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γ-Glutamyltransferase rather than total bilirubin predicts outcome in chronic heart failure.

Abstract：

BACKGROUND:Gamma-glutamyltransferase (GGT) and total bilirubin (T-Bil) are elevated and of prognostic significance in chronic heart failure (CHF). This study sought to compare these novel cardiovascular risk markers in CHF. METHODS AND RESULTS:We evaluated 1,087 ambulatory patients from our heart failure program. Long-term follow-up was available in 1,056 patients. The combined end point was defined as death of any cause or heart transplantation. Prevalence of elevated GGT was 43% in men and 48% in women, that of T-Bil 17% and 8%, respectively. Both variables were significantly correlated with severity of heart failure. GGT and T-Bil were associated with transplant-free survival in bivariate analysis (P values <.001 and .006, respectively). However, GGT (hazard ratio [HR] 1.28, 95% confidence interval [CI] 1.13-1.44; P < .001), but not T-Bil, remained an independent predictor of prognosis in the multivariate model. Also, categorized GGT levels beyond the gender-specific normal ranges were predictive of the combined end point (HR 1.55, 95% CI 1.23-1.95). Elevation of both GGT and T-Bil further increased the risk of reaching the end point (HR 2.57, 95% CI 1.74-3.18). CONCLUSIONS:GGT and T-Bil are associated with disease severity in CHF. However, only GGT is independently associated with adverse outcome. Our findings further highlight the clinical importance of GGT in cardiovascular disease.

journal_name

J Card Fail

journal_title

Journal of cardiac failure

authors

Ess M,Mussner-Seeber C,Mariacher S,Lorsbach-Koehler A,Pachinger O,Frick M,Ulmer H,Poelzl G

doi

10.1016/j.cardfail.2011.02.012

subject

Has Abstract

pub_date

2011-07-01 00:00:00

pages

577-84

issue

7

eissn

1071-9164

issn

1532-8414

pii

S1071-9164(11)00103-5

journal_volume

17

pub_type

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