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Novel Parameter to Predict Left Ventricular Filling Pressure: Product of Log B-Type Natriuretic Peptide and Ratio of Mitral Inflow Early and Late Diastolic Filling Velocities.

Abstract：

BACKGROUND:Several echocardiographic parameters are currently used to evaluate left ventricular (LV) filling pressure. However, these parameters are not always consistent in the clinical setting. We aimed to determine a novel parameter by multiplying log B-type natriuretic peptide (lnBNP) and the ratio of mitral inflow early and late diastolic filling velocities (E/A) for the prediction of pulmonary capillary wedge pressure (PCWP). METHODS AND RESULTS:One hundred ninety-eight patients suspected of chronic heart failure were analyzed. The product of lnBNP and E/A (BNP × E/A) showed the highest correlation coefficient with mean PCWP (R = 0.7326) compared with E/A (R = 0.7010) and E/e' (R = 0.3922). Multivariate logistic regression analysis revealed that BNP × E/A was associated with elevated PCWP (odds ratio 1.640, 95% confidence interval 1.312-2.197; P <.01). In the receiver operating characteristic curve analysis for detecting elevated PCWP, BNP × E/A showed the largest area under the curve (AUC) compared with E/A and E/e' (0.880 vs 0.827 and 0.788, respectively; P <.05). BNP × E/A still showed large AUC (0.842) for detection of elevated PCWP in patients with normal LV ejection fraction. CONCLUSION:BNP × E/A is a useful parameter for detecting elevated PCWP regardless of the LV ejection fraction.

journal_name

J Card Fail

journal_title

Journal of cardiac failure

authors

Oikawa M,Kobayashi A,Wada K,Sato T,Suzuki S,Yoshihisa A,Nakazato K,Suzuki H,Saitoh SI,Ishida T,Takeishi Y

doi

10.1016/j.cardfail.2017.10.008

subject

Has Abstract

pub_date

2018-01-01 00:00:00

pages

29-32

issue

1

eissn

1071-9164

issn

1532-8414

pii

S1071-9164(17)31231-9

journal_volume

24

pub_type

杂志文章

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