Abstract:
BACKGROUND:Decreased heart rate recovery (HRR) is a predictor of mortality in patients with coronary artery disease and preserved left ventricular function. We investigated the changes in HRR and assessed the impact of beta-blockade therapy on these parameters in patients with symptomatic congestive heart failure (CHF). METHODS AND RESULTS:HRR, defined as the difference from peak exercise heart rate (HR) to HR measured at 1, 2, and 3 minutes after maximal exercise test, was studied in 23 stable CHF patients and 12 healthy subjects. Patients with CHF performed a maximal exercise test using a Ramp protocol before and after 6 months of therapy with either metoprolol or carvedilol. Patients with CHF exhibited a significantly attenuated HRR compared with healthy subjects at 1 minute (17.8 +/- 5.8 versus 26.8 +/- 16.2 beats), 2 minutes (34.0 +/- 10.6 versus 48.0 +/- 11.2 bpm) and 3 minutes (41.0 +/- 12.4 versus 60.0 +/-12.4 bpm) after exercise (P<.05 for all parameters). Beta-blocker therapy for 6 months did not significantly improve HRR. CONCLUSION:HRR is markedly attenuated in stable CHF patients compared with healthy subjects. Long-term beta-blocker therapy appears to cause no significant improvement in HRR up to 3 minutes after maximal exercise.
journal_name
J Card Failjournal_title
Journal of cardiac failureauthors
Racine N,Blanchet M,Ducharme A,Marquis J,Boucher JM,Juneau M,White Mdoi
10.1054/jcaf.2003.47keywords:
subject
Has Abstractpub_date
2003-08-01 00:00:00pages
296-302issue
4eissn
1071-9164issn
1532-8414pii
S1071916403000940journal_volume
9pub_type
杂志文章abstract:BACKGROUND:Atrial fibrillation (AF) is a common arrhythmia which contributes to morbidity and mortality in patients with heart failure (HF). Atrial remodeling is a key substrate for the development of AF in HF. However, experimental models that study AF in the setting of HF have important limitations. We evaluated a ne...
journal_title:Journal of cardiac failure
pub_type: 杂志文章
doi:10.1016/j.cardfail.2007.10.021
更新日期:2008-04-01 00:00:00
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journal_title:Journal of cardiac failure
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journal_title:Journal of cardiac failure
pub_type: 杂志文章
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journal_title:Journal of cardiac failure
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journal_title:Journal of cardiac failure
pub_type: 杂志文章,评审
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journal_title:Journal of cardiac failure
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journal_title:Journal of cardiac failure
pub_type: 杂志文章
doi:10.1016/j.cardfail.2008.01.015
更新日期:2008-06-01 00:00:00
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journal_title:Journal of cardiac failure
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journal_title:Journal of cardiac failure
pub_type: 杂志文章,评审
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journal_title:Journal of cardiac failure
pub_type: 杂志文章
doi:10.1016/j.cardfail.2010.09.017
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journal_title:Journal of cardiac failure
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journal_title:Journal of cardiac failure
pub_type: 杂志文章
doi:10.1016/j.cardfail.2014.08.005
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journal_title:Journal of cardiac failure
pub_type: 杂志文章
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更新日期:2008-12-01 00:00:00
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journal_title:Journal of cardiac failure
pub_type: 杂志文章
doi:10.1016/j.cardfail.2010.03.010
更新日期:2010-08-01 00:00:00
abstract::Stimulation of the V1a receptor for arginine vasopressin produces myocardial and vascular effects similar to those of angiotensin II while stimulation of the V2 receptor causes fluid retention. There are no data with sustained blockade of the V1a receptor while single-dose experiments suggest benefit. Acute and chroni...
journal_title:Journal of cardiac failure
pub_type: 杂志文章,评审
doi:10.1016/j.cardfail.2017.12.011
更新日期:2018-02-01 00:00:00
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journal_title:Journal of cardiac failure
pub_type: 杂志文章,meta分析,评审
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abstract::Contracting myocytes are highly variable in size and generally resemble elliptical cylinders in shape. Although their arrangement within the ventricular wall is rather complex, their length runs in a tangential manner, and their transverse axis runs transmurally. Consequently, it was proposed many years ago that chang...
journal_title:Journal of cardiac failure
pub_type: 杂志文章
doi:10.1054/jcaf.2002.129280
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journal_title:Journal of cardiac failure
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journal_title:Journal of cardiac failure
pub_type: 杂志文章,多中心研究,随机对照试验
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更新日期:2008-08-01 00:00:00
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journal_title:Journal of cardiac failure
pub_type: 杂志文章
doi:10.1016/j.cardfail.2009.10.018
更新日期:2010-02-01 00:00:00
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journal_title:Journal of cardiac failure
pub_type: 临床试验,杂志文章,随机对照试验
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更新日期:2004-12-01 00:00:00
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journal_title:Journal of cardiac failure
pub_type: 杂志文章
doi:10.1016/j.cardfail.2007.10.019
更新日期:2008-03-01 00:00:00
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journal_title:Journal of cardiac failure
pub_type: 杂志文章,多中心研究
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更新日期:2009-11-01 00:00:00
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journal_title:Journal of cardiac failure
pub_type: 杂志文章
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更新日期:2011-11-01 00:00:00
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journal_title:Journal of cardiac failure
pub_type: 杂志文章
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更新日期:2011-10-01 00:00:00
abstract:BACKGROUND:It was not until 1919 that the diuretic properties of mercury were observed in patients with syphilis; in the same year the beneficial effects of mercurial diuretics were shown in a patient with severe rheumatic heart disease and anasarca. However, mercury had been used much earlier for the treatment of drop...
journal_title:Journal of cardiac failure
pub_type: 传,历史文章,杂志文章
doi:10.1054/jcaf.2001.26564
更新日期:2001-09-01 00:00:00
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journal_title:Journal of cardiac failure
pub_type: 杂志文章
doi:10.1016/j.cardfail.2020.04.020
更新日期:2020-11-01 00:00:00