Abstract:
BACKGROUND:Although beta-blockers were well-tolerated by heart failure (HF) patients in clinical trials, tolerability of these drugs in a general population of HF patients is not well-described. METHODS:We studied a total of 308 encounters with beta-blockers therapy in 268 ambulatory HF patients. Side effects and frequency and predictors of discontinuation of therapy were studied. Independent predictors of discontinuation were assessed. RESULTS:Weight gain (59%), fatigue (56%), dizziness (41%), and dyspnea (29%) were the most common side effects. Fifty-one patients (19%) were discontinued on therapy with any 1 particular beta-blocker. Fatigue (30%) and hypotension (28%) were the most common reasons for discontinuation. Forty (78%) of these were given a trial with a different beta-blocker. Of these, 22 (55%) attempts with a different beta-blocker were tolerated. Thus the overall absolute discontinuation rate was only 7% for patients who were given a trial with different beta-blockers or 11% for the entire study population. Independent predictors of discontinuation of therapy included advanced symptoms, nonischemic etiology, history of pulmonary disease, and higher diuretic doses. CONCLUSION:Side effects with beta-blockers in a general population of HF patients are common; however, with changes in medical management, most patients can tolerate them eventually. In case of intolerance to one kind, a trial with a different beta-blocker is indicated.
journal_name
J Card Failjournal_title
Journal of cardiac failureauthors
Butler J,Khadim G,Belue R,Chomsky D,Dittus RS,Griffin M,Wilson JRdoi
10.1054/jcaf.2003.34keywords:
subject
Has Abstractpub_date
2003-06-01 00:00:00pages
203-9issue
3eissn
1071-9164issn
1532-8414pii
S1071916403000459journal_volume
9pub_type
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journal_title:Journal of cardiac failure
pub_type: 杂志文章
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更新日期:2004-06-01 00:00:00
abstract:OBJECTIVE:Disease management programs (DMPs) may reduce short-term readmission or death after heart failure (HF) hospitalization. We sought to determine if targeting of DMP to the highest-risk patients could improve efficiency. METHODS AND RESULTS:Patients (n = 412) admitted with HF were randomized to usual care or an...
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abstract:BACKGROUND:Heart failure (HF) dramatically affects the lives of both patients and their caregivers, yet limited research exists examining the relationship between emotional well-being of HF patients and their caregivers. Therefore, we conducted a study to (1) describe and compare the emotional well-being of HF patients...
journal_title:Journal of cardiac failure
pub_type: 杂志文章
doi:10.1054/jcaf.2002.128005
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pub_type: 杂志文章,评审
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journal_title:Journal of cardiac failure
pub_type: 杂志文章,meta分析,评审
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journal_title:Journal of cardiac failure
pub_type: 杂志文章,多中心研究,随机对照试验
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pub_type: 杂志文章,多中心研究
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pub_type: 杂志文章
doi:10.1054/jcaf.2003.47
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pub_type: 杂志文章
doi:10.1016/j.cardfail.2005.08.001
更新日期:2006-02-01 00:00:00
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journal_title:Journal of cardiac failure
pub_type: 杂志文章,多中心研究,随机对照试验
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journal_title:Journal of cardiac failure
pub_type: 杂志文章
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更新日期:2000-03-01 00:00:00
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pub_type: 杂志文章
doi:10.1054/jcaf.2002.32196
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pub_type: 杂志文章
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pub_type: 杂志文章
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更新日期:2017-12-01 00:00:00
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journal_title:Journal of cardiac failure
pub_type: 杂志文章,多中心研究
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pub_type: 杂志文章
doi:10.1054/jcaf.2003.4
更新日期:2003-02-01 00:00:00
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pub_type: 杂志文章
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journal_title:Journal of cardiac failure
pub_type: 杂志文章
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更新日期:2018-08-01 00:00:00
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pub_type: 杂志文章,评审
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pub_type: 杂志文章
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journal_title:Journal of cardiac failure
pub_type: 杂志文章
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更新日期:2011-05-01 00:00:00
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journal_title:Journal of cardiac failure
pub_type: 杂志文章
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更新日期:2020-07-01 00:00:00