An experimental model of death from anaphylactic shock with compound 48/80 and postmortem changes in levels of histamine in blood.

Abstract:

:The present study was made on an experimental animal model of a death from anaphylaxis, in which postmortem changes in levels of histamine and 1-methylhistamine, in whole blood were measured. Instead of the usual immunological method administering compound 48/80, a degranulating agent of mast cell and the effect closely resembling the immuno-reaction, resulted in reliable death in a short time. The animals that died rapidly after the injection of compound 48/80, were found to have large increases in levels of histamine and 1-methylhistamine soon after the administration. These results were similar to the results of injecting histamine exogenously. On the other hand, the animals that died after a longer time showed no increases in levels of those amines within about 24 h, but 24 hours after death histamine levels were only increased tremendously without rise in 1-MHA levels. These phenomena closely resembled those in the control animals that were treated with overdoses of Nembutal.

journal_name

Forensic Sci Int

authors

Hieda Y,Kageura M,Hara K,Takamoto M,Fukuma Y,Kashimura S

doi

10.1016/0379-0738(90)90233-o

subject

Has Abstract

pub_date

1990-03-01 00:00:00

pages

159-69

issue

1-2

eissn

0379-0738

issn

1872-6283

pii

0379-0738(90)90233-O

journal_volume

45

pub_type

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