当前位置： SCI文献检索 > JOURNAL OF CARDIAC FAILURE期刊下所有文献 > TRPM4 Modulates Right Ventricular Remodeling Under Pressure Load Accompanied With Decreased Expression Level.

TRPM4 Modulates Right Ventricular Remodeling Under Pressure Load Accompanied With Decreased Expression Level.

Abstract：

BACKGROUND:Survival of patients with congenital heart defects including increased right ventricular pressure load (ie, tetralogy of Fallot) or pulmonary hypertension is dependent on the function of the right ventricle (RV). RV remodeling has several effects with progressive transition from compensated status to heart failure. Transient receptor potential melastatin 4 (TRPM4) forms cation channels expressed in myocardium, which was shown to modulate cardiac remodeling in the left ventricle of mice. Aim of this study was to identify the role of TRPM4 for contractile function and remodeling of the RV in a rat model of right ventricular pressure load. METHODS AND RESULTS:We performed experiments with untreated rats and under monocrotaline (MCT)-induced pressure load comparing wild-type (Trpm4+/+) and TRPM4-deficient (Trpm4-/-) rats. RV function was characterized by echocardiography and contractility measurements of isolated papillary muscles. RV hypertrophy was investigated by echocardiography and by determination of hypertrophy indices. Pulmonary arterial remodeling was evaluated by echocardiography and histology. TRPM4 protein expression in RV of human, rat and mouse was detected by Western blot and quantified in rat. TRPM4 proteins were detected in RV myocardium of rat and mouse, which were not detectable in TRPM4-deficient animals. Proteins of the same size were found in RV of a pediatric patient with tetralogy of Fallot. In untreated status, Trpm4+/+ and Trpm4-/- rats showed comparable RV contractile function and dimensions. Under pressure load (42 days after MCT injection), RV hypertrophy was significantly increased in Trpm4-/- rats compared with Trpm4+/+ controls, whereas MCT-mediated alterations in cardiac contractility and pulmonary arterial remodeling were not affected by TRPM4 inactivation in rats. Finally, TRPM4 protein expression in RV was drastically reduced in MCT-treated rats, whereas left ventricle of the same animals showed no alteration in TRPM4 expression. CONCLUSIONS:Right ventricular pressure load evoked by MCT treatment in rats leads to a prominent downregulation of TRPM4 protein expression in the RV and complete deletion of TRPM4 expression aggravates right ventricular hypertrophy. Thus, therapeutic modulation of TRPM4 expression and activity might represent a novel approach to target right ventricular remodeling in patients with pulmonary hypertension or otherwise loaded RV.

journal_name

J Card Fail

journal_title

Journal of cardiac failure

authors

Frede W,Medert R,Poth T,Gorenflo M,Vennekens R,Freichel M,Uhl S

doi

10.1016/j.cardfail.2020.02.006

subject

Has Abstract

pub_date

2020-07-01 00:00:00

pages

599-609

issue

7

eissn

1071-9164

issn

1532-8414

pii

S1071-9164(19)30440-3

journal_volume

26

pub_type

杂志文章

相关文献

JOURNAL OF CARDIAC FAILURE文献大全
  • The extracellular connections: the role of integrins in myocardial remodeling.

    abstract：BACKGROUND:Integrins are a large family of heterodimeric cell surface receptors that are present on all cells. These molecules link the extracellular matrix to the intracellular cytoskeleton and are multifunctional, playing roles in cell organization and differentiation, migration, alteration of gene expression, and ce...

    journal_title：Journal of cardiac failure

    pub_type： 杂志文章,评审

    doi：10.1054/jcaf.2002.129263

    authors： Ross RS

    更新日期：2002-12-01 00:00:00

  • A synthetic non-degradable polyethylene glycol hydrogel retards adverse post-infarct left ventricular remodeling.

    abstract：BACKGROUND:Left ventricular remodeling after myocardial infarction is a key component of heart failure and it has long been postulated that it may result from increased wall stress. It has recently been suggested that an injectable, non-degradable polymer may limit pathological remodeling in a manner analogous to that ...

    journal_title：Journal of cardiac failure

    pub_type： 杂志文章

    doi：10.1016/j.cardfail.2009.03.003

    authors： Dobner S,Bezuidenhout D,Govender P,Zilla P,Davies N

    更新日期：2009-09-01 00:00:00

  • Comparison of direct body composition assessment methods in patients with chronic heart failure.

    abstract：BACKGROUND:We examined the validity of leg-to-leg bioelectrical impedance analysis (BIA) and near-infrared interactance (NIR) to assess body composition in chronic heart failure (CHF) patients. METHODS AND RESULTS:A total of 140 patients with CHF were enrolled in this cross-sectional study between June 2008 and July 2...

    journal_title：Journal of cardiac failure

    pub_type： 杂志文章

    doi：10.1016/j.cardfail.2010.06.416

    authors： Oreopoulos A,Kalantar-Zadeh K,McAlister FA,Ezekowitz JA,Fonarow GC,Johnson JA,Norris CM,Padwal RS

    更新日期：2010-11-01 00:00:00

  • Prognostic impact of combined late gadolinium enhancement on cardiovascular magnetic resonance and peak oxygen consumption in ambulatory patients with nonischemic dilated cardiomyopathy.

    abstract：BACKGROUND:Peak oxygen consumption (peak VO₂) and late gadolinium enhancement (LGE) on cardiovascular magnetic resonance (CMR) are prognostic in heart failure. We investigated whether LGE-CMR and peak VO₂combined had additive value in risk stratifying patients with nonischemic dilated cardiomyopathy (DCM). METHODS AND...

    journal_title：Journal of cardiac failure

    pub_type： 杂志文章

    doi：10.1016/j.cardfail.2014.08.005

    authors： Yamada T,Hirashiki A,Okumura T,Adachi S,Shimazu S,Shimizu S,Morimoto R,Takeshita K,Naganawa S,Kondo T,Murohara T

    更新日期：2014-11-01 00:00:00

  • Intravenous salt supplementation with low-dose furosemide for treatment of acute decompensated heart failure.

    abstract：BACKGROUND:Theoretically, salt supplementation should promote diuresis through increasing the glomerular filtration rate (GFR) during treatment of acute decompensated heart failure (ADHF) even with low-dose furosemide; however, there is little evidence to support this idea. METHODS AND RESULTS:This was a prospective, ...

    journal_title：Journal of cardiac failure

    pub_type： 杂志文章,随机对照试验

    doi：10.1016/j.cardfail.2014.01.012

    authors： Okuhara Y,Hirotani S,Naito Y,Nakabo A,Iwasaku T,Eguchi A,Morisawa D,Ando T,Sawada H,Manabe E,Masuyama T

    更新日期：2014-05-01 00:00:00

  • Emotional well-being of heart failure patients and their caregivers.

    abstract：BACKGROUND:Heart failure (HF) dramatically affects the lives of both patients and their caregivers, yet limited research exists examining the relationship between emotional well-being of HF patients and their caregivers. Therefore, we conducted a study to (1) describe and compare the emotional well-being of HF patients...

    journal_title：Journal of cardiac failure

    pub_type： 杂志文章

    doi：10.1054/jcaf.2002.128005

    authors： Evangelista LS,Dracup K,Doering L,Westlake C,Fonarow GC,Hamilton M

    更新日期：2002-10-01 00:00:00

  • Pulmonary hypertension and systemic hypotension as limitations to exercise in chronic heart failure.

    abstract：:The authors have previously shown that the resistance ratio (RR) is increased in patients with congestive heart failure (CHF), and that the patients with the highest RRs have an increased mortality. The authors hypothesized that CHF patients with the lowest maximum oxygen consumption and the most impaired Weber functi...

    journal_title：Journal of cardiac failure

    pub_type： 杂志文章

    doi：10.1016/1071-9164(94)90005-1

    authors： Mabee SW,Metra M,Reed DE,Dei Cas L,Cody RJ

    更新日期：1994-10-01 00:00:00

  • Tolerability to beta-blocker therapy among heart failure patients in clinical practice.

    abstract：BACKGROUND:Although beta-blockers were well-tolerated by heart failure (HF) patients in clinical trials, tolerability of these drugs in a general population of HF patients is not well-described. METHODS:We studied a total of 308 encounters with beta-blockers therapy in 268 ambulatory HF patients. Side effects and freq...

    journal_title：Journal of cardiac failure

    pub_type： 杂志文章,多中心研究

    doi：10.1054/jcaf.2003.34

    authors： Butler J,Khadim G,Belue R,Chomsky D,Dittus RS,Griffin M,Wilson JR

    更新日期：2003-06-01 00:00:00

  • The minute ventilation/carbon dioxide production slope is prognostically superior to the oxygen uptake efficiency slope.

    abstract：BACKGROUND:Ventilatory efficiency, commonly assessed by the minute ventilation (VE)-carbon dioxide production (VCO2) slope, has proven to be a strong prognostic marker in the heart failure (HF) population. Recently, the oxygen uptake efficiency slope (OUES) has demonstrated prognostic value, but additional comparisons ...

    journal_title：Journal of cardiac failure

    pub_type： 杂志文章,多中心研究

    doi：10.1016/j.cardfail.2007.03.004

    authors： Arena R,Myers J,Hsu L,Peberdy MA,Pinkstaff S,Bensimhon D,Chase P,Vicenzi M,Guazzi M

    更新日期：2007-08-01 00:00:00

  • Characteristics of patients who die with heart failure and a low ejection fraction in the new millennium.

    abstract：BACKGROUND:Therapies for heart failure (HF) with a low ejection fraction (EF) have delayed disease progression and prolonged survival, but the implications of these therapies on the end stages of HF have not been examined. METHODS AND RESULTS:Patients seen by the Brigham and Women's cardiomyopathy service with an EF <...

    journal_title：Journal of cardiac failure

    pub_type： 杂志文章

    doi：10.1016/j.cardfail.2005.08.001

    authors： Teuteberg JJ,Lewis EF,Nohria A,Tsang SW,Fang JC,Givertz MM,Jarcho JA,Mudge GH,Baughman KL,Stevenson LW

    更新日期：2006-02-01 00:00:00

  • Severe mechanical dyssynchrony causes regional hibernation-like changes in pigs with nonischemic heart failure.

    abstract：BACKGROUND:Sustained left ventricular (LV) dyssynchrony can lead to heart failure (HF) in the absence of coronary artery stenosis. We tested whether myocardial hibernation underlies the LV functional impairment caused by high-frequency pacing, an established model of nonischemic dilated cardiomyopathy. METHODS AND RES...

    journal_title：Journal of cardiac failure

    pub_type： 杂志文章

    doi：10.1016/j.cardfail.2009.06.436

    authors： Lionetti V,Aquaro GD,Simioniuc A,Di Cristofano C,Forini F,Cecchetti F,Campan M,De Marchi D,Bernini F,Grana M,Nannipieri M,Mancini M,Lombardi M,Recchia FA,Pingitore A

    更新日期：2009-12-01 00:00:00

  • Serum pregnancy-associated plasma protein a in patients with heart failure.

    abstract：BACKGROUND:Pregnancy-associated plasma protein A (PAPP-A) proteolyzes insulin-like growth factor (IGF)-binding proteins and thus increases IGF-1 bioactivity. PAPP-A has been reported to be involved in various pathophysiologic abnormalities; however, the clinical significance of PAPP-A has not been examined in cases of ...

    journal_title：Journal of cardiac failure

    pub_type： 杂志文章

    doi：10.1016/j.cardfail.2011.05.011

    authors： Funayama A,Shishido T,Netsu S,Ishino M,Sasaki T,Katoh S,Takahashi H,Arimoto T,Miyamoto T,Nitobe J,Watanabe T,Kubota I

    更新日期：2011-10-01 00:00:00

  • New therapeutic strategies for heart failure: left ventricular remodeling as a target.

    abstract：:Structural remodeling of the left ventricle involves myocyte growth and matrix changes that result in chamber enlargement, contractile dysfunction and dyssynchrony. Clinical and experimental data document that these structural changes correlate with progressive worsening of the syndrome of heart failure, that the chan...

    journal_title：Journal of cardiac failure

    pub_type： 杂志文章,评审

    doi：10.1016/j.cardfail.2004.09.007

    authors： Cohn JN

    更新日期：2004-12-01 00:00:00

  • Comorbid diabetes and end-of-life expenditures among Medicare beneficiaries with heart failure.

    abstract：BACKGROUND:Diabetes is associated with increased risk of mortality in heart failure. We examined the association of diabetes with expenditures, hospitalizations, and procedures among Medicare beneficiaries with heart failure during the last 6 months of life. METHODS AND RESULTS:In a 5% national Medicare sample, the pr...

    journal_title：Journal of cardiac failure

    pub_type： 杂志文章

    doi：10.1016/j.cardfail.2011.09.011

    authors： Blecker S,Herbert R,Brancati FL

    更新日期：2012-01-01 00:00:00

  • Rationale and design of the enoximone clinical trials program.

    abstract：BACKGROUND:Chronic heart failure is a disease syndrome characterized in its advanced stages by a poor quality of life, frequent hospitalizations, and a high risk of mortality. In advanced and ultra-advanced chronic heart failure, many treatment options, such as cardiac transplantation and mechanical devices, are severe...

    journal_title：Journal of cardiac failure

    pub_type： 杂志文章

    doi：10.1016/j.cardfail.2005.10.013

    authors： Lowes BD,Shakar SF,Metra M,Feldman AM,Eichhorn E,Freytag JW,Gerber MJ,Liard JF,Hartman C,Gorczynski R,Evans G,Linseman JV,Stewart J,Robertson AD,Roecker EB,Demets DL,Bristow MR

    更新日期：2005-12-01 00:00:00

  • Racial differences in treatment-seeking delays among heart failure patients.

    abstract：BACKGROUND:Treatment-seeking delays for heart failure (HF) symptoms are significantly high. However, earlier studies did not closely examine race as a characteristic that could potentially influence delay times. The purpose of this study was (1) to describe racial differences in treatment-seeking delays for HF symptoms...

    journal_title：Journal of cardiac failure

    pub_type： 杂志文章

    doi：10.1054/jcaf.2002.129234

    authors： Evangelista LS,Dracup K,Doering LV

    更新日期：2002-12-01 00:00:00

  • Persistent anemia after implantation of the total artificial heart.

    abstract：BACKGROUND:The total artificial heart (TAH) replaces the heart with 2 pneumatic pumps and 4 tilting disk mechanical valves. It was hypothesized that patients receiving TAH support have persistent hemolysis that resolves after heart transplantation (HT). METHODS AND RESULTS:Hematocrit (HCT) was compared in patients on ...

    journal_title：Journal of cardiac failure

    pub_type： 杂志文章

    doi：10.1016/j.cardfail.2012.03.003

    authors： Mankad AK,Tang DG,Clark WB,Flattery M,Harton S,Katlaps GJ,Stribling WK,Cooke RH,Hess ML,Kasirajan V,Shah KB

    更新日期：2012-06-01 00:00:00

  • Effects of Angiotensin-Neprilysin Inhibition in Canines with Experimentally Induced Cardiorenal Syndrome.

    abstract：BACKGROUND:Sacubitril/valsartan (Sac/Val), a combined angiotensin-II receptor blocker (Val) and neprilysin inhibitor (Sac) in a 1:1 molar ratio, was shown to decrease the risk of cardiovascular death or heart failure (HF) hospitalization in patients with HF and reduced left ventricular (LV) ejection fraction. This stud...

    journal_title：Journal of cardiac failure

    pub_type： 杂志文章

    doi：10.1016/j.cardfail.2020.08.009

    authors： Sabbah HN,Zhang K,Gupta RC,Xu J,Singh-Gupta V

    更新日期：2020-11-01 00:00:00

  • Effects of lisinopril in patients with heart failure and chronic atrial fibrillation.

    abstract：:Although atrial fibrillation is common in patients with heart failure, patients with atrial fibrillation are often excluded from congestive heart failure trials or are not analyzed separately. Consequently, while the effect of angiotensin-converting enzyme inhibitors in patients with sinus rhythm is well established, ...

    journal_title：Journal of cardiac failure

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1016/s1071-9164(05)80004-1

    authors： Van Den Berg MP,Crijns HJ,Van Veldhuisen DJ,Griep N,De Kam PJ,Lie KI

    更新日期：1995-12-01 00:00:00

  • Fatigue, inflammation, and projected mortality in heart failure.

    abstract：BACKGROUND:Fatigue is a prominent and poorly understood symptom of heart failure with reduced ejection fraction (HFrEF). The purpose of this study was to determine whether fatigue correlated with immune biomarkers and prognosis. METHODS/RESULTS:In patients with HFrEF (N = 59) and healthy controls (N = 25), we prospect...

    journal_title：Journal of cardiac failure

    pub_type： 杂志文章

    doi：10.1016/j.cardfail.2012.07.003

    authors： Fink AM,Gonzalez RC,Lisowski T,Pini M,Fantuzzi G,Levy WC,Piano MR

    更新日期：2012-09-01 00:00:00

  • Anabolics and cardiomyopathy in a bodybuilder: case report and literature review.

    abstract：BACKGROUND:Athletes use androgenic-anabolic steroids to increase strength and muscle mass. Several case reports suggest that it may lead to dilated cardiomyopathy. METHODS AND RESULTS:We report a case of a 41-year-old bodybuilder with severe systolic dysfunction and Class IV heart failure despite maximal medical thera...

    journal_title：Journal of cardiac failure

    pub_type： 杂志文章,评审

    doi：10.1016/j.cardfail.2008.12.014

    authors： Ahlgrim C,Guglin M

    更新日期：2009-08-01 00:00:00

  • The effect of a randomized trial of home telemonitoring on medical costs, 30-day readmissions, mortality, and health-related quality of life in a cohort of community-dwelling heart failure patients.

    abstract：BACKGROUND:Telemonitoring has been advocated as a way of decreasing costs and improving outcomes, but no study has looked at true Medicare payments and 30-day readmission rates in a randomized group of well treated patients. OBJECTIVE:The aim of this work was to analyze Medicare claims data to identify effects of home...

    journal_title：Journal of cardiac failure

    pub_type： 杂志文章,随机对照试验

    doi：10.1016/j.cardfail.2014.04.016

    authors： Blum K,Gottlieb SS

    更新日期：2014-07-01 00:00:00

  • Dietary habits are related to outcomes in patients with advanced heart failure awaiting heart transplantation.

    abstract：BACKGROUND:Empirical evidence supporting the benefits of dietary recommendations for patients with advanced heart failure is scarce. We prospectively evaluated the relation of dietary habits to pre-transplant clinical outcomes in the multisite observational Waiting for a New Heart Study. METHODS AND RESULTS:A total of...

    journal_title：Journal of cardiac failure

    pub_type： 杂志文章,多中心研究

    doi：10.1016/j.cardfail.2013.02.004

    authors： Spaderna H,Zahn D,Pretsch J,Connor SL,Zittermann A,Schulze Schleithoff S,Bramstedt KA,Smits JM,Weidner G

    更新日期：2013-04-01 00:00:00

  • Relevance of water gymnastics in rehabilitation programs in patients with chronic heart failure or coronary artery disease with normal left ventricular function.

    abstract：BACKGROUND:Exercise training is included in cardiac rehabilitation programs to enhance physical capacity and cardiovascular function. Among the existing rehabilitation programs, exercises in water are increasingly prescribed. However, it has been questioned whether exercises in water are safe and relevant in patients w...

    journal_title：Journal of cardiac failure

    pub_type： 杂志文章,随机对照试验

    doi：10.1016/j.cardfail.2011.04.008

    authors： Teffaha D,Mourot L,Vernochet P,Ounissi F,Regnard J,Monpère C,Dugué B

    更新日期：2011-08-01 00:00:00

  • Can Biomarkers Provide Right Ventricular-Specific Prognostication in the Perioperative Setting?

    abstract：:Since the introduction of biomarkers in the late 1980s, considerable research has been dedicated to their validation and application. As a result, many biomarkers are now commonly used in clinical practice. However, the role of biomarkers in the prediction of right ventricular failure (RVF) and in the prognostication ...

    journal_title：Journal of cardiac failure

    pub_type： 杂志文章

    doi：10.1016/j.cardfail.2019.09.007

    authors： Jabagi H,Ruel M,Sun LY

    更新日期：2020-09-01 00:00:00

  • Body mass and survival in patients with chronic heart failure without cachexia: the importance of obesity.

    abstract：BACKGROUND:Cachexia in chronic heart failure carries a poor prognosis, but little is known about the influence of body mass on the prognosis of noncachectic heart failure patients. METHODS:We studied 589 consecutive chronic heart failure patients followed for at least a year, in whom there were accurate baseline data ...

    journal_title：Journal of cardiac failure

    pub_type： 杂志文章

    doi：10.1054/jcaf.2003.4

    authors： Davos CH,Doehner W,Rauchhaus M,Cicoira M,Francis DP,Coats AJ,Clark AL,Anker SD

    更新日期：2003-02-01 00:00:00

  • Aortic Insufficiency During HeartMate 3 Left Ventricular Assist Device Support.

    abstract：BACKGROUND:Aortic insufficiency (AI) is associated with morbidity and mortality in patients with continuous-flow left ventricular assist devices (LVADs), whereas its impact on the HeartMate 3 LVAD cohorts remains uninvestigated. We aimed to investigate the clinical impact of AI on patients with HeartMate 3 LVADs. METH...

    journal_title：Journal of cardiac failure

    pub_type： 杂志文章

    doi：10.1016/j.cardfail.2020.05.013

    authors： Imamura T,Narang N,Kim G,Nitta D,Fujino T,Nguyen A,Grinstein J,Rodgers D,Ota T,Jeevanandam V,Sayer G,Uriel N

    更新日期：2020-10-01 00:00:00

  • Alterations of alpha-adrenergic modulations of coronary microvascular tone in dogs with heart failure.

    abstract：BACKGROUND:It remains unclear whether coronary microvascular response to alpha-adrenergic activation alters in chronic heart failure (CHF). METHODS AND RESULTS:We investigated the alpha-adrenergic receptor-mediated effects on coronary pressure-flow relationship (CPFR) in a tachycardia-induced canine heart failure mode...

    journal_title：Journal of cardiac failure

    pub_type： 杂志文章

    doi：10.1016/j.cardfail.2005.01.003

    authors： Tamagawa K,Saito T,Oikawa Y,Maehara K,Yaoita H,Maruyama Y

    更新日期：2005-06-01 00:00:00

  • High-intensity interval exercise in chronic heart failure: protocol optimization.

    abstract：BACKGROUND:There are little data on the optimization of high-intensity aerobic interval exercise (HIIE) protocols in patients with chronic heart failure (CHF). Therefore, we compared acute cardiopulmonary responses to 4 different HIIE protocols to identify the optimal one. METHODS AND RESULTS:Twenty men with stable sy...

    journal_title：Journal of cardiac failure

    pub_type： 杂志文章,随机对照试验

    doi：10.1016/j.cardfail.2011.10.010

    authors： Meyer P,Normandin E,Gayda M,Billon G,Guiraud T,Bosquet L,Fortier A,Juneau M,White M,Nigam A

    更新日期：2012-02-01 00:00:00

  • Quality assurance and cardiopulmonary exercise testing in clinical trials.

    abstract：BACKGROUND:Peak oxygen uptake (VO2) measured during cardiopulmonary exercise testing (CPX) is often used as an outcome measure in clinical trials. The purposes of this study are (a) to report the outcomes of a quality assurance (QA) procedure instituted in multisite clinical trials by a CPX data core laboratory and (b)...

    journal_title：Journal of cardiac failure

    pub_type： 杂志文章

    doi：10.1016/j.cardfail.2008.01.001

    authors： Brawner CA,Ehrman JK,Aldred H,Schairer JR,Keteyian SJ

    更新日期：2008-05-01 00:00:00