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Effects of glucocorticoids in potentiating diuresis in heart failure patients with diuretic resistance.

Abstract：

:Diuretic resistance in heart failure is defined as a state in which diuretic response is diminished or lost before the therapeutic goal of relief from congestion has been reached. Diuretic resistance is very common and is associated with poor outcomes. Over the past decade, several new drugs and devices targeting decongestion and improvement in renal function in patients with heart failure have failed to show benefit in randomized clinical trials. Glucocorticoids had been used to manage diuretic resistance before the advent of loop diuretics. More recent evidence appears to confirm that glucocorticoids may also help to overcome resistance to loop diuretics. This review tries to summarize the available evidence and potential mechanisms related to glucocorticoid therapy in patients with heart failure and its effect on diuretic resistance.

journal_name

J Card Fail

journal_title

Journal of cardiac failure

authors

Liu C,Liu K

doi

10.1016/j.cardfail.2014.06.353

subject

Has Abstract

pub_date

2014-09-01 00:00:00

pages

625-9

issue

9

eissn

1071-9164

issn

1532-8414

pii

S1071-9164(14)00584-3

journal_volume

20

pub_type

杂志文章,评审

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