Tandem mass spectrometry: a helpful tool in hair analysis for the forensic expert.

Abstract:

:The Bavarian State Bureau of Investigation in Munich has the exclusive responsibility for investigation of criminal acts. One considerable expertise is that of hair analysis. According to the legal system in Germany, there is a special interest when some clients' hair tested positive for illicit drugs. An accused with a lot of drugs in his hair will be treated as a supposed addict and will be guaranteed extenuating circumstances. The instrumentation used for hair analysis is a powerful analytical tool: a Varian 3400 gas chromatograph linked to a Finnigan Tandem-MS (TSQ 700). The methanol extraction method is used for the detection of illegal drugs and metabolites: amphetamine, methamphetamine, MDA, MDMA (ecstasy), MDE, MBDB, methadone, THC, EDDP (metabolite of methadone), cocaine, benzoylecgonine, cocaethylene, opiates (dihydrocodeine, codeine, heroin, 6-monoacetylmorphine, morphine, acetylcodeine). For the detection of 9-carboxy-THC by negative chemical ionization the hair sample is hydrolyzed under alkaline conditions. Solid-phase extraction is used for clean-up. The LOQ for the determination of 11-nor-delta-9-tetrahydrocannabinol-9-carboxylic-acid is 0.16 pg/mg hair. An unsurpassed combination for rendering an expert opinion based on hair analysis may be: a forensic expert using diligence and experience, coupled with the performance of a sophisticated analytical instrument.

journal_name

Forensic Sci Int

authors

Uhl M

doi

10.1016/s0379-0738(99)00161-9

keywords:

subject

Has Abstract

pub_date

2000-01-10 00:00:00

pages

169-79

issue

1-3

eissn

0379-0738

issn

1872-6283

pii

S0379-0738(99)00161-9

journal_volume

107

pub_type

杂志文章
  • Postmortem catecholamine levels in pericardial and cerebrospinal fluids with regard to the cause of death in medicolegal autopsy.

    abstract::Previous studies have suggested that postmortem serum catecholamine levels reflect the magnitude of physical stress responses or toxic/hyperthermic neuronal dysfunction during the death process. The present study investigated postmortem adrenaline (Adr), noradrenaline (Nad), and dopamine (DA) levels in pericardial flu...

    journal_title:Forensic science international

    pub_type: 杂志文章

    doi:10.1016/j.forsciint.2013.02.008

    authors: Ishikawa T,Quan L,Michiue T,Kawamoto O,Wang Q,Chen JH,Zhu BL,Maeda H

    更新日期:2013-05-10 00:00:00

  • Driving under the influence of toluene.

    abstract::Toluene is the most common volatile used for sniffing among adolescents. During 1983-1987, 114 drivers were arrested in Norway with blood toluene concentrations (BTCs) greater than 10 microM. Only four of these drivers were women. The age range was 15-34 years, and the mean age was 21. The mean BTC was 109 microM. The...

    journal_title:Forensic science international

    pub_type: 杂志文章

    doi:10.1016/0379-0738(90)90170-4

    authors: Gjerde H,Smith-Kielland A,Normann PT,Morland J

    更新日期:1990-01-01 00:00:00

  • Perspective distortion in craniofacial superimposition: Logarithmic decay curves mapped mathematically and by practical experiment.

    abstract::The superimposition of a face photograph with that of a skull for identification purposes necessitates the use of comparable photographic parameters between the two image acquisition sessions, so that differences in optics and consequent recording of images does not thwart the morphological analysis. Widely divergent,...

    journal_title:Forensic science international

    pub_type: 杂志文章

    doi:10.1016/j.forsciint.2015.09.009

    authors: Stephan CN

    更新日期:2015-12-01 00:00:00

  • Non-equilibrium pH gradient electrophoresis (NEPHGE) on ultrathin polyacrylamide gels containing separators: improved erythrocyte phosphoglucomutase (PGM) and esterase D (EsD) diagnosis in red cell lysates and bloodstains.

    abstract::Two rapid and reliable electrophoretic techniques for PGM1 and EsD typing on ultrathin polyacrylamide gels are described. They have been based on non-equilibrium pH gradient electrophoresis and on the addition of chemical spacers (EPPS for PGM1 and HEPES for EsD) to the gel mixture. ...

    journal_title:Forensic science international

    pub_type: 杂志文章

    doi:10.1016/0379-0738(89)90197-7

    authors: Destro-Bisol G,Spinella A

    更新日期:1989-07-01 00:00:00

  • Microbial degradation of illicit drugs, their precursors, and manufacturing by-products: implications for clandestine drug laboratory investigation and environmental assessment.

    abstract::Chemicals associated with clandestine drug laboratories are often disposed of covertly into soil, sewerage systems, or public waste management facilities. There are two significant issues relating to such dumps of materials; they might contain valuable evidence as to drug manufacture, and they might be a source of pol...

    journal_title:Forensic science international

    pub_type: 杂志文章

    doi:10.1016/s0379-0738(03)00110-5

    authors: Janusz A,Kirkbride KP,Scott TL,Naidu R,Perkins MV,Megharaj M

    更新日期:2003-06-24 00:00:00

  • Differentiation of blue ballpoint pen inks by positive and negative mode LDI-MS.

    abstract::Usually, the differentiation of inks on questioned documents is carried out by optical methods and thin layer chromatography (TLC). Therefore, spectrometric methods were also proposed in forensic literature for the analysis of dyes. Between these techniques, laser desorption/ionization mass spectrometry (LDI-MS) has d...

    journal_title:Forensic science international

    pub_type: 杂志文章

    doi:10.1016/j.forsciint.2010.05.027

    authors: Gallidabino M,Weyermann C,Marquis R

    更新日期:2011-01-30 00:00:00

  • Breath alcohol elimination rate as a function of age, gender, and drinking practice.

    abstract::The objective of this study was to determine whether breath alcohol elimination rate varies as a function of age, gender, and drinking practice, factorially combined. Eighty-four men and 84 women drank enough alcohol to produce peak BrACs of .110 g/210 L for heavy and moderate drinkers and BrACs of .090 g/210 L for li...

    journal_title:Forensic science international

    pub_type: 杂志文章

    doi:10.1016/j.forsciint.2013.09.017

    authors: Fiorentino DD,Moskowitz H

    更新日期:2013-12-10 00:00:00

  • The colonisation of remains by the muscid flies Muscina stabulans (Fallén) and Muscina prolapsa (Harris) (Diptera: Muscidae).

    abstract::In the field, the muscid flies Muscina stabulans (Fallén) and Muscina prolapsa (Harris) only colonised buried baits in June, July and August. The two-species co-occurred on baits buried at 5cm but only M. prolapsa colonised baits buried at 10cm. Other species of insect were seldom recovered from buried baits regardles...

    journal_title:Forensic science international

    pub_type: 杂志文章

    doi:10.1016/j.forsciint.2016.06.013

    authors: Gunn A

    更新日期:2016-09-01 00:00:00

  • Trace isotope analysis of Ricinus communis seed core for provenance determination by laser ablation-ICP-MS.

    abstract::The castor bean plant, Ricinus communis, grows wild throughout many regions of Australia. The seeds of the plant contain the schedule 1 chemical agent ricin, a type II ribosomal inhibiting protein. Currently there are limited analytical techniques that can be applied in analysis of the seeds to establish attribution. ...

    journal_title:Forensic science international

    pub_type: 杂志文章

    doi:10.1016/j.forsciint.2016.11.029

    authors: Bagas CK,Scadding RL,Scadding CJ,Watling RJ,Roberts W,Ovenden SPB

    更新日期:2017-01-01 00:00:00

  • The detection of petechial haemorrhages of the conjunctivae in dependency on the postmortem interval.

    abstract::Petechial haemorrhages of the conjunctivae are not specific for lethal throttling or strangulation, but they belong to the important indicators for such mechanisms. In experimental models it is shown that petechial bleedings of the conjunctivae disappear with the occurrence of advanced signs of putrefaction or in case...

    journal_title:Forensic science international

    pub_type: 杂志文章

    doi:10.1016/0379-0738(94)90243-7

    authors: Betz P,Penning R,Keil W

    更新日期:1994-01-01 00:00:00

  • Different likelihood ratio approaches to evaluate the strength of evidence of MDMA tablet comparisons.

    abstract::Two likelihood ratio (LR) approaches are presented to evaluate the strength of evidence of MDMA tablet comparisons. The first one is based on a more 'traditional' comparison of MDMA tablets by using distance measures (e.g., Pearson correlation distance or a Euclidean distance). In this approach, LRs are calculated usi...

    journal_title:Forensic science international

    pub_type: 杂志文章

    doi:10.1016/j.forsciint.2009.06.006

    authors: Bolck A,Weyermann C,Dujourdy L,Esseiva P,van den Berg J

    更新日期:2009-10-30 00:00:00

  • Semi-quantitative analysis of cefaclor in human serum by capillary high performance liquid chromatography/fast atom bombardment mass spectrometry.

    abstract::Capillary high performance liquid chromatography (HPLC) was combined with frit fast atom bombardment (FAB) mass spectrometry (MS) and a detailed procedure has been established for on-line analysis of cefaclor in human serum. The capillary column (0.3 mm i.d.) enabled the introduction of entire effluent to the frit int...

    journal_title:Forensic science international

    pub_type: 杂志文章

    doi:10.1016/0379-0738(93)90313-y

    authors: Sato K,Kobayashi K,Moore CM,Mizuno Y,Katsumata Y

    更新日期:1993-04-01 00:00:00

  • Hair analysis: a worthless tool for therapeutic compliance monitoring.

    abstract::Hair analysis has been presented by some authors as a possible tool of investigation for estimating patients' compliance to long-term therapies. This paper summarises the different publications that have been devoted to this topic and highlights the available statistically data presented to support this proposition. Q...

    journal_title:Forensic science international

    pub_type: 杂志文章,meta分析

    doi:10.1016/0379-0738(94)01626-g

    authors: Tracqui A,Kintz P,Mangin P

    更新日期:1995-01-05 00:00:00

  • Validation of an ELISA-based screening assay for the detection of amphetamine, MDMA and MDA in blood and oral fluid.

    abstract::The use of amphetamine and 'ecstasy' (MDMA) has increased exponentially in many European countries since the late nineties, leading to a rapid growth in the number of clinical and forensic analyses. Therefore, a rapid screening procedure for these substances in biological specimens has become an important part of rout...

    journal_title:Forensic science international

    pub_type: 临床试验,杂志文章

    doi:10.1016/j.forsciint.2005.04.019

    authors: Laloup M,Tilman G,Maes V,De Boeck G,Wallemacq P,Ramaekers J,Samyn N

    更新日期:2005-10-04 00:00:00

  • Allele frequencies for STR loci of the Powerplex 16 multiplex system in five endogamous populations of India.

    abstract::Allele frequencies for the 15 STR locus of PowerPlex 16 were analyzed in 95 healthy unrelated individuals belonging to five important population groups inhabiting different part of India. Fifteen loci studied are Penta E, D18S51, D21S11, THO1,D3S1358, FGA, TPOX, D8S1179, vWA, Amelogenin, Penta D, CSF1PO, D16S539, D7S8...

    journal_title:Forensic science international

    pub_type: 杂志文章

    doi:10.1016/s0379-0738(02)00021-x

    authors: Kashyap VK,Sarkar N,Trivedi R

    更新日期:2002-04-18 00:00:00

  • Bitemarks: distortion and covariation of the maxillary and mandibular dentition as impressed in human skin.

    abstract::In bitemark analysis the extent of distortion of both maxillary and mandibular arches and how one affects the other has not been studied. A single dentition was used to create 49 bites on unembalmed cadavers. Landmarks were placed on digital images of the bitemarks and scanned images of the biting dentition. A sample ...

    journal_title:Forensic science international

    pub_type: 杂志文章

    doi:10.1016/j.forsciint.2012.08.044

    authors: Sheets HD,Bush PJ,Bush MA

    更新日期:2012-11-30 00:00:00

  • Short range shooting distance estimation using variable pressure SEM images of the surroundings of bullet holes in textiles.

    abstract::Modifications of cotton and polyester textiles due to shots fired at short range were analyzed with a variable pressure scanning electron microscope (VP-SEM). Different mechanisms of fiber rupture as a function of fiber type and shooting distance were detected, namely fusing, melting, scorching, and mechanical breakag...

    journal_title:Forensic science international

    pub_type: 杂志文章

    doi:10.1016/j.forsciint.2016.12.033

    authors: Hinrichs R,Frank PRO,Vasconcellos MAZ

    更新日期:2017-03-01 00:00:00

  • Quantitative determination of CBD and THC and their acid precursors in confiscated cannabis samples by HPLC-DAD.

    abstract::Analysis of cannabis has gained new importance worldwide, mainly for quality control within the legalized recreational and medical cannabis industry, but also for forensic differentiation between drug-type cannabis and legal products such as fiber hemp and CBD-rich/THC-poor cannabis. We herein present an HPLC-DAD meth...

    journal_title:Forensic science international

    pub_type: 杂志文章

    doi:10.1016/j.forsciint.2019.03.046

    authors: Hädener M,König S,Weinmann W

    更新日期:2019-06-01 00:00:00

  • Evaluating the utility of hexapod species for calculating a confidence interval about a succession based postmortem interval estimate.

    abstract::Carrion insect succession patterns have long been used to estimate the postmortem interval (PMI) during a death investigation. However, no published carrion succession study included sufficient replication to calculate a confidence interval about a PMI estimate based on occurrence data. We exposed 53 pig carcasses (16...

    journal_title:Forensic science international

    pub_type: 杂志文章

    doi:10.1016/j.forsciint.2014.05.007

    authors: Perez AE,Haskell NH,Wells JD

    更新日期:2014-08-01 00:00:00

  • DNA-testing for immigration cases: the risk of erroneous conclusions.

    abstract::Making the correct decision based on results from DNA analyses and other information in family reunification cases can be complicated for a number of reasons. These include stratified populations, cultural differences in family constellations, families with different population origin, and complicated family relations...

    journal_title:Forensic science international

    pub_type: 杂志文章

    doi:10.1016/j.forsciint.2006.12.015

    authors: Karlsson AO,Holmlund G,Egeland T,Mostad P

    更新日期:2007-10-25 00:00:00

  • Genetic profiling of a central Venezuelan population using 15 STR markers that may be of forensic importance.

    abstract::The AmpFlSTR Identifiler kit has recently been accepted for use in DNA databasing of forensic samples in the FBI's National DNA Index System. In the present study, we used this kit to analyze the allele distribution of 15 short tandem repeat markers (STR) in individuals living in Caracas city, Venezuela. The allele fr...

    journal_title:Forensic science international

    pub_type: 杂志文章

    doi:10.1016/s0379-0738(03)00259-7

    authors: Chiurillo MA,Morales A,Mendes AM,Lander N,Tovar F,Fuentes A,Ramírez JL

    更新日期:2003-09-09 00:00:00

  • The use of fingerprints available on the web in false identity documents: Analysis from a forensic intelligence perspective.

    abstract::Fingerprints present in false identity documents were found on the web. In some cases, laterally reversed (mirrored) images of a same fingerprint were observed in different documents. In the present work, 100 fingerprints images downloaded from the web, as well as their reversals obtained by image editing, were compar...

    journal_title:Forensic science international

    pub_type: 杂志文章

    doi:10.1016/j.forsciint.2016.02.041

    authors: Girelli CM

    更新日期:2016-05-01 00:00:00

  • The recovery of latent fingermarks and DNA using a silicone-based casting material.

    abstract::There are many techniques available for the recovery of fingermarks at scenes of crime including the possibility of taking casts of the marks. Casts can be advantageous in cases where other destructive recovery techniques might not be suitable, such as when recovering finger marks deposited on valued or immobile items...

    journal_title:Forensic science international

    pub_type: 杂志文章

    doi:10.1016/j.forsciint.2008.04.001

    authors: Shalhoub R,Quinones I,Ames C,Multaney B,Curtis S,Seeboruth H,Moore S,Daniel B

    更新日期:2008-07-04 00:00:00

  • Tire traces - discrimination and classification of pyrolysis-GC/MS profiles.

    abstract::Tire traces can be observed on several crime scenes as vehicles are often used by criminals. The tread abrasion on the road, while braking or skidding, leads to the production of small rubber particles which can be collected for comparison purposes. This research focused on the statistical comparison of Py-GC/MS profi...

    journal_title:Forensic science international

    pub_type: 杂志文章

    doi:10.1016/j.forsciint.2012.10.013

    authors: Gueissaz L,Massonnet G

    更新日期:2013-07-10 00:00:00

  • Challenges in the identification of new thermolabile psychoactive substances: The 25I-NBOH case.

    abstract::The continuous emergence of NPS over the last years poses a series of novel challenges for forensic analysts. Most of those new compounds are synthesized with minimal chemical modifications to the structure of already known chemicals in order to avoid regulations. Some of these new compounds may undergo chemical chang...

    journal_title:Forensic science international

    pub_type: 杂志文章

    doi:10.1016/j.forsciint.2020.110306

    authors: Belchior de Andrade AF,Elie M,Weck C,Jardim Zacca J,de Souza MP,Caldas LNB,Gonzalez-Rodriguez J

    更新日期:2020-07-01 00:00:00

  • Fingermark detection on non-porous and semi-porous surfaces using NaYF4:Er,Yb up-converter particles.

    abstract::This article describes the first use of an anti-Stokes material, or up-converter, for the development of latent fingermarks on a range of non-porous surfaces. Anti-Stokes materials can absorb long-wavelength light and emit light at a shorter wavelength. This property is unusual in both natural and artificial materials...

    journal_title:Forensic science international

    pub_type: 杂志文章

    doi:10.1016/j.forsciint.2010.09.020

    authors: Ma R,Bullock E,Maynard P,Reedy B,Shimmon R,Lennard C,Roux C,McDonagh A

    更新日期:2011-04-15 00:00:00

  • Postmortem submersion interval (PMSI) estimation from the microbiome of Sus scrofa bone in a freshwater river.

    abstract::Due to inherent differences between terrestrial and aquatic systems, methods for estimating the postmortem interval (PMI) are not directly applicable to remains recovered from water. Recent studies have explored the use of microbial succession for estimating the postmortem submersion interval (PMSI); however, a non-di...

    journal_title:Forensic science international

    pub_type: 杂志文章

    doi:10.1016/j.forsciint.2020.110480

    authors: Cartozzo C,Simmons T,Swall J,Singh B

    更新日期:2021-01-01 00:00:00

  • Metric characterization of the human coxal bone on a recent Italian sample and multivariate discriminant analysis to determine sex.

    abstract::The ability of human pelvic bones to sexually differentiate has been of great interest in forensic anthropology for quite some time as it allows for the determination of skeletal sex by combining metric and morphological data. However, the criteria for determining the sex of a skeleton must be calibrated according to ...

    journal_title:Forensic science international

    pub_type: 杂志文章

    doi:10.1016/j.forsciint.2012.06.014

    authors: Vacca E,Di Vella G

    更新日期:2012-10-10 00:00:00

  • Instability of calcium channel antagonists during sample preparation for LC-MS-MS analysis of serum samples.

    abstract::1,4-Dihydropyridines calcium channel antagonists (1,4-DHP CCAs) are photolabile and the products of their photodecomposition have no pharmaceutical activity. In our previous work we have presented a screening procedure for eleven 1,4-DHPs in plasma by LC-MS-MS using multiple reaction motoring. The laboratory process i...

    journal_title:Forensic science international

    pub_type: 杂志文章

    doi:10.1016/j.forsciint.2004.11.014

    authors: Baranda AB,Alonso RM,Jiménez RM,Weinmann W

    更新日期:2006-01-06 00:00:00

  • Nutmeg (myristicin) poisoning--report on a fatal case and a series of cases recorded by a poison information centre.

    abstract::In literature, cases of nutmeg abuse have been described repeatedly, but only one fatal case of poisoning was reported [1]. In the present case, myristicin (4 microg/ml) was detected for the first time in the postmortal serum of a 55-year-old woman. Identification was achieved with the aid of UV-VIS spectroscopy and T...

    journal_title:Forensic science international

    pub_type: 杂志文章

    doi:10.1016/s0379-0738(00)00369-8

    authors: Stein U,Greyer H,Hentschel H

    更新日期:2001-04-15 00:00:00