nonhospitalized black patients with heart failure. We examined racial differences in factors contributing to hospita...
journal_title：Journal of cardiac failure
pub_type： 杂志文章
doi：10.1016/j.cardfail.2004.04.002
更新日期：2005-02-01 00:00:00
abstract：BACKGROUND:Patients with chronic heart failure (CHF) complain of breathlessness and fatigue on exertion, have reduced peak oxygen consumption (pV(O(2))), and an increased ventilatory response to exercise (V(E)/V(CO(2)) slope). These limitations correlate with abnormalities of spirometry (forced expiratory volume in 1 s...
journal_title：Journal of cardiac failure
pub_type： 杂志文章
doi：10.1054/jcaf.2002.126916
更新日期：2002-08-01 00:00:00
abstract：BACKGROUND:Despite ample data from randomized clinical trials (RCTs), the management of advanced heart failure (HF) varies greatly. We examined the most common refractory questions arising in routine inpatient management of advanced HF. METHODS:From the inpatient HF service at 1 hospital, we prospectively recorded cli...
journal_title：Journal of cardiac failure
pub_type： 杂志文章
doi：10.1016/j.cardfail.2003.10.006
更新日期：2004-06-01 00:00:00
abstract：BACKGROUND:The objective of this study was to determine whether participation in a quality improvement (QI) collaborative for heart failure (HF) was associated with better interpersonal aspects of care and health outcomes. METHODS AND RESULTS:We conducted a cross-sectional telephone survey of patients in 6 organizatio...
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pub_type： 杂志文章
doi：10.1016/j.cardfail.2005.03.010
更新日期：2005-08-01 00:00:00
abstract：BACKGROUND:Wolff-Parkinson-White (WPW) has been associated with left ventricular noncompaction (LVNC) in children. Little is known about the prevalence of this association, clinical outcomes, and treatment options. METHODS:Retrospective review of subjects with LVNC. LVNC was defined by established criteria; those with...
journal_title：Journal of cardiac failure
pub_type： 杂志文章
doi：10.1016/j.cardfail.2019.09.014
更新日期：2019-12-01 00:00:00
abstract：BACKGROUND:The effect of hospital quality of care on hospital readmission for patients with congestive heart failure (CHF) has not been widely studied. METHODS AND RESULTS:We examined the effects of clinical factors, hospital quality of care, and cardiologist involvement on 3-month readmission rates in patients with C...
journal_title：Journal of cardiac failure
pub_type： 杂志文章
doi：10.1054/jcaf.2001.28931
更新日期：2001-12-01 00:00:00
abstract：BACKGROUND:Dietary sodium excess and malnutrition have been associated with poor outcomes in heart failure (HF). Few previous studies have examined the barriers to following a low-sodium, nutritionally robust diet in hospitalized patients with HF. METHODS AND RESULTS:As part of a dietary intervention pilot study, 76 i...
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pub_type： 杂志文章
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更新日期：2020-03-01 00:00:00
abstract：BACKGROUND:We recently reported that serum levels of pentosidine, one of the well-defined advanced glycation end products (AGE), was an independent prognostic factor for heart failure. Receptor for AGEs (RAGE) is expressed in a variety of tissues, and RAGE has a C-truncated secretory isoform of the receptor protein, te...
journal_title：Journal of cardiac failure
pub_type： 杂志文章
doi：10.1016/j.cardfail.2007.10.019
更新日期：2008-03-01 00:00:00
abstract：BACKGROUND:Phosphodiesterase-5A inhibitors (PDE5i) are sometimes used in patients with advanced heart failure with reduced ejection fraction before heart transplant or left ventricular assist device implantation to decrease right ventricular (RV) afterload and mitigate the risk of right heart failure. Conflicting evide...
journal_title：Journal of cardiac failure
pub_type： 杂志文章
doi：10.1016/j.cardfail.2020.11.007
更新日期：2020-11-21 00:00:00
abstract：BACKGROUND:The aim of this study was to evaluate the effects of carvedilol therapy on left atrial (LA) function in patients with heart failure from nonischemic dilated cardiomyopathy. METHODS AND RESULTS:Thirty-five patients (42.4 +/- 13.5 years) in New York Heart Association functional Class II-III have been studied....
journal_title：Journal of cardiac failure
pub_type： 杂志文章
doi：10.1016/j.cardfail.2006.10.011
更新日期：2007-03-01 00:00:00
abstract：BACKGROUND:Fluid overload is common in heart failure (HF) and obesity; however, the relationship between the extent of intravascular volume expansion and indices such as body mass index (BMI) in obese and non-obese patients with HF has not been defined to address the issue of a HF obesity phenotype. METHODS:Total bloo...
journal_title：Journal of cardiac failure
pub_type： 杂志文章
doi：10.1016/j.cardfail.2019.09.010
更新日期：2020-02-01 00:00:00
abstract：BACKGROUND:Enzyme replacement therapy (ERT) for infantile-onset Pompe disease effectively reduces the left ventricular (LV) mass. This study sought to explore detailed process of LV reverse remodeling after ERT with the use of tissue Doppler and stain rate imaging. METHODS AND RESULTS:Nine infants and children with Po...
journal_title：Journal of cardiac failure
pub_type： 杂志文章
doi：10.1016/j.cardfail.2011.07.011
更新日期：2011-11-01 00:00:00
abstract：INTRODUCTION:Orthotopic heart transplantation (OHT) is contraindicated in morbidly obese patients with end-stage heart failure (HF), for whom cardiac allograft is the only means for long-term survival. Bariatric surgery may allow them to achieve target body mass index (BMI) for OHT METHODS: From 4/2014 to 12/2018, 26 m...
journal_title：Journal of cardiac failure
pub_type： 杂志文章
doi：10.1016/j.cardfail.2020.04.020
更新日期：2020-11-01 00:00:00
