Abstract：
:Loss of estrogens or androgens causes bone loss by increasing the rate of bone remodeling, and also causes an imbalance between resorption and formation by prolonging the lifespan of osteoclasts and shortening the lifespan of osteoblasts. Conversely, treatment with androgens, as well as estrogens, maintains cancellous bone mass and integrity, regardless of age or sex. Both androgens, via the androgen receptor (AR), and estrogens, via the estrogen receptors (ERs) can exert these effects, but the relative contribution of these 2 pathways remains uncertain. Androgens, like estrogens, stimulate endochondral bone formation at the start of puberty, whereas they induce epiphyseal closure at the end of puberty, thus, they have a biphasic effect. Androgen action on the growth plate is, however, clearly mediated via aromatization into estrogens and interaction with ER alpha. Androgens increase, while estrogens decrease radial growth. This differential effect of the sex steroids may be important because bone strength in males seems to be determined by higher periosteal bone formation and, therefore, greater bone dimensions. Experiments in mice suggest that both the AR and ER alpha pathways are involved in androgen action on radial bone growth. ER beta may mediate growth-limiting effects of estrogens in the female but does not seem to be involved in the regulation of bone size in males. In conclusion, androgens may protect men against osteoporosis via maintenance of cancellous bone mass and expansion of cortical bone. This androgen action on bone is mediated by the AR and ER alpha.
journal_name
Minerva Endocrinoljournal_title
Minerva endocrinologicaauthors
Lindberg MK,Vandenput L,Movèrare Skrtic S,Vanderschueren D,Boonen S,Bouillon R,Ohlsson Ckeywords:
subject
Has Abstractpub_date
2005-03-01 00:00:00pages
15-25issue
1eissn
0391-1977issn
1827-1634journal_volume
30pub_type
杂志文章,评审abstract：:The major issue currently being faced in the management of prostate cancer is the inability to distinguish between indolent prostate tumors that will not present clinically from more aggressive and metastatic prostate cancers that will impact on men's lives. Only a small proportion of prostate cancers can be accounted...
journal_title：Minerva endocrinologica
pub_type： 杂志文章,评审
doi：
更新日期：2012-06-01 00:00:00
abstract：:The treatment of NIDDM patients with secondary failure to sulfonylureas is still a debated problem. In this study we compared in NIDDM patients with secondary failure to glyburide, the effect of adding a single, low-dose bed time either NPH or ultralent insulin injection (0.15-0.2 U/kg) to the previously ineffective s...
journal_title：Minerva endocrinologica
pub_type： 临床试验,杂志文章,随机对照试验
doi：
更新日期：1996-06-01 00:00:00
abstract：:As it's well known from the clinic, human syndromes depending on pituitary GH, ACTH and PRL secreting tumors are associated with alteration of glucose homeostasis. There is an hypothetical but convincing explanation for this, based on a number of concrete observations and experiments. The main mechanism for glucose in...
journal_title：Minerva endocrinologica
pub_type： 杂志文章,评审
doi：
更新日期：1990-07-01 00:00:00
abstract：:Medullary thyroid carcinoma arises from the C cells, which produce a characteristic hormone, calcitonin. At present, surgery is the main treatment modality. Medullary thyroid carcinoma is usually treated with total thyroidectomy and with removal of nodes in the central portion of the neck and upper mediastinum. Cervic...
journal_title：Minerva endocrinologica
pub_type： 杂志文章,评审
doi：
更新日期：1998-12-01 00:00:00
abstract：BACKGROUND:A limited number of human and animal studies suggest that a relationship exists between phthalates and obesity, although this is not supported by all research. The purpose of this study was to investigate the relationship between Body Mass Index (BMI) and the levels of phthalates in human blood and urine sam...
journal_title：Minerva endocrinologica
pub_type： 杂志文章
doi：10.23736/S0391-1977.16.02295-1
更新日期：2017-03-01 00:00:00
abstract：:To investigate whether inappropriate LH secretion in Polycystic Ovary Syndrome (PCO) was related to a reduction of inhibitory opioid control on the GnRH-LH system, 23 women affected by PCO (12 obese, BMI: 37.1 +/- 3.9 and 11 non obese, BMI: 21.5 + 2.4) and 19 fertile women (10 obese, BMI: 38.8 + 1.8 and 9 non obese, B...
journal_title：Minerva endocrinologica
pub_type： 杂志文章
doi：
更新日期：1992-07-01 00:00:00
abstract：BACKGROUND:This study evaluates the effectiveness of continuous glucose monitoring (CGM) in diabetes patients who were on routine dialysis. METHODS:Literature search was conducted in electronic databases and studies were selected by following precise eligibility criteria. Random-effects meta-analyses were performed to...
journal_title：Minerva endocrinologica
pub_type： 杂志文章
doi：10.23736/S0391-1977.20.03284-8
更新日期：2020-12-03 00:00:00
abstract：BACKGROUND:Polycystic ovary syndrome (PCOS) is a complex endocrine disorder with well-established metabolic abnormalities. In the present study, untargeted metabolomics technology was applied to analyze the serum and follicular fluid samples from women with polycystic ovary syndrome and healthy controls using 1H nuclea...
journal_title：Minerva endocrinologica
pub_type： 杂志文章
doi：10.23736/S0391-1977.20.03199-5
更新日期：2020-10-26 00:00:00
abstract：:The majority of patients with differentiated thyroid cancer are cured with standard primary treatments including surgery, radioactive iodine and TSH suppression. A small proportion of patients who develop radioactive iodine-refractory metastatic disease have few treatment options. Recent discovery of the molecular mec...
journal_title：Minerva endocrinologica
pub_type： 杂志文章,评审
doi：
更新日期：2012-12-01 00:00:00
abstract：:The desire to reproduce is a base human instinct. However, for many individuals, the chances of being able to have a genetic child are compromised by a number of factors. For some, therapies aimed at treating serious medical illness, such as cancer; result in a deleterious impact on the function of eggs and sperm in t...
journal_title：Minerva endocrinologica
pub_type： 杂志文章,评审
doi：10.23736/S0391-1977.17.02666-9
更新日期：2018-03-01 00:00:00
abstract：:We treated with PEI 81 patients carriers of autonomous thyroid nodule, 65 toxic and 16 non toxic, all with undetectable serum TSH and suppressed extranodular tissue on scintigraphy. The treatment schedule was: 1-2 sessions per week, 1-8 ml per session, 3-13 sessions in total, In relation to the size and the therapeuti...
journal_title：Minerva endocrinologica
pub_type： 杂志文章
doi：
更新日期：1993-12-01 00:00:00
abstract：BACKGROUND:Whether Doppler ultrasonography (DU) may be of help in characterizing thyroid nodes is still under debate: both good and unsatisfactory results have been claimed, either in evaluating the presence of malignancy or in identifying hyperfunctional structures. METHODS:In this paper, the scintigraphic and Dopple...
journal_title：Minerva endocrinologica
pub_type： 临床试验,杂志文章
doi：
更新日期：1999-03-01 00:00:00
abstract：:It is known that young female cancer survivors are at higher risk for decreased fertility and early menopause. Because the risk of these outcomes varies by age, cancer type, treatment regimen and other patient-specific characteristics, there is a need for valid tools for measuring and predicting reproductive function ...
journal_title：Minerva endocrinologica
pub_type： 杂志文章,评审
doi：
更新日期：2010-12-01 00:00:00
abstract：:In 51 patients with gastric adenocarcinoma the fasting blood concentrations of hCG, beta hCG, alpha subunits, ADH, calcitonin, enteroglucagon, gastrin, GH, melatonin, somatostatin, estradiol, CEA and pepsinogen I in the peripheral vein were estimated by radioimmunoassay at the time of diagnosis and, in those who under...
journal_title：Minerva endocrinologica
pub_type： 杂志文章
doi：
更新日期：1991-07-01 00:00:00
abstract：:Hyponatremia is common in neurosurgical patients and is associated with significant morbidity and mortality. Despite significant research efforts to date, we still lack a complete understanding of the pathophysiological mechanisms underlying hyponatremia in this patient setting. The purpose of this narrative review is...
journal_title：Minerva endocrinologica
pub_type： 杂志文章,评审
doi：
更新日期：2014-03-01 00:00:00
abstract：:This review concerns the relation between most frequent thyroid gland diseases and diabetes mellitus in adult patients. Special attention is paid to autoimmune thyroiditis, Graves' disease, thyroid autoimmunity in pregnant diabetic women, and iodine metabolism. We focused on mechanisms leading to coexistence of both e...
journal_title：Minerva endocrinologica
pub_type： 杂志文章,评审
doi：
更新日期：2005-12-01 00:00:00
abstract：:Cushing's syndrome is a serious endocrine condition for which no treatment has been proven fully satisfactory at least for its pituitary dependent form (Cushing's disease). Indeed, despite some advances in pharmacology (cyproheptadine, bromocriptine, lisuride) and in surgical and radiation procedures at pituitary leve...
journal_title：Minerva endocrinologica
pub_type： 杂志文章,评审
doi：
更新日期：1990-01-01 00:00:00
abstract：:New-onset diabetes after transplantation (NODAT) or posttransplant diabetes mellitus is a frequent metabolic complication of organ transplantation. Diabetes incidence rates among transplant recipients are higher than in the general population. The estimated rates are 9-18% after kidney, 20-33% after liver, 26-40% afte...
journal_title：Minerva endocrinologica
pub_type： 杂志文章,评审
doi：
更新日期：2012-09-01 00:00:00
abstract：:A 49-year-old man presented with a 6-month history of weight loss, muscular weakness, easy fatigue, impotence, decreased visual acuity, campimetry defects. The results of radiologic and endocrine testing disclosed the presence of pituitary dysfunction due to pituitary stalk section caused by a giant suprasellar aneury...
journal_title：Minerva endocrinologica
pub_type： 杂志文章
doi：
更新日期：1989-10-01 00:00:00
abstract：:Diabetes mellitus (DM) is a group of metabolic disorders of carbohydrate metabolism in which glucose is underutilized, resulting in hyperglycemia. Reproductive impairment in poorly controlled diabetes mellitus type 1 (T1DM) results from a combined effect of insulin deficiency and hyperglycemia that disrupt the functio...
journal_title：Minerva endocrinologica
pub_type： 杂志文章,评审
doi：10.23736/S0391-1977.16.02477-9
更新日期：2017-09-01 00:00:00
abstract：BACKGROUND:The surgical approach to Differentiated Thyroid Carcinoma (DTC) is controversial. Aim of this study is to evaluate the opportunity of total thyroidectomy as treatment of choice for DTC in children. METHODS:We examined the tumor features at diagnosis, the complications of surgery and the clinical outcome in ...
journal_title：Minerva endocrinologica
pub_type： 杂志文章
doi：
更新日期：2000-06-01 00:00:00
abstract：:Sex steroids are essential for reproduction and development in animals and humans, and sex steroids also play an important role in neuroprotection following brain injury. New data indicate that sex-specific responses to brain injury occur at the cellular and molecular levels. This review summarizes the current underst...
journal_title：Minerva endocrinologica
pub_type： 杂志文章,评审
doi：
更新日期：2010-06-01 00:00:00
abstract：BACKGROUND:Mild hypothyroidism (thyroid stimulating hormone [TSH] less than 10 mIU/L) induces reversible cognitive dysfunction, which can be evaluated by event related potentials (ERP). So far, only little is known about the impact of subclinical hypothyroidism on ERP as electrophysiological markers of cognitive activi...
journal_title：Minerva endocrinologica
pub_type： 杂志文章
doi：10.23736/S0391-1977.16.02327-0
更新日期：2017-03-01 00:00:00
abstract：:Subclinical hypothyroidism - i.e., a condition characterized by serum TSH concentrations above the normal reference range in the presence of normal serum T4 levels - affects 4 to 20% of the population living in iodine-sufficient areas. The present work reviews the clinical challenges regarding, on the one hand, the si...
journal_title：Minerva endocrinologica
pub_type： 杂志文章
doi：10.23736/S0391-1977.20.03176-4
更新日期：2020-08-03 00:00:00
abstract：:Very-low-calorie ketogenic diet (VLCKD) is a promising lifestyle intervention for the management of overweight and obesity. It is characterized by a restriction of both calories and carbohydrates, while assuring the adequate proteins, fats and micronutrients intake. Significant results in terms of excess body weight l...
journal_title：Minerva endocrinologica
pub_type： 杂志文章
doi：10.23736/S0391-1977.20.03356-8
更新日期：2020-11-19 00:00:00
abstract：: ...
journal_title：Minerva endocrinologica
pub_type： 杂志文章
doi：10.23736/S0391-1977.18.02852-3
更新日期：2019-03-01 00:00:00
abstract：:The World population is facing a health challenge never seen since the Spanish influenza of one hundred years ago. During the last months, the scientific community has been debating on the potential harmful effect of Angiotensin-converting-enzyme inhibitors (ACEi) or Angiotensin II receptor Type 1 receptor blockers (A...
journal_title：Minerva endocrinologica
pub_type： 杂志文章
doi：10.23736/S0391-1977.20.03402-1
更新日期：2021-01-12 00:00:00
abstract：:Breast cancer is the second most frequent type of cancer worldwide and the most commonly occurring malignancy in women, and its incidence is increasing in most developed and developing countries. There is growing evidence that lifestyle factors, in particular diet may be associated with higher Breast Cancer risk. Some...
journal_title：Minerva endocrinologica
pub_type： 杂志文章
doi：10.23736/S0391-1977.20.03266-6
更新日期：2020-09-24 00:00:00
abstract：:Growth hormone (GH) has been recently approved by the Italian Health Authorities for use in transition patients with childhood onset-growth hormone deficiency (CO-GHD). GH in addition to promote linear growth influences several key metabolic processes. In particular, in the transition period, from late adolescent to e...
journal_title：Minerva endocrinologica
pub_type： 杂志文章,评审
doi：
更新日期：2015-03-01 00:00:00
abstract：BACKGROUND:The aim of this study was to evaluate long-term effectiveness and safety of liraglutide in real world. METHODS:A diabetes clinic in Italy systematically collected data of all patients treated with liraglutide. Generalized hierarchical linear regression models for repeated measures were applied to assess tre...
journal_title：Minerva endocrinologica
pub_type： 杂志文章
doi：
更新日期：2016-03-01 00:00:00
