Abstract：
BACKGROUND:The present study examined the influence of rapid intravenous fluid loading (RFL) on airway structure and pulmonary vascular volumes using computed tomography imaging and the subsequent impact on pulmonary function in healthy adults (n = 16). METHODS AND RESULTS:Total lung capacity (DeltaTLC = -6%), forced vital capacity (DeltaFVC = -14%), and peak expiratory flow (DeltaPEF = -19%) decreased, and residual volume (DeltaRV = +38%) increased post-RFL (P < .05). Airway luminal cross-sectional area (CSA) decreased at the trachea, and at airway generation 3 (P < .05), wall thickness changed minimally with a tendency for increasing in generation five (P = .13). Baseline pulmonary function was positively associated with airway luminal CSA; however, this relationship deteriorated after RFL. Lung tissue volume and pulmonary vascular volumes increased 28% (P < .001) post-RFL, but did not fully account for the decline in TLC. CONCLUSIONS:These data suggest that RFL results in obstructive/restrictive PF changes that are most likely related to structural changes in smaller airways or changes in extrapulmonary vascular beds.
journal_name
J Card Failjournal_title
Journal of cardiac failureauthors
Ceridon ML,Snyder EM,Strom NA,Tschirren J,Johnson BDdoi
10.1016/j.cardfail.2009.08.005subject
Has Abstractpub_date
2010-02-01 00:00:00pages
175-85issue
2eissn
1071-9164issn
1532-8414pii
S1071-9164(09)01039-2journal_volume
16pub_type
杂志文章abstract：BACKGROUND:Current US and European guidelines recommend that ejection fraction (EF) be measured at least once in patients with congestive heart failure (CHF). However, it is not known how age and sex influence adherence to this recommendation. METHODS:We reviewed a national sample of Medicare patients discharged with ...
journal_title：Journal of cardiac failure
pub_type： 杂志文章
doi：10.1054/jcaf.2003.16
更新日期：2003-04-01 00:00:00
abstract：BACKGROUND:Exercise training improves endothelium-dependent vasodilation in animals. This study was designed to determine whether forearm exercise training improves endothelium-dependent vasodilation in control subjects and patients with heart failure, a disease associated with abnormal endothelium-dependent vasodilati...
journal_title：Journal of cardiac failure
pub_type： 临床试验,杂志文章
doi：10.1016/s1071-9164(98)80006-7
更新日期：1998-09-01 00:00:00
abstract：:The complexity of standard medical treatment for heart failure is growing, and such therapy typically involves 5 or more different medications. Given these pressures, there is increasing interest in harnessing cardiovascular biomarkers for clinical application to more effectively guide diagnosis, risk stratification, ...
journal_title：Journal of cardiac failure
pub_type：
doi：10.1016/j.cardfail.2013.05.012
更新日期：2013-08-01 00:00:00
abstract：:Contracting myocytes are highly variable in size and generally resemble elliptical cylinders in shape. Although their arrangement within the ventricular wall is rather complex, their length runs in a tangential manner, and their transverse axis runs transmurally. Consequently, it was proposed many years ago that chang...
journal_title：Journal of cardiac failure
pub_type： 杂志文章
doi：10.1054/jcaf.2002.129280
更新日期：2002-12-01 00:00:00
abstract：BACKGROUND:Improvement of left ventricular (LV) systolic dysfunction can occur in patients with dilated cardiomyopathy (DCM), and it is more frequently observed if patients have no delayed enhancement (DE) in cardiac magnetic resonance imaging (CMR). However, even in the absence of DE, not all patients have functional ...
journal_title：Journal of cardiac failure
pub_type： 杂志文章
doi：10.1016/j.cardfail.2015.12.011
更新日期：2016-04-01 00:00:00
abstract：BACKGROUND:Some of the most frequent manifestations of heart involvement in human immunodeficiency virus (HIV) infection include right and left ventricular dysfunction. The pathogenesis remains obscure. METHODS AND RESULTS:This prospective clinical and echocardiographic study involved 181 patients at all stages of HIV...
journal_title：Journal of cardiac failure
pub_type： 临床试验,杂志文章
doi：10.1016/s1071-9164(98)90504-8
更新日期：1998-03-01 00:00:00
abstract：:Elevated plasma levels of endothelin (ET) have been reported to accompany the development of heart failure (HF), and therefore, this potent vasoconstrictive peptide has been postulated to contribute to the altered pulmonary hemodynamics that occur in this disease process. The overall goal of this study was to examine ...
journal_title：Journal of cardiac failure
pub_type： 杂志文章
doi：10.1016/s1071-9164(97)90025-7
更新日期：1997-12-01 00:00:00
abstract：BACKGROUND:The abnormalities in coronary hemodynamics in systolic heart failure are frequent. Myocardial oxygen demand and consumption are increased and myocardial perfusion is also impaired, which may result in myocardial ischemia, necrosis, and apoptosis. This is potentially a contributing factor for progressive hear...
journal_title：Journal of cardiac failure
pub_type： 杂志文章,评审
doi：10.1016/j.cardfail.2009.01.001
更新日期：2009-03-01 00:00:00
abstract：BACKGROUND:The effect of elevated heart rate (HR) on outcomes after heart transplantation (HT) has not been well established. The aim of this study was to assess predictors of elevated HR following HT and its impact on outcomes. METHODS AND RESULTS:We retrospectively evaluated 394 patients who underwent HT at 2 academ...
journal_title：Journal of cardiac failure
pub_type： 杂志文章,多中心研究
doi：10.1016/j.cardfail.2019.01.009
更新日期：2019-04-01 00:00:00
abstract：:Heart failure is a major public health problem and is increasing in incidence throughout the industrialized world. Despite recent advances in pharmacotherapy, the overall mortality remains high and largely unchanged. Ultrafiltration has received increased attention in the treatment of acute decompensated congestive he...
journal_title：Journal of cardiac failure
pub_type： 杂志文章,评审
doi：10.1016/j.cardfail.2008.07.230
更新日期：2008-11-01 00:00:00
abstract：:Since the introduction of biomarkers in the late 1980s, considerable research has been dedicated to their validation and application. As a result, many biomarkers are now commonly used in clinical practice. However, the role of biomarkers in the prediction of right ventricular failure (RVF) and in the prognostication ...
journal_title：Journal of cardiac failure
pub_type： 杂志文章
doi：10.1016/j.cardfail.2019.09.007
更新日期：2020-09-01 00:00:00
abstract：BACKGROUND:A greater understanding of how beliefs and perceptions inform LVAD placement refusals can help ensure that standards for informed decision making are met. We report on the factors that influence refusal and what accounts for changes in decliners' decision-making process when, and if, that occurs. METHOD AND...
journal_title：Journal of cardiac failure
pub_type： 杂志文章
doi：10.1016/j.cardfail.2015.06.008
更新日期：2015-10-01 00:00:00
abstract：BACKGROUND:Patients with chronic heart failure (CHF) complain of breathlessness and fatigue on exertion, have reduced peak oxygen consumption (pV(O(2))), and an increased ventilatory response to exercise (V(E)/V(CO(2)) slope). These limitations correlate with abnormalities of spirometry (forced expiratory volume in 1 s...
journal_title：Journal of cardiac failure
pub_type： 杂志文章
doi：10.1054/jcaf.2002.126916
更新日期：2002-08-01 00:00:00
abstract：BACKGROUND:Zinc is an essential cofactor for energy transfer and physiological heart function, has antioxidant properties, and is involved in multiple signaling pathways. We aimed to investigate the associations between serum zinc levels with prognosis, as well as underlying cardiac function and exercise capacity, in p...
journal_title：Journal of cardiac failure
pub_type： 杂志文章
doi：10.1016/j.cardfail.2018.02.011
更新日期：2018-06-01 00:00:00
abstract：BACKGROUND:Digitalis glycosides are known to improve the hemodynamic and neurohormonal perturbations that contribute to heart failure (HF)-induced renal dysfunction (RD). The objective of this study was to determine if randomization to digoxin is associated with improvement in renal function (IRF) and to evaluate if pa...
journal_title：Journal of cardiac failure
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.cardfail.2013.03.002
更新日期：2013-05-01 00:00:00
abstract：:Propionyl-L-carnitine (PLC) is a naturally occurring compound that has been considered for the treatment of congestive heart failure (CHF). The rationale for its use in this pathology is related to its effects on cardiac and skeletal muscle. Chronic treatment with PLC improves the contraction of isolated and aerobic p...
journal_title：Journal of cardiac failure
pub_type： 杂志文章,评审
doi：10.1016/s1071-9164(97)90018-x
更新日期：1997-09-01 00:00:00
abstract：:Knowledge of left-sided cardiac filling pressures has an important role in the management of patients with chronic heart failure. However, the use of a pulmonary artery catheter to measure pulmonary capillary wedge pressure is generally reserved for hospitalized patients with decompensated heart failure, leaving only ...
journal_title：Journal of cardiac failure
pub_type： 杂志文章,评审
doi：
更新日期：2000-06-01 00:00:00
abstract：:Stimulation of the V1a receptor for arginine vasopressin produces myocardial and vascular effects similar to those of angiotensin II while stimulation of the V2 receptor causes fluid retention. There are no data with sustained blockade of the V1a receptor while single-dose experiments suggest benefit. Acute and chroni...
journal_title：Journal of cardiac failure
pub_type： 杂志文章,评审
doi：10.1016/j.cardfail.2017.12.011
更新日期：2018-02-01 00:00:00
abstract：BACKGROUND:Heightened activity of the sympathetic nervous system in heart failure patients is a major contributor to disease progression and death. I-123 metaiodobenzylguanidine (MIBG) provides an accurate, noninvasive method to assess cardiac sympathetic nerve activity. METHODS:Thirty-seven patients with New York Hea...
journal_title：Journal of cardiac failure
pub_type： 临床试验,杂志文章
doi：10.1054/s1071-9164(03)00134-9
更新日期：2003-10-01 00:00:00
abstract：BACKGROUND:Chronic heart failure is a disease syndrome characterized in its advanced stages by a poor quality of life, frequent hospitalizations, and a high risk of mortality. In advanced and ultra-advanced chronic heart failure, many treatment options, such as cardiac transplantation and mechanical devices, are severe...
journal_title：Journal of cardiac failure
pub_type： 杂志文章
doi：10.1016/j.cardfail.2005.10.013
更新日期：2005-12-01 00:00:00
abstract：INTRODUCTION:This study was designed to determine if physicians' attitudes and recommendations surrounding implantable cardioverter-defibrillators (ICDs) are regionally associated with ICD use. METHODS AND RESULTS:A national sample of 9969 members of the American College of Cardiology was surveyed electronically. Resp...
journal_title：Journal of cardiac failure
pub_type： 杂志文章
doi：10.1016/j.cardfail.2010.11.009
更新日期：2011-04-01 00:00:00
abstract：BACKGROUND:The purpose of this study was to compare the effects of immediate-release (IR) metoprolol and extended-release (XL) metoprolol on measures of heart rate variability in chronic systolic heart failure patients. METHODS AND RESULTS:Thirteen metoprolol-treated heart failure patients were randomized to a 2-way c...
journal_title：Journal of cardiac failure
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.cardfail.2005.12.002
更新日期：2006-04-01 00:00:00
abstract：BACKGROUND:Cardiac resynchronization therapy (CRT) induces structural and electrical remodeling (ER) in heart failure (HF) patients. Our aim was to assess time course of ER of native conduction and mechanical remodeling after CRT and impact of CRT-induced ER on clinical outcome. METHODS AND RESULTS:We prospectively in...
journal_title：Journal of cardiac failure
pub_type： 杂志文章
doi：10.1016/j.cardfail.2016.10.014
更新日期：2017-03-01 00:00:00
abstract：BACKGROUND:Coronary artery disease is the most common cause of heart failure (HF) in developed countries. The aim of this study was to elucidate the mechanisms of reduction of arrhythmias after sacubitril/valsartan (LCZ696) therapy in a myocardial infarction (MI)-HF rabbit model. METHODS AND RESULTS:Chronic MI in rabb...
journal_title：Journal of cardiac failure
pub_type： 杂志文章
doi：10.1016/j.cardfail.2020.03.007
更新日期：2020-06-01 00:00:00
abstract：BACKGROUND:Frailty reflects decreased resilience to physiological stressors; its prevalence and prognosis are not fully defined in heart failure with preserved ejection fraction (HFpEF). METHODS:The Short Physical Performance Battery (SPPB) was prospectively obtained in 114 outpatients with HFpEF. The SPPB tests gait ...
journal_title：Journal of cardiac failure
pub_type： 杂志文章
doi：10.1016/j.cardfail.2018.09.002
更新日期：2019-01-01 00:00:00
abstract：:Clinical trials designed to evaluate the effect of drugs and devices on the symptoms and clinical status in chronic heart failure have frequently produced conflicting, inconclusive, or misleading results. These difficulties can be explained by the fact that previous studies have relied on efficacy measures that have i...
journal_title：Journal of cardiac failure
pub_type： 杂志文章
doi：10.1054/jcaf.2001.25652
更新日期：2001-06-01 00:00:00
abstract：BACKGROUND:Our aim was to study the potential effect of neighborhood deprivation on incident heart failure (HF) in patients with diabetes mellitus (DM). METHODS:The study population included adults (n = 434,542) aged 30 years or older with DM followed from 2005 to 2015 in Sweden for incident HF. The association betwee...
journal_title：Journal of cardiac failure
pub_type： 杂志文章
doi：10.1016/j.cardfail.2019.04.017
更新日期：2020-03-01 00:00:00
abstract：BACKGROUND:Survival of patients with congenital heart defects including increased right ventricular pressure load (ie, tetralogy of Fallot) or pulmonary hypertension is dependent on the function of the right ventricle (RV). RV remodeling has several effects with progressive transition from compensated status to heart f...
journal_title：Journal of cardiac failure
pub_type： 杂志文章
doi：10.1016/j.cardfail.2020.02.006
更新日期：2020-07-01 00:00:00
abstract：BACKGROUND:In patients with heart failure and preserved ejection fraction (HF-PEF) randomized in the Americas as part of the Treatment of Preserved Cardiac Function Heart Failure with an Aldosterone Antagonist (TOPCAT) trial, treatment with spironolactone enhanced the risk of hyperkalemia but reduced the risk of hypoka...
journal_title：Journal of cardiac failure
pub_type： 杂志文章,多中心研究,随机对照试验
doi：10.1016/j.cardfail.2018.03.002
更新日期：2018-05-01 00:00:00
abstract：BACKGROUND:Interleukin (IL)-1 has profound effects on nonimmune cells and organs, including the heart. The effects of IL-1 on transgenic hearts have not yet been described. METHODS AND RESULTS:We generated transgenic mice overexpressing the human IL-1 gene under control of the cytomegalovirus enhancer/chicken beta-act...
journal_title：Journal of cardiac failure
pub_type： 杂志文章
doi：10.1054/jcaf.2001.28221
更新日期：2001-12-01 00:00:00
