Effect of exercise training on autonomic derangement and neurohumoral activation in chronic heart failure.

Abstract:

BACKGROUND:In chronic heart failure (CHF), persistent autonomic derangement and neurohumoral activation cause structural end-organ damage, decrease exercise capacity, and reduce quality of life. Beneficial effects of pharmacotherapy and of exercise training in CHF have been documented at various functional and structural levels. However, pharmacologic treatment can not yet reduce autonomic derangement and neurohumoral activation in CHF to a minimum. Various studies suggest that exercise training is effective in this respect. METHODS AND RESULTS:After reviewing the available evidence we conclude that exercise training increases baroreflex sensitivity and heart rate variability, and reduces sympathetic outflow, plasma levels of catecholamines, angiotensin II, vasopressin, and brain natriuretic peptides at rest. CONCLUSIONS:Exercise training has direct and reflex sympathoinhibitory beneficial effects in CHF. The mechanism by which exercise training normalizes autonomic derangement and neurohumoral activation is to elucidate for further development of CHF-related training programs aimed at maximizing efficacy while minimizing workload.

journal_name

J Card Fail

authors

Gademan MG,Swenne CA,Verwey HF,van der Laarse A,Maan AC,van de Vooren H,van Pelt J,van Exel HJ,Lucas CM,Cleuren GV,Somer S,Schalij MJ,van der Wall EE

doi

10.1016/j.cardfail.2006.12.006

subject

Has Abstract

pub_date

2007-05-01 00:00:00

pages

294-303

issue

4

eissn

1071-9164

issn

1532-8414

pii

S1071-9164(06)01298-X

journal_volume

13

pub_type

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