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Determination of cocaine and its metabolites in brain tissue using high-flow solid-phase extraction columns and high-performance liquid chromatography.

Abstract：

:A new solid-phase extraction procedure for the determination of cocaine and some of its metabolites in brain tissue, using high-flow co-polymeric sorbents is reported as a substantial improvement on our recently reported procedure. The recovery of cocaine, norcocaine and cocaethylene was excellent as was the reproducibility of the extraction. The use of high-flow sorbents allowed the easy extraction of tissue without the need for a time-consuming lipase digestion, regardless of sample viscosity or physical nature. The use of these solid-phase columns provided many advantages over the more commonly used solvent extraction, including an increase in extraction speed and efficiency, reduced operator time, reduced solvent use and disposal volumes and exceptional extract quality. The procedure was successfully applied to rabbit brains spiked with cocaine, benzoylecgonine, norcocaine and cocaethylene.

journal_name

Forensic Sci Int

journal_title

Forensic science international

authors

Moore C,Browne S,Tebbett I,Negrusz A

doi

10.1016/0379-0738(92)90197-5

keywords:

subject

Has Abstract

pub_date

1992-03-01 00:00:00

pages

215-9

issue

2

eissn

0379-0738

issn

1872-6283

pii

0379-0738(92)90197-5

journal_volume

53

pub_type

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