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Increased body temperature after reperfused acute myocardial infarction is associated with adverse left ventricular remodeling.

Abstract：

BACKGROUND:Fever is frequently observed in patients with acute myocardial infarction (AMI); however, its prognostic significance remains to be determined. We sought to determine the prognostic significance of increased body temperature (BT) after AMI. METHODS AND RESULTS:We examined 156 consecutive patients with reperfused first anterior AMI. Axillary BT was serially measured every 6 hours for a week. Patients were divided into quartiles by peak BT from the lowest to highest levels. Peak BT within the first week showed a significant positive correlation with peak C-reactive protein level (P < .0001), but not with peak creatine kinase level. There were positive correlations of peak BT with the incidence of pump failure (P = .022), left ventricular (LV) aneurysm (P = .029), and readmission for heart failure (P = .006). Higher peak BT was associated with greater LV end-diastolic volume (P = .031), greater end-systolic volume (P = .008), and lower LV ejection fraction (P = .014) 2 weeks after AMI. Multiple logistic regression analyses revealed that peak BT quartile was an independent predictor of in-hospital cardiac events (odds ratio = 1.61/quartile, P = .008). Furthermore, peak BT quartile was a significant predictor of readmission for heart failure by Cox proportional hazard model analysis (P = .048). CONCLUSIONS:Increased BT after AMI was associated with a worse clinical outcome and infarct expansion, suggesting a relationship between systemic inflammatory response and LV remodeling.

journal_name

J Card Fail

journal_title

Journal of cardiac failure

authors

Naito K,Anzai T,Yoshikawa T,Maekawa Y,Sugano Y,Kohno T,Mahara K,Okabe T,Asakura Y,Ogawa S

doi

10.1016/j.cardfail.2006.09.006

subject

Has Abstract

pub_date

2007-02-01 00:00:00

pages

25-33

issue

1

eissn

1071-9164

issn

1532-8414

pii

S1071-9164(06)01205-X

journal_volume

13

pub_type

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