Abstract:
BACKGROUND:In chronic heart failure (CHF), persistent autonomic derangement and neurohumoral activation cause structural end-organ damage, decrease exercise capacity, and reduce quality of life. Beneficial effects of pharmacotherapy and of exercise training in CHF have been documented at various functional and structural levels. However, pharmacologic treatment can not yet reduce autonomic derangement and neurohumoral activation in CHF to a minimum. Various studies suggest that exercise training is effective in this respect. METHODS AND RESULTS:After reviewing the available evidence we conclude that exercise training increases baroreflex sensitivity and heart rate variability, and reduces sympathetic outflow, plasma levels of catecholamines, angiotensin II, vasopressin, and brain natriuretic peptides at rest. CONCLUSIONS:Exercise training has direct and reflex sympathoinhibitory beneficial effects in CHF. The mechanism by which exercise training normalizes autonomic derangement and neurohumoral activation is to elucidate for further development of CHF-related training programs aimed at maximizing efficacy while minimizing workload.
journal_name
J Card Failjournal_title
Journal of cardiac failureauthors
Gademan MG,Swenne CA,Verwey HF,van der Laarse A,Maan AC,van de Vooren H,van Pelt J,van Exel HJ,Lucas CM,Cleuren GV,Somer S,Schalij MJ,van der Wall EEdoi
10.1016/j.cardfail.2006.12.006subject
Has Abstractpub_date
2007-05-01 00:00:00pages
294-303issue
4eissn
1071-9164issn
1532-8414pii
S1071-9164(06)01298-Xjournal_volume
13pub_type
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journal_title:Journal of cardiac failure
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journal_title:Journal of cardiac failure
pub_type: 临床试验,杂志文章
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更新日期:1998-09-01 00:00:00
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pub_type: 杂志文章,meta分析,评审
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journal_title:Journal of cardiac failure
pub_type: 杂志文章,评审
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journal_title:Journal of cardiac failure
pub_type: 杂志文章,多中心研究
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journal_title:Journal of cardiac failure
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更新日期:2018-08-01 00:00:00
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journal_title:Journal of cardiac failure
pub_type: 杂志文章,评审
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更新日期:2007-04-01 00:00:00
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pub_type: 杂志文章
doi:10.1016/j.cardfail.2013.10.004
更新日期:2013-11-01 00:00:00
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pub_type: 杂志文章
doi:10.1054/jcaf.2002.31157
更新日期:2002-02-01 00:00:00
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journal_title:Journal of cardiac failure
pub_type: 杂志文章
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更新日期:2011-04-01 00:00:00
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journal_title:Journal of cardiac failure
pub_type: 杂志文章
doi:10.1016/j.cardfail.2014.08.005
更新日期:2014-11-01 00:00:00
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pub_type: 杂志文章,多中心研究,随机对照试验
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journal_title:Journal of cardiac failure
pub_type: 临床试验,杂志文章,随机对照试验
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更新日期:1995-12-01 00:00:00
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更新日期:2008-06-01 00:00:00
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journal_title:Journal of cardiac failure
pub_type: 杂志文章
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journal_title:Journal of cardiac failure
pub_type: 更正并重新发布的文章,杂志文章,随机对照试验
doi:
更新日期:2014-05-01 00:00:00
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pub_type: 杂志文章
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pub_type: 杂志文章
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journal_title:Journal of cardiac failure
pub_type: 杂志文章
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更新日期:2005-03-01 00:00:00