Abstract：
:Buprenorphine is available in Singapore as substitution treatment for opioid dependence since 2002. This study surveys buprenorphine related deaths in Singapore between September 2003 and December 2004. The aims are to establish the autopsy prevalence of buprenorphine related deaths and the demographical and toxicological profile of the cases. Toxicological screening was performed for all unnatural deaths, deaths involving known drug addicts, as well as when autopsy revealed no obvious cause of death. Twenty-one cases had buprenorphine detected in post-mortem blood and/or urine samples. Eighteen were sudden deaths. There were two fatal falls from height and one death by hanging. All subjects were male. The age range was 24-48 years. Fourteen subjects were between 30 and 39 years of age. The mean age was 35 years. The majority (62%) were Chinese. Eleven (52%) were known drug abusers. For sudden deaths, two groups were identified. Six cases died from natural causes. Blood buprenorphine levels ranged from undetected (detected in urine) to 3.2 ng/mL (mean 1.4 ng/mL). Twelve cases were attributed directly and indirectly to mixed drug poisoning. Blood buprenorphine levels ranged from undetected (detected in urine) to 17 ng/mL (mean 3.2 ng/mL). Nineteen cases showed concurrent abuse of buprenorphine and benzodiazepine, diazepam being the most frequently detected, followed by nitrazepam and midazolam. The availability of buprenorphine as substitution therapy is associated with an increase in buprenorphine related deaths. The danger of co-abuse of buprenorphine and benzodiazepines is highlighted.
journal_name
Forensic Sci Intjournal_title
Forensic science internationalauthors
Lai SH,Yao YJ,Lo DSdoi
10.1016/j.forsciint.2006.03.037subject
Has Abstractpub_date
2006-10-16 00:00:00pages
80-6issue
1-3eissn
0379-0738issn
1872-6283pii
S0379-0738(06)00390-2journal_volume
162pub_type
杂志文章abstract：:With the constantly increasing sensitivity and robustness of liquid chromatography-mass spectrometry-based instruments combined with enhanced reproducibility as well as mass accuracy and resolution, LC-MS(/MS) has become an integral part of sports drug testing programs particularly concerning the detection of peptide ...
journal_title：Forensic science international
pub_type： 杂志文章
doi：10.1016/j.forsciint.2011.06.015
更新日期：2011-12-10 00:00:00
abstract：:The mathematical modeling of the microbial ethanol production under strict anaerobic experimental conditions for some bacterial species has been proposed by our research group as the first approximation to the quantification of the microbial ethanol production in cases where other alcohols were produced simultaneously...
journal_title：Forensic science international
pub_type： 杂志文章
doi：10.1016/j.forsciint.2013.07.021
更新日期：2013-10-10 00:00:00
abstract：:Generalized arterial calcification in infancy is a rare genetic disorder characterized by abnormal calcification of large and medium sized arteries and marked myointimal proliferation resulting in arterial stenosis. The condition is often fatal secondary to complications of cardiac ischemia, hypertension and cardiac f...
journal_title：Forensic science international
pub_type： 杂志文章
doi：10.1016/j.forsciint.2015.06.017
更新日期：2015-09-01 00:00:00
abstract：:(1) The polymerase chain reaction (PCR) was used to amplify Rh-related cDNAs from erythroid cells cultured by the selective two-phase liquid culture system for human erythroid progenitors in peripheral blood. Two Rh polypeptide cDNAs have been isolated from the PCR products and tentatively designated RhPI cDNA and RhP...
journal_title：Forensic science international
pub_type： 杂志文章,评审
doi：10.1016/0379-0738(96)01935-4
更新日期：1996-06-28 00:00:00
abstract：:The use of amphetamine and 'ecstasy' (MDMA) has increased exponentially in many European countries since the late nineties, leading to a rapid growth in the number of clinical and forensic analyses. Therefore, a rapid screening procedure for these substances in biological specimens has become an important part of rout...
journal_title：Forensic science international
pub_type： 临床试验,杂志文章
doi：10.1016/j.forsciint.2005.04.019
更新日期：2005-10-04 00:00:00
abstract：INTRODUCTION:Age assessment based on dental development is often requested in order to assess whether an individual is older or younger than 18 years of age. There are several statistical approaches to estimate age based upon third molar development. The aim of this study was to apply the principles of transition analy...
journal_title：Forensic science international
pub_type： 杂志文章
doi：10.1016/j.forsciint.2020.110145
更新日期：2020-03-01 00:00:00
abstract：:In analogy to our previously published procedure for the differentiation of regioisomeric fluoroamphetamines a method was developed, to differentiate ring positional isomeric fluorocathinones by product ion spectrometry of ions generated by chemical ionization (CI) under GC-MS conditions using methane as reagent gas. ...
journal_title：Forensic science international
pub_type： 杂志文章
doi：10.1016/j.forsciint.2012.08.011
更新日期：2012-11-30 00:00:00
abstract：:Laser-induced breakdown spectroscopy (LIBS), X-ray fluorescence spectroscopy (XRF) and scanning electron microscopy/energy dispersive X-ray spectroscopy (SEM/EDX) are compared in terms of their discrimination power when applied to Australian soil specimens. SEM/EDX and XRF are frequently used in forensic laboratories ...
journal_title：Forensic science international
pub_type： 杂志文章
doi：10.1016/j.forsciint.2014.10.018
更新日期：2014-12-01 00:00:00
abstract：:The extent of aspartic acid racemization in human dentin can be used to assess chronological age of the individual. This novel chemical method of aging human remains has potential applications in forensic sciences. Six autopsy cases have been analyzed for D/L aspartic acid contents, and their ages at death calculated....
journal_title：Forensic science international
pub_type： 杂志文章
doi：10.1016/0379-0738(86)90080-0
更新日期：1986-11-01 00:00:00
abstract：:In Dunedin (South Island, New Zealand), a sexual assault is reported to police approximately once every two to three weeks, with some reports fictitious. Identifying a fictitious claim is difficult, and damage to apparel, especially knickers, may be the only form of evidence. In this paper, the tear behaviour of three...
journal_title：Forensic science international
pub_type： 杂志文章
doi：10.1016/j.forsciint.2011.10.029
更新日期：2012-04-10 00:00:00
abstract：:The presence of Ethyl glucuronide (EtG) in hair provides a strong indication of ethanol consumption and its investigation is of interest in both clinical and forensic contexts because of the wide window of detection. However, due to the possibility of false negative results in cases of small ethanol intake or excessiv...
journal_title：Forensic science international
pub_type： 杂志文章
doi：10.1016/j.forsciint.2019.110071
更新日期：2020-01-01 00:00:00
abstract：:This paper presents real world acceleration data for an ambulance driving up and over a curb. A full scale reenactment was performed for a litigated case in which a patient on a gurney in an ambulance claimed a variety of bodily injuries after the ambulance struck a curb. A height and weight matched surrogate rode on ...
journal_title：Forensic science international
pub_type： 杂志文章
doi：10.1016/j.forsciint.2014.01.023
更新日期：2014-04-01 00:00:00
abstract：:1,4-Dihydropyridines calcium channel antagonists (1,4-DHP CCAs) are photolabile and the products of their photodecomposition have no pharmaceutical activity. In our previous work we have presented a screening procedure for eleven 1,4-DHPs in plasma by LC-MS-MS using multiple reaction motoring. The laboratory process i...
journal_title：Forensic science international
pub_type： 杂志文章
doi：10.1016/j.forsciint.2004.11.014
更新日期：2006-01-06 00:00:00
abstract：:The Bavarian State Bureau of Investigation in Munich has the exclusive responsibility for investigation of criminal acts. One considerable expertise is that of hair analysis. According to the legal system in Germany, there is a special interest when some clients' hair tested positive for illicit drugs. An accused with...
journal_title：Forensic science international
pub_type： 杂志文章
doi：10.1016/s0379-0738(99)00161-9
更新日期：2000-01-10 00:00:00
abstract：:To outline the recent features of methamphetamine-related fatalities from the medico-legal point of view, a retrospective investigation of forensic autopsy cases involving methamphetamine during a 5-year period (1994-1998) in the southern half of Osaka city and surrounding areas (about 1.57 million population) was und...
journal_title：Forensic science international
pub_type： 杂志文章
doi：10.1016/s0379-0738(00)00281-4
更新日期：2000-09-11 00:00:00
abstract：:Myxoid heart disease (MHD), more commonly known as mitral valve prolapse, is a very common cardiac abnormality affecting 5-10% of the general population. This article reviews the history, symptoms, physical findings, pathology, associated conditions and complications of this entity. Special emphasis is given to sudden...
journal_title：Forensic science international
pub_type： 杂志文章,评审
doi：10.1016/0379-0738(89)90177-1
更新日期：1989-03-01 00:00:00
abstract：:A new solid-phase extraction procedure for the determination of cocaine and some of its metabolites in brain tissue, using high-flow co-polymeric sorbents is reported as a substantial improvement on our recently reported procedure. The recovery of cocaine, norcocaine and cocaethylene was excellent as was the reproduci...
journal_title：Forensic science international
pub_type： 杂志文章
doi：10.1016/0379-0738(92)90197-5
更新日期：1992-03-01 00:00:00
abstract：:The present study was made on an experimental animal model of a death from anaphylaxis, in which postmortem changes in levels of histamine and 1-methylhistamine, in whole blood were measured. Instead of the usual immunological method administering compound 48/80, a degranulating agent of mast cell and the effect close...
journal_title：Forensic science international
pub_type： 杂志文章
doi：10.1016/0379-0738(90)90233-o
更新日期：1990-03-01 00:00:00
abstract：:In the last years the research output of forensic medicine has sometimes been regarded as insufficient and as of poor quality, especially when parameters as impact factors and external funding were taken into account. However, forensic medicine has different tasks compared to clinical medicine. The main difference bet...
journal_title：Forensic science international
pub_type： 杂志文章,评审
doi：10.1016/j.forsciint.2006.05.009
更新日期：2007-01-17 00:00:00
abstract：:Forensic pathologists are familiar with alcohol abusers, who are found dead and in whom the cause of death cannot be ascertained. In order to examine the possible role of ketoacidosis for the cause of death in this group of alcohol abusers, the concentrations of ketone bodies (acetone, acetoacetate, D-beta-hydroxybuty...
journal_title：Forensic science international
pub_type： 杂志文章
doi：10.1016/0379-0738(95)01783-6
更新日期：1995-10-30 00:00:00
abstract：:Forensic assessment of skeletal material includes age estimation of unknown individuals. When dealing with extremely fragmented human remains that lack macro-features used in age estimation, histological assessment of the skeletal elements can be employed. Historically, microscopic methods for age assessment used by f...
journal_title：Forensic science international
pub_type： 杂志文章
doi：10.1016/j.forsciint.2020.110335
更新日期：2020-08-01 00:00:00
abstract：:The interpretation of vehicle paint traces in forensic casework hinges on a number of factors including the type of paint, colour, number of layers, and background information. Vehicle colour surveys are an important source of information for the forensic paint examiner when interpreting the level of significance of a...
journal_title：Forensic science international
pub_type： 杂志文章
doi：10.1016/j.forsciint.2014.12.010
更新日期：2015-03-01 00:00:00
abstract：:Tissue-specific differential DNA methylation has been an attractive target for the development of markers for discrimination of body fluids found at crime scenes. Though mostly stable, DNA methylation patterns have been shown to vary between different ethnic groups, in different age groups as well as between healthy a...
journal_title：Forensic science international
pub_type： 杂志文章
doi：10.1016/j.forsciint.2020.110372
更新日期：2020-09-01 00:00:00
abstract：:The increase in the use of photographs on individual identification credentials such as driving licences, credit cards, security passes and passports has led, for the purpose of criminal activities, to the falsification of genuine documents bearing photographs of the perpetrating criminal. These photographs may be use...
journal_title：Forensic science international
pub_type： 杂志文章
doi：10.1016/s0379-0738(00)00290-5
更新日期：2000-11-13 00:00:00
abstract：:Recovery, identification, and burial of casualties from World War I and II is still a topic of interest in many countries. In Slovakia, recent discoveries of such remains are usually accidental. Unfortunately, in many cases the remains are disrupted and without any material culture present, rendering the identificatio...
journal_title：Forensic science international
pub_type： 杂志文章
doi：10.1016/j.forsciint.2020.110673
更新日期：2021-02-01 00:00:00
abstract：:A single nucleotide polymorphism (SNP) multiplex has been developed to analyse highly degraded and low copy number (LCN) DNA template, i.e. <100 pg, for scenarios including mass disaster identification. The multiplex consists of 20 autosomal non-coding loci plus Amelogenin for sex determination, amplified in a single ...
journal_title：Forensic science international
pub_type： 杂志文章
doi：10.1016/j.forsciint.2004.12.011
更新日期：2005-11-10 00:00:00
abstract：:Fatalities due to an extreme ambient temperature might present with poor or nonspecific pathologies; thus, the diagnosis of the cause of death in such cases is one of the most difficult tasks in forensic pathology. The present study investigated the molecular pathology of alveolar damage involving pulmonary edema with...
journal_title：Forensic science international
pub_type： 杂志文章
doi：10.1016/j.forsciint.2013.03.007
更新日期：2013-05-10 00:00:00
abstract：:An extensive literature review and new post-irradiation experimental results are presented of genotyping blood stains and hair, and physical examinations of latent fingerprints, hairs, and fibers. Results indicate that successful development of nuclear short tandem repeat (STR) and mitochondrial DNA sequence profiles ...
journal_title：Forensic science international
pub_type： 杂志文章,评审
doi：10.1016/j.forsciint.2018.01.012
更新日期：2018-03-01 00:00:00
abstract：:Therapeutic (or non-toxic) postmortem guaifenesin blood and liver concentrations have not been previously described. Peripheral blood guaifenesin concentrations were compared to central blood and liver concentrations in eight medical examiner cases. Specimens were initially screened for alcohol and simple volatiles, d...
journal_title：Forensic science international
pub_type： 杂志文章
doi：10.1016/j.forsciint.2014.10.029
更新日期：2014-12-01 00:00:00
abstract：:Traditionally, sperms are isolated from vaginal cell mixtures by preferential extraction methods. Although these methods work well when there is a reasonable amount of DNA present, they are problematic when there are limited amounts (ca. 250 pg). In particular, the analysis of sperm from microscope slides has proven d...
journal_title：Forensic science international
pub_type： 杂志文章
doi：10.1016/s0379-0738(03)00267-6
更新日期：2003-10-14 00:00:00
