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Different substrates of non-sustained ventricular tachycardia in post-infarction patients with and without left ventricular dilatation.

Abstract：

BACKGROUND:We investigated the relationship between nonsustained ventricular tachycardia (NSVT) and left ventricular (LV) dilatation, function, remodeling, and scar tissue extent in patients with previous myocardial infarction (MI). METHODS AND RESULTS:Eighty-two patients (ages 64+/-10 years) with first previous MI were referred for 24-hour electrocardiogram recording and cine and delayed enhancement (DE) cardiac magnetic resonance (CMR). LV volumes, ejection fraction, systolic wall thickening, sphericity index, and core and peri-infarctual areas of scar tissue by CMR were evaluated. LV dilatation was observed in 39 patients. Episodes of NSVT were recorded in 32 patients: 23 with LV dilatation and 9 without. In the entire population, NSVT was related to ejection fraction, LV volumes, LV mass, and sphericity index; end-systolic volume (P=.001) resulted in the only independent predictor at multivariate analysis. In patients without LV dilatation, the occurrence of NSVT was only positively related with percentage of contracting segments with DE (P=.008). Conversely, in patients with LV dilatation, increase in LV mass (P=.020) and end-systolic volume (P=.038) were independent predictors of NSVT. CONCLUSIONS:Necrotic and viable myocardium coexistence within the same wall segments predicted occurrence of NSVT in patients without LV dilatation, whereas LV mass and end-systolic volume were predictors of NSVT in those with LV dilatation.

journal_name

J Card Fail

journal_title

Journal of cardiac failure

authors

Di Bella G,Passino C,Aquaro GD,Rovai D,Strata E,Arrigo F,Emdin M,Lombardi M,Pingitore A

doi

10.1016/j.cardfail.2009.09.001

subject

Has Abstract

pub_date

2010-01-01 00:00:00

pages

61-8

issue

1

eissn

1071-9164

issn

1532-8414

pii

S1071-9164(09)01044-6

journal_volume

16

pub_type

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