Methadone extraction from minimal amounts of biological fluids.

Abstract:

:A new solid phase extraction method was studied to extract methadone from small amounts of biological samples, by using little disposable columns prepacked with reverse phase sorbents. Two different commercial kinds of reversed phase columns prepacked with octadecylsilane (ODS) were tested; the results were compared to those obtained by a direct liquid/liquid extraction method. Gas chromatograms of extracts obtained by means of ODS reversed phase columns showed a good signal/noise ratio resulting in higher sensitivity (20 ng/ml as detection limit), in comparison with the liquid/liquid extraction method.

journal_name

Forensic Sci Int

authors

Chiarotti M,Offidani C,de Giovanni N

doi

10.1016/0379-0738(86)90157-x

subject

Has Abstract

pub_date

1986-08-01 00:00:00

pages

43-8

issue

1

eissn

0379-0738

issn

1872-6283

pii

0379-0738(86)90157-X

journal_volume

32

pub_type

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