Abstract：
BACKGROUND:The importance of repeated clinical assessments of patients with heart failure is widely accepted. The frequency of such follow-up is not established and is likely to depend on the natural history and variability of patients' health status and the availability and use of appropriate treatments. METHODS AND RESULTS:We analyzed data from a multicenter prospective cohort study of heart failure outpatients comparing baseline variables including New York Heart Association (NYHA) class, summary score on the Kansas City Cardiomyopathy Questionnaire (KCCQ), and performance on a 6-minute walk test with results of a repeat evaluation at 6 weeks. We also compared patient and physician assessment of change in disease status among patients with advanced symptoms (NYHA class III with a recent antecedent hospitalization or class IV) and those with milder degrees of limitation (NYHA classes I, II, and stable III). Patients with advanced symptoms had greater short-term variability in health status as reflected by the KCCQ summary score and a visual analog scale. A greater proportion of patients with advanced heart failure experienced moderate or greater clinical change. Patient and physician global assessments were congruent with more direct measures of health status. CONCLUSION:Patients with advanced heart failure have greater short-term variability in status, supporting the need for frequent clinical follow-up and appropriate power calculations for clinical trials that are designed to measure meaningful changes over a short period.
journal_name
J Card Failjournal_title
Journal of cardiac failureauthors
Hauptman PJ,Masoudi FA,Weintraub WS,Pina I,Jones PG,Spertus JA,Cardiovascular Outcomes Research Consortium.doi
10.1016/j.cardfail.2003.12.008keywords:
subject
Has Abstractpub_date
2004-10-01 00:00:00pages
397-402issue
5eissn
1071-9164issn
1532-8414pii
S1071916403008108journal_volume
10pub_type
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journal_title：Journal of cardiac failure
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journal_title：Journal of cardiac failure
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journal_title：Journal of cardiac failure
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journal_title：Journal of cardiac failure
pub_type： 杂志文章
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journal_title：Journal of cardiac failure
pub_type： 杂志文章,评审
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journal_title：Journal of cardiac failure
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journal_title：Journal of cardiac failure
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journal_title：Journal of cardiac failure
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journal_title：Journal of cardiac failure
pub_type： 杂志文章,多中心研究
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journal_title：Journal of cardiac failure
pub_type： 杂志文章,多中心研究
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journal_title：Journal of cardiac failure
pub_type： 杂志文章
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