当前位置： SCI文献检索 > JOURNAL OF CARDIAC FAILURE期刊下所有文献 > Glucagon-like peptide-1 infusion improves left ventricular ejection fraction and functional status in patients with chronic heart failure.

Glucagon-like peptide-1 infusion improves left ventricular ejection fraction and functional status in patients with chronic heart failure.

Abstract：

BACKGROUND:Insulin resistance is present in the setting of congestive heart failure. Glucagon-like peptide-1 (GLP-1) is a naturally occurring incretin with both insulinotropic and insulinomimetic properties. METHODS AND RESULTS:We investigated the safety and efficacy of a 5-week infusion of GLP-1 (2.5 pmol/kg/min) added to standard therapy in 12 patients with New York Heart Association class III/IV heart failure and compared the results with those of 9 patients with heart failure on standard therapy alone. Echocardiograms, maximum myocardial ventilation oxygen consumption (VO2 max), 6-minute walk test, and Minnesota Living with Heart Failure quality of life score (MNQOL) were assessed. Baseline demographics, background therapy, and the degree of left ventricular dysfunction were similar between groups. GLP-1 significantly improved left ventricular ejection fraction (21 +/- 3% to 27 +/- 3% P < .01), VO2 max (10.8 +/- .9 ml/O2/min/kg to 13.9 +/- .6 ml/O2/min/kg; P < .001), 6-minute walk distance (232 +/- 15 m to 286 +/- 12 m; P < .001) and MNQOL score (64 +/- 4 to 44 +/- 5; P < .01). Benefits were seen in both diabetic and non-diabetic patients. There were no significant changes in any of the parameters in the control patients on standard therapy. GLP-1 was well tolerated with minimal episodes of hypoglycemia and gastrointestinal side effects. CONCLUSION:Chronic infusion of GLP-1 significantly improves left ventricular function, functional status, and quality of life in patients with severe heart failure.

journal_name

J Card Fail

journal_title

Journal of cardiac failure

authors

Sokos GG,Nikolaidis LA,Mankad S,Elahi D,Shannon RP

doi

10.1016/j.cardfail.2006.08.211

subject

Has Abstract

pub_date

2006-12-01 00:00:00

pages

694-9

issue

9

eissn

1071-9164

issn

1532-8414

pii

S1071-9164(06)01109-2

journal_volume

12

pub_type

杂志文章

相关文献

JOURNAL OF CARDIAC FAILURE文献大全
  • Potential effects of digoxin on long-term renal and clinical outcomes in chronic heart failure.

    abstract：BACKGROUND:Digitalis glycosides are known to improve the hemodynamic and neurohormonal perturbations that contribute to heart failure (HF)-induced renal dysfunction (RD). The objective of this study was to determine if randomization to digoxin is associated with improvement in renal function (IRF) and to evaluate if pa...

    journal_title：Journal of cardiac failure

    pub_type： 杂志文章,随机对照试验

    doi：10.1016/j.cardfail.2013.03.002

    authors： Testani JM,Brisco MA,Tang WH,Kimmel SE,Tiku-Owens A,Forfia PR,Coca SG

    更新日期：2013-05-01 00:00:00

  • Heart Failure With Midrange Ejection Fraction in Patients Admitted for Acute Decompensation: A Report from the Japanese Multicenter Registry.

    abstract：BACKGROUND:Patients having heart failure with midrange ejection fraction (HFmrEF: 40% ≤ EF < 50%) are increasingly being considered a new subset of the population with heart failure. Despite recent advances in heart-failure treatment strategies, the prognosis of these patients has not improved substantially over time. ...

    journal_title：Journal of cardiac failure

    pub_type： 杂志文章,多中心研究

    doi：10.1016/j.cardfail.2019.05.010

    authors： Takei M,Kohsaka S,Shiraishi Y,Goda A,Nagatomo Y,Mizuno A,Suzino Y,Kohno T,Fukuda K,Yoshikawa T

    更新日期：2019-08-01 00:00:00

  • The extracellular connections: the role of integrins in myocardial remodeling.

    abstract：BACKGROUND:Integrins are a large family of heterodimeric cell surface receptors that are present on all cells. These molecules link the extracellular matrix to the intracellular cytoskeleton and are multifunctional, playing roles in cell organization and differentiation, migration, alteration of gene expression, and ce...

    journal_title：Journal of cardiac failure

    pub_type： 杂志文章,评审

    doi：10.1054/jcaf.2002.129263

    authors： Ross RS

    更新日期：2002-12-01 00:00:00

  • Comorbid diabetes and end-of-life expenditures among Medicare beneficiaries with heart failure.

    abstract：BACKGROUND:Diabetes is associated with increased risk of mortality in heart failure. We examined the association of diabetes with expenditures, hospitalizations, and procedures among Medicare beneficiaries with heart failure during the last 6 months of life. METHODS AND RESULTS:In a 5% national Medicare sample, the pr...

    journal_title：Journal of cardiac failure

    pub_type： 杂志文章

    doi：10.1016/j.cardfail.2011.09.011

    authors： Blecker S,Herbert R,Brancati FL

    更新日期：2012-01-01 00:00:00

  • Peak oxygen consumption and outcome in heart failure patients chronically treated with beta-blockers.

    abstract：BACKGROUND:Peak oxygen consumption (VO(2)) is an important criterion for listing patients for cardiac transplantation. Beta-blockers improve survival without affecting peak VO(2). We questioned the value of peak VO(2) in predicting outcome in patients treated with beta-blockers. METHODS AND RESULTS:We reviewed the rec...

    journal_title：Journal of cardiac failure

    pub_type： 杂志文章

    doi：10.1016/s1071-9164(03)00593-1

    authors： Shakar SF,Lowes BD,Lindenfeld J,Zolty R,Simon M,Robertson AD,Bristow MR,Wolfel EE

    更新日期：2004-02-01 00:00:00

  • Cardiac myocyte remodeling in hypertrophy and progression to failure.

    abstract：:Contracting myocytes are highly variable in size and generally resemble elliptical cylinders in shape. Although their arrangement within the ventricular wall is rather complex, their length runs in a tangential manner, and their transverse axis runs transmurally. Consequently, it was proposed many years ago that chang...

    journal_title：Journal of cardiac failure

    pub_type： 杂志文章

    doi：10.1054/jcaf.2002.129280

    authors： Gerdes AM

    更新日期：2002-12-01 00:00:00

  • Patterns of cardiac toxicity associated with irreversible proteasome inhibition in the treatment of multiple myeloma.

    abstract：:Carfilzomib is a novel irreversible proteasome inhibitor (PI) used with increasing frequency to treat patients with relapsed and/or refractory multiple myeloma (RRMM). This agent is an effective treatment for this challenging population, but proteasome inhibition has the potential of significant cardiac toxicity via t...

    journal_title：Journal of cardiac failure

    pub_type： 杂志文章

    doi：10.1016/j.cardfail.2014.11.008

    authors： Grandin EW,Ky B,Cornell RF,Carver J,Lenihan DJ

    更新日期：2015-02-01 00:00:00

  • Coronavirus Disease-2019 in Heart Transplant Recipients in Southeastern Michigan: A Case Series.

    abstract：BACKGROUND:Since coronavirus disease 2019 (COVID-19) was first identified in Wuhan, China, in December 2019, the number of cases has risen exponentially. Clinical characteristics and outcomes among patients with orthotopic heart transplant (OHT) with COVID-19 remain poorly described. METHODS:We performed a retrospecti...

    journal_title：Journal of cardiac failure

    pub_type： 杂志文章

    doi：10.1016/j.cardfail.2020.05.008

    authors： Ketcham SW,Adie SK,Malliett A,Abdul-Aziz AA,Bitar A,Grafton G,Konerman MC

    更新日期：2020-06-01 00:00:00

  • Low-to-moderate alcohol intake and health status in heart failure patients.

    abstract：BACKGROUND:Although heart failure (HF) guidelines recommend alcohol abstinence, existing evidence indicates that alcohol may not worsen survival and no data about associations between alcohol and health status (patients' symptoms, function, and quality of life) exist. METHODS AND RESULTS:Alcohol use was quantified in ...

    journal_title：Journal of cardiac failure

    pub_type： 杂志文章,多中心研究

    doi：10.1016/j.cardfail.2004.11.009

    authors： Salisbury AC,House JA,Conard MW,Krumholz HM,Spertus JA

    更新日期：2005-06-01 00:00:00

  • Sex-Specific Effects of Adrenergic-Induced Left Ventricular Remodeling in Spontaneously Hypertensive Rats.

    abstract：OBJECTIVE:The aim of this work was to determine whether adrenergic-induced left ventricular (LV) dilation and eccentric remodeling in pressure-overload hypertrophy is sex specific. METHODS AND RESULTS:Chronic β-adrenoreceptor activation was produced in male and female spontaneously hypertensive rats (SHRs) by means of...

    journal_title：Journal of cardiac failure

    pub_type： 杂志文章

    doi：10.1016/j.cardfail.2016.09.017

    authors： Michel FS,Magubane M,Mokotedi L,Norton GR,Woodiwiss AJ

    更新日期：2017-02-01 00:00:00

  • Inotropes and beta-blockers: is there a need for new guidelines?

    abstract：:Beta-adrenergic blocking agents are standard treatment for patients with mild-to-moderate heart failure. When patients receiving beta-blockers decompensate they often need treatment with a positive inotropic agent. The beta-agonist dobutamine may not produce much increase in cardiac output during full-dose beta-blocke...

    journal_title：Journal of cardiac failure

    pub_type： 杂志文章,评审

    doi：10.1054/jcaf.2001.26655

    authors： Bristow MR,Shakar SF,Linseman JV,Lowes BD

    更新日期：2001-06-01 00:00:00

  • Coronary hemodynamics in heart failure and effects of therapeutic interventions.

    abstract：BACKGROUND:The abnormalities in coronary hemodynamics in systolic heart failure are frequent. Myocardial oxygen demand and consumption are increased and myocardial perfusion is also impaired, which may result in myocardial ischemia, necrosis, and apoptosis. This is potentially a contributing factor for progressive hear...

    journal_title：Journal of cardiac failure

    pub_type： 杂志文章,评审

    doi：10.1016/j.cardfail.2009.01.001

    authors： Chatterjee K

    更新日期：2009-03-01 00:00:00

  • Doxercalciferol, a pro-hormone of vitamin D, prevents the development of cardiac hypertrophy in rats.

    abstract：BACKGROUND:Activated vitamin D analog, paricalcitol, has been shown to attenuate the development of cardiac hypertrophy in Dahl salt sensitive (DSS) rats. To determine whether an antihypertrophic effect is class specific, we tested if doxercalciferol (a pro-hormone vitamin D2 analog) could also attenuate the developmen...

    journal_title：Journal of cardiac failure

    pub_type： 杂志文章

    doi：10.1016/j.cardfail.2011.08.006

    authors： Choi JH,Ke Q,Bae S,Lee JY,Kim YJ,Kim UK,Arbeeny C,Thadhani R,Kang PM

    更新日期：2011-12-01 00:00:00

  • Incident Hyperkalemia, Hypokalemia, and Clinical Outcomes During Spironolactone Treatment of Heart Failure With Preserved Ejection Fraction: Analysis of the TOPCAT Trial.

    abstract：BACKGROUND:In patients with heart failure and preserved ejection fraction (HF-PEF) randomized in the Americas as part of the Treatment of Preserved Cardiac Function Heart Failure with an Aldosterone Antagonist (TOPCAT) trial, treatment with spironolactone enhanced the risk of hyperkalemia but reduced the risk of hypoka...

    journal_title：Journal of cardiac failure

    pub_type： 杂志文章,多中心研究,随机对照试验

    doi：10.1016/j.cardfail.2018.03.002

    authors： Desai AS,Liu J,Pfeffer MA,Claggett B,Fleg J,Lewis EF,McKinlay S,O'Meara E,Shah SJ,Sweitzer NK,Solomon S,Pitt B

    更新日期：2018-05-01 00:00:00

  • Association of functional and health status measures in heart failure.

    abstract：BACKGROUND:A wide variety of instruments have been used to assess the functional capabilities and health status of patients with chronic heart failure (HF), but it is not known how well these tests are correlated with one another, nor which one has the best association with measured exercise capacity. METHODS AND RESU...

    journal_title：Journal of cardiac failure

    pub_type： 杂志文章

    doi：10.1016/j.cardfail.2006.04.004

    authors： Myers J,Zaheer N,Quaglietti S,Madhavan R,Froelicher V,Heidenreich P

    更新日期：2006-08-01 00:00:00

  • Quality assurance and cardiopulmonary exercise testing in clinical trials.

    abstract：BACKGROUND:Peak oxygen uptake (VO2) measured during cardiopulmonary exercise testing (CPX) is often used as an outcome measure in clinical trials. The purposes of this study are (a) to report the outcomes of a quality assurance (QA) procedure instituted in multisite clinical trials by a CPX data core laboratory and (b)...

    journal_title：Journal of cardiac failure

    pub_type： 杂志文章

    doi：10.1016/j.cardfail.2008.01.001

    authors： Brawner CA,Ehrman JK,Aldred H,Schairer JR,Keteyian SJ

    更新日期：2008-05-01 00:00:00

  • Angiotensin receptor neprilysin inhibition in heart failure: mechanistic action and clinical impact.

    abstract：:Heart failure (HF) is an increasingly common syndrome associated with high mortality and economic burden, and there has been a paucity over the past decade of new pharmacotherapies that improve outcomes. However, recent data from a large randomized controlled trial compared the novel agent LCZ696, a dual-acting angiot...

    journal_title：Journal of cardiac failure

    pub_type： 杂志文章,评审

    doi：10.1016/j.cardfail.2015.07.008

    authors： Buggey J,Mentz RJ,DeVore AD,Velazquez EJ

    更新日期：2015-09-01 00:00:00

  • Right ventricular phenotypic characteristics in subjects with primary pulmonary hypertension or idiopathic dilated cardiomyopathy.

    abstract：BACKGROUND:Studies of animal models and human subjects with cardiomyopathies suggest that cardiac myocyte and ventricular chamber remodeling show distinct phenotypic characteristics that may be dependent on specific signaling pathways. METHODS AND RESULTS:In this study, we characterize right ventricular (RV) chamber s...

    journal_title：Journal of cardiac failure

    pub_type： 杂志文章

    doi：10.1016/s1071-9164(99)90024-6

    authors： Quaife RA,Lynch D,Badesch DB,Voelkel NF,Lowes BD,Robertson AD,Bristow MR

    更新日期：1999-03-01 00:00:00

  • Proposal for a new clinical end point to evaluate the efficacy of drugs and devices in the treatment of chronic heart failure.

    abstract：:Clinical trials designed to evaluate the effect of drugs and devices on the symptoms and clinical status in chronic heart failure have frequently produced conflicting, inconclusive, or misleading results. These difficulties can be explained by the fact that previous studies have relied on efficacy measures that have i...

    journal_title：Journal of cardiac failure

    pub_type： 杂志文章

    doi：10.1054/jcaf.2001.25652

    authors： Packer M

    更新日期：2001-06-01 00:00:00

  • Anabolics and cardiomyopathy in a bodybuilder: case report and literature review.

    abstract：BACKGROUND:Athletes use androgenic-anabolic steroids to increase strength and muscle mass. Several case reports suggest that it may lead to dilated cardiomyopathy. METHODS AND RESULTS:We report a case of a 41-year-old bodybuilder with severe systolic dysfunction and Class IV heart failure despite maximal medical thera...

    journal_title：Journal of cardiac failure

    pub_type： 杂志文章,评审

    doi：10.1016/j.cardfail.2008.12.014

    authors： Ahlgrim C,Guglin M

    更新日期：2009-08-01 00:00:00

  • Prolonged electrical muscle stimulation exercise improves strength, peak VO2, and exercise capacity in patients with stable chronic heart failure.

    abstract：BACKGROUND:Exercise training can help patients with chronic heart failure but may be limited in its applicability due to age and other comorbidities. This investigation evaluated training responses to prolonged electrical muscle stimulation (EMS) in patients with stable chronic heart failure. METHODS AND RESULTS:In a ...

    journal_title：Journal of cardiac failure

    pub_type： 杂志文章,随机对照试验

    doi：10.1016/j.cardfail.2008.11.005

    authors： Banerjee P,Caulfield B,Crowe L,Clark AL

    更新日期：2009-05-01 00:00:00

  • Cardiac Adenylyl Cyclase and Phosphodiesterase Expression Profiles Vary by Age, Disease, and Chronic Phosphodiesterase Inhibitor Treatment.

    abstract：BACKGROUND:Pediatric heart failure (HF) patients have a suboptimal response to traditional HF medications, although phosphodiesterase-3 inhibition (PDE3i) has been used with greater success than in the adult HF population. We hypothesized that molecular alterations specific to children with HF and HF etiology may affec...

    journal_title：Journal of cardiac failure

    pub_type： 杂志文章

    doi：10.1016/j.cardfail.2016.07.429

    authors： Nakano SJ,Sucharov J,van Dusen R,Cecil M,Nunley K,Wickers S,Karimpur-Fard A,Stauffer BL,Miyamoto SD,Sucharov CC

    更新日期：2017-01-01 00:00:00

  • Variation by race in factors contributing to heart failure hospitalizations.

    abstract：BACKGROUND:Previous studies have shown a paradox of lower mortality in black compared with white patients after hospitalization for heart failure, in contrast to the overall higher mortality reported for nonhospitalized black patients with heart failure. We examined racial differences in factors contributing to hospita...

    journal_title：Journal of cardiac failure

    pub_type： 杂志文章

    doi：10.1016/j.cardfail.2004.04.002

    authors： Singh H,Gordon HS,Deswal A

    更新日期：2005-02-01 00:00:00

  • Pharmacologic and Endovascular Reversal of Left Ventricular Remodeling.

    abstract：:Pathologic left ventricular (LV) remodeling as described by adverse changes in LV mass, volume, geometry, and composition in response to mechanical and systemic neurohormonal activation portends a poor prognosis in patients with underlying LV systolic dysfunction. Conversely, reversal of LV remodeling is associated wi...

    journal_title：Journal of cardiac failure

    pub_type： 杂志文章,评审

    doi：10.1016/j.cardfail.2016.03.017

    authors： Jaiswal A,Nguyen VQ,Carry BJ,le Jemtel TH

    更新日期：2016-10-01 00:00:00

  • Brief Report: Patient Activation Among Urban Hospitalized Patients With Heart Failure.

    abstract：BACKGROUND:Patient activation influences patients' ability to meaningfully engage in critical heart failure self-care. The purpose of this study was to identify whether patient activation is associated with patient-reported health outcomes in an urban and racially diverse inpatient sample of patients with heart failure...

    journal_title：Journal of cardiac failure

    pub_type： 杂志文章

    doi：10.1016/j.cardfail.2017.08.452

    authors： Masterson Creber R,Chen T,Wei C,Lee CS

    更新日期：2017-11-01 00:00:00

  • How does cardiac resynchronization therapy improve exercise capacity in chronic heart failure?

    abstract：BACKGROUND:Studies have shown that neither ejection fraction nor hemodynamic abnormalities during exercise in chronic heart failure (HF) correlate with symptoms of fatigue and exhaustion. The concept that exercise limitation in patients with chronic HF is due to abnormal hemodynamics during exercise has been revised to...

    journal_title：Journal of cardiac failure

    pub_type： 杂志文章,评审

    doi：10.1016/j.cardfail.2005.03.002

    authors： Middlekauff HR

    更新日期：2005-09-01 00:00:00

  • Utilization of trained volunteers decreases 30-day readmissions for heart failure.

    abstract：:Background: This study evaluated the effectiveness of using trained volunteer staff in reducing 30-day readmissions of congestive heart failure (CHF) patients.Methods: From June 2010 to December 2010, 137 patients (mean age 73 years) hospitalized for CHF were randomly assigned to either: an interventional arm (arm A) ...

    journal_title：Journal of cardiac failure

    pub_type： 更正并重新发布的文章,杂志文章,随机对照试验

    doi：

    authors： Sales VL,Ashraf MS,Lella LK,Huang J,Bhumireddy G,Lefkowitz L,Feinstein M,Kamal M,Caesar R,Cusick E,Norenberg J,Lee J,Brener S,Sacchi TJ,Heitner JF

    更新日期：2014-05-01 00:00:00

  • Autoantibodies Specifically Against β1 Adrenergic Receptors and Adverse Clinical Outcome in Patients With Chronic Systolic Heart Failure in the β-Blocker Era: The Importance of Immunoglobulin G3 Subclass.

    abstract：OBJECTIVE:To elucidate the prevalence and role of β1 adrenergic receptor autoantibodies (β1AR-AAb) belonging to the immunoglobulin (Ig)G3 subclass in patients with heart failure (HF) treated with β-adrenergic blockers. BACKGROUND:Several cardiac AAbs have been reported to be present in sera from patients with dilated ...

    journal_title：Journal of cardiac failure

    pub_type： 杂志文章

    doi：10.1016/j.cardfail.2016.03.005

    authors： Nagatomo Y,Li D,Kirsop J,Borowski A,Thakur A,Tang WH

    更新日期：2016-06-01 00:00:00

  • Bariatric Surgery in End-Stage Heart Failure: Feasibility in Successful Attainment of a Target Body Mass Index.

    abstract：INTRODUCTION:Orthotopic heart transplantation (OHT) is contraindicated in morbidly obese patients with end-stage heart failure (HF), for whom cardiac allograft is the only means for long-term survival. Bariatric surgery may allow them to achieve target body mass index (BMI) for OHT METHODS: From 4/2014 to 12/2018, 26 m...

    journal_title：Journal of cardiac failure

    pub_type： 杂志文章

    doi：10.1016/j.cardfail.2020.04.020

    authors： Val FRD,Cheon O,Menser T,Kash B,Jones SL,Baek J,Bhimaraj A,Estep J,Sherman V,Tariq N

    更新日期：2020-11-01 00:00:00

  • Myocardial hypertrophy in transgenic mice overexpressing human interleukin 1alpha.

    abstract：BACKGROUND:Interleukin (IL)-1 has profound effects on nonimmune cells and organs, including the heart. The effects of IL-1 on transgenic hearts have not yet been described. METHODS AND RESULTS:We generated transgenic mice overexpressing the human IL-1 gene under control of the cytomegalovirus enhancer/chicken beta-act...

    journal_title：Journal of cardiac failure

    pub_type： 杂志文章

    doi：10.1054/jcaf.2001.28221

    authors： Isoda K,Kamezawa Y,Tada N,Sato M,Ohsuzu F

    更新日期：2001-12-01 00:00:00