Abstract：
:The continuous emergence of NPS over the last years poses a series of novel challenges for forensic analysts. Most of those new compounds are synthesized with minimal chemical modifications to the structure of already known chemicals in order to avoid regulations. Some of these new compounds may undergo chemical changes during analysis leading to misidentification and detrimental legal consequences. GC-MS is one of the most widely used analytical techniques employed by forensic laboratories all over the world for drug analysis. Nevertheless, thermolabile NPS, such as 25I-NBOH can generate artefacts in the traditional GC-MS analysis. In this paper, we describe the fragmentation mechanism of the 25I-NBOH into a major peak corresponding to 2C-I and a minor one corresponding to the associated ortho-phenolic benzyl ether (o-PBE), which exact identity is directly linked with the solvent used for the analysis. Also, a series of method adjustments is displayed, encompassing variation on the injector temperature, split ratio and flow ratio, although with no success to prevent 25I-NBOH thermo degradation in the GC injector. Furthermore, differential scanning calorimetry and thermogravimetric analysis demonstrated that 25I-NBOH's thermal stability is due to a smaller temperature window between fusion and decomposition points. Finally, we perform derivatization experiments and demonstrate how to overcome 25I-NBOH degradation in the GC/MS analysis.
journal_name
Forensic Sci Intjournal_title
Forensic science internationalauthors
Belchior de Andrade AF,Elie M,Weck C,Jardim Zacca J,de Souza MP,Caldas LNB,Gonzalez-Rodriguez Jdoi
10.1016/j.forsciint.2020.110306subject
Has Abstractpub_date
2020-07-01 00:00:00pages
110306eissn
0379-0738issn
1872-6283pii
S0379-0738(20)30168-7journal_volume
312pub_type
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